Current Optics and Photonics

Optical Society of Korea (한국광학회)
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Non-ablative Fractional Thulium Laser Irradiation Suppresses Early Tumor Growth

  • Yoo, Su Woong (Department of Biomedical Science and Engineering, Institute of Integrated Technology (IIT)) ;
  • Park, Hee-Jin (School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST)) ;
  • Oh, Gyungseok (School of Mechanical Engineering, Gwangju Institute of Science and Technology (GIST)) ;
  • Hwang, Soonjoo (Department of Biomedical Science and Engineering, Institute of Integrated Technology (IIT)) ;
  • Yun, Misun (Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital) ;
  • Wang, Taejun (Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology) ;
  • Seo, Young-Seok (R & D center, WONTECH Co., Ltd.) ;
  • Min, Jung-Joon (Department of Nuclear Medicine, Chonnam National University Medical School and Hwasun Hospital) ;
  • Kim, Ki Hean (Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology) ;
  • Kim, Eung-Sam (Department of Biological Sciences, Chonnam National University) ;
  • Kim, Young L. (Weldon School of Biomedical Engineering, Purdue University) ;
  • Chung, Euiheon (Department of Biomedical Science and Engineering, Institute of Integrated Technology (IIT))
  • Received : 2016.12.15
  • Accepted : 2016.12.26
  • Published : 2017.02.25
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Abstract

In addition to its typical use for skin rejuvenation, fractional laser irradiation of early cancerous lesions may reduce the risk of tumor development as a byproduct of wound healing in the stroma after the controlled injury. While fractional ablative lasers are commonly used for cosmetic/aesthetic purposes (e.g., photorejuvenation, hair removal, and scar reduction), we propose a novel use of such laser treatments as a stromal treatment to delay tumorigenesis and suppress carcinogenesis. In this study, we found that non-ablative fractional laser (NAFL) irradiation may have a possible suppressive effect on early tumor growth in syngeneic mouse tumor models. We included two syngeneic mouse tumor models in irradiation groups and control groups. In the irradiation group, a thulium fiber based NAFL at 1927 nm was used to irradiate the skin area including the tumor injection region with 70 mJ/spot, while no laser irradiation was applied to the control group. Numerical simulation with the same experimental condition showed that thermal damage was confined only to the irradiation spots, sparing the adjacent tissue area. The irradiation groups of both tumor models showed smaller tumor volumes than the control group at an early tumor growth stage. We also detected elevated inflammatory cytokine levels a day after the NAFL irradiation. NAFL treatment of the stromal tissue could potentially be an alternative anticancer therapeutic modality for early tumorigenesis in a minimally invasive manner.

Keywords

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