• Title/Summary/Keyword: pi

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Roles of PI3K and Rac Pathways in H-ras Induced Invasion and Motility

  • Ilchung Shin;Kim, Seonhoe;Aree Moon
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.144-144
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    • 2003
  • Phosphatidylinositol 3-kinase (PI3K) and Rac play important roles that regulate cellular functions including cell survival and .migration. In the present study, we investigated the functional roles of PI3K and Rac1 pathways in H-ras-induced invasive phenotype and motility of MCF10A cells.(omitted)

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A PI-PD Controller Design for Position Control of an IPMSM (IPMSM의 위치제어를 위한 PI-PD 제어기 설계)

  • Jang, Ju-Hyeong;Kim, Sang-Hoon
    • Proceedings of the KIPE Conference
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    • 2016.11a
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    • pp.97-98
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    • 2016
  • 본 논문은 위치, 속도, 전류 제어기들이 직렬로 연결된 전동기 구동시스템에서 속도 제어기를 사용하지 않는 위치 제어를 위한 PI-PD 제어기 설계법을 제안한다. 기존의 PI-PD 위치 제어기 설계법과 달리 제안된 제어기의 설계법은 위치 제어기의 대역폭에 따라 이득 값을 설정할 수 있다. 제안된 위치 제어기 설계 성능을 검증하기 위해 IPMSM 구동시스템에서 실험을 통해 유효성을 확인하였다.

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Studies on the Availability of Marine Bacteria and the Environmental Factors for the Mass Culture of the High Quality of Rotifer and Artemia 1. Change of Fatty Acid and Amino Aicd Composition During Cultivation of Rotifer, Brachionus plicatilis by Marine Bacteria Erythrobacter sp. $S\;\pi-I$ (고품질의 Rotifer와 Artemia의 생산을 위한 해양세균 이용과 대량생산에 따른 환경인자에 관한 연구 1. Erythrobacter sp. $S\;\pi-I$에 의한 Rotifer, Brachionus plicatilis의 배양시 지방산과 아미노산 조성의 변화)

  • LEE Won-Jae;PARK You-Soo;PARK Young-Tae;KIM Sung-Jae;KIM Kwang-Yang
    • Korean Journal of Fisheries and Aquatic Sciences
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    • v.30 no.3
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    • pp.319-328
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    • 1997
  • To develop a beneficial microbial feed for the cultivation of rotifer, Brachionus plicatilis, an aerobic photosynthetic bacterium, Erythrobacter sp. $S\;\pi-I$ was isolated from marine structure at Haeundae beach in Pusan, Korea. Feeding effects of Erythrobacter sp. $S\;\pi-I$ on the growth of rotifer were analyzed comparing to other feeds such as PSB (purple nonsulfur bacteria), Chlorella sp. and baker's yeast. Erythrobacter sp. $S\;\pi-I$ contained more linoleic acid $(C_{18:3\omega3})$ and oleic acid $(C_{18:1\omega9})$ and amino acids than PSB (purple nonsulfur bacteria), Chlorella sp. and baker's yeast. The rotifer fed on Erythrobacter sp. $S\;\pi-I$ showed better effects than those fed on other feeds in the individual growth, size and weight. Also, the rotifer especially contained more eicosapentaenoic acid $(C_{20:5\omega3})$ and docosahexaenoic acid $(C_{22:6\omega3})$ in case of Erythrobacter sp. $S\;\pi-I$ feeding than the other feeds. In case of the feed of PSB and baker's yeast docosahexaenoic acid $(C_{22:6\omega3})$ did not show. In amino acid analysis, the rotifer fed on Erthrobacter sp, $S\;\pi-I$ showed more amino acid content comparing to those fed on other diets. Especially, arginine, isoleucine, histidine, lysine, methionine, phenylalanine, threonine, which are essential amino acid for fish growth, showed high contents. These results suggested that the aerobic photosynthetic bacterium, Erythrobacter sp. $S\;\pi-I$ would be a beneficial microbial teed for the cultivation of rotifer.

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Design of a Neural Network PI Controller for F/M of Heavy Water Reactor Actuator Pressure (신경회로망과 PI제어기를 이용한 중수로 핵연료 교체 로봇의 구동압력 제어)

  • Lim, Dae-Yeong;Lee, Chang-Goo;Kim, Young-Baik;Kim, Young-Chul;Chong, Kil-To
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.13 no.3
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    • pp.1255-1262
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    • 2012
  • Look into the nuclear power plant of Wolsong currently, it is controlled in order to required operating pressure with PI controller. PI controller has a simple structure and satisfy design requirements to gain setting. However, It is difficult to control without changing the gain from produce changes in parameters such as loss of the valves and the pipes. To solve these problems, the dynamic change of the PI controller gain, or to compensate for the PI controller output is desirable to configure the controller. The aim of this research and development in the parameter variations can be controlled to a stable controller design which is reduced an error and a vibration. Proposed PI/NN control techniques is the PI controller and the neural network controller that combines a parallel and the neural network controller part is compensated output of the controller for changes in the parameters were designed to be robust. To directly evaluate the controller performance can be difficult to test in real processes to reflect the characteristics of the process. Therefore, we develope the simulator model using the real process data and simulation results when compared with the simulated process characteristics that showed changes in the parameters. As a result the PI/NN controller error and was confirmed to reduce vibrations.

Soluble Polyimide Binder for Silicon Electrodes in Lithium Secondary Batteries (리튬이차전지 실리콘 전극용 용해성 폴리이미드 바인더)

  • Song, Danoh;Lee, Seung Hyun;Kim, Kyuman;Ryou, Myung-Hyun;Park, Won Ho;Lee, Yong Min
    • Applied Chemistry for Engineering
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    • v.26 no.6
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    • pp.674-680
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    • 2015
  • A solvent-soluble polyimide (PI) polymeric binder was synthesized by a two-step reaction for silicon (Si) anodes for lithium-ion batteries. Polyamic acid was first prepared through ring opening between two monomers, bicyclo[2,2,2]oct-7-ene-2,3,5,6-tetracarboxylic dianhydride (BCDA) and 4,4-oxydianiline (ODA), followed by condensation reaction. Using the synthesized PI polymeric binder (molecular weight = ~10,945), the coating slurry was then prepared and Si anode was fabricated. For the control system, Si anode based on polyvinylidene fluoride (PVDF, molecular weight = ~350,000) having the same constituent ratio was prepared. During precycling, PI polymeric binder revealed much improved discharge capacity ($2,167mAh\;g^{-1}$) compared to that of using PVDF polymeric binder ($1,740mAh\;g^{-1}$), while the Coulombic efficiency of two systems were similar. PI polymeric binder improved the cycle retention ability during cycles compared to that of using PVDF, which is attributed to an improved adhesion property inside Si anode diminishing the dimensional stress during Si volume changes. The adhesion property of each polymeric binder in Si anode was confirmed by surface and interfacial cutting analysis system (SAICAS) (Si anode based on PI polymeric binder = $0.217kN\;m^{-1}$ and Si anode based on PVDF polymeric binder = $0.185kN\;m^{-1}$).

Theoretical Studies on Orbital Interactions and Conformation of ${\alpha}$-Substituted Acetones (${\alpha}$-치환 아세톤의 궤도간 상호작용과 형태에 관한 이론적 연구)

  • Ikchoon Lee;Kiyull Yang;Wang Ki Kim;Byung Hoo Kong;Byung Choon Lee
    • Journal of the Korean Chemical Society
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    • v.30 no.1
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    • pp.9-18
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    • 1986
  • MNDO and STO-3G calculations were performed to determine relative stabilities of rotamers for ${\alpha}$-substituted acetones, $CH_2XCOCH_3$, X = F, Cl, OH, SH, and $NH_2$. It was found that rotamers corresponding to gauche forms are preferred for all the ${\alpha}$-substituents except for X = F and NH$_2$, for which the cis forms were the preferred ones. The stability of gauche form was dictated by the stabilizing two-orbital-two-electron interaction ${\sigma}_{cx}$-${\pi}_{co}^*$, operating uniquely in the gauche form due to the substantial vicinal overlap and energy gap narrowing between ${\sigma}_{cx}$ and ${\pi}_{co}^*$ orbitals. The energy gap narrowing was caused by the lowering of ${\pi}_{co}^*$ level due to the hyperconjugative ${\sigma}_{cx}^*$-${\pi}_{co}^*$ interactions; the red shift in the n-${\pi}^*$ transition was another effect of the relatively large ${\sigma}_{cx}^*$-${\pi}_{co}^*$ splitting. Various ${\sigma}-{\pi}$ interactions in the gauche form were found to be stronger in the third-row hetero atom system, X = Cl and SH. Interactions between nonbonding orbital on N, $n_N$ and vicinal C-C ${\sigma}$ bond were shown to be stronger in the trans than in the cis orientation.

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The Legal Issues of Private Investigation Service in WTO/FTA System : Study of South Korea (WTO/ FTA 체제에서 민간조사업의 법적문제)

  • Ko, Ji-Hoon;Park, Hyeon-Ho
    • Korean Security Journal
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    • no.27
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    • pp.161-195
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    • 2011
  • As crimes have increased to an extent that the police cannot cope with, there have been continuous discussions for the introduction of Private Investigation (hereafter PI) in Korea. However, attempts to legislate for the introduction of PI have failed every time PI bills for the introduction of PI were proposed. This was fundamentally because arguments both for and against the introduction of PI were sharply divided depending on the priorities. However, regardless of those clash of views, an apparent need for the legislation of PI service has arisen. As Korea opens its service market to other countries through GATS and FTAs, currently existing domestic PI law has been found to be inconsistent with international agreements such as GATS and KOREA-US(KORUS) FTA. This paper found that the Act on Usage and Protection of Credit Information which regulates PI service is inconsistent with the Article 12.4(a)(i) and (iii) of KORUS FTA and the Article 7.11 and the Article 7.13 of KOREA-EU FTA. If Korea does not modify the existing laws and establish new laws in relation to PI, such inconsistencies could lead to international trade disputes which could amount to billions of dollars. In this regard, the passage of the PI bill is necessary.

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Entertainers' Conceptual Perception and Behavioral Pattern on their "Positive Influence" ('선한 영향력'에 관한 엔터테이너들의 개념 인식과 발현 양태)

  • Kim, Jeong-Seob
    • Journal of Korea Entertainment Industry Association
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    • v.14 no.4
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    • pp.199-209
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    • 2020
  • "Positive Influence(PI)" of popular star has recently emerged as a social concern, but the lack of prior research has led to confusion over its concept and range of activity. On this point, this study carried out to lay the groundwork for discussions on the systematization of related theories, focused on identifying the current situations by analyzing articles for 15 months from January 2019 to March 2020 when related reports were in full swing. As a result of the analysis of the remarks from the entertainers mentioned in the articles, they were not clearly aware of the concept while doing good deeds under the name of PI in light of the study outcome by Aegean and Singer(2013). The motivations for good deed were classified into six types, including difficulty empathy, fandom reward, participation urge, nidana emphasis, experience subjugation, and memory evocation in the order of frequency of cases. Specific behaviors of PI were followed by donations of money and valuables for 54.4 percent, participation of social agendas for 14.0 percent, volunteering for 13.2 percent, joining campaign for 11.4 percent, other good deeds for 4.0 percent, and philanthropy for 3.0 percent. In occupational analysis, the concentration of donations was also evident. Their activities in the fields of human rights sensitivity, environmental protection and self-management, which are expected to have great effects with their influence, have been extremely poor. The results of the study first require academia to establish a interdisciplinary concept for PI. It also suggests that entertainers and their agencies should take far more strategic approach to evolve the PI event in a way that utilizes the advantages of each job group, such as actors, singers and comedians, and expands the diversity of areas.

A PI Control Algorithm with Zero Static Misadjustment for Tracking the Harmonic Current of Three-Level APFs

  • He, Yingjie;Liu, Jinjun;Wang, Zhaoan;Zou, Yunping
    • Journal of Power Electronics
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    • v.14 no.1
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    • pp.175-182
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    • 2014
  • Tracking harmonic current quickly and precisely is one of the keys to designing active power filters (APF). In the past, the current state feedback decoupling PI control was an effective means for three-phase systems in the current control of constant voltage constant frequency inverters and high frequency PWM reversible rectifiers. This paper analyzes in detail the limitation of the conventional PI conditioner in the APF application field and presents a novel PI control method. Canceling the delay of one sampling period and the misadjustment for tracking the harmonic current is the key problem of this PI control. In this PI control, the predictive output current value is obtained by a state observer. The delay of one sampling period is remedied in this digital control system by the state observer. The predictive harmonic command current value is obtained by a repetitive predictor synchronously. The repetitive predictor can achieve better predictions of the harmonic current. By this means, the misadjustment of the conventional PI control for tracking the harmonic current is cancelled. The experiment results with a three-level NPC APF indicate that the steady-state accuracy and dynamic response of this method are satisfying when the proposed control scheme is implemented.

Odorant Stimulation Promotes Survival of Rodent Olfactory Receptor Neurons via PI3K/Akt Activation and Bcl-2 Expression

  • Kim, So Yeun;Yoo, Seung-Jun;Ronnett, Gabriele V;Kim, Eun-Kyoung;Moon, Cheil
    • Molecules and Cells
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    • v.38 no.6
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    • pp.535-539
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    • 2015
  • Olfactory stimulation activates multiple signaling cascades in order to mediate activity-driven changes in gene expression that promote neuronal survival. To date, the mechanisms involved in activity-dependent olfactory neuronal survival have yet to be fully elucidated. In the current study, we observed that olfactory sensory stimulation, which caused neuronal activation, promoted activation of the phosphatidylinositol 3'-kinase (PI3K)/Akt pathway and the expression of Bcl-2, which were responsible for olfactory receptor neuron (ORN) survival. We demonstrated that Bcl-2 expression increased after odorant stimulation both in vivo and in vitro. We also showed that odorant stimulation activated Akt, and that Akt activation was completely blocked by incubation with both a PI3K inhibitor (LY294002) and Akt1 small interfering RNA. Moreover, blocking the PI3K/Akt pathway diminished the odorantinduced Bcl-2 expression, as well as the effects on odorant-induced ORN survival. A temporal difference was noted between the activation of Akt1 and the expression of Bcl-2 following odorant stimulation. Blocking the PI3K/Akt pathway did not affect ORN survival in the time range prior to the increase in Bcl-2 expression, implying that these two events, activation of the PI3K pathway and Bcl-2 induction, were tightly connected to promote post-translational ORN survival. Collectively, our results indicated that olfactory activity activated PI3K/Akt, induced Bcl-2, and promoted long term ORN survival as a result.