• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 춘계학술대회
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• pp.391-393
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• 2022

The preparation of polynuclear metal dendritic molecule for photodynamic diagnosis(PDD) or photodynamic therapy(PDT) has been interested on design and synthesis of metal-to-metal long ranged macromolecule. Herein, imine bond or amide bond as chemical bond is an important role on the construction of energy transfer or electron transfer system. Therefore, we will be presented on the role of chemical bond for the preparation of polynuclear metal dendritic molecule.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 춘계학술대회
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• pp.467-469
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• 2021

The dendritic molecule has focused on the target material for photodynamic therapy, and used as the energy harvesting molecule for the application of medicinal field. Those molecules have also researched on the molecule design for the preparation of new dendritic material on PDD and PDT. In this presentation, new dendritic molecules are introduced on the development of DPPZ dendritic molecule for PDT and the efficient synthetic process.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2021년도 추계학술대회
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• pp.646-648
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• 2021

The syntheses and properties of polynuclear metal complexes have been reported to develop the easy syntheses and noble photo-characteristics of those complexes for photodynamic diagnosis (PDD) or photodynamic therapy (PDT). We have been focused on the design and synthesis of polynuclear lanthanide dendritic molecule due to long life time of fluorescence. Therefore, we will be presented on the design of home (Eu or Gd) or hetero (Tb or Lu) polynuclear lanthanide dendritic molecule.

• 한국정보통신학회:학술대회논문집
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• 한국정보통신학회 2022년도 추계학술대회
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• pp.291-293
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• 2022

The preparation of dendritic molecule for photodynamic diagnosis (PDD) or photodynamic therapy (PDT) has been interested on design and synthesis of macromolecule toward a new generation. Herein, the binding site of polyether group is an important role on the construction of macromolecule toward a new generation. Therefore, we will be presented on the preparation of dendritic molecule having the binding site.

• 대한의생명과학회지
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• 제15권2호
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• pp.153-160
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• 2009

Photodynamic therapy(PDT) is a treatment utilizing the generation of singlet oxygen and other reactive oxygen species(ROS), which selectively accumulate in target cells. The aim of present work is to investigate the photodynamic therapy mechanism of 9-HpbD-a-mediated PDT in HeLa cell lines. We studied the general reactive oxygen species(G-ROS) activation after 9-HpbD-a PDT using fluorescence stain with $H_2DCF-DA$. G-ROS activation observed after 9-HpbD-a PDT and higher activation condition was 1 hour after PDT at 0.5 ${\mu}g/ml$ 9-HpbD-a concentration. Sodium azide and reduced glutathione(the singlet oxygen quencher) could protect HeLa cells from cell death induced by 9-HpbD-a PDT. But D-mannitol(the hydroxyl radical scavenger) could not protect cell death. Singlet oxygen played a decisive role in 9-HpbD-a PDT induced HeLa cell death. Type II reaction was the main type of ROS formation at 9-HpbD-a PDT.

• 대한기관식도과학회지
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• 제15권1호
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• pp.60-63
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• 2009

The photodynamic therapy (PDT) is a new treatment modality of destroying malignant tumors and pre-malignant lesions based on the use of photodynamical damage to tumor cells under the photochemical reactions. But the clinical reports of photodynamic application on the benign tumor of the internal organs were extremely rare. So we decribed our experience of one case of benign tracheal tumor successfully treated by PDT.

• 대한방사선기술학회지:방사선기술과학
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• 제44권2호
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• pp.141-146
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• 2021

This study aimed to explore whether photodynamic therapy using Radachlorin and diode laser is an effective inhibitor of Candida albicans. Suspensions of Candida albicans were obtained, inoculated in petri dishes with Radachlorin, and incubated for 30 min. Then, the laser light of a diode laser was irradiated at at energy densities of 3 J/cm², 5 J/cm², 7 J/cm². As a result, Candida albicans showed a killing rate of 91.5% at an energy density of 7 J/cm². This study found that photodynamic therapy using a Radachlorin and diode laser was effective for the inhibition of Candida albicans.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제28권3호
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• pp.234-238
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• 2002

구강악안면외과 영역의 전암병소와 종양의 치료를 위하여 국소적으로 ALA, 전신적으로 Forscan의 광감각제를 도포하거나 주입하여 기능적, 심미적으로 좋은 결과를 얻을 수 있었다. 아직 장기적인 추적조사가 요구되지만 광역학 요법은 기존의 수술법, 항암요법, 방사선치료와 함께 종양의 새로운 치료방법으로 이용될 수 있을 것으로 사료된다.

• 한국재료학회:학술대회논문집
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• 한국재료학회 2005년도 춘계학술발표대회 및 제8회 신소재 심포지엄 논문개요집
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• pp.326-326
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• 2005

• 한국정보통신학회:학술대회논문집
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• 한국해양정보통신학회 2005년도 춘계종합학술대회
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• pp.1101-1103
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• 2005

최근 레이저 진단 및 치료의 동향, 즉 조직선택성을 갖는 레이저 치료와 새로운 광-조직 작용을 갖는 레이저 진단에 관하여 조사 발표하고, PDT 및 PDD의 새로운 연구발전 방향을 제시한다.