Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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EFFECTS OF CYP2D6*10 GENOTYPE AND CYP3A4 INHIBITION ON THE DISPOSITION AND NEUROLOGICAL SIDE EFFECTS OF HALOPERIDOL IN HUMAN SUBJECTS

  • Park, Ji-Young (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Shon, Ji-Hong (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Yoon, Young-Ran (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Kim, Kyung-Ah (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Kim, Min-Jung (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Shim, Ju-Chul (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Cha, In-June (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital) ;
  • Shin, Jae-Gook (Department of Pharmacology, Inje University, College of Medicine, Clinical Pharmacology Center, Pusan Paik Hospital)
  • Published : 2001.05.01
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Abstract

Cytochrome P450 (CYP) 2D6 and CYP3A4 have been reported to be involved in the major metabolic pathways and formations of neurotoxic metabolites (HPP$\^$+/, RHPP$\^$+/) from haloperidol (HAL). However, no in vivo study has been addressed to the involvement of both CYP isoforms on the formation of toxic HAL metabolites.(omitted)

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