• YAKHAK HOEJI
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• v.46 no.2
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• pp.124-128
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• 2002

The nitrone-based free radical trapping reagent, $\alpha$-phenyl-n-tert-butyl nitrone (PBN) has been proposed as therapeutic agent for stroke. We used this for model drug of development of new drug for neuroprotection. The purpose of this study was to evaluate the blood-brain barrier (BBB) permeability of PBN in Sprague-Dawly (SD) rats. The BBB transport of PBN was investigated in SD rats using internal carotid artery perfusion (ICAP) method at a rate of 4 mι/min for 15 second. We also obtained pharmacokinetic parameters of PBN using single intravenous injection technique. When we estimated BBB permeability of PBN with ICAP method, the brain volume of distribution of PBN was 60.0 $\pm$ 12.0 $\mu\textrm{g}$/ι. The brain uptake of PBN after IV injection at 120 min was 0.15 $\pm$ 0.01%ID/g. The PBN was transported to the brain through the BBB well in rats, because PBN is small molecule (MW 177) and lipid-soluble (log P 1.23) compound.

• Journal of the Korean Geosynthetics Society
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• v.7 no.4
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• pp.1-8
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• 2008

Soil vapor extraction (SVE) is an effective and cost efficient method of removing volatile organic compounds (VOCs) and petroleum hydrocarbons from unsaturated soils. However, soil vapor extraction becomes ineffective in soils with low gas permeability, for example soils with air permeabilities less than 1 Darcy. The aim of this study is to investigate numerically the performance of a prefabricated vertical drain (PVD) as a SVE well, and the pattern of the induced air flow. A validated numerical model for a single PVD extraction well is developed based on the result of a well-designed laboratory model test. The validity of the simple analytical approach to determine air permeability based on the results of model tests is also discussed.

• Journal of the Korean Geotechnical Society
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• v.32 no.1
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• pp.55-62
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• 2016

This study presents the numerical results of soil-water characteristic curve for sandy soil by pore network model. The Jumunjin sand is subjected to the high resolution 3D X-ray computed tomographic imaging and its pore structure is constructed by the web of pore body and pore channel. The channel radius, essential to the computation of capillary pressure, is obtained based on the skeletonization and Euclidean Distance transform. The experimentally obtained soil-water characteristic curve corroborates the numerically estimated one. The pore channel radius defined by minimum radii of pore throat results in the slightly overestimation of air entry value, while the overall evolution of capillary pressure resides in the acceptable range. The relative permeability computed by a series of suggested models runs above that obtained by pore network model at high degree of saturation.

• Journal of the Korea institute for structural maintenance and inspection
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• v.8 no.2
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• pp.123-136
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• 2004

Terzaghi's one-dimensional consolidation theory has some important assumption, which can't be applicable to predict the behavior of soft clay ground. Especially, predictions using infinitesimal strain and linear material function related with permeability can give rise to mistake in comparison with the result of real behavior in site. For this reason, Gibson et al. established a rigorous formulation for the one-dimensional nonlinear finite strain consolidation theory, which can consider non-linearity of material function. But it is difficult to apply this theory to predict the behavior of common soft clay ground with vertical drain. In this study, consolidation model which can consider the vertical and horizontal flow of a fully saturated clay layer, self-weight of soil and nonlinear characteristics of compressibility and permeability are derived. Numerical analysis scheme, which can be applied to consolidation analysis by derived consolidation model in this study was developed. The characteristics of material function were examined using laboratory testing such as standard consolidation test, Rowe-cell test and modified consolidation test.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.24 no.4
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• pp.247-256
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• 2012

The purpose of this study is to decide the permeability and the rate of flow in a way of both site investigation and backward analysis and the most reasonable numerical analysis by performing a seepage model test for measuring the deformation swept volume of the embankment body in order to review a stability of the sea dyke being composed of multi-layers depending on variation of infiltration. As a result of the review, it could be forecasted that sweeping loss would be taken place at the boundary between bed protection works and embankment materials of the sea dyke due to a permeability difference of the multi-layered bed foundation structures and the sea dyke deformation would be occurred as a result thereby. As result of a numerical analysis for the seepage model test, it could be observed that critical velocity method was found to be smaller than the numerical analysis value but its tendency was similar and therefore it was judged that this method could be applied for the actual cross section.

• Tunnel and Underground Space
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• v.17 no.3 s.68
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• pp.234-243
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• 2007

In this paper, it was aimed to enhance core processes required in establishing hydrogeological models constructed using borehole investigation results. Water Conducting Feature(WCF) information was extracted from borehole investigation, and HydroDFN model was constructed based on the WCF information. The HydroDFN model was sub-divided by cubic blocks, and equivalent permeability of each sub-divided block was calculated and compared with the results of hydraulic test at the borehole. Through these analysis processes, suggestion for identifying and prescribing WCF parameters in the construction of HydroDFN model was made.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.248-251
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• 2005

To investigate the degeneration process in the intervertebral disc, a three dimensional (3D) poroelastic finite-element (FE) model was developed. Disc was modeled as two different regions, such as annulus modeled with fiber reinforced 20 node poroelastic ground matrix and nucleus having large porosity. Excess Von Mises stress in the disc element assumed to be a possible source of degeneration under compressive loading condition. Recursive calculation was continued until the desired convergence was attained by changing the permeability and porosity of those elements, which could be predicted from the previous iteration. The degenerated disc model showed that relatively small compressive stresses were generated in the nucleus elements compared to normal disc. Its distribution along the sagittal plane was matched well with a previously reported experimental result. Contrasts to this result, pore pressures in the nucleus were higher than those in the normal disc. Total stress indicated similar values for two different models. This new approach using poroelastic modeling could provide the explanation of the interaction between fluid and solid matrix in the disc during the degeneration process.

• Geomechanics and Engineering
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• v.24 no.1
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• pp.43-55
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• 2021

Peatland is distributed in China widely, and organic matters in soil frequently induce problems in the construction and maintenance of highway engineering due to the high permeability and compressibility. In this paper, a selected site of Dali-Lijiang expressway was surveyed in China. A numerical model was built to predict the settlement of the foundation of the selected section employing the soft soil creep (SSC) model in PLAXIS 8.2. The model was subsequently verified by the result of field observance. Consequently, the parameters of 17 types of soils from different regions in China with organic contents varying from 1.1-74.9% were assigned to the numerical model to study the settlement characteristics. The calculated results showed that the duration of primary consolidation and proportion of primary settlement in the total settlement decreased with increasing organic content. Two empirical equations, for total consolidation settlement and secondary settlement, were proposed using multiple linear regression based on the calculated results from the numerical models. The analysis results of the significances of certain soil parameters demonstrated that the natural compression index, secondary compression index, cohesion and friction angle have significant linear relevance with both the total settlement and secondary settlement, while the initial coefficient of permeability exerts significant influence on the secondary settlement only.

• International Journal of Concrete Structures and Materials
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• v.7 no.3
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• pp.225-238
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• 2013

In this study, a two-layer feed-forward neural network was constructed and applied to determine a mapping associating mix design and testing factors of cement-nano silica (NS)-rice husk ash ternary blended concrete samples with their performance in conductance to the water absorption properties. To generate data for the neural network model (NNM), a total of 174 field cores from 58 different mixes at three ages were tested in the laboratory for each of percentage, velocity and coefficient of water absorption and mix volumetric properties. The significant factors (six items) that affect the permeability properties of ternary blended concrete were identified by experimental studies which were: (1) percentage of cement; (2) content of rice husk ash; (3) percentage of 15 nm of $SiO_2$ particles; (4) content of NS particles with average size of 80 nm; (5) effect of curing medium and (6) curing time. The mentioned significant factors were then used to define the domain of a neural network which was trained based on the Levenberg-Marquardt back propagation algorithm using Matlab software. Excellent agreement was observed between simulation and laboratory data. It is believed that the novel developed NNM with three outputs will be a useful tool in the study of the permeability properties of ternary blended concrete and its maintenance.

• Journal of the Korean Geotechnical Society
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• v.16 no.4
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• pp.107-116
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• 2000

In this study, the permeability reduction in the soil-filter systems due to clogging phenomenon was evaluated. An extensive research program was performed using two typical weathered residual soils which were sampled at Shinnae-dong and Poi-dong area in Seoul. Two separate simulation tests with weathered residual soil were performed: one was the filtration test(cross-plane flow test); and the other was the drainage material in the field. The compatibility of the sol-filter system was investigated with emphasis on the clogging phenomenon. The hydraulic behaviour of the soil-filter system was evaluated by changing several testing conditions. Also, experimental results of the permeability reduction are compared with the results obtained from the theoretical model which can monitor the spatial variation of the permeability with time.