• Journal of Pharmaceutical Investigation
• /
• v.40 no.spc
• /
• pp.1-7
• /
• 2010

Since the introduction of the biopharmaceutics classification system (BCS) in 1995, it has viewed as an effective tool to categorize drugs in terms of prediction for bioavailability (BA) and bioequivalence (BE). The BCS consist of four drug categories: class I (highly soluble and highly permeable), class II (low soluble and highly permeable), class III (highly soluble and low permeable) and class IV (low soluble and low permeable), and almost all drugs belong to one of these categories. Likewise, classifying drugs into four categories according to their solubility and permeability is simple and relatively not controversial, and thus the FDA adopted the BCS as a science-based approach in establishing a series of regulatory guidance for the industry. Actually, many pharmaceutical companies have gained a lot of benefits, which directly connect to cost loss and failure decrease in the early stage of drug development. Recently, instead of solubility, using dissolution characteristics (e.g. intrinsic dissolution rate) have provided an improvement in the classification in correlating more closely with in vivo drug dissolution rather than solubility by itself. Furthermore, a newly modified-version of BCS, biopharmaceutics drug disposition classification system (BDDCS), which classify drugs into four categories according to solubility and metabolism, has been introduced and gained much attention as a new insight in respect with the drug classification. This report gives a brief overview of the BCS and its implication, and also introduces the recent new trend of drug classification.

• Journal of the Korean Society for Marine Environment & Energy
• /
• v.7 no.3
• /
• pp.131-136
• /
• 2004

The transmission coefficients of impermeable submerged breakwater on permeable bottom are computed numerically using a boundary element method. The analysis method is based on the wave pressure function with the continuity in the analytical region including fluid and structures. Wave motion over permeable bottom is simulated by introducing a linear dissipation coefficient and an added mass coefficient. The results indicate that the wave over permeable bottom travels being damped, and that transmission coefficients for permeable bottom are smaller than those for impermeable bottom, and result from the change of width and height of submerged breakwater.

• Ecology and Resilient Infrastructure
• /
• v.3 no.2
• /
• pp.110-116
• /
• 2016

The rapid expansion of buildings and paved roads increases the risk of flood disaster in an urban area. One of the solutions can be the use of permeable pavements. This study evaluated the permeability of permeable blocks used for the roadway pavement. Joint fillers and mat sands of the investigated blocks met the corresponding standards. The flexural strength of the blocks was 5.29 MPa to meet these standards. Based on interior permeability test results after pollution, the four products evaluated were categorized into the following three levels: One for the $1^{st}$ level, one for the $2^{nd}$ level and two for the $3^{rd}$ level. From the field permeability test and pervious concrete infiltration test results nine months after their construction, all the products except one passed the quality standards of 0.1 mm/s.

• Journal of Wetlands Research
• /
• v.19 no.3
• /
• pp.296-302
• /
• 2017

Generally, a parking lot is constructed using asphalt or concrete. Such materials are impermeable, which means that a parking lot will directly release pollutants to any nearby water system during a rainfall event. An increased quantity of nonpoint source pollutants harms the ecohydrological system and causes further environmental damage leading to dysfunctional water circulation systems. Therefore, there is an urgent need for the design and application of Low Impact Development (LID) systems that allow more effective prevention of water circulation problems and management of nonpoint source pollution. This study aims to support such efforts by analyzing a permeable paver parking lot constructed using one of the LID techniques and comparing it to a conventional one in terms of the concentration of pollutants, nonpoint source pollution load and runoff rainfall lag effects during a rainfall event; it could serve as a reference for the construction of permeable paver parking lots in the future.

• Journal of The Korean Society of Agricultural Engineers
• /
• v.55 no.3
• /
• pp.9-12
• /
• 2013

The pavement is generally used on the highways, local loads, roads for bicycle riding and neighborhood living facility such as parking lot, plaza, park and sports facilities. However, the pavement material that is usually used on the most of roads is impermeable asphalt-concrete and cement-concrete. If the pavement material is impermeable, many problems can be happened on the drainage facilities in the rainy season. Additionally, a lot of rainwater on the pavement surface cannot permeate to the underground and flows to the sewage ditch, stream and river, etc. If a lot of rainwater flows at once, the floods can be out along the streams and rivers. So, underground water can be exhausted. Micro organisms cannot live in the underground. Recently, many studies has been conducted to exploit the permeable concrete that has high performance permeability. However, it is required to develop the permeable concrete which has high strength and durability. In this study, permeable and strength tests were performed to investigate the permeable characteristics of porous concrete according to fine aggregate content and substitution ratio of blast furnace slag. In this test, crushed stones with 10~20 mm and sand with 5~10 mm were used as a coarse aggregate and a fine aggregate respectively. The substitution ratio of blast furnace slag to cement weight is 0 %, 15 %, and 30 %. The ratio of fine aggregate to total aggregate is 0 %, 18 %, and 35 %. As a result, permeability coefficient was decreased according to fine aggregate ratio of total aggregate. Compressive strength was also decreased according to substitution ratio of blast furnace slag.

• Corrosion Science and Technology
• /
• v.7 no.1
• /
• pp.40-44
• /
• 2008

Passive metal forms an interfacial diffuse layer on the surface of passive film by its reaction with $H^+$ or $OH^-$ ions in solution depending on solution pH. There is a critical pH, called pH point of iso-selectivity ($pH_{pis}$) at which the nature of the diffuse layer is changed from the anion-permeable at pH<$pH_{pis}$ to the cation-permeable at pH>$pH_{pis}$. The $pH_{pis}$ for a passivated Fe was determined by examining the effects of pH on the thickness of passive film and on the dissolution reaction occurring on the passive film under a gavanostatic reduction in borate-phosphate buffer solutions at various pH of 7~11. The steady-state thickness of passive film formed on Fe showed the maximum at pH 8.5~9, and further the nature of film dissolution reaction was changed from a reaction producing $Fe^{3+}$ ion at $pH\leq8.5$ to that producing $FeO_2{^-}$ at $pH\geq9$, suggesting that the $pH_{pis}$ of Fe is about pH 8.5~9. In addition, the passive film formed at pH 8.5~9, $pH_{pis}$, was found to be the most protective with the lowest defect density as confirmed by the Mott-Schottky analysis. Pitting potential was decreased with increasing $Cl^-$ concentration at $pH\leq8.5$ due probably to the formation of anion permeable diffuse layer, but it was almost constant at $pH\geq9$ irrespective of $Cl^-$ concentration due primarily to the formation of cation permeable diffuse layer on the film, confirming again that $pH_{pis}$ of Fe is 8.5~9.

• Fashion & Textile Research Journal
• /
• v.2 no.3
• /
• pp.220-226
• /
• 2000

This study was to determine the characteristics of vapor-permeable waterproof finished fabric by the coating method. 4 different kinds of coating fabrics (A : wet, porous, polyurethane, B : dry, no porous, polyurethane, C : shape memory polyurethane and D : dry, porous polyurethane) were used, which were developed recently With this sample, moisture transport rate ($40^{\circ}C$, 45%RH & $40^{\circ}C$, 95%RH), changes of coating side's shape by washing times, water repellency rate, contracted length, qmax, heat conductivity, heat keeping rate, heat keeping rate with cotton, heat keeping rate on humidity temperature and humidity within clothing etc. were checked. And it was done in a climate chamber under $20{\pm}2^{\circ}C$, $65{\pm}5%RH$. The results of this study were as follow; In the moisture vapor transmission of sample B and C increased on high temperature and high humidity while sample A and D decreased, on this condition. Qmax rate had high relation with ground fabric's surface properties and the order was A>C>D>B. Heat conductivity had high relation with thickness and surface properties. Heat keeping rates on sweat condition showed around half percents of heat keeping rates on normal condition, but had no relation with moisture vapor transport rate. Changes of the fabric's properties by washing times were different in accordance with the construction of fabrics and the coating resin. Sample C had tow heat keeping rate on the high temperature and humidity and high heat keeping rate on the low temperature and humidity Moisture transport rate of vapor-permeable waterproof finished fabrics had high relation with the properties of ground fabrics on low humidity condition, but on the high humidity condition, it was highly related with the properties of coating resin.

• KSCE Journal of Civil and Environmental Engineering Research
• /
• v.33 no.2
• /
• pp.559-571
• /
• 2013

Recently, due to increase of the impervious layer, the storage of surface layer has been reduced. Otherwise the peak runoff and the total surface runoff have been raised. Because of larger amount of the peak runoff and the rapid time of concentration, the flood damage of the urban watershed was increased. The groundwater level is descended by reducing the amount of rainfall that infiltrated into the soil. Thereby the hydrologic cycle is degenerated by the dry stream. Therefore, in this study, the evaluation and the quantitative analysis of the percolation effect were performed through the infiltration experiment of permeable pavement, which is one of the ways that can reduce the problem of the dry stream. Also the SWMM model is used to analyze the effect of the hydrologic cycle for permeable pavement in Changwon stream and Nam stream watersheds, with the coefficient of permeability from the infiltration experiments.

• Journal of Korea Water Resources Association
• /
• v.47 no.1
• /
• pp.49-62
• /
• 2014

As the Urban area grows and more land is developed both within the city and in surrounding areas, hydrologic functions of the natural water cycle are altered. Urbanization creates impervious areas that negatively impact stormwater runoff characteristics. these changes to the natural hydrologic cycle result in the increased flooding, decreased groundwater recharge, increased urban heat island effects. Finally, the land use and other activities result in accumulation and washoff of pollutants from surface, resulting in water quality degradation. Therefore, in this study, evaluating and quantitative analysis of the percolation effect through infiltration experiment of permeable pavement, which is one of the ways that can reduce the problem of the dry stream. Also the SWMM model is used to study the effect of the hydrologic cycle for permeable pavement block contribution.

• Journal of Korea Water Resources Association
• /
• v.31 no.3
• /
• pp.223-234
• /
• 1998

Recently, the interests of the construction of the permeable submerged breakwaters have been increased to preserve and to improve the coastal environment, and to control the incident waves and littoral transport. It is very important to predict the wave transformation precisely over the permeable submerged breakwaters. This study discusses nonlinear wave transformation and characteristics by using BEM based on the frequency domain method of the 3rd-order Stokes waves. The Dupuit-Forchheimer formula is applied to the analysis of the fluid resistance of rubble stones, and the equation about equivalent linear frictional coefficient is newly modified based on the Lorentz's condition for the equivalent work. The numerical results are compared with the experimental ones for verification. These two results give a close agreement each other. It is confirmed that the present method of the 3rd-order Stokes waves estimates more precisely than that of the 2nd-order Stokes waves.