• Asian-Australasian Journal of Animal Sciences
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• v.27 no.3
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• pp.303-309
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• 2014

The increasing importance of meat quality has implications for animal breeding programs. Research has revealed much about the genetic background of pigs, and many studies have revealed the importance of various genetic factors. Since meat quality is a complex trait which is affected by many factors, consideration of the overall phenotype is very useful to study meat quality. For integrating the phenotypes, we used principle component analysis (PCA). The significant SNPs refer to results of the GRAMMAR method against PC1, PC2 and PC3 of 14 meat quality traits of 181 Duroc pigs. The Genome-wide association study (GWAS) found 26 potential SNPs affecting various meat quality traits. The loci identified are located in or near 23 genes. The SNPs associated with meat quality are in or near five genes (ANK1, BMP6, SHH, PIP4K2A, and FOXN2) and have been reported previously. Twenty-five of the significant SNPs also located in meat quality-related QTL regions, these result supported the QTL effect indirectly. Each single gene typically affects multiple traits. Therefore, it is a useful approach to use integrated traits for the various traits at the same time. This innovative approach using integrated traits could be applied on other GWAS of complex-traits including meat-quality, and the results will contribute to improving meat-quality of pork.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1998.11a
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• pp.197-197
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• 1998

Chronic electroconvulsive shock(ECS) was shown to Increase phosphatidylinositol-4,5-bisphosphate(PIP$_2$) breakdown and the activity of PLC with the accumulation of inositol-1,4,5-triphosphate(IP3). The purpose of the present study was to determine the effect of ECS on the expression of phospholipase C(PLC) isotypes in rat brain. Two groups of animals were prepared: sham and ECS treated groups. Rats in ECS treated groups received maximal ECS(70mA, 0.5second, 60㎐) by constant current stimulator through ear-clip to induce tonic extension seizures for 12 consecutive days. The expression of PLC isotypes in rat brain was determined by immunohistochemical procedure using sagital section of rat brain. The immunoreactivity of PLC${\beta}$1 was observed in corpus striatum, hippocampus, thalamus and that of PLC${\gamma}$1 in corpus striatum, hippocampus, thalamus, frontal cortex, parietooccipital cortex, limbic forebrain, pons, medulla, superior colliculus, inferior colliculus, rest of midbrain. The amount of PLC was analyzed by Western blot using antibodies against PLC${\beta}$1 and PLC${\gamma}$1. Chronic ECS reduced the immunoreactivity of PLC${\beta}$1 in corpus striatum, hippocampus, thalamus but had little effect on PLC${\gamma}$1. To quantify this change, quantitative Western blot using antibodies against PLC${\beta}$1 and PLC${\gamma}$1 was conducted. The immunoreactivity of PLC${\beta}$1 in ECS treated rat whole brain was decreased by 40 % in cytosolic fraction and 26 % in membrane fraction. This different effect of ECS on PLC isotypes may results from the difference of their activation mechanisms and the different effects of ECS on them. The results from the present study suggest that chronic ECS primalily affects neurotransmitter receptors related IP$_3$ signaling in rat brain.

• Journal of the Korea Safety Management & Science
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• v.14 no.2
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• pp.41-48
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• 2012

수공구 사용시 과도한 힘은 작업성 근골격계 질환을 일으킬 수 있는 주요 원인중 하나이다. 이와 관련하여, 수공구 파지시 인체 내부에 부과되는 근력과 외적으로 작용된 힘 간의 비율을 이해하는 것이 중요하며, 이는 근육에 부과되는 과도한 힘을 최소화 시키고, 작업에 필요한 힘의 효율성을 극대화 시키는데 필수적이라 할 수 있다. 이러한 비율과 관련하여 많은 연구가 되어 왔으나, 대부분 수리적 인체역학적 모델과 같은 간접적 추정 방법에 의거하고 있는 실정이다. 이러한 인체역학적 모델을 검증하고 개선하기 위하여 해부용 팔 (cadaver)을 활용한 직접적인 근력과 악력 측정이 필수적이다. 본 연구에서는 이러한 해부용 팔을 이용하여 상지 굴근(hand flexor)을 자동으로 제어하고 근력과 함께 악력을 측정할 수 있는 Hand Motion Simulator를 개발하고, 이를 통하여 다양한 사이즈의 손잡이 파지시 요구되는 근력과 외적으로 적용된 악력을 비교함으로써 수공구 손잡이 사이즈에 따른 근력의 효율성에 대하여 측정을 해 보았다. 또한, 적용된 굴근 (FDP & FDS) 간의 힘 비율에 따른 파지법의 차이를 조사해 보았다. 내부에 주어진 근력은 외부로 작용된 악력보다 5.3배 높은 부하가 작용하였으며 이러한 수공구 손잡이 파지시 힘의 효율성 역시 FDP 와 FDS 간의 비율이 3:2 였을 때, 그리고 손잡이 크기가 작을수록 높은 결과를 보였다. 반대로 손잡이의 크기가 커질수록 힘의 효율성은 저하되었다. 또한, 손가락 관절 각도의 경우 FDP와 FDS간의 비율에 따라 상이한 자세를 나타내었다. FDP 굴근의 비율이 높을 경우 손가락 끝마디 관절 (DIP) 의 굴곡을 보였으며, FDS 굴근 비율이 높을 경우 손가락 두 번째 관절(PIP)의 굴곡을 보였다. 본 연구를 통한 결과는 추후 상지작업자에 대한 근골격계 질환 예방 기준안 마련 및 수공구 설계를 위한 기초자료로 활용이 가능할 것으로 보인다.

• Bulletin of the Korean Chemical Society
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• v.31 no.1
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• pp.75-81
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• 2010

The reaction of N,N-diethyl carbamates of 1H-[1,2,3]triazolo[4,5-b]pyridin-1-ol (4-HOAt) 7, 3H-[1,2,3]triazolo[4,5-b]pyridin-3-ol (7-HOAt) 8, 1H-benzo[d][1,2,3]triazol-1-ol (HOBt) 9, 6-chloro-1H-benzo[d][1,2,3]triazol-1-ol (Cl-HOBt) 10, 6-(trifluoromethyl)-1H-benzo[d][1,2,3]triazol-1-ol ($CF_3$-HOBt) 11, and 6-nitro-1H-benzo[d][1,2,3]triazol-1-ol ($NO_2$-HOBt) 12 with morpholine and piperidine in $CH_3CN$ underwent acyl nucleophilic substitution to give the corresponding carboxamide derivatives. The reactants and products were identified by elemental analysis, IR and NMR. We measured the kinetics of these reactions spectrophotometrically in $CH_3CN$ at a range of temperatures. The rates of morpholinolysis and piperidinolysis were found to fit the Hammett equation and correlated with $\sigma$-Hammett values. The values were 1.44 - 1.21 for morpholinolysis and 1.95 - 1.72 for piperidinolysis depending on the temperature. The $Br{\phi}$nsted-type plot was linear with a $\beta_lg = -0.49 \pm 0.02$ and $-0.67 \pm 0.03$. The kinetic data and structure-reactivity relationships indicate that the reaction of 9-12 with amines proceeds by a concerted mechanism. The deviation from linearity of the correlation ${\Delta}H^#$ vs. ${\Delta}S^#$ and plot of $logk_{pip}$ vs. $logk_{morph}$ and $Br{\phi}$nsted-type correlation indicate that the reactions of amines with carbamates 7 and 8 is attributed to the electronic nature of their leaving groups.

• Journal of Convergence for Information Technology
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• v.8 no.2
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• pp.141-148
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• 2018

The purpose of this paper is to explore the scope of realization of multiple perspectives so that the implementation of the right to be forgotten is more realistic than the ideal information deletion concept. We examined domestic and foreign legal system and technology/service trends, and reflected the classification realization level of service realization, processing type and information characteristics of personal information processor, and legislative/technical factors for multi-level scope analysis. As a result, we have presented a matrix of the range of realization of the right to be forgotten and the scope of diversified regulation by the subject of protection. This study will be extended to the convergence of law and engineering, and will contribute to the prediction of social costs and expansion of the market by identifying the scope of 'deletion rights'.

• The Journal of Society for e-Business Studies
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• v.15 no.1
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• pp.89-101
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• 2010

In some industries, manufacturing firms' distinctive competences include not only product superiority but also service excellence. For example, in a highly volatile and dynamic market, flexibility and responsiveness are more valued than just the product cost. And sales order processing, in that respect is a very important process. However, previous studies on sale order processing have considered only due-date assignments or dealt with production scheduling to minimize production cost or delivery lead time. Due to recent advances in information technology, a new approach is possible in dealing with sales order processing. For example, RFID(Radio Frequency IDentification) and ubiquitous computing technology adds real time visibility and traceability to supply chain. In this study, we develop a new due-date re-negotiation process for sales order management and propose a new business integration model to support the re-negotiation process based on RFID, ubiquitous computing technology and RosettaNet's PIPs.

• The Research Journal of the Costume Culture
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• v.18 no.4
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• pp.741-754
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• 2010

The current study aims to link Korean tradition to modern culture; to re-produce patterns of lotus depicted in Minwha, The study also aims to discover the beauty of Korean tradition and to modernize it. The current study is based upon document searches(including research papers) and the Internet searches. Through these searches, it investigates the concept of Minhwa, the origin of lotus depiction and its symbolic meanings, the traits of such pattern. Based upon this investigation, the study attempts to modernize the patterns of lotus and apply the modernized patterns to designing shirts. The process which employs the lotus patterns illustrated in Minhwa to shirt design includes four sub-processes: selecting, allocating, coloring, and selecting production techniques. The sub- process of selecting patterns is two folded: the first stage covers carbon-copying the distinctive features of lotus, lotus leaf, lotus bud, lotus pip, and lotus stem; the second stage is making these features suitable to shirt sizes. For the process of coloring those shirts, Piccaso's work(Pablo Picasso, 1881~1973) has been selected and the colors in his work have been adopted to dye the rest of the shirts as well as the lotus features. The process of selecting production techniques includes ornament tail in order to modernize the patterns allocated in the shirts. Once these processes are completed, the shirts are made on a scale of real-life size. These processes of creating shirt design by modernizing traditional patterns will hopefully contribute to researchers expanding the domain of shirt design.

• Archives of Plastic Surgery
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• v.34 no.1
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• pp.64-69
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• 2007

Purpose: The key of treatment in syndactyly is to separate the fused digits safely, and to create a normal web space with enough cutaneous coverage. Despite many techniques have described the correction of syndactyly, skin graft still remains the annoying one. We designed the pentagonal flap from hand dorsum to reconstruct the web space reliably and try to minimize the need for skin graft. Methods: Between July 2003 and August 2005, six cases of syndactyly were corrected at UCLA Medical Center and Hallym University Sacred Heart Hospital using dorsal pentagonal flap for web space reconstruction and straight incisions for the sides of digits to minimize the need for skin graft. The proximal edge of the pentagonal flap was designed in V shape to allow for easy closure of the donor site after advancement. The pentagonal flap was advanced volarly with the underlying dermofat tissues to form a digital web. In some cases, skin defects were unavoidable and covered with full thickness skin graft from the inguinal area. Results: Syndactyly were seen in 4 cases of Apert syndrome, 1 postburn scar webbing with PIP joint contracture and 1 recurrence after the incomplete reconstruction. In all Apert syndrome, straight line incision was used along the sides of the fingers and skin graft was needed. But, in 2 cases of incomplete type, we could save the need for skin graft only for the correction of syndactyly. We could get a good looking web space without any complications such as flap or graft loss. Conclusion: As a modification of Sherif's V-Y dorsal metacarpal flap, we believe pentagonal flap could be one of the easiest and safest way to reconstruct the web space of syndactyly in functional and cosmetic standpoint.

• Journal of Chest Surgery
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• v.25 no.5
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• pp.469-479
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• 1992

Searching for the clinical effects of colloid solutions that used to increasing the oncotic pressure of priming solutions at the cardiopulmonary bypass, 29 patients [who were diagnosised as simple VSD around 10kg of body weight and scheduled to be operated from June 1990 to December 1990 at Sejong General Hospital] were divided randomly and prospectively to the two groups: A group [15] was received 4gm% albumin as addition to the priming solutions and B Group [14] the same amount of Ringer`s lactated solution. 34 clinical parameters [Body weight, sex, age, body surface area, Qp/Qs, pulmonary arterial pressure, cardiopulmonary bypass time, anesthetic time, intraoperatively infused crystalloid and colloid amount, hemoglobin, hematocrit, serum sodium concentration, serum osmolarity, urine osmolarity, urine specific gravity, serum concentration, serum osmolarity, urine osmolarity, urine specific gravity, serum protein, serum albumin concentration, urine output, central venous pressure, postoperatively infused colloid amount, immedediate post-operative peak inspiratory pressure, cardiac index, blood pressure and pump flow during cardiopulmonary bypass, inotro-pic assist, diuretics, extubation period, total drain amount, duration of ICU] were measured and compaired between the two groups. There were no differences of preoperative and operative clinical parameters. And postoper-atively, practically there were no nearly differences at the clinical outcomes between the two groups, but some parameters [cardiac index, PIP, BP and pumpflow during CPB, etc] contributed to being preferable to the Group A at certain times [P<0.05]. Conclusively, it might be thought that the priming solution of cardiopulmonary bypass added by colloid solution had some beneficial effects on the patients, especially younger and associated with complex anomaly to be expected taken longer time of cardiopulmonary bypass, and more studies about the neonatal and complex anomaly cases were needed in that points.

• The Journal of the Korea institute of electronic communication sciences
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• v.16 no.5
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• pp.899-908
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• 2021

Since the modern weapon system is composed of a complex system, it is quite difficult to derive the priority of performance improvement factors. In addition, research on the method for prioritizing quantitative performance improvement factors considering the opinions of stakeholders is insufficient. In this study, in order to quantitatively derive the priorities of performance improvement factors for K1 tanks and K2 tanks, a survey was conducted with experts with experience in tank development, and the preface data was analyzed using AHP, scoring method, and TOPSIS methods. As a result, priorities were quantitatively derived. The results of this study are expected to be used as decision-making indicators for stakeholders in the future weapon system development and performance improvement stage.