• Journal of Sasang Constitutional Medicine
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• v.35 no.4
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• pp.105-115
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• 2023

Objectives Post-herpetic neuralgia(PHN) is one of the common complications in patients diagnosed with herpes zoster. The purpose of this case study is to suggest the effect of Galgunhaegui-tang and korean medicine treatment for post-herpetic neuralgia patient. Methods A 62-year-old Herpes Zoster patient suffered from rash with post-herpectic neuralgia was identified as Taeeumin Gansuyolriyolbyong. The patient's chief complaint was assessed by counting the number of oral analgesics taken and using Visual Analog Scale(VAS) score. The patient was treated with Galgunhaegui-tang and Korean medicine treatment. Results After 9 days of admission treatment including Galgunhaegui-tang, VAS of PHN was decreased from 7.5 to 4 and the number of taking oral analgesic was decreased from 2 to 1. Conclusions This case study indicates that Galgunhaegui-tang and Korean medicine treatment may improve the pain of PHN.

• The Journal of Natural Sciences
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• v.11 no.1
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• pp.65-73
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• 1999

C-P compounds(Pn; phosphonate) such as glyphosate(GPS), aminoethylphosphonate(AEPn) and methyl-phosphonate(MPn) biodegrading genes were cloned from Pseudomonas sp. strain #A1 Which assimilated GPS as sole phosphorous source. Carrying out the in vivo molecular cloning by means of Mini-Mu plasmid, the size of clones($AEPn^+$, $MPn^+$, $GPS^+$) for the gene to degrade C=P compounds are 10-19Kb, 10Kb, and 12-18 Kb, respectively. Moreover, they expressed the phenotype for each Pn when they were transformed into $\Delta phn$ mutants. Hence, it is postulated that Pseudomonas sp.#A1 has three kind of Pn degradative pathway, separately. The phn clones($AEPn^+$, $MPn^+$, $GPS^+$) are verified as the members of PHO regulon because of their phoBR-dependent characteristics.

• Journal of Korean Public Health Nursing
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• v.30 no.3
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• pp.526-543
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• 2016

Purpose: The purpose of this study was to explore how public health nurses (PHNs) perceive their roles and duties (R&D), as well as to investigate the change of their R&D, how they manage and solve problems. Methods: The data were collected through focus group interviews. Data were analyzed using Morgan (1998) and Krueger (1998)'s four step analysis. A total of 17 experienced PHNs participated in this study. Results: The results found 5 themes and 19 sub-themes: R&D of health managers and health service providers, factors affecting the changes of PHN's R&D, R&D in adjusting with trends and expanding work field (R&D being reduced, increasing R&D, need to expand R&D), problem with the structure and quality of workforce (lack of nurse manpower, lack of promotion opportunities, increasing non-regular workers, lack of refinement as an expert), and strategies for solving personnel issues (strengthening the job capacity, cultivating professional refinement, strengthening outside activities and political activities, strengthening the roles of PHN-related associations and academy, engagement policy of non-regular workers, expansion of the activity area) Conclusion: PHNs need to recognize their changing R&D and ways they manage and solve problems to enhance their professionalism.

• Journal of Oral Medicine and Pain
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• v.35 no.1
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• pp.93-99
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• 2010

Herpes zoster (HZ) is the secondary manifestation of an earlier infection with the varicella-zoster virus in one or more dermatomes. As reactivation of the virus is linked to an age-related diminished virus-specific and cell-mediated immunity, HZ develops mainly in elderly people. Acute zoster is painful, but does not incur lasting morbidity. Reactivation of the varicella-zoster virus in the trigeminal nerve (Herpes zoster) occur with severe pain and rash in the oro-facial region. The acute pain decreases as the rash begins to heal. Postherpetic neuralgia(PHN), the most frequent complication of herpes zoster, is usually defined as pain in the involved dermatome that is still present 3 month after rash onset. The clinical characteristics of PHN are, eposodic stabbing pain, burning pain and allodynia, with hypoesthesia and/or dysesthesia. $Neurometer^{(R)}$(neuroselective sensory nerve conduction threshold: sNCT, Automated current perception threshold: CPT, neurotron incorporated. Baltimore, Maryland. 21209 U.S.A.) is convenient, rapid and noninvasive, and allows objective assessment of sensory disturbance. This case is about the postherptic neuralgia patient assessed with $Neurometer^{(R)}$. From this case, we reviewed the pathophysiology and the treatment of PHN and recommend the assessment of pain intensity with $Neurometer^{(R)}$ as quantitative and objective method.

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.257.2-257
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• 2000

• Proceedings of the Zoological Society Korea Conference
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• 2000.10a
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• pp.258.1-258
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• 2000

• Journal of agricultural medicine and community health
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• v.43 no.2
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• pp.114-124
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• 2018

Objectives: The purpose of this study is to examine the modern history of public health(PH) and suggest a way forward for PH nursing(PHN). Methods: This paper is a review article that derives results from literature review. Results: In the period of beginning (up to 1944), PHN began as the PH Department was created in the Hygiene Bureau in 1908 and tasks about nurses were legislated. PHN was limited to infectious disease tasks and performed mostly by missionaries. In the period of foundation formation (1945 to 1961), the Republic of Korea was founded, and PH policies and tasks were defined with the establishment of the central government organization and the applicable laws. In the period of foundation establishment (1962 to 1979), the Regional PH Act was amended, and as a result, PH Centers(PHCs) spread across the country. In the period of foundation expansion (1980 to 1994), the PH referral system of PHCs, PH Units, and Primary Health Care Post was established. In the period of organization in each area (1995 to 2005), PH programs reflecting changes in disease structure and public needs for the quality of life. A regional health care plan was launched. In the period of funtion expansion (2006 to present day), Centers for support health living were established. Conclusions: In the future, PH nurses need to have a macroscopic perspective that views PH through the overall PH system, and to expand from the existing healthcare concept to the national and global healthcare one.

• The Korean Journal of Pain
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• v.34 no.4
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• pp.463-470
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• 2021

Background: Although neuropathic pain is a severe and common pain, its pathophysiology has not been elucidated yet. Studies in recent years have focused on the immune system's role in the pathogenesis of neuropathic pain. The aim of this study was to investigate the role of immunological mechanisms in neuropathic pain and the effect of pregabalin by measuring immunological marker levels in peripheral blood before and after pregabalin treatment in postherpetic neuralgia (PHN) patients with neuropathic pain. Methods: Forty patients diagnosed with PHN were included in the study. CD4, T follicular cells (Tfh: CD4⁺CXCR5⁺PD1⁺), Th17 (CD4⁺CCR6⁺ and CD4⁺IL17A⁺), regulatory T cells (Treg: CD4⁺ CD25⁺foxp3⁺), Th1 (CD4⁺ CXCR3⁺ and CD4⁺ IFN-γ⁺) and Th2 (CD4⁺ IL-4⁺) cell ratios were measured in peripheral blood samples before treatment and after 3 months of treatment. Results: When immunological marker and inflammation parameter levels were compared before and after treatment, the helper T cell ratio (CD3⁺, CD4⁺) was 30.28 ± 12.27% before treatment and 34.93 ± 11.70% after treatment, so there was a statistically significant increase (P = 0.028). Th17 was 4.75 ± 5.02% before treatment and 5.80 ± 3.13% after treatment, and there was a statistically significant increase (P = 0.036). Conclusions: Immunological mechanisms play an essential role in the pathogenesis of neuropathic pain, immunologically based treatment approach will be the critical point of treatment.

• Journal of Microbiology
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• v.43 no.5
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• pp.443-450
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• 2005

The multi-host pathogen, Pseudomonas aeruginosa, possesses an extraordinary versatility which makes it capable of surviving the adverse conditions provided by environmental, host, and, presumably, competing microbial factors in its natural habitats. Here, we investigated the P. aeruginosa-Bacillus subtilis interaction in laboratory conditions and found that some P. aeruginosa strains can outcompete B. subtilis in mixed planktonic cultures. This is accompanied by the loss of B. subtilis viability. The bactericidal activity of P. aeruginosa is measured on B. subtilis plate cultures. The bactericidal activity is attenuated in pqsA, mvfR, lasR, pilB, gacA, dsbA, rpoS, and phnAB mutants. These results suggest that P. aeruginosa utilizes a subset of conserved virulence pathways in order to survive the conditions provided by its bacterial neighbors.

• Economic and Environmental Geology
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• v.31 no.1
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• pp.21-29
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• 1998

Broadband receiver functions are developed from teleseismic P waveforms recorded at Wonju (KSRS), Inchon (IRIS), and Pohang (PHN), and are analyzed to examine the crustal structure beneath the three stations. The teleseismic receiver functions are inverted in the time domain to the vertical P wave velocity structure beneath the stations. Clear P-to-S converted phases from the Moho interface are observed in teleseismic seismograms recorded at the three stations. We estimated the crustal velocity structures beneath the stations using the receiver function inversion. The general features of inversion results are as follows: (1) For Pohang station, there is a high velocity gradient at a 4~5 km deep for SE and NW back azimuth and a low velocity zone at around 10 km deep. The Moho depth is 28 km for NW direction. (2) The shallow crustal structure beneath Wonju station is somewhat complex and there is a high-velocity zone ($V_p{\simeq}6.8km/sec$) at 3 to 4 km deep. The average crustal thickness is 33 km, and a transition zone exists at a 30~33 km deep of lower crust, of which velocity is abruptly changed 6.4 to 7.9 km/sec. (3) For Inchon station, the crustal velocity gradient monotonously increases up to the Moho discontinuity and the velocity is abruptly changed from 6.2 km/sec to 7.9 km/sec at 29 km deep.