• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.28 no.12
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• pp.502-508
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• 2016

An optimized PI controller design method is presented to promote the control performance of an oil cooler system for high precision machine tools. First, a transfer function model of the oil cooler system with a variable rotating speed compressor was obtained by the perturbation method as the first order system with a negligible dead time. Then, the closed-loop control system was described as the second order system with a zero. Its dynamic behaviors are mostly governed by characteristic parameters, the damping ratio, and the natural frequency which is incorporated in PI gains. Next, an optimum integral of the time-weighted absolute error (ITAE) criterion was applied to the second order system. The characteristic parameters can be determined by the given design specifications, percent overshoots and settling times and comparisons with the ITAE criterion. Hence, the PI gains were plainly identified in a deterministic way. Finally, the PI gains were fine-tuned to obtain desirable dynamics in real systems, considering the zero effect and parameter variations. The validity of the proposed method was proven by computer simulations and real experiments for selected cases.

• Molecules and Cells
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• v.41 no.6
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• pp.532-544
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• 2018

Gastrointestinal stromal tumours (GIST) are the most common mesenchymal tumors of the gastrointestinal (GI) tract. In order to investigate a new treatment fot GIST, we hypothesized the effect of miR-374b targeting PTEN gene-mediated PI3K/Akt signal transduction pathway on proliferation and apoptosis of human gastrointestinal stromal tumor (GIST) cells. We obtained GIST tissues and adjacent normal tissues from 143 patients with GIST to measure the levels of miR-374b, PTEN, PI3K, Akt, caspase9, Bax, MMP2, MMP9, ki67, PCNA, P53 and cyclinD1. Finally, cell viability, cell cycle and apoptosis were detected. According to the KFGG analysis of DEGs, PTEN was involved in a variety of signaling pathways and miRs were associated with cancer development. The results showed that MiR-374b was highly expressed, while PTEN was downregulated in the GIST tissues. The levels of miR-374b, PI3K, AKT and PTEN were related to tumor diameter and pathological stage. Additionally, miR-374b increased the mRNA and protein levels of PI3K, Akt, MMP2, MMP9, P53 and cyclinD1, suggesting that miR-374b activates PI3K/Akt signaling pathway in GIST-T1 cells. Moreover, MiR374b promoted cell viability, migration, invasion, and cell cycle entry, and inhibited apoptosis in GIST cells. Taken together, the results indicated that miR-374b promotes viability and inhibits apoptosis of human GIST cells by targeting PTEN gene through the PI3K/Akt signaling pathway. Thus, this study provides a new potential target for GIST treatment.

• The Korean Journal of Physiology and Pharmacology
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• v.24 no.5
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• pp.423-431
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• 2020

This study aimed to evaluate the effect of curcumin on brain hypoxic-ischemic (HI) damage in neonatal rats and whether the phosphoinositide 3-kinase (PI3K)/Akt/vascular endothelial growth factor (VEGF) signaling pathway is involved. Brain HI damage models were established in neonatal rats, which received the following treatments: curcumin by intraperitoneal injection before injury, insulin-like growth factor 1 (IGF-1) by subcutaneous injection after injury, and VEGF by intracerebroventricular injection after injury. This was followed by neurological evaluation, hemodynamic measurements, histopathological assessment, TUNEL assay, flow cytometry, and western blotting to assess the expression of p-PI3K, PI3K, p-Akt, Akt, and VEGF. Compared with rats that underwent sham operation, rats with brain HI damage showed remarkably increased neurological deficits, reduced right blood flow volume, elevated blood viscosity and haematocrit, and aggravated cell damage and apoptosis; these injuries were significantly improved by curcumin pretreatment. Meanwhile, brain HI damage induced the overexpression of p-PI3K, p-Akt, and VEGF, while curcumin pretreatment inhibited the expression of these proteins. In addition, IGF-1 treatment rescued the curcumin-induced down-regulated expression of p-PI3K, p-Akt, and VEGF, and VEGF overexpression counteracted the inhibitory effect of curcumin on brain HI damage. Overall, pretreatment with curcumin protected against brain HI damage by targeting VEGF via the PI3K/Akt signaling pathway in neonatal rats.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.222-222
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• 2007

RF circuit을 구현하는데 있어서 기판의 전기적 특성을 정확하게 아는 것은 원하는 결과를 추출하기 위해 매우 중요하다. 본 연구에서는 현재 사용되고 있는 PI 기판의 전기적인 특성인 유효 유전율과 loss tangent 값을 T-resonator률 이용해 정확하게 측정하고자 했다. T-resonator는 microstrip 구조로 구현 되었으며 conductor material은 Cu를 사용하였다. PI 기판의 두께는 25um, Cu의 두께는 PI 기판의 종류에 따라 12um 와 18um, T-resonator line width는 50um로 구현하였다. 또한 공진 주파수에 따라 stub 길이가 다른 10개의 T-resonator를 제작하였다. PI 기판의 유효 유전율을 구하기 위해 stub 길이의 open-end effect와 T-junction effect를 고려하였으며 수식을 통해 정확한 유효 유전률을 추출하였다. 또한 PI 기판의 loss tangent 추출에 필요한 dielectric loss를 추출하기 위해 unload quality factor를 분석하였다. Unload quality factor는 dielectric loss, conductor loss, radiation loss를 구성되며 conductor loss와 radiation loss를 수식에 의해 구하고 dielectric loss를 추출 하였다. 추출 된 dielectric loss를 통해 각각의 T-resonator의 loss tangent 값을 구하였다. T-resonator를 이용한 PI 기판의 측정은 비교적 복잡한 수식에 의해 이루어지지만 정확한 data를 얻을 수 있고 다른 재료의 전기적 특성을 추출하는데 응용이 가능하다.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.210-210
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• 2007

RF circuit을 구현하는데 있어서 기판의 전기적 특성을 정확하게 아는 것은 매우 중요하다. 왜냐하면 초고주파로 갈수록 기판의 전기적인 특성이 circuit에 많은 영향을 미치고 이러한 영향을 고려한 circuit를 설계해야 원하는 결과를 얻을 수 있기 때문이다. 본 연구에서는 현재 사용되고 있는 PI 기판의 전기적인 특성인 유효 유전율과 loss tangent 값을 캐패시터를 이용해 정확하게 측정하고자 했다. 캐패시터의 conductor material은 Cu를 사용하였고 PI 기판의 투께는 25um 를 이용하였다. PI 기판의 유효 유전율은 캐패시터 측정에 의한 data률 EM simulation tool 을 통해 분석한 후 간단한 수식에 의해 구했다. 또한 PI 기판의 loss tangent 값을 구하기 위해 캐패시터의 dissipation factor를 분석하였다. 캐패시터의 dissipation factor는 dielectric loss, AC 저항에 의한 loss, DC 저항에 의한 loss를 포함한다, DC 저항에 의한 loss는 dissipation factor에 차지하는 비율이 낮기 때문에 생략이 가능하다. 하지만 AC 저항에 의한 loss는 주파수에 비례하여 값이 커지게 된다. 따라서 주파수가 올라 갈수록 dissipation factor도 상승하게 되는데 주파수의 전 대역에서 AC 저항에 의한 loss를 보정해주면 dielectric loss를 얻을 수 있다. 추출된 dielectric loss를 통해 PI 기판의 loss tangent 값을 구하였다. 캐패시터를 이용한 PI 기판의 전기적 특성 추출은 간단한 구조를 통해 얻을 수 있기 때문에 다른 재료의 기판의 전기적 특성을 추출하는데도 이용이 용이하다.

• Journal of the Korean Ceramic Society
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• v.56 no.1
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• pp.71-76
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• 2019

Monochromatic amber phosphor in glasses (PiGs) for automotive LED applications were fabricated with $YAG:Ce^{3+}$, $CaAlSiN_3:Eu^{2+}$ phosphors and Pb-free silicate glass. After synthesis and thickness-thinning process, PiGs were mounted on high-power blue LED to make monochromatic amber LEDs. PiGs were simple mixtures of 566 nm yellow YAG, 615 nm red $CaAlSiN_3:Eu^{2+}$ phosphor and transparent glass frit. The powders were uniaxially pressed and treated again through CIP (cold isostatic pressing) at 200 MPa for 20 min to increase packing density. After conventional thermal treatment at $550^{\circ}C$ for 30 min, PiGs were applied by using GPS (gas pressure sintering) to obtain a fully dense PiG plate. As the phosphor content increased, the density of the sintered body decreased and PiGs containing 30 wt% phosphor had full sintered density. Changes in photoluminescence spectra and color coordination were investigated by varying the ratio of $YAG/CaAlSiN_3$ and the thickness of the plates. Considering the optical spectrum and color coordinates, PiG plates with $240{\mu}m$ thickness showed a color purity of 98% and a wavelength of about 605 nm. Plates exhibit suitable optical characteristics as amber light-converting material for automotive LED applications.

• Journal of Integrative Natural Science
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• v.15 no.3
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• pp.131-136
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• 2022

Cell migration is essential for diverse cellular processes including wound healing, immune response, development, and cancer metastasis. Pi3-kinase (PI3K) is a key regulator for actin cytoskeleton and phosphorylates phosphatidylinositol (4,5)-diphosphate (PIP2) to phosphatidylinositol (3,4,5)-trisphosphate (PIP3). High levels of PIP3 by PI3Ks are associated with increased levels of F-actin and pseudopod extension at the leading edge of migrating cells such as neutrophils and Dictyostelium. LY294002 is a well-known PI3K specific inhibitor. Here, we investigated the effect of LY294002 on cell migration. First, we evaluated the appropriate concentration of dimethyl sulfoxide (DMSO) for using as a solvent for LY294002. DMSO is a highly polar organic reagent and one of the most common solvent for organic and inorganic chemicals. Cell morphology and cell migration were unaffected at the concentrations less than 0.1 % DMSO. Therefore, stock solution of LY294002 was prepared so that the final concentration of DMSO was 0.1 % or less when treated. When cells were treated with LY294002, cell migration was increased in a concentration-dependent manner. The maximum speed was detected in the presence of 30 µM LY294002. These results suggest that PI3Ks play a inhibitory role in regulating cell migration in our experimental conditions.

• Journal of the Korea Society of Computer and Information
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• v.16 no.10
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• pp.101-109
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• 2011

The Riemann's zeta function $\zeta(s)$ has been known as answer for a number of primes $\pi$(x) less than given number x. In prime number theorem, there are another approximation function $\frac{x}{lnx}$,Li(x), and R(x). The error about $\pi$(x) is R(x) < Li(x) < $\frac{x}{lnx}$. The logarithmic integral function is Li(x) = $\int_{2}^{x}\frac{1}{lnt}dt$ ~ $\frac{x}{lnx}\sum\limits_{k=0}^{\infty}\frac{k!}{(lnx)^k}=\frac{x}{lnx}(1+\frac{1!}{(lnx)^1}+\frac{2!}{(lnx)^2}+\cdots)$. This paper shows that the $\pi$(x) can be represent with finite Li(x), and presents generalized prime counting function $\sqrt{{\alpha}x}{\pm}{\beta}$. Firstly, the $\pi$(x) can be represent to $Li_3(x)=\frac{x}{lnx}(\sum\limits_{t=0}^{{\alpha}}\frac{k!}{(lnx)^k}{\pm}{\beta})$ and $Li_4(x)=\lfloor\frac{x}{lnx}(1+{\alpha}\frac{k!}{(lnx)^k}{\pm}{\beta})}k\geq2$ such that $0{\leq}t{\leq}2k$. Then, $Li_3$(x) is adjusted by $\pi(x){\simeq}Li_3(x)$ with ${\alpha}$ and error compensation value ${\beta}$. As a results, this paper get the $Li_3(x)=Li_4(x)=\pi(x)$ for $x=10^k$. Then, this paper suggests a generalized function $\pi(x)=\sqrt{{\alpha}x}{\pm}{\beta}$. The $\pi(x)=\sqrt{{\alpha}x}{\pm}{\beta}$ function superior than Riemann's zeta function in representation of prime counting.

• Bulletin of the Korean Chemical Society
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• v.34 no.6
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• pp.1913-1916
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• 2013

• Proceedings of the Korean Institute of Industrial Safety Conference
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• 2003.05a
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• pp.390-395
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• 2003

PMSM 드라이브의 벡터제어를 위한 속도제어기는 일반적으로 PI 알고리즘을 사용한다.［1］PI 알고리즘에서는 플랜트의 동적 특성을 동정하기 위하여 연속적인 측정이 가능한 플랜트 파라미터의 자동동조 또는 적응 알고리즘을 추가하여 사용하기도 한다. 그러나 PI 제어기는 플랜트의 변동이 발생하여 연속적으로 적응추종을 해야할 경우, 계산이 매우 복잡하고 응답특성이 저하된다.(중략)