• Journal of the Korean Society of Marine Environment & Safety
• /
• v.21 no.4
• /
• pp.315-326
• /
• 2015

Temporal and spatial variations of surface water temperature in Jinju Bay for the period of 2010~2011 were studied using the data from temperature monitoring buoys deployed at 17 stations in the south coast of Korea. Water temperature shows the maximum late in January and the minimum early in August. Seasonal variation of water temperatures at the north part of the bay is smaller than the middle and the south. In summer, the lowest and the highest of maximum water temperature are distributed around Jijok Channel which is located at the south of the bay. The fluctuations of water temperatures at Noryang and Daebang Channel are smaller than others because of vertical mixing caused by passage of strong tidal currents. Wind and strong currents affect on the stratification of the surface water layer near Daebang Channel. High temperatures come in frequently around the north area when eastward constant flows appear at neap tide as blowing westerly in the springtime at Noryang Channel. Spectral analyses of temperature records show significant peaks at 7~20 day periods at Noryang Channel, 7~20 day and semidiurnal at the west coast of Changsun Island and Jijok Channel and 7~20 day and diurnal at the middle of the bay. Temperature fluctuation at Noryang Channel shows high coherence and has leading phase with those at other stations in the bay. However, the phase of temperature fluctuation at Noryang Channel falls behind that at Daebang Channel. Daebang Channel has an influence on the temperature fluctuation only at the west and middle part of the bay. Cross-correlation analyses for the temperature fluctuation show that Jinju Bay could be classified into six areas; Noryang Channel, the area of convergence and divergence at the north, Daebang Channel, the west coast of Changsun Island, the mixing area at the middle of the bay and the south inside of the bay, respectively.

• Progress in Medical Physics
• /
• v.17 no.3
• /
• pp.136-143
• /
• 2006

The respiratory gating radiation therapy which Irradiates only in the stable respiratory period with analyzing the periodic motion of a reflective marker on the patient's abdomen has been applied to the precise radiation treatment in order to minimize the effect of organ motion induced by the respiration. This respiratory gating system establishes irradiation region using the amplitude-based or phase-based method. Although phase-based method Is preferred because of the stability in the real treatment conditions, it has some limits to explain the exact correlation between the marker motion and organ motion. Even when the variation of amplitude which can introduce target motion considered as an error is produced, the phase-based method has the possibility to irradiate including the error positions. In this study, the error analysis program was developed for the verification of the tumor position's variation correlated with the variation of marker's amplitude which can be occurred during a phase-based respiratory sating treatment. The analysis program was tested with a virtual treatment record file and with a record file using moving phantom which were modified considering the irregular amplitude's variation simulating the real clinical situations. In both cases, accurate discrimination of error points and error calculation were produced. When the treatment record files of a real patient were analyzed with the program, the accurate recognition and calculation of the error points were also verified. The analysis program developed in this study will be applied as a useful tool for the analysis of errors due to the irregular variation of patients' respiration during the phase-base respiratory gating radiation treatment.

• Journal of Pharmaceutical Investigation
• /
• v.31 no.4
• /
• pp.265-271
• /
• 2001

In order to elucidate the influence of intestinal and hepatic first-pass effect on the pharmacokinetics of triflusal, the biotransformation of triflusal in the gastrointestinal tract and liver was designed. Moreover, we tried to establish an HPLC method applicable for bioassay and available to pharmacokinetics, not only with the simultaneous determination of triflusal and its active metabolite, 2-hydroxy-4-trifluoromethyl benzoic acid (HTB), but also with improving sensitivity. After the administration of triflusal (10 mg/kg) and HTB (10 mg/kg) into femoral vein, portal vein (only triflusal) and oral route (only triflusal), pharmacokinetic parameters were investigated from the plasma concentration-time profiles of triflusal and HTB in rats. An HPLC method was developed for the simultaneous determination of triflusal and HTB in rat plasma, urine and bile. The HPLC analysis was carried out using a C18 column and acetonitrile-methanol-water (25:10:65, v/v/v) as the mobile phase and UV detection at 234 nm. Furosemide was used as the internal standard. The calibration curves were linear over the concentration range $0.05-5.0\;{\mu}g/ml$ for triflusal and $0.2-200.0\;{\mu}g/ml$ for HTB with correlation coefficients greater than 0.999 and with intra-day or inter-day coefficients of variation not exceeding 10.0%. This assay procedure was applied to the study of metabolite pharmacokinetics of triflusal and HTB in rats. It was supposed that triflusal was almost metabolized in vivo because urinary and biliary excreted amounts of triflusal could be ignored as it was lower than 1.2% of the administered dose. According to the gastrointestinal and hepatic biotransformation pathways of triflusal, it was found that triflusal was hydrolyzed by about 5% in intestine and metabolized by about 53% in liver, and that the bioavailability of triflusal after oral administration of triflusal was 0.44, and also that the fraction of total elimination rate of triflusal which formed HTB in liver $(F_{mi},\;%)$ was about 98%. These results showed that triflusal was almost metabolized in liver, and the total elimination of triflusal in the body was dependent to the formation rate of HTB from triflusal in liver.

• The Journal of Korean Institute of Communications and Information Sciences
• /
• v.38A no.5
• /
• pp.401-408
• /
• 2013

Dual-layer differential codebook using 8-PSK (phase shift keying) constellation as its codeword elements, is proposed for Long term evolution (LTE) and/or LTE-Advanced systems. Due to the temporal correlation of the adjacent channel matrices, the consecutive precoding matrices are likely to be similar. This approach quantize only the differential information of the channel instead of the whole channel subspace, which virtually increase the codebook size to realize more accurate quantization of the channel. Especially, the proposed codebook has the same properties of LTE release-8 codebook that is, constant modulus, complexity reduction, and nested property. The mobile station can be designed by using less expensive non-linear amplifier utilizing constant modulus property. Computer simulations show that the capacity of the proposed dual-layer codebook performs almost 1.2dB better than those of any other non-differential codebooks with the same amount of feedback information.

• Physical Therapy Rehabilitation Science
• /
• v.2 no.2
• /
• pp.99-103
• /
• 2013

Objective: Clinical measures that quantify upper extremity function are needed for the accurate evaluation of patients and to plan an intervention strategy. The purpose of this study was to examine the relationship between the Unified Parkinson's Disease Rating Scale (UPDRS)-Motor Exam and upper extremity performance as a quantifying clinical tool of upper extremity function in persons with Parkinson's disease. Design: Cross-sectional study. Methods: Thirty-two idiopathic Parkinson's Disease persons participated in this study. To investigate the relationship between the UPDRS-motor exam, Box and Block test (BBT), and Action Research Arm Test (ARAT) by two physical therapists. The examination took up to 1 hour, and the participants were invited to rest between each clinical measure in order to minimize the effects of fatigue. Clinical measures were assessed while the subjects were in the "on" phase of their medication cycle, generally 1-3 hour after taking their anti-Parkinson's medications. Results: In more affected side, the UPDRS-motor exam was significantly negative correlated with the BBT (p<0.05) but it was not significantly correlated with the ARAT. In less affected side, only positively correlation was significantly shown between BBT and ARAT (p<0.05). On the other hand, between BBT and ARAT were not significantly correlated with the UPDRS-motor exam. Conclusions: The UPDRS-motor exam is effective tool which was significantly correlated with manual dexterity in more affected upper extremity. But The UPDRS-motor exam is not effective tool in less affected upper extremity.

• Korean Medical Education Review
• /
• v.19 no.2
• /
• pp.90-100
• /
• 2017

The necessity of embracing selective courses in medical curriculum is increasing due to the expansion of medical knowledge and changes in the health care environment. In contrast to the abundant evidence regarding elective or selective courses during the clinical phase, articles focusing on the preclinical period are relatively scarce. This study aims to explore the development, implementation, and evaluation of newly-adopted selective courses in the first-year medical curriculum in a medical school which recently underwent a major curricular revision. First of all, the Curriculum Committee established goals and operating principles of the courses, and then the committee encouraged all participating professors to attend a related faculty development workshop after finalizing the list of courses. A survey was conducted at the end of each course for evaluation. Of the 36 courses opened in 2016, the overall satisfaction of students was $4.98{\pm}1.06$ (out of 6) and showed a strong correlation with students' previous expectations, reasoning- and participation-oriented teaching, and outcome of the courses including increased motivation. In the open-ended responses, students and professors described not only intended outcomes such as acquisition of medical knowledge and increased interest in new topics, but also unintended outcomes including positive impression for selective courses and even high satisfaction and rewarding experiences, especially from the teachers' perspective. Although long-term outcomes remain to be seen, the results of this study show the feasibility and impact of selective courses and will contribute to effective implementation in other medical schools.

• Anxiety and mood
• /
• v.2 no.1
• /
• pp.22-27
• /
• 2006

Objectives : There is a paucity of data on the long-term course of obsessive-compulsive disorder (OCD) and chronological relationship between OC symptoms and their related symptoms such as anxiety and depression. The purpose of this study was to investigate the longitudinal course of OC symptoms as well as anxiety and depression which are believed to be associated with OC symptoms. Methods : Data for 155 patients with OCD who completed general evaluation for OCD were used. Forty four were excluded to minimize the effect of the different age of onset on the clinical course. One hundred eleven patients finally participated in the analysis. Cross-sectional correlations between each symptom as well as between such symptoms and the duration of illness were analyzed. Further correlation analysis was done within two groups that were divided by 7 years of the duration of illness. Results : There were significant correlations not only between the severity of OC symptoms and anxiety but also between anxiety and depressive symptom, regardless of the duration of illness. These correlations between such symptoms were also found within patients with the duration of illness below 7 years, whereas these were not within the group with the duration of illness above 8 years. Conclusion : Patients with OCD in this study shows the moderate to severe level of OC symptoms irrespective of the duration of illness. Our finding also suggests that the OC symptoms, especially obsessions are closely related to anxiety and depressive symptoms and these relationships might be pronounced in relatively early phase of the OCD after onset.

• Radiation Oncology Journal
• /
• v.35 no.2
• /
• pp.121-128
• /
• 2017

Purpose: To report the results of a correlation analysis of skin dose assessed by in vivo dosimetry and the incidence of acute toxicity. This is a phase 2 trial evaluating the feasibility of intraoperative radiotherapy (IORT) as a boost for breast cancer patients. Materials and Methods: Eligible patients were treated with IORT of 20 Gy followed by whole breast irradiation (WBI) of 46 Gy. A total of 55 patients with a minimum follow-up of 1 month after WBI were evaluated. Optically stimulated luminescence dosimeter (OSLD) detected radiation dose delivered to the skin during IORT. Acute toxicity was recorded according to the Common Terminology Criteria for Adverse Events v4.0. Clinical parameters were correlated with seroma formation and maximum skin dose. Results: Median follow-up after IORT was 25.9 weeks (range, 12.7 to 50.3 weeks). Prior to WBI, only one patient developed acute toxicity. Following WBI, 30 patients experienced grade 1 skin toxicity and three patients had grade 2 skin toxicity. Skin dose during IORT exceeded 5 Gy in two patients: with grade 2 complications around the surgical scar in one patient who received 8.42 Gy. Breast volume on preoperative images (p = 0.001), ratio of applicator diameter and breast volume (p = 0.002), and distance between skin and tumor (p = 0.003) showed significant correlations with maximum skin dose. Conclusions: IORT as a boost was well-tolerated among Korean women without severe acute complication. In vivo dosimetry with OSLD can help ensure safe delivery of IORT as a boost.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
• /
• v.26 no.7
• /
• pp.627-635
• /
• 2015

We propose a dual-layer differential equal-gain codebook design methodology for LTE-Advanced(LTE-A), IEEE802.ac, and radar system having multiple transmit and receive antennas, and make computer simulations to evaluate its link-level performaces. M-ary phase shift keying constellation is used as its codeword elements to utilize low-cost power amplifiers at mobile stations. Especially, the proposed codebook can meet radar systems requirement for the high-powered equal-gain transmission property. Due to the temporal correlation of the adjacent channel, the proposed differential codebook can quantize only the differential information of the channel instead of the whole channel subspace, which virtually increase the codebook size to realize more accurate quantization of the channel. The proposed codebook has the same properties of LTE codebook that is, constant modulus, complexity reduction, and nested property. Computer simulations show that the proposed codebook performs better than the conventional 8-ary codebooks with the same amount of feedback information.

• Korean Journal of Applied Biomechanics
• /
• v.27 no.1
• /
• pp.9-18
• /
• 2017

Objective: The purpose of this study was to identify kinematic variables that govern successful performance and judges' scores and to establish correlative relationships among those of Yurchenko layout with a full twist in female vaults. Method: Four video cameras with sampling rate of 60 Hz collected 32 motion data of Yurchenko vaults from twenty-two female participants (age: $18.6{\pm}3.6years$, height: $153.0{\pm}6.5cm$, mass: $44.7{\pm}7.3kg$) during national competition. Posting processing and calculations of kinematic variables were performed in Kwon 3D XP and $Matlab^{(R)}$ programs. Correlation and regression analyses were applied to find the relationships between the obtained scores and kinematic variables. Deterministic model (Hay & Reid, 1988) was used to investigate the strength of correlative relationships among kinematic variables. Results: The obtained scores from the judges' decision were mainly affected by post-flight peak height, horse contact time, knee angle at landing, and horse takeoff angle. Strong blocking during horse contact was required to get successful performance and obtain high scores. Modified deterministic model showed that round-off entrance and takeoff angles and resultant velocity of the center of mass (CM) during the roundoff phase were the starting variables affecting performance in the following kinematics. Knee angle at landing, a highly influential variable on the obtained point, was only determined by judges' decision without significant correlative relationship with previous kinematic variables. Conclusion: The obtained scores highly depended on kinematic variables of post-flight and horse contact phases that were affected by those from the previous phases including round-off postures and resultant velocity of the body center of mass.