• Computers and Concrete
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• v.2 no.3
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• pp.203-214
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• 2005

In the Part 1 paper (Gawin, et al. 2005) some experimental results concerning micro-structural tests, permeability measurements and stress-strain tests of four types of High Performance Concrete, exposed to elevated temperatures (up to $700^{\circ}C$) are presented and discussed. On the basis of these experimental results parameters of the constitutive relationships describing influence of damage and temperature upon material intrinsic permeability at high temperature were determined. In this paper the effects of various formulations of damage-permeability coupling on results of computer simulations are analysed and compared with the results obtained by means of the previously proposed approach, that does not take into account the thermo-chemical concrete damage directly. Numerical solutions are obtained using the recently developed fully coupled model of hygro-thermal and damage phenomena in concrete at elevated temperatures. High temperature effects are considered by means of temperature and pressure dependence of several material parameters. Based on the mathematical model, the computer code HITECOSP was developed. Material parameters of the model were measured by several European laboratories, which participated in the "HITECO" research project. A model problem, concerning hygro-thermal behaviour and degradation of a HPC structure during fire, is solved. The influence of two different constitutive descriptions of the concrete permeability changes at high temperature, including thermo-chemical and mechanical damage effects, upon the results of computer simulations is analysed and discussed.

• Geotechnical Engineering
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• v.13 no.2
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• pp.77-90
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• 1997

A resonable and economical method which can predict permeability of rock mass in underground is needed to overcome the uncertainty of groundwater behavior. For this par pose, one prediction method of permeability has been studied. The artificial neural networks model using error back propagation algorithm, . one of the teaching techniques, is utilized for this purpose. In order to verify the applicability of this model, in-situ permeability results are simulated. The simulation results show the potentiality of utilizing the neural networks for effective permeability prediction of rock mass.

• Proceedings of the Korean Society for Rock Mechanics Conference
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• 2000.09a
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• pp.129-137
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• 2000

This paper presents groundwater flow characteristics in discontinuous rock mass using fracture network program(NAPSAC) by statistical approach. Equivalent permeability coefficients are estimated from borehole data around Mabuk test tunnel site and fracture map on the arch of the tunnel. The reliability of fracture network model is obtained from determination of input data for statistical fracture network analysis from the real data(data of fracture network, data of hydraulic tests). The variation of permeability and mean anisotropic permeability coefficients are calculated from the realized model by increasing the size. As a result of analysis, a strong anisotropy of permeability is observed according to the direction of the fracture sets around the test tunnel.

• Tunnel and Underground Space
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• v.10 no.3
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• pp.378-386
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• 2000

This paper presents groundwater flow characteristics in discontinuous rock mass using fracture network program(NAPSAC) by statistical approach. Equivalent permeability coefficients are estimated from borehole data around Mabuk test tunnel site and fracture map on the arch of the tunnel. The reliability of fracture network model is obtained from determination of input data for statistical fracture network analysis from the real data(data of fracture network, data of hydraulic tests). The variation of permeability and mean anisotropic permeability coefficients are calculated from the realized model by increasing the size. As a result of analysis, a strong anisotropy of permeability is observed according to the direction of the fracture sets around the test tunnel.

• Coupled systems mechanics
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• v.11 no.2
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• pp.93-106
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• 2022

The total embankment settlement consists of three stages: the initial settlement, the primary consolidation settlement, and the secondary consolidation settlement. The total embankment settlement is largely controlled by the primary consolidation settlement, which is usually computed with numerical models that implement Biot's theory of consolidation. The key parameter that affects the primary consolidation time is the coefficient of permeability. Due to the complex stress and strain states in the foundation soil under the embankment, to be able to predict the consolidation time more precisely, aside from porosity-dependency, the strain-dependency of the coefficient of permeability should be also taken into account in numerical analyses. In this paper, we propose a two-dimensional plane strain numerical model of embankment primary consolidation, which implements Biot's theory of consolidation with both porosity-dependent and strain-dependent coefficient of permeability. We perform several numerical simulations. First, we demonstrate the influence of the strain-dependent coefficient of permeability on the computed results. Next, we validate our numerical model by comparing computed results against in-situ measurements for two road embankments: one near the city of Saga, and the other near the city of Boston. Finally, we give our concluding remarks.

• Geomechanics and Engineering
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• v.37 no.2
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• pp.179-187
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• 2024

In this paper, a unified time-dependent constitutive model of Darcy flow and non-Darcy flow is proposed. The influencing factors of flow velocity are discussed, which demonstrates that permeability coefficient is the most significant factor. Based on this, the dynamic evolution characteristics of water inrush during tunneling through fault fracture zone is analyzed under the constant permeability coefficient condition (CPCC). It indicates that the curves of flow velocity and hydrostatic pressure can be divided into typical three stages: approximate high-velocity zone inside the fault fracture zone, velocity-rising zone near the tunnel excavation face and attenuation-low velocity zone in the tunnel. Furthermore, given the variation of permeability coefficient of the fault fracture zone with depth and time, the dynamic evolution of water flow in the fault fracture zone under the variable permeability coefficient condition (VPCC) is also studied. The results show that the time-related factor (α) affects the dynamic evolution distribution of flow velocity with time, the depth-related factor (A) is the key factor to the dynamic evolution of hydrostatic pressure.

• Journal of Pharmaceutical Investigation
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• v.38 no.3
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• pp.183-189
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• 2008

The present study compared the feasibility of Caco-2 and MDCK cells as an efficient in-vitro model for the drug classification based on Biopharmaceutics Classification System (BCS) as well as an in-vitro model for drug interactions mediated by P-gp inhibition or P-gp induction. Thirteen model drugs were selected to cover BCS Class I{\sim}IV$ and their membrane permeability values were evaluated in both Caco-2 and MDCK cells. P-gp inhibition studies were conducted by using vinblastine and verapamil in MDCK cells. P-gp induction studies were also performed in MDCK cells using rifampin and the P-gp expression level was determined by western blot analysis. Compared to Caco-2 cells, MDCK cells required shorter period of time to culture cells before running the transport study. Both Caco-2 and MDCK cells exhibited the same rank order relationship between in-vitro permeability values and human permeability values of all tested model compounds, implying that those in-vitro models may be useful in the prediction of human permeability (rank order) of new chemical entities at the early drug discovery stage. However, in the case of BCS drug classification, Caco-2 cells appeared to be more suitable than MDCK cells. P-gp induction by rifampin was negligible in MDCK-cells while MDCK cells appeared to be feasible for P-gp inhibition studies. Taken all together, the present study suggests that Caco-2 cells might be more applicable to the BCS drug classification than MDCK-cells, although MDCK cells may provide some advantage in terms of capacity and speed in early ADME screening process.

• Computers and Concrete
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• v.24 no.6
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• pp.571-578
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• 2019

This study aimed to investigate the permeable nature of pervious concretes (PC) through the moving particle simulation (MPS) method. In the simulation, the complex structure of a pervious concrete was virtually demonstrated as a lattice model (LM) of spherical beads, where the test of permeability was conducted. Results of the simulation were compared with the experimental ones for validation. As a result, MPS results showed the permeability index of the LM as almost twice as big as the actual PCs. A proposed virtual model was created to prevent the stuck of water flow in the MPS simulation of PC or LM. Successful simulation results were demonstrated with the model.

• Journal of the Korean Institute of Gas
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• v.23 no.3
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• pp.7-19
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• 2019

In this study, a model was developed for estimating deliverability considering the pressure dependent permeability and predicting production profile with Material Balance Equation(MBE) for Coalbed Methane(CBM) fields. The estimated deliverability was compared with the conventional deliverability based on CBM well testing data with coefficient of determination($R^2$). As a result, the former was 0.76 and the latter was 0.69. It was confirmed that the deliverability which consider the pressure dependent permeability is more adoptable when representing the productivity of CBM fields. Through this process, in order to calculate pressure dependent permeability when well testing data exist, a method to infer reservoir pressure within the radius of investigation was proposed. The production profile of 31 gas wells was predicted for 15 years, using the estimated deliverability and the MBE. After that, the results was compared with simulation results of the literature. The simulation results did not account the pressure dependent permeability and the developed model results considered that. As the applied field permeability rised 1.17 times, field production rate was increased approximately 15% than the literature results. According to other researches, the permeability of CBM fields can be rise 6 ~ 25 times. For these cases, the production profiles may have significant difference with conventional gas fields.

• Proceedings of the Membrane Society of Korea Conference
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• 2004.05a
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• pp.33-38
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• 2004

Molecular modeling of gas permeation through zeolite membranes with/without intercrystalline region was carried out. Molecular dynamics (MD) and Monte Carlo (MC) simulations were performed to estimate the diffusion coefficient and adsorption parameters respectively, and our proposed combined method of molecular simulation techniques with a permeation theory (CMP) was used to estimate gas permeability. The calculated permeability of gases (Ar, He, Ne, $N_2$, $0_2$, $CH_4$) at 301 K for the single crystal membrane model was about one order of magnitude larger than the experiential values, although the dependence on the molecular weight of the permeating species agreed with experiments. On the other hand, the estimated permeability using the diffusivity and adsorption parameters of the intercrystalline region model was in good agreement with the experiments. The consistency between experiments and the estimated values means the importance of considering the intercrystalline region and the validity of CMP method to predict the performance of zeolite membranes.