• Journal of the Korean GEO-environmental Society
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• v.7 no.3
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• pp.43-54
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• 2006

In this paper, the uniaxial, triaxial compression tests and consolidation tests on the clay sample substituted initial pore water for pollutant were performed to evaluate the change in geotechnical properties of the contaminated clay. The contaminant transport analysis on embankment type landfill using the MT3D model was also performed to evaluate the extent of transport and diffusion. There was tendency that strength, compressibility and permeability has increased with the increase in the concentration of NaCl solution. The increase in the strength and compressibility of sample saturated with leachate was higher than samples saturated with NaCl solution, but in the permeability coefficient was lower. As the result of contaminant transport analysis, the predicted concentration was in high with the increase in the initial concentration of $Cl^-$ ion and increased in a non-linear form. The transportation distance calculated with use of regression equation between the distance from contaminant source and the concentration of $Cl^-$ ion was increased with the increase in the initial concentration.

• The Korean Journal of Nuclear Medicine
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• v.18 no.1
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• pp.45-53
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• 1984

The purpose of this study is to observe the changes of pulmonary capillary permeability and various hemodynamic parameters before and after Positive End-Expiratory Pressure(PEEP) in Adult Respiratory Distress Syndrome (ARDS). Using a canine oleic acid induced ARDS model, we measured the pulmonary capillary permeability with a slope of lung: heart radioactivity ratio, hemodynamic parameters with Swan-Ganz catheter and blood gas tensions. 1) In normal and ARDS dogs, the PEEP didn't significantly influence the slope of lung: heart radioactivity ratio. But in ARDS group the slope index was increased compaired with that of control group (p<0.05). 2) Also in ARDS group, $PaO_2$ was significantly decreased, and $PaCO_2,\;PvCO_2$, MPAP, $AaDO_2$, Qs/Qt were significantly increased compared with those of control group (p<0.05). 3) In normal dogs, the PEEP didn't influence blood pH or gas tension, $AaDO_2$, Qs/Qt, or hemodynamics. 4) In ARDS dogs, however, the PEEP significantly increased $PaO_2$ and decreased $AaDO_2$, Qs/Qt (p<0.05).

• Journal of the Korean Geotechnical Society
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• v.27 no.2
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• pp.27-34
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• 2011

This study analyzes the determination of slope failure model due to changes in ground condition followed by heavy rainfall. With a simulated rainfall system, the movement of a slope from the rainfall penetrating the unsaturated soil is investigated with respect to various conditions of pore-water pressure, earth pressure, and moisture content, considering rainfall duration and permeability. As a result of the experiment, under the persistent precipitation of 50mm/h, pore-water pressure of weathered granite soil started increasing from the upper position of the slope, and then the pressure increased in middle and bottom portion of it in timely manner. In case of the pore-water pressure of the standard soil, the pressure increased from the middle and bottom portion, and the cause of the different order is suspected to be the difference in permeability between the standard soil and the weathered granite soil. As an outcome, though the result may vary by each foundation, there exists a danger of slope failure not only when the cumulative rainfall is more than 120 mm but also when the saturation level amounts to 60~75%.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.36 no.11
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• pp.1297-1303
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• 2012

In this paper, the standard procedures for measuring the moisture sorption properties of thin polymeric materials such as polyethylene terephthalate (PET) by using the thermo-gravimetric method to characterize the moisture diffusion in the polymer are presented, and the sorption properties are quantified. The moisture diffusivity and solubility are characterized to investigate the effect of temperature and humidity on the moisture sorption properties according to the Arrhenius equation. The validation of the obtained sorption properties using thermogravimetry is discussed with the measured permeability based on Fickian diffusion. The nonlinear behavior of the concentration dependent moisture diffusion is investigated experimentally, and the nonlinearity is characterized numerically for the case of having an interface with an inorganic material such as a metal. The Fickian/Non-Fickian model based on the obtained moisture sorption properties is compared and discussed.

• Journal of the Korean Geotechnical Society
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• v.21 no.6
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• pp.5-18
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• 2005

In this study, the influence of progressive consolidation from the drainage boundary on the subsequent process of consolidation was investigated. Analytical theory and numerical program f3r consolidation of clayey soil were developed based on finite difference method, in which spatial variation of permeability and volume compressibility were implemented. And model ground with normally consolidated clayey soils and a vertical drain at its center were simulated. Various types of soils with different relations between coefficient of volume compressibility and permeability and void ratio were applied. Also numerical simulations based on the properties of the normally consolidated clay at Nakdong River basin and reconstituted kaolinite soil were performed to recognize its practical impact. Consequently, it is found out that retardation of consolidation induced by progressive consolidation is very important to understand consolidation behavior on field conditions and its effect is remarkable at the initial state of consolidation, and increases with plasticity index and applied load.

• Applied Chemistry for Engineering
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• v.1 no.2
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• pp.140-146
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• 1990

Polydimethylsiloxane(PDMS) containing [N, N'-bis (3- (salicylidene amino) propyl) amine Co(II)] (Co(saldpt)) as a fixed oxygen carrier was synthesized. UV-visible spectra of the membrane demonstrated that Co(saldpt) binded molecular oxygen specificaaly and reversibly. From time lag method experiment, it was found that both oxygen permeability and diffusibity increase with decreasing upstream pressure, while solubility maintain nearly constant. The maximum oxygen permeability and oxygen selectivity over nitrogen obtained was 18.6 barrer and 4, respectively, at 25 mmHg and $40^{\circ}C$ from the the PDMS membrane containing 1 wt% of Co(saldpt). Facilitation behavior was explained in terms of the dual sorption model.

• Journal of the Korean GEO-environmental Society
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• v.8 no.4
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• pp.27-39
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• 2007

This paper investigates numerically characteristics of the fluid flow in spatially correlated variable-aperture fractures under effective normal stress conditions. Spatially correlated aperture distributions are generated by using the geostaistical method (i.e. Turning Bands algorithm). In order to represent a nonlinear relationship between the effective normal stress and the fracture aperture, a simple mechanical formula is combined with a local flow model. Obtained numerical results indicate that the fluid flow is significantly affected by the geometry of aperture distribution varying according to the applied effective normal stress as well as the spatial correlation length of aperture distribution. Moreover, by using results simulated in this study, the modified Louis formula representing the relationship between the effective normal stress and the effective permeability of fracture is proposed.

• Journal of Ginseng Research
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• v.47 no.2
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• pp.265-273
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• 2023

Background: The intestinal microbiota is an important regulator of bone health. In previous studies we have shown that intestinal microbiota dysbiosis, induced by treatment with broad spectrum antibiotics (ABX) followed by natural repopulation, results in gut barrier dysfunction and bone loss. We have also shown that treatment with probiotics or a gut barrier enhancer can inhibit dysbiosis-induced bone loss. The overall goal of this project was to test the effect of Korean Red Ginseng (KRG) extract on bone and gut health using antibiotics (ABX) dysbiosis-induced bone loss model in mice. Methods: Adult male mice (Balb/C, 12-week old) were administered broad spectrum antibiotics (ampicillin and neomycin) for 2 weeks followed by 4 weeks of natural repopulation. During this 4-week period, mice were treated with vehicle (water) or KRG extract. Other controls included mice that did not receive either antibiotics or KRG extract and mice that received only KRG extract. At the end of the experiments, we assessed various parameters to assess bone, microbiota and in vivo intestinal permeability. Results: Consistent with our previous results, post-ABX- dysbiosis led to significant bone loss. Importantly, this was associated with a decrease in gut microbiota alpha diversity and an increase in intestinal permeability. All these effects including bone loss were prevented by KRG extract treatment. Furthermore, our studies identified multiple genera including Lactobacillus and rc4-4 as well as Alistipes finegoldii to be potentially linked to the effect of KRG extract on gut-bone axis. Conclusion: Together, our results demonstrate that KRG extract regulates the gut-bone axis and is effective at preventing dysbiosis-induced bone loss in mice.

• Childhood Kidney Diseases
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• v.10 no.1
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• pp.8-17
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• 2006

Purpose : We describe the changes of rat glomerular epithelial cells when exposed to high levels of glucose and advanced glycosylation endproducts(AGE) in the in vitro diabetic condition. We expect morphological alteration of glomerular epithelial cells and permeability changes experimentally and we may correlate the results with a mechanism of proteinuria in DM. Methods : We made 0.2 M glucose-6-phsphate solution mixed with PBS(pH 7.4) containing 50 mg/mL BSA and pretense inhibitor for preparation of AGE. As control, we used BSA. We manufactured and symbolized five culture dishes as follows; B5 - normal glucose(5 mM) + BSA, B30 - high glucose(30 mM) + BSA, A5 - normal glucose(5 mM) + AGE, A30 - high glucose(30 mM) + AGE, A/B 25 - normal glucose(5 mM) + 25 mM of mannitol(osmotic control). After the incubation period of both two days and seven days, we measured the amount of heparan sulfate proteoglycan(HSPG) in each dish by ELISA and compared them with the B5 dish at 2nd and 7th incubation days. We observed the morphological changes of epithelial cells in each culture dish using scanning electron microscopy(SEM). We tried the permeability assay of glomerular epithelial cells using cellulose semi-permeable membrane measuring the amount of filtered BSA through the apical chamber for 2 hours by sandwich ELISA. Results : On the 2nd incubation day, there was no significant difference in the amount of HSPG between the 5 culture dishes. But on the 7th incubation day, the amount of HSPG increased by 10% compared with the B5 dish on the 2nd day except the A30 dish(P<0.05). Compared with the B5 dish on the 7th day the amount of HSPG in A30 and B30 dish decreased to 77.8% and 95.3% of baseline, respectively(P>0.05). In the osmotic control group (A/B 25) no significant correlation was observed. On the SEM, we could see the separated intercellular junction and fused microvilli of glomerular epithelial cells in the culture dishes where AGE was added. The permeability of BSA increased by 19% only in the A30 dish on the 7th day compared with B5 dish on the 7th day in the permeability assay(P<0.05). Conclusion: We observed not only the role of a high level of glucose and AGE in decreasing the production of HSPG of glomerular epithelial cells in vitro, but also their additive effect. However, the role of AGE is greater than that of glucose. These results seems to correlate with the defects in charge selective barrier. Morphological changes of the disruption of intercellular junction and fused microvilli of glomerular epithelial cells seem to correlate with the defects in size-selective barrier. Therefore, we can explain the increased permeability of glomerular epithelial units in the in vitro diabetic condition.

• Progress in Superconductivity and Cryogenics
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• v.22 no.2
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• pp.38-43
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• 2020

This paper presents comparative research on characteristics of air-cored and iron-cored high-temperature superconductor (HTS) field winding synchronous motors. The 100 kW air-cored model is designed analytically by Spatial Harmonic Method, and based on this model, the iron-cored model having the same output power is designed for comparison. Due to the substantial difference of permeability property between air and iron-core, there is a difference of magnetic field magnitude and angle with respect to the HTS tape c-axis, resulting in a different critical current of the field winding considering the anisotropic property of HTS tape. For a detailed comparison between two models, the following key motor characteristics are calculated through the Finite Element Method (FEM) simulation: 1) critical current; 2) HTS wire length; and 3) torque characteristics. From the simulation results, it can be confirmed that the critical current value of the iron-cored model increases by 33 %. Also, in the case of the superconducting wire consumption, those of the iron-cored and air-cored models are 95.3 m and 815.6 m, respectively. So the wire usage can be reduced to about 88 % by using iron core. However, in terms of torque characteristics, the torque ripple of the iron-cored model is about twice as large as that of the air-cored model, which may be a disadvantage on vibration and acoustic noise.