• Title/Summary/Keyword: pharmacology

Search Result 9,502, Processing Time 0.037 seconds

EFFECTS OF CYP2D6*10 GENOTYPE AND CYP3A4 INHIBITION ON THE DISPOSITION AND NEUROLOGICAL SIDE EFFECTS OF HALOPERIDOL IN HUMAN SUBJECTS

  • Park, Ji-Young;Shon, Ji-Hong;Yoon, Young-Ran;Kim, Kyung-Ah;Kim, Min-Jung;Shim, Ju-Chul;Cha, In-June;Shin, Jae-Gook
    • Proceedings of the Korean Society of Toxicology Conference
    • /
    • 2001.05a
    • /
    • pp.149-149
    • /
    • 2001
  • Cytochrome P450 (CYP) 2D6 and CYP3A4 have been reported to be involved in the major metabolic pathways and formations of neurotoxic metabolites (HPP$\^$+/, RHPP$\^$+/) from haloperidol (HAL). However, no in vivo study has been addressed to the involvement of both CYP isoforms on the formation of toxic HAL metabolites.(omitted)

  • PDF