• Journal of the Korean GEO-environmental Society
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• v.14 no.10
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• pp.59-64
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• 2013

Effects of weathering intensity on the adsorption of heavy metals such as lead(Pb) and copper(Cu) onto decomposed granite soils were investigated by a series of batch tests. The chemical components such as $SiO_2$, $K_2O$ and $Na_2O$ having relatively high solubility were reduced and the oxidized $Fe_2O_3$ content was increased with the increase of weathering intensity. Weathering of granite soils increased the ignition loss and specific surface area, while it decreased the permeability. The lead and copper adsorptions onto the decomposed granites were enhanced with the increase of weathering intensity, mainly due to the increase of specific surface area and clayed contents. Adsorption of lead and copper onto the weathered granites could be more adequately described by the pseudo-second-order kinetic model than the pseudo-first-order model.

• Journal of Korea Water Resources Association
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• v.36 no.1
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• pp.129-142
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• 2003

In this study, the conduct of underground water flow system with 3 dimensions is interpreted in order to examine closely the actual condition regarding the flow of the underground water which is forecast from the tunnel segment and the interpretation result which selects the design and the construction technique of the tunnel segment was applied. Also, an obstacle to construct that relates with the underground water flow in construction duration in advance will be able to apply with information that is necessary in order to establish the countermeasure. The objective tunnel is the BEOPGI tunnel segment that is 2 parallel tunnels that are a one-way 2 lane and the parameters of the MODFLOW model executing the boring investigation and the permeability examination were presumed. The underground water flow of the excavation tunnel inside was interpreted by the MODFLOW model using the parameters which is presumed and two values which compared with calculated value and observed value are the same almost. Also, when the underground water discharge quantify that followed in tunnel excavation tries to compare, the underground water total discharge quantity from tunnel point of start until destination was presumed as 0.0269㎥/day/$m^2$.

• Geomechanics and Engineering
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• v.21 no.4
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• pp.357-369
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• 2020

Different from the conventional planar fracture and simplified Newton model, for power-law slurries with a lower water-cement ratio commonly used in grouting engineering, flow model in geological rough fractures is built based on ten standard profiles from Barton (1977) in this study. The numerical algorithm is validated by experimental results. The flow mechanism, grout superiority, and water plugging of pseudo plastic slurry are revealed. The representations of hydraulic grouting properties for JRCs are obtained. The results show that effective plugging is based on the mechanical mechanisms of the fluctuant structural surface and higher viscosity at the middle of the fissure. The formulas of grouting parameters are always variable with the roughness and shear movement, which play a key role in grouting. The roughness can only be neglected after reaching a threshold. Grouting pressure increases with increasing roughness and has variable responses for different apertures within standard profiles. The whole process can be divided into three stationary zones and three transition zones, and there is a mutation region (10 < JRCs < 14) in smaller geological fractures. The fitting equations of different JRCs are obtained of power-law models satisfying the condition of -2 < coefficient < 0. The effects of small apertures and moderate to larger roughness (JRCs > 10.8) on the permeability of surfaces cannot be underestimated. The determination of grouting parameters depends on the slurry groutability in terms of its weakest link with discontinuous streamlines. For grouting water plugging, the water-cement ratio, grouting pressure and grouting additives should be determined by combining the flow conditions and the apparent widths of the main fracture and rough surface. This study provides a calculation method of grouting parameters for variable cement-based slurries. And the findings can help for better understanding of fluid flow and diffusion in geological fractures.

• Computers and Concrete
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• v.25 no.2
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• pp.119-132
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• 2020

There is a growing interest in the use of by-product materials such as ceramics as alternative materials in construction. The aim of this study is to investigate the mechanical properties and durability of sustainable concrete containing waste ceramic powder (WCP), and to predict the results using artificial neural network (ANN). In this order, different water to binder (W/B) ratios of 0.3, 0.4, and 0.5 were considered, and in each W/B ratio, a percentage of cement (between 5-50%) was replaced with WCP. Compressive and tensile strengths, water absorption, electrical resistivity and rapid chloride permeability (RCP) of the concrete specimens having WCP were evaluated by related experimental tests. The results showed that by replacing 20% of the cement by WCP, the concrete achieves compressive and tensile strengths, more than 95% of those of the control concrete, in the long term. This percentage increases with decreasing W/B ratio. In general, by increasing the percentage of WCP replacement, all durability parameters are significantly improved. In order to validate and suggest a suitable tool for predicting the characteristics of the concrete, ANN model along with various multivariate regression methods were applied. The comparison of the proposed ANN with the regression methods indicates good accuracy of the developed ANN in predicting the mechanical properties and durability of this type of concrete. According to the results, the accuracy of ANN model for estimating the durability parameters did not significantly follow the number of hidden nodes.

• Journal of Ginseng Research
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• v.46 no.3
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• pp.464-472
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• 2022

Background: Gut microbiota influence the central nervous system through gut-brain-axis. They also affect the neurological disorders. Gut microbiota differs in patients with Alzheimer's disease (AD), as a potential factor that leads to progression of AD. Oral intake of Korean Red Ginseng (KRG) improves the cognitive functions. Therefore, it can be proposed that KRG affect the microbiota on the gut-brain-axis to the brain. Methods: Tg2576 were used for the experimental model of AD. They were divided into four groups: wild type (n = 6), AD mice (n = 6), AD mice with 30 mg/kg/day (n = 6) or 100 mg/kg/day (n = 6) of KRG. Following two weeks, changes in gut microbiota were analyzed by Illumina HiSeq4000 platform 16S gene sequencing. Microglial activation were evaluated by quantitative Western blot analyses of Iba-1 protein. Claudin-5, occludin, laminin and CD13 assay were conducted for Blood-brain barrier (BBB) integrity. Amyloid beta (Aβ) accumulation demonstrated through Aβ 42/40 ratio was accessed by ELISA, and cognition were monitored by Novel object location test. Results: KRG improved the cognitive behavior of mice (30 mg/kg/day p < 0.05; 100 mg/kg/day p < 0.01), and decreased Aβ 42/40 ratio (p < 0.01) indicating reduced Aβ accumulation. Increased Iba-1 (p < 0.001) for reduced microglial activation, and upregulation of Claudin-5 (p < 0.05) for decreased BBB permeability were shown. In particular, diversity of gut microbiota was altered (30 mg/kg/day q-value<0.05), showing increased population of Lactobacillus species. (30 mg/kg/day 411%; 100 mg/kg/day 1040%). Conclusions: KRG administration showed the Lactobacillus dominance in the gut microbiota. Improvement of AD pathology by KRG can be medicated through gut-brain axis in mice model of AD.

• Journal of the Korean Geotechnical Society
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• v.24 no.10
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• pp.45-55
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• 2008

In this study, the in-situ model test has been conducted to estimate and analyze consolidation behavior of the ground by using the miniature test that reconstructs economically geotechnical behavior of in-situ full scale structure. To analyze the relation of effective stress, void ratio and coefficient of permeability at the self-weight consolidation stage, the low stress seepage consolidation test has been conducted and the involution function of constitutive equation had been obtained from the result of the curve fitted seepage consolidation test. As a result of the numerical analysis that had been conducted on the representative section using a constitute equation, final settlement was similar to those of self-weight consolidation of the centrifugal model test. But it was more or less smaller. It seems that these trends are caused by the difference between estimated values.

• Journal of the Korean GEO-environmental Society
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• v.25 no.7
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• pp.29-34
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• 2024

Frost heave is one of the significant engineering characteristics of frozen ground and causes severe damages on geo-structures. Although thermo-hydro coupled analyses have been developed to predict frost heave behavior, these analyses involve excessive input parameters and have primarily been validated for frost heave in clayey soils. Frost heave mainly occurs in silty soils, which have relatively higher permeability compared to clayey soils, necessitating careful attention. This study introduces empirical models and verifies their reliability for silty soils. By using the validated model, the correlation of key input parameters is derived, which is expected to enhance the applicability of thermal-mechanical analysis for geo-structures on frozen ground in the future.

• Journal of Animal Reproduction and Biotechnology
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• v.39 no.1
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• pp.2-11
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• 2024

Background: The small intestine plays a crucial role in animals in maintaining homeostasis as well as a series of physiological events such as nutrient uptake and immune function to improve productivity. Research on intestinal organoids has recently garnered interest, aiming to study various functions of the intestinal epithelium as a potential alternative to an in vivo system. These technologies have created new possibilities and opportunities for substituting animals for testing with an in vitro model. Methods: Here, we report the establishment and characterisation of intestinal organoids derived from jejunum tissues of adult pigs. Intestinal crypts, including intestinal stem cells from the jejunum tissue of adult pigs (10 months old), were sequentially isolated and cultivated over several passages without losing their proliferation and differentiation using the scaffold-based and three-dimensional method, which indicated the recapitulating capacity. Results: Porcine jejunum-derived intestinal organoids showed the specific expression of several genes related to intestinal stem cells and the epithelium. Furthermore, they showed high permeability when exposed to FITC-dextran 4 kDa, representing a barrier function similar to that of in vivo tissues. Collectively, these results demonstrate the efficient cultivation and characteristics of porcine jejunum-derived intestinal organoids. Conclusions: In this study, using a 3D culture system, we successfully established porcine jejunum-derived intestinal organoids. They show potential for various applications, such as for nutrient absorption as an in vitro model of the intestinal epithelium fused with organ-on-a-chip technology to improve productivity in animal biotechnology in future studies.

• Journal of the Korea institute for structural maintenance and inspection
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• v.11 no.4
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• pp.138-146
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• 2007

Geotechnical performance at the soft ground is strongly dependent on the properties of the soil beneath and adjacent to the structure of interest. These soil properties can be described using deterministic and/or probabilistic models. Deterministic models typically use a single discrete descriptor for the parameter of interest. Probabilistic models describe parameters by using discrete statistical descriptors or probability distribution density functions. The consolidation process depends on several uncertain parameters including the coefficients of consolidation and coefficients of permeability in vertical and horizontal directions. The implication of this uncertain parameter in the design of prefabricated vertical drains for soil improvement is discussed. A sensitivity analysis of the degree of consolidation and calculation of settlements to these uncertain parameters is presented for clayey deposits.

• Journal of Soil and Groundwater Environment
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• v.13 no.1
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• pp.13-23
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• 2008

The triaxial compression tests and consolidation tests using NaCl solution and leachates as substitute pore (or saturated) water in samples were carried out to find out the behavior characteristics of strength, deformation and permeability coefficient of contaminated clay. Also, the chemical property analysis on the clay samples using scanning electron microscope and energy dispersive x-ray spectrometer were involved. The magnitudes of composition ratio were shown in the order of O, C, Si, Al, and Fe as a result of chemical composition analysis for clay samples. Besides, as the results of triaxial compression tests and consolidation tests, the shear strength, compression and permeability properties were increased with increasing in the concentration of contaminant (NaCl). It may be considered that these circumstances be caused by the changes of soil structure to flocculent structure due to the decrease in the thickness of diffuse double layer with increasing in the concentration of electrolyte. MT3D model was also using to grasp the procedures that the groundwater may be contaminated by the leachates permeated through the clay liner. The results of contaminant transport analysis showed a tendency that the predicted concentration of groundwater was higher with increasing in the initial concentration of $Cl^-$ ion and increased as a nonlinear curves with time. The transportation distance calculated by the use of regression equation between the distance from contaminant source and the concentration of $Cl^-$ ion was increased with increasing the initial concentration.