• Title/Summary/Keyword: physical damage

Search Result 1,257, Processing Time 0.025 seconds

A Study on Traveling Characteristics and Evaluation about Noise of Hydraulic Turbine Dynamo in Dam (댐 수차 발전기 소음의 전달특성과 평가에 관한 연구)

  • Yun, Jae-Hyun;Kook, Jung-Hoon;Kim, Jae-Soo
    • Journal of Korean Society of Environmental Engineers
    • /
    • v.30 no.7
    • /
    • pp.705-711
    • /
    • 2008
  • In case of the domestic condition, as the initiating from Sumjin River Dam, total 14 units of multipurpose dams had been constructed in 1965 for the roles of flood control, waterpower generation, irrigation, water supply, industrial water supply. In the case of such multipurpose dam, it produces electric energy by converting the potential energy utilizing its head and quantity of the water into kinetic energy. However, in this process, since during the time when the turbine connected to the hydraulic turbine dynamo revolves and there occurs a loud noise, it brings the physical, mental bad influences to those people also a decline of an effective working efficiency. On such point of view, after selection of various 16 measurement points, this study has measured and analyzed the travelling characteristics of noise generated at the hydraulic turbine dynamo in Daechung Dam, and also has evaluated the degree of indoor noise using the evaluation index such as PSIL, NC. As the result of noise-evaluation, in case of Daechung Dam, since the noise damage grade appears very seriously at various spaces, it is considering that its soundproof measure would be necessitated keenly. Also, it is considered that such data could be utilized as the valuable material hereafter for establishment of an efficient noise-reduction countermeasure and a comfortable working environment for the hydraulic turbine dynamo plant.

Nanopharmaceutical Approach for Enhanced Anti-cancer Activity of Betulinic Acid in Lung-cancer Treatment via Activation of PARP: Interaction with DNA as a Target -Anti-cancer Potential of Nano-betulinic Acid in Lung Cancer-

  • Das, Jayeeta;Samadder, Asmita;Das, Sreemanti;Paul, Avijit;Khuda-Bukhsh, Anisur Rahman
    • Journal of Pharmacopuncture
    • /
    • v.19 no.1
    • /
    • pp.37-44
    • /
    • 2016
  • Objectives: This study examined the relative efficacies of a derivative of betulinic acid (dBA) and its poly (lactide-co-glycolide) (PLGA) nano-encapsulated form in A549 lung cancer cells in vivo and in co-mutagen [sodium arsenite (SA) + benzo[a]pyrene (BaP)]-induced lung cancer in mice in vivo. Methods: dBA was loaded with PLGA nanoparticles by using the standard solvent displacement method. The sizes and morphologies of nano-dBA (NdBA) were determined by using transmission electron microscopy (TEM), and their intracellular localization was verified by using confocal microscopy. The binding and interaction of NdBA with calf thymus deoxyribonucleic acid (CT-DNA) as a target were analyzed by using conventional circular dichroism (CD) and melting temperature (Tm) profile data. Apoptotic signalling cascades in vitro and in vivo were studied by using an enzyme-linked immunosorbent assay (ELISA); the ability of NdBA to cross the blood-brain barrier (BBB) was also examined. The stage of cell cycle arrest was confirmed by using a fluorescence-activated cell-sorting (FACS) data analysis. Results: The average size of the nanoparticles was ~ 110 nm. Confocal microscopy images confirmed the presence of NdBA in the cellular cytoplasm. The bio-physical properties of dBA and NdBA ascertained from the CD and the Tm profiles revealed that NdBA had greater interaction with the target DNA than dBA did. Both dBA and NdBA arrested cell proliferation at G0/G1, NdBA showing the greater effect. NdBA also induced a greater degree of cytotoxicity in A549 cells, but it had an insignificant cytotoxic effect in normal L6 cells. The results of flow cytometric, cytogenetial and histopathological studies in mice revealed that NdBA caused less nuclear condensation and DNA damage than dBA did. TEM images showed the presence of NdBA in brain samples of NdBA fed mice, indicating its ability to cross the BBB. Conclusion: Thus, compared to dBA, NdBA appears to have greater chemoprotective potential against lung cancer.

A Study of Burn Accidents in Children towards Developing a Program for Prevention (어린이 화상사고의 실태와 예방대책 프로그램 개발에 대한 연구)

  • Han, Jeong-Seok;Seo, Mi-Hye
    • The Korean Nurse
    • /
    • v.36 no.4
    • /
    • pp.61-74
    • /
    • 1997
  • This study is a descriptive study which was done to examine the circumstances surrounding burn accidents in children in order to develop a burn prevention program. The subjects for the study were the mothers of 107 children admitted to two burn specialty hospitals in seoul and the mothers of 172 healthy children attending day care or kindergarten. The tool used in the study was developed by the researchers, pretested and refined. Cronbach's alpha was 0.72. Data collection was done between November 1995 and April 1996. Statistically analysis was done using SAS Version 6.04 and the data was analyzed using test, chi square, regression and logistic analysis. A suumary of the results shows the following : Eighty percent of the children in both groups lived in nuclear families but comparatively more of the children with burn accidents lived in apartments. More of the parents in the group of healthy children had university education and held white collar or professional jobs, while the parents of the children with burn accidents were slightly younger than the parents of the healthy children. but not significantly younger. A significantly greater number of families of children with burn accidents had more than one child and the characteristics of the children with burn accidents that they were more frequently boys, either first or last born and very active. Most of the burn accidents occurred in fall or winter. sometime between noon and midnight and the majority occurred in the home and were caused by hot liquid. In 86% of the cases emergency care was not given at home but the child was brought to the hospital emergency unit. Most of the burns were second degree or greater. involved the arms or legs. required admission, and 41.5% occurred when the parents were preparing or eating meals. In a test of knowledge of preventive measures, the mothers of children who had suffered burn accidents scored slightly higher than the mothers who had no experience with burn accidents, but this was not statistically significant. As to what to do in the case of a fire, the mothers of the healthy children had more knowledge about who to notify. but 70% of the mothers in both groups did not know how to escape from the house if it was of fire. 80 to 96% did not know what do to in case of a fire, such as rolling if clothes were on fire. 80% did not know what emergency care to give for a burn, and 74 to 87% did not know when it is appropriate to try to put out a fire. It can be concluded from this study that. since the results show that the most frequent situation which resulted in burn accidents was when the parents were not aware of the danger of burns or were not paying attention to the child. and when there were no protective devices to prevent burns. and that accidents most frequently occurred at home. the most effective way of preventing accidents is to develop in the parents a "safety mind", Since burn accidents in children are usually more severe than in adults. the physical. emotional. psychological and social damage is greater. In order to develop and awareness of this in the general public. the use of mass media. books and pamphlets and other educational media that provide education on prevention of burn accidents need to be utilized.

  • PDF

Development of a Drainage System to Mitigate Moisture Damage for Bridge Deck Pavements (교면포장의 수분손상 저감을 위한 체류수 배수공법 개발)

  • Lee, Hyun-Jong;Kim, Hyung-Bae;Seo, Jae-Woon
    • International Journal of Highway Engineering
    • /
    • v.9 no.2 s.32
    • /
    • pp.129-140
    • /
    • 2007
  • A major purpose of this study is to develop a drainage system that can quickly drain water penetrated into pavement layers to mitigate pot holes which is one of the major distress types in bridge deck pavements. This system can be established by applying a thin drainage layer between waterproof and pavement layers. The most important elements for this system are the performance of waterproof layer and construction technique for the thin drainage layer. The porous asphalt mix with the maximum aggregate size of 10mm is first developed based on the porous asphalt mix design guide proposed by NCAT, and various physical and mechanical tests are performed to confirm that the porous mix satisfies all the specification requirements. In addition, a series of laboratory tests including low-temperature bending and bonding strength tests for the MMA(Methyl Methacrylate) type of waterproofing material. It is observed from the tests that the MMA material satisfies all the specification requirements. To evaluate the Reld performance of the drainage system, a field study has been conducted on a relatively small size bridge. The QC/QA tests are conducted on the both waterproofing and pavement materials. It has been found that the drainage system works well to drain the water penetrated into the pavement layers.

  • PDF

Effect of Packaging Methods on Postharvest Quality of $Tah$ $Tasai$ Chinese Cabbage ($Brassica$ $campestris$ var. $narinosa$) Baby Leaf Vegetable (어린잎 채소 다채의 포장방법이 품질에 미치는 영향)

  • Lee, Jung-Soo;Lee, Youn-Suk
    • Food Science and Preservation
    • /
    • v.19 no.1
    • /
    • pp.1-6
    • /
    • 2012
  • The effect of the packing methods for enhancing the shelf life and improving the postharvest quality of the $tah$ $tasai$ Chinese cabbage baby leaf vegetable was studied during storage. Fresh baby leaf vegetables were packed in four commercial packaging types: (1) a non-perforated bag with a 0.03-mm oriented polypropylene (OPP) film; (2) a perforated bag with 1.0-mm-diameter holes on an OPP film; (3) a 0.40-mm polyethylene terephthalate (PET) container with a hinged lid; and (4) an expanded polystyrene (EPS) tray wrapped with a 0.02-mm polyvinyl chloride (PVC) film. The quality parameters, such as the weight loss, moisture content change, color difference, and appearance of the baby leaf vegetables were investigated. The baby leaf vegetables in the PET container and in the non-perforated OPP film bag showed relatively low weight loss, high moisture content, and good external appearance compared to those in the EPS tray and in the perforated OPP film bag during limited storage periods, at $16^{\circ}C$. The PET container also protected the baby leaf vegetables from physical damage. The study results will enable the selection of a better packaging system for extending the freshness and increasing the market ability of baby leaf vegetables.

Constructing the Forest Fire Extinguishment Helicopter Management System by Integrating GPS and GIS (GPS와 GIS를 통합한 산불진화 헬기 관리시스템 구축)

  • Jo, Myung-Hee;Kim, Joon-Bum;Jo, Yun-Won;Shin, Dong-Ho
    • Journal of the Korean Association of Geographic Information Studies
    • /
    • v.6 no.1
    • /
    • pp.48-58
    • /
    • 2003
  • Recently in order to extinguish the large scale of forest fire efficiently and rapidly the forest fire extinguishment equipment such as helicopters and vehicles has been mobilized. In this situation, the most consideration for the effective extinguishment is to understand the forest fire surrounding area and situation very well and arrange and manage the extinguishment equipment timely. In this paper, the client/serve-based forest fire extinguishment helicopter management system was constructed by integrating GPS(global positioning system) and GIS(geographic information system) technologies. This system manages and considers not only extinguishment equipment information such as helicopters and vehicles including manpower arrangement but also extinguishment environment information such as storing reservoir status and road situation and so on. For this, the real time tracking of helicopter location was first acquired through GPS technology then all the information about forest fire surrounding area was offered through the user-friendly interface of GIS concept. The result of constructing this system helps to extinguish a large scale of forest fire rapidly and effectively within shorter time then reduces physical damage and much manpower mobilization.

  • PDF

Cellular Toxic Effects and Action Mechanisms Of 2,2', 4,6,6'-Pentachlorobiphenyl

  • Kim Sun-Hee;Shin Kum-Joo;Kim Dohan;Kim Yun-Hee;Ryu Sung Ho;Suh Pann-Ghill
    • 한국생물공학회:학술대회논문집
    • /
    • 2004.07a
    • /
    • pp.1-20
    • /
    • 2004
  • Polychlorinated biphenyls (PCBs), one a group of persistent and widespread environmental pollutants, have been considered to be involved in immunotoxicity, carcinogenesis, and apoptosis. However, the toxic effects and physical properties of a PCB congener are dependent on the structure. In the present study, we investigate the toxic effects and action mechanisms of PCBs In cells. Among the various congeners tested, 2,2',4,6,6'-PeCB-pentachlorobiphenyl (PeCB), a highly ortho-substituted congener having negligible binding affinity for aryl hydrocarbon receptor (AhR), caused the most potent toxicity and specific effects in several cell types. 2,2',4,6,6'-PeCB induced apoptotic cell death of human monocytic cells, suggesting that PCB-induced apoptosis may be linked to immunotoxicity. In addition, 2,2',4,6,6'-PeCB induced mitotic arrest by interfering with mitotic spindle assembly in NIH3T3 fibroblasts, followed by genetic instability which triggers p53 activation. Which suggests that 2,2',4,6,6'-PeCB may be involved in cancer development by causing genetic instability through mitotic spindle damage. On the other hand, 2,2',4,6,6'-PeCB increased cyclooxygenase-2 (COX-2) involved in cell survival through ERK1/2 MAPK and p53 in Rat-1 fibroblasts and mouse embryonic fibroblasts, triggering compensatory mechanism for abating its toxicity. Taken together, these results demonstrate that PCB congeners of different structure have distinct mechanism of action and 2,2',4,6,6'-PeCB causes several toxicity as well as compensatory mechanism in cells.

  • PDF

Performance Evaluation of Recycled Aggregate Concrete Made of Recycled Aggregate Modified by Carbonation (탄산화 개질 순환 골재를 사용한 순환 골재 콘크리트의 성능 평가)

  • Ha, Jung-Soo;Shin, Jin-Hak;Chung, Lan;Kim, Han-Sic
    • Journal of the Korea Concrete Institute
    • /
    • v.28 no.4
    • /
    • pp.445-454
    • /
    • 2016
  • With the increase of decrepit facilities, construction waste increased to a certain level and now the increase is more or less stabilized. Yet construction waste still constitutes the largest portion of the overall wastes. Also, it is inevitable to spend a huge amount of the national budget due to the aggravating shortage of aggregate caused by prohibition on collection of natural aggregates as well as due to the damage to the land and environment caused by development of the sources of aggregates. As a countermeasure to the situation, the Ministry of Land, Infrastructure and Transport promulgated the quality standard for recycled aggregate to manage the usage of recycled aggregate according to its quality. But use of recycled aggregate for the purpose of high added value still remains nominal. Therefore, this research aims to study the applicability of recycled aggregate concrete as structural concrete by evaluating the quality improvement effects and the performance of the recycled aggregate concrete including recycled fine aggregate and recycled coarse aggregate that have undergone carbonation for 4 days and 14 days respectively in the condition of 60% RH, 20% $CO_2$ and $20^{\circ}C$ temperature, suggested for carbonation modifying from the advance research. The result shows carbonation modify contributed to quality improvement with 0.91% decrease in absorption rate for recycled fine aggregate and 0.7% decrease in absorption rate for recycled coarse aggregate. The physical properties and durability of the recycled aggregate made of aggregate modified by carbonation showed results similar to general concrete, which confirmed the possibility of applying the recycled aggregate made of recycled aggregate modified by carbonation to structural concrete.

Application of Au-Sn Eutectic Bonding in Hermetic Rf MEMS Wafer Level Packaging (Au-Sn 공정 접합을 이용한 RF MEMS 소자의 Hermetic 웨이퍼 레벨 패키징)

  • Wang Qian;Kim Woonbae;Choa Sung-Hoon;Jung Kyudong;Hwang Junsik;Lee Moonchul;Moon Changyoul;Song Insang
    • Journal of the Microelectronics and Packaging Society
    • /
    • v.12 no.3 s.36
    • /
    • pp.197-205
    • /
    • 2005
  • Development of the packaging is one of the critical issues for commercialization of the RF-MEMS devices. RF MEMS package should be designed to have small size, hermetic protection, good RF performance and high reliability. In addition, packaging should be conducted at sufficiently low temperature. In this paper, a low temperature hermetic wafer level packaging scheme for the RF-MEMS devices is presented. For hermetic sealing, Au-Sn eutectic bonding technology at the temperature below $300{\times}C$ is used. Au-Sn multilayer metallization with a square loop of $70{\mu}m$ in width is performed. The electrical feed-through is achieved by the vertical through-hole via filled with electroplated Cu. The size of the MEMS Package is $1mm\times1mm\times700{\mu}m$. By applying $O_2$ plasma ashing and fabrication process optimization, we can achieve the void-free structure within the bonding interface as well as via hole. The shear strength and hermeticity of the package satisfy the requirements of MIL-STD-883F. Any organic gases or contamination are not observed inside the package. The total insertion loss for the packaging is 0.075 dB at 2 GHz. Furthermore, the robustness of the package is demonstrated by observing no performance degradation and physical damage of the package after several reliability tests.

  • PDF

Analysis of the Maximum Pressure Difference of PSI(pound per square inch) depending on the Size of the Y-shape Connecting Tube of the Automatic Contrast Medium Injector (CT 검사 시 조영제 자동주입기 Y자 연결관의 크기에 따른 PSI(pound per square inch)의 차이 분석)

  • Kim, Hyeon-jin;Im, In-chul
    • Journal of the Korean Society of Radiology
    • /
    • v.11 no.4
    • /
    • pp.247-252
    • /
    • 2017
  • Radiologists who experience extravasation of the contrast medium even once suffer mentally during testing due to the fear of its reoccurrence. Establishing a plan for preventing it beforehand is necessary above all because patients experience severe physical and mental pain and become distrusting of medical staff and treatment. Therefore, the present study attempts to prevent extravasation, which is the result of damage from pressure applied to the patient's blood vessels, by lowering PSI, and conducted a comparative analysis of PSI changes during contrast medium injection depending on the diameter of the Y-shape connecting tube which connects the automatic injector and the intravenous injection of the patient. In the case of product A in which the diameter of the Y-shape connecting tube is about 2mm, the average PSI for all ages was 98.5 and standard deviation was 9.72. In the case of product B in which the diameter of the Y-shape connecting tube is about 3mm, the average PSI for all ages was 62.0 and standard deviation was 8.59. Product B with its wider diameter decreased in average pressure by 37.05% when compared to product A, and when product B is used with the p-value at 0.00, pressure decreased even more, achieving statistically significant results.