Proceedings of the Korean Society of Applied Pharmacology
/
2005.11a
/
pp.49-66
/
2005
Panax ginseng has been useful for the treatment of diverse disease in oriental countries for thousands of years. In addition, a folk medicine prescribed by seven herbal drugs including Panax ginseng has been antinarcotics in the treatment of morphine-dependent patients. Many articles have been reported on these works. Therefore, we review the protective effects of Panax ginseng on the neurotoxicity induced by abuse drugs. Ginseng total saponins (GTS) extracted and isolated by Panax ginseng antagonized Morphine-induced analgesia, and inhibited the development of analgesic tolerance to and physical dependence on morphine. GTS inhibited morphine-6 dehydrogenase, which catalyzes production of mophinone from morphine, and increased hepatic glutathione level responsible to toxicity. Therefore, we hypothesized that these dual actions of ginseng can be associated with the detoxication of morphine. In addition, the inhibitory or facilitated effects of GTS on electrically evoked contraction in guinea pig ileum ($\mu$-receptors) and mouse vas deferens($\delta$-receptors) were not mediated through opioid receptors, suggesting non-opioid mechanisms. On the hand, antagonism of U-50,488H ($\kappa$-agonist)-induced antinociception is mediated by serotonergic mechanisms. GTS also inhibited hyperactivity, reverse tolerance (sensitization) and conditioned place preference-induced by psychostimulants such as methamphetamine, cocaine and morphine. On the other hand, GTS reduced the dopamine levels induced by methamphetamine. Moreover, GTS blocked the development of dopamine receptor activation, showing antidopaminergic effect. We suggest that GTS Prevent the methamphetamine-induced striatal dopaminergic neurotoxicity. In addition, Ginsenoside also attenuates morphine-induced cAMP signaling pathway. These results suggested that GTS might be useful for the therapy of the adverse actions of drugs with abuse liability.
Purpose: This study was conducted in order to investigate the level of intimate partner violence (IPV), beliefs and attitudes toward IPV and depression in victims of IPV and to identify factors influencing their depression. Methods: This was a descriptive study using a questionnaire. The Woman Abuse Screening Tool was used for examination of IPV, and the tool developed by Saunders, Lynch, Grayson & Linz(1987) and Haj - Yahia (2003) was used for examination of beliefs and attitudes toward IPV. The CES -D Scale was used for evaluation of depression. Results: A total of 172 victims were recruited. The level of IPV was low ($1.36{\pm}0.30$ out of 3) and the level depression was mild depression ($11.57{\pm}11.30$, out of 60). Beliefs and attitudes toward IPV were not positive (2.51 out of 5). A significant relationship was observed between beliefs and attitudes toward IPV, level of IPV and depression. Factor influencing depression was physical abuse, and that was explained by 13.5% (F=3.600, p=.001). Conclusion: According to these results, depression was a significant symptom in victims of IPV, therefore, health care providers should recognize depression as a significant indicator of IPV and should evaluate women with depression regarding their experience with IPV.
Purpose: The purpose of this study was to examine the personal, family, and community factors that affect addictive behavior of adolescents. Methods: This study was conducted using a descriptive survey design. Subjects included 398 adolescents in three middle schools and four high schools located in three cities. Data were obtained from these subjects between July 11 and July 19, 2013 using self-report questionnaires. Analysis of the data was performed using the SPSS 19.0 program. Results: Of the participants, 62.0% were included in the non-addictive group, and 38.0% in the risk for addictive behavior group. Significant factors related to addictive behavior includes eight personal factors: alcohol consumption, sexual experience, suicidal ideation, experience of being a runaway, time spent using the smartphone, and time management skills; five family factors: physical abuse by parents, parental alcohol abuse, parental rearing attitudes [the type of rearing attitude among emotional warmth, rejection, and overprotection]; and two community factors: number of peers who practice risk behavior and relationship with peers. Conclusion: Based on the outcomes of this study, it is suggested that a school health program to decrease adolescent addictive behavior should consider personal, family, and community factors.
Purpose: The purpose of this study was to determine the relationship between customer contact service and mental health among Korean taxi drivers. Methods: This was a secondary analysis of data collected from the 2015 Korean Working Conditions Survey. The sample included 496 taxi drivers in South Korea. The effect of customer contact service on mental health was analyzed using logistic regression analysis. The independent variables were general characteristics, working conditions, and hazardous factors in interactive service. Results: The prevalence of poor mental health was 56.3%. Taxi drivers experienced emotional involvement (17.2%), hiding feeling (32.0%), and contact with angry clients (18.3%) in their job. During the first month of their work, 33.7% experienced verbal abuse and 12.3% threats/humiliating behaviors. In bivariate analysis, verbal abuse, threats/humiliating behaviors, and physical violence were associated with mental health of taxi drivers. Multiple logistic regression analysis revealed 'emotional involvement' and 'contact with angry clients' were significant predictors of mental health. Conclusion: The findings of this study may be useful in developing intervention programs to improve the mental health of taxi drivers in South Korea.
Objective : The objective of this study was to examine the association between childhood adversity and parenting attitude and neuroticism in adulthood. Methods : Forty nine women were recruited from community and completed Early Trauma Inventory-Short Form (ETI-SF). We compared scores on the Maternal Behavior Research Instrument (MBRI), Neuroticism of NEO Personality Inventory (NEO-PI), and Beck Depression Inventory (BDI) between women with and without childhood adversity. Results : Compared to women without childhood adversity, women with childhood adversity showed more rejecting parenting attitude and higher Depression and Self-Consciousness scores on Neuroticism domain of NEO-PI. Total ETI-SF scores and emotional abuse scores were positively correlated with rejecting attitude scores on the MBRI and BDI scores. Physical abuse scores were positively correlated with rejecting attitude scores. There were positive correlations between rejecting attitude scores on the MBRI, Neuroticism scores on the NEO-PI, and BDI scores. Conclusion : Our results suggest that childhood adversity may have a negative impact on parenting attitude and emotional state in adulthood. For girls who experienced traumatic event, early intervention is needed to prevent the development of neurotic temperament and rejecting parenting in adulthood.
Purpose: This study was done to develop a web-based education program for nurses working in nursing homes. The focus was on the rights of older adults. Methods: The program was designed based on the Network-Based Instructional System Design (NBISD) model and was operated and evaluated between July 2007 and June 2008. Results: Out of nursing records of 40 residents from a nursing home, the final 7 cases were deducted through classification using the Resource Utilization Group (RUG)-III. The data on needs for education was collected from 28 nurses working in 15 nursing homes located in Seoul and Gyeonggi Province, who agreed to complete a self-report questionnaire. A comprehensive review of the literature and two focus groups interviews were used to search for risk factors and guidelines for protection of human rights. The education program was developed based on Kolb's experiential learning model and composed of 5 units, which included content on types of human rights and rights to death with dignity, elder abuse, physical liberty, and self-determination. The program was positively evaluated showing a score of 3.35 (SD=0.37) out of 4. Conclusion: The educational program developed in this study should promote nurses' sensitivity to the rights of elders and improve nurses' behaviors in protecting the rights of elders residing in nursing homes.
Purpose: This study aimed to identify the relationship between the experiences of workplace violence and post-traumatic stress disorder and the moderating effect of resilience and social support at work on the relationship in tertiary hospital nurses. Methods: This was a descriptive correlation study to confirm the moderating effect of resilience and social support at work on the factors affecting post-traumatic stress disorder for nurses who have experienced violence. A total of 146 registered nurses were recruited from a tertiary hospital from March to July 2020. The Participants who worked for more than one year and experienced violence at work completed self-reported questionnaires that measured the experiences of workplace violence and post-traumatic stress disorder, resilience, social support at work, and demographic information. The collected data were analyzed using t-test, ANOVA, Pearson's correlation coefficient, and hierarchical regression analysis. Results: The nurses experienced verbal abuse an average of 3.70±2.06 times a week, physical threat an average of 2.30±1.71 times a month, and physical assault an average of 0.76±0.82 times a year. The Experiences of workplace violence were significantly increased post-traumatic stress disorder. The result also showed that resilience moderated the relationship between the experience of verbal abuse and post-traumatic stress disorder in hospital nurses. However, there was no significant moderating effect of social support between workplace violence and post-traumatic stress disorder. Conclusion: The experiences of workplace violence influenced post-traumatic stress disorder in nurses and were moderated by resilience. Therefore, hospital administrators need to develop and provide a workplace violence prevention and resilience reinforcement program to reduce post-traumatic stress disorder in nurses. In addition, we suggest further research on the effect of social support in a workplace on the experiences of violence.
The purpose of this study is to provide fundamental data supporting facilitation of a formal health education performed by school nurses as health educators. To evaluate the teacher expertise of school nurses as health educators, this study analyzed the present status of health education and the recognition of self-confidence in teaching ability of school nurses. Self addressing questionnaire were mailed out to 340 secondary school nurses in Seoul and out of them 244 nurses (71.8%) responded to the survey. Analysis of the data was made using t-test and ANOVA in SAS program. The major results are as follows : 1. The total health instruction performance rate was 84.6% (204). Regular health instruction was carried out by 66 nurses and the rest of the 155 subjects gave irregular instruction on health education. 2. Regular health education classes was offered as a part of physical education class hour by 89.4% of the respondents whereas only 10.6% of them had formal health education classes. The survey showed that irregular health education classes were mainly held in physical education class hours (70.3%) and 14.8% had opportunities for additional classes on health education. 3. The average class for regular health education was 5 hours per week but for irregular health education classes were only one hour per semester (32.9%). 4. Among the 11 categories of health education, education on drug abuse and body structure and function and physical development occupied 95.6%, 69.6% respectably while physical training, family health, social health occupied 10.8%, 12.7%. 5. Health education was given much more at public schools (88.2%) than at private schools. 6. 232 (95.0%) school nurses agreed with the necessity of formalizing health education classes and 227 (93.1%) wanted to change their status from school nurses to formal health teachers. 7. There is a tendency to change the status from school nurse to formal health teacher, and the necessity of having a formal curriculum on health education while less recognized by the older and longer-careered nurses was more recognized by those nurses with higher education. 8. The lack of administrative support (79.5%), work burden (77.9%), and lack of teaching competency (22.1%) were the greatest problems. 9. Education on drug abuse was stressed the most whereas physical training was most neglected. 10. There is a tendency that older and longer-careered school nurses thought less positively of their status, and then 98 (81.1%) school nurses acknowledged themselves as professional teachers. 11. 176 (72.5%) school nurses agreed with the necessity of continuing education : health knowledge and teaching skills for formal health teachers. 12. 179 (73.8%) school nurses had a positive attitude and undergraduate preparation and the practice of professional health teachers. 13. The school nurses had self-confidence in their teaching competence, teaching strategies and knowledge in all 11 health education areas.
The purpose of this study is to examine the utility of the modified form of CTS2(the revised Conflict Tactic Scales) for use of children on university students fo Korea. To attain this purpose, we modified Straus's CTS2(the revised Conflict Tactic Scale) for use of children. It consist of negotiation subscale, physical assault subscale, psychological aggression subscale and injury subscale without sexual coercion subscale. The subjects consisted of 288 students from 19 to 24 of age. As results of analysis(correlation, factor analysis, Cronbach' α), reliability of subscales of CTS2 range from .83 to .98 and total reliability of CTS2 is .93 And there are evidences of construct validity(the convergent validity and discriminant validity) fo CTS2. we examine the prevalence of wife abuse behavior in our subjects' parents. There are the high prevalence of psychological aggression(75.7%) and physical assault(43.4%)
Purpose: The purpose of this study were to explore workplace violence experiences and to analyze differences of violence experiences based on the department and harmers to nurses in hospitals. Method: Data were collected from the self-reported survey of 496 nurses and nurse aids in three hospitals in D area in Korea from April to May in 2007. The data were analyzed by descriptive statistics and logistic regression analysis using SPSS Win 12.0. Result: The nurses in hospitals experienced offensive verbal abuse (88.4%), verbal threat (36.5%), physical violence (24.5%), serious physical violence (2.2%), and sexual harrassment (25.7%) during last one year in hospitals. Nursing staffs in hospital demonstrated different violent experiences by age and service areas. Conclusion: These findings revealed high rates of violence experiences of nursing staffs in hospital. Thus, hospitals should develop policies, guidelines, and programs for preventing and managing workplace violence.
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