• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2013년도 추계학술대회
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• pp.283-285
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• 2013

피부의 관리를 위한 방법 중 광을 이용한 케어는 비침습적인 방법으로 세포를 활성화 시켜 도움을 주는 매우 유용한 방법이다. 최근에는 낮은 에너지의 LED를 광원으로 이용하는 LLLT (Low Level Light Therapy)가 많이 적용이 된다. 본 논문에서는 피부 미용기기에서 많이 사용되고 있는 가시광 영역의 적색과 황색, 그리고 적외선 영역의 LED를 이용하여 array를 제작하였다. 제작된 LED array는 5V의 전압과 50mA의 전류로 구동되며, 적색이 평균 $10.7mW/cm^2$, 황색이 평균 $1.8mW/cm^2$, 적외선이 평균 $5.5mW/cm^2$의 광출력을 갖는다. 이를 배양된 human cell plate에 각각 10, 20, 40분의 시간으로 조사하였으며, LED array와 조사면 사이에 20 mm의 거리를 두어 균일한 광량이 조사 될 수 있도록 하였다. 실험결과, wound healing의 경우는 적색광을 조사하였을 때, injury line의 길이가 $604.36{\mu}m$에서 10분 조사 시 $368.92{\mu}m$, 20분 조사 시 $298.04{\mu}m$, 40분 조사 시 $491.22{\mu}m$로 줄어드는 효과를 보였으며 특히 20분간 조사하였을 경우의 효과가 가장 좋았다. Cell regeneration의 경우는 황색광을 20분간 조사하였을 경우에 UV 에 의해 손상된 세포 수가 가장 크게 줄어드는 것을 확인할 수 있었다. 결과적으로 photorejuvenation 효과를 줄 수 있는 wound healing과 cell regeneration에는 적색 및 황색광의 LED array를 20분간 조사하였을 때가 가장 효과적이었으며, 적외광의 경우에는 모든 실험에서 효과가 없음을 확인할 수 있었다.

• Medical Lasers
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• 제8권1호
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• pp.13-18
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• 2019

Background and Objectives High-intensity focused ultrasound (HIFU) can produce small zones of thermal damage. A HIFU procedure is non-invasive and it can achieve rejuvenation of facial skin. Fractional CO₂ laser resurfacing delivers thermal damage to the pixilated columnar zone of the skin and so evoke collagen remodeling, the same as HIFU. In many cases, the patients who want rejuvenation with HIFU are also good candidates for cutaneous photorejuvenation such as can be accomplished via fractional CO₂ resurfacing. If patients are treated in a single session by remodeling both the superficial and deep compartments of skin by using both modalities, then improvement in rhytides and tightening of sagging skin will optimize the aesthetic result. Materials and Methods Between May 2014 and January 2018, a total of 44 patients were treated with combination HIFU and fractional CO₂ laser resurfacing according to our protocol. First, the HIFU was applied to the entire face with an average of 300 treatment lines. Immediately after HIFU treatment, the ultrasound gel was washed off and then fractional CO₂ laser resurfacing was performed. We evaluated the patients using 4-point grading scales. The clinician examined the skin for evidence of complications after the completion of treatment. Results All the patients' skin quality showed improvement. Further. the clinical results after duel modality treatment were substantially better than that after the use of either modality alone. The recovery times and the incidence of adverse events when quickly and consecutively performing both treatments were similar as compared to those with employing stepwise treatment. We encountered no complications whatsoever. Conclusion When compared with stepwise therapy, combination therapy with HIFU and fractional CO₂ resurfacing offers better, safer and more effective clinical results. Thus, for targeting multiple layers of aging facial skin, this combination therapy can be safely performed in a single treatment session.

• Current Optics and Photonics
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• 제1권1호
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• pp.51-59
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• 2017

In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.