• 동의생리병리학회지
• /
• 제28권2호
• /
• pp.223-232
• /
• 2014

Most of salivary cortisol are an unbound free form reflecting physiological function later. Thus, it is used frequently to evaluate the HPA-Axis and physiological function. Although the needs of salivary cortisol measurement in Korean Medicine is higher and higher, there are not many studies, because the reliability of salivary cortisol measurement is not high. To make the reliability high and encourage to use it in Korean Medicine, the goal of this study is to suggest the standard method of saliva collecting for cortisol measurement through the review of previous studies using salivary cortisol and to encourage to use it in clinical fields in Korean Medicine. The results are as followed; First, salivary cortisol has many benefits, i. e. easy collecting, non-invasive collecting, and reflecting the physiological function. Second, the collecting time and method are kept sternly, because the methods of saliva collecting vary depending on the goal of study. Third, the specific tools for saliva collecting are recommended to prevent contamination. In conclusion, if the standard methods of saliva collecting is kept to measure salivary cortisol, it would be very useful in many fields of Korean Medicine.

• The Korean Journal of Physiology and Pharmacology
• /
• 제4권4호
• /
• pp.271-274
• /
• 2000

• Journal of Nutrition and Health
• /
• 제33권5호
• /
• pp.556-565
• /
• 2000

• 고려인삼학회:학술대회논문집
• /
• 고려인삼학회 2002년도 학술대회지
• /
• pp.113-116
• /
• 2002

• 한국산학기술학회논문지
• /
• 제15권3호
• /
• pp.1448-1457
• /
• 2014

평균수명이 연장되면서 노인인구비율 증가와 함께 각종 노인성 질환이 증가하고 있다. 노인성 질환을 대상으로 한약재를 이용한 치료적 접근위주의 연구는 시도되고 있으나, 건강관리 차원에서 예방적 접근방법으로 한방건강 음료로서의 한방차에 대한 연구는 미미한 실정이다. 본 연구는 노인요양시설을 이용하는 노인을 대상으로 한방차의 섭취가 생리적 기능과 행동변화에 미치는 효과를 확인하기 위한 비동등성 대조군 전후 설계의 유사 실험연구이다. 대상자는 실험군 20명, 대조군 18명으로 총 38명이었다. 2013년 5월부터 6월까지 1회 100ml씩, 일 3회, 30일간 본 연구에서 개발한 한방차를 적용하였고, 양자분석기로 생리적 기능을, 구조화된 설문지로 행동변화를 측정하였다. 수집된 자료는 SPSS/WIN 18.0 프로그램을 이용하여 분석하였다. 분석 결과 실험군에서 생리적 기능 중 혈류순환(t=-4.466, p<.001), 간기능(t=-2.855, p=.007), 뇌기능(t=-2.545, p=.015), 골밀도(t=-6.125, p<.001), 혈당(t=-4.180, p=<.001)과 행동변화의 하위지수인 정서적 요인(t=2.389, p=.023)에서 유의한 변화가 나타났다. 따라서 노인의 생리적 기능 향상과 정서적 안정에 긍정적인 효과가 나타난 한방차의 음용은 노인요양시설에서 노인 건강을 위한 효과적인 중재 방법으로 활용될 수 있다고 사료된다.

• Journal of Korean Biological Nursing Science
• /
• 제17권3호
• /
• pp.219-227
• /
• 2015

Purpose: This study was conducted to review physiological mechanisms of internet addiction and to construct a theoretical framework for cognitive behavioral therapy for internet addicts. Methods: We searched for relevant literature in the PubMed and RISS databases using the terms "internet addiction", "internet game addiction", "internet abuser", and "online game". Only English, full-text articles published from 2000 to 2015 were included in this review of physiological indicators of internet addiction. Finally, 12 articles were selected for review. Results: The theoretical framework developed based on the review proposes that excessive internet use itself may induce physiological stress responses with an increase of stress-related hormones and neurotransmitters. Prolonged abnormal responses of these physiological features produce negative structural and functional changes in the prefrontal cortex, which is mainly involved in cognitive and executive functions. These changes may result in decreased cognitive function. As a stressor, excessive internet use leads to transforming voluntary use into involuntary, habitual use and thus promotes the development of internet addiction. Conclusion: The proposed theoretical framework encompasses cognitive processes that may contribute to the effects of internet use-induced physiological stress on internet addiction. We believe that this framework has important implications for developing cognitive behavioral strategies for internet addicts.

• Journal of Mechanical Science and Technology
• /
• 제17권2호
• /
• pp.296-309
• /
• 2003

The periodicity of the physiological flow has been the major interest of analytic research in this field up to now Among the mechanical forces stimulating the biochemical reaction of endothelial cells on the wall, the wall shear stresses show the strongest effect to the biochemical product. The objective of present study is to find the effects of velocity waveform on the wall shear stresses and pressure distribution along the artery and to present some correlation of the velocity waveform with the clinical observations. In order to investigate the complex flow phenomena in the bifurcated tube, constitutive equations, which are suitable to describe the rheological properties of the non-Newtonian fluids, are determined, and pulsatile momemtum equations are solved by the finite volume prediction. The results show that pressure and wall shear stresses are related to the velocity waveform of the physiological flow and the blood viscosity. And the variational tendency of the wall shear stresses along the flow direction is very similar to the applied sinusoidal and physiological velocity waveforms, but the stress values are quite different depending on the local region. Under the sinusoidal velocity waveform, a Newtonian fluid and blood show big differences in velocity. pressure, and wall shear stress as a function of time, but the differences under the physiological velocity waveform are negligibly small.

• 한국의류산업학회지
• /
• 제7권1호
• /
• pp.75-80
• /
• 2005

The purpose of this study was to investigate the effects of silt ventilation system on physiological responses. We measured rectal temperature, local skin temperature, clothing microclimate, blood pressure, heart rate, energy metabolism, body weight loss and subjective sensation during 70 minute, 50 min exercise period and 20 min rest period. The five women subjects randomly wore sportswear without slit ventilation system(NS sportswear) and sportswear with slit ventilation system(S sportswear) under the environmental condition of $25^{\circ}C$, 50%RH. The results of this study are as follows; Rectal temperature, mean skin temperature, clothing microclimate, blood pressure, heart rate, energy metabolism and body weight loss were significantly lower level in 'S sportswear'. In 'S sportswear', subjects replied less hot, less uncomfortable and less wet. Slit ventilation system can be used for bellow effect which is meaningful device of convection during exercise. We could find out that 'S sportswear' has advantage in physiological function.

• The Korean Journal of Physiology
• /
• 제24권1호
• /
• pp.131-144
• /
• 1990

It is well known that the atrial natriuretic peptide (ANP) has a prepro-hormone of 151 amino-acids which loses their hydrophobic signal peptide to form 126 amino acid prohormone. The whole prohormone is released and then cleaved by proteases into more than one circulating forms. Recently, Winters et al. (1988a, b) reported that high concentrations of N-terminal fragments of prepro-ANP $(26{\sim}55),\;(56{\sim}92)\;and\;(104{\sim}123)$ were detected in human plasma. However, their physiological roles have not been established. The present study was conducted to determine whether the N-terminal fragments of pro-ANP have any effect on the renal function and to compare the effect with those of G-terminal fragments of pro-ANP The results indicate that intrarenal arterial infusions of prepro-ANP $(26{\sim}41),\;(26{\sim}55),\;(56{\sim}92)\;and\;(104{\sim}123)$ induced no significant changes in renal function. Whereas ${\alpha}-human$ ANP $(prepro-ANP,\;124{\sim}151)$ and pro-ANP caused a significant increase in urine volume, renal plasma flow, glomerular filtration rate, urinary excretions of sodium, chloride and potassium, and fractional excretion of sodium. These results suggest that the N-terminal fragments of pro-ANP are ineffective, while the C-terminal fragments retain the natriuretic and diuretic activities.

• 대한의생명과학회지
• /
• 제20권2호
• /
• pp.49-55
• /
• 2014

RalBP1 is an ATP-dependent non-ABC transporter, responsible for the major transport function in many cells including many cancer cell lines, causing efflux of glutathione-electrophile conjugates of both endogenous metabolites and environmental toxins. RalBP1 is expressed in most human tissues, and is over-expressed in non-small cell lung cancer cell lines and in many other tumor types. Blockade of RalBP1 by various approaches has been shown to increase sensitivity to radiation and chemotherapeutic drugs, leading to cell apoptosis. In xenograft tumor models in mice, RalBP1 blockade or depletion results in complete and sustained regression across many cancer cell types including lung cancer cells. In addition to its transport function, RalBP1 has many other cellular and physiological functions, based on its domain structure which includes a unique Ral-binding domain and a RhoGAP catalytic domain, as well as docking sites for multiple signaling proteins. Additionally, RalBP1 is also important for stromal cell function in tumors, as it was recently shown to be required for efficient endothelial cell function and angiogenesis in solid tumors. In this review, we discuss the cellular and physiological functions of RalBP1 in normal and lung cancer cells.