• Journal of Acupuncture Research
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• v.27 no.6
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• pp.101-109
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• 2010

Objectives : This study was to compare effects of scalp acupuncture with usual acupuncture on peripheral facial palsy in comparison with usual acupuncture only. Methods : We investigated 40 cases of patients with peripheral facial palsy, and devided patients into two groups: We treated one group by scalp acupuncture with usual acupuncture and did the other group by usual acupuncture only. To evaluate the effectiveness of treatment applied for two groups, we used Gross Grading System of House-Brackmann(H-B grade), Yanagihara's Unweighed Grading System(Y system). Results : 1. In H-B grade group B(common acupuncture therapy and scalp acupuncture)'s score was reduced than group A(common acupuncture therapy), but there was no statistical significance. 2. In Y-system group B was higher than group A, but there was no statistical significance. Conclusions : There was no stastical significance between two groups : treated by scalp acupuncture with usual acupuncture and usual acupuncture therapy only, on peripheral facial palsy.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.4 no.1
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• pp.68-75
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• 2011

The performance of peripheral devices is improving rapidly to meet the needs of users for multimedia data. Therefore, the peripheral interface with wide bandwidth and high transmission rate becomes necessary to handle large amounts of data in real time for multiple high-performance devices. PCI Express is a fast serial interface with the use of packets that are compatible with previous PCI and PCI-X. In this paper, we design and verify general peripheral interface using serial link. It includes two kinds of traffic class (TC) labels which are mapped to virtual channels (VC). The design adopts TC/VC mapping and the scheme of arbitration by priority. The design uses a packet which can be transmitted through up to four transmission lanes. The design of general peripheral interface is described in Verilog HDL and verified using ModelSim. For FPGA verification, Xilinx ISE and SPARTAN XC3S400 are used.We used Synopsys Design Compiler as a synthesis tool and the used library was MagnaChip 0.35um technology.

• The Korean Journal of Physiology
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• v.17 no.2
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• pp.169-176
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• 1983

It is well known that the acupuncture has been used effectively for the relief of certain types of pain. Although the precise mechanism of action of acupuncture analgesia is unknown, it is generally accepted that their analgesic properties are related to the activation of endogenous opiate system in central nervous system. And it is suggested that pain-relieving properties of acupunture may be related to a stimulation of peripheral nerve underlying the acupuncture point on the skin. However, the efficacy of acupuncture has no relationship between the site of pain and the acupuncture point. Consequently, the present study was undertaken to investigate electroacupuncture analgesia in relation to the site of peripheral nerve stimulation. Cats were decerebrated ischemically and the flexion reflex as an index of pain was elicited by stimulating the sural nerve (20V, 0.5 msec duration) and recored as a compound action potential from the nerve innervated to the posterior biceps femoris muscle in the ipsilateral hindlimb. Bilateral common peroneal nerve and contralateral superficial radial nerve were selected as the site of peripheral nerve stimulation. For the stimulation of peripheral nerve, a stimulus of 20 V intensity, 2 msec-duration and 2 Hz-frequency was applied for 60 min respectively. The results obtained are summarized as follows: 1) Both stimulation of contralateral common peronal nerve and contralateral superficial radial nerve did not change the flexion reflex and there were no significant differences between them. 2) Stimulation of ipsilateral common peroneal nerve markedly depress the flexion reflex, the effect being reversed by naloxone application. These results suggest that stimulation of ipsilateral common peroneal nerve has the analgesic effect but both stimulation of contralteral common peroneal nerve and contralateral superficial radial nerve to the pain site where flexion reflex was elicited have no analgesic effect.

• The Korean Journal of Pain
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• v.23 no.3
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• pp.179-185
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• 2010

Background: Vincristine-induced peripheral neuropathy is a major dose limiting side effect and thus effective therapeutic strategy is required. In this study, we investigated the antinociceptive effect of memantine and morphine on a vincristine-induced peripheral neuropathy model in rats. Methods: Male Sprague-Dawley rats weighing 220-240 g were used in all experiments. Rats subsequently received daily intraperitoneal injections of either vincristine sulfate (0.1 ml/kg/day) or saline (0.1 ml/kg/day) over 12 days, immediately following behavioral testing. For assessment of mechanical allodynia, mechanical stimuli using von Frey filament was applied to the paw to measure withdrawal threshold. The effects of N-methyl-D-aspartate receptors antagonist (memantine; 2.5, 5, 10 mg/kg intraperitoneal), opioid agonist (morphine; 2.5, 5, 10 mg/kg intraperitoneal) and vehicle (saline) on vicristine-induced neuropathy were evaluated. Results: Mechanical allodynia developed over the course of ten daily injections of vincristine relative to groups receiving saline at the same time. Morphine abolished the reduction in paw withdrawal threshold compared to vehicle and produced dose-responsiveness. Only the highest dose of memantine (10 mg/kg) was able to increase paw withdrawal threshold compared to vehicle. Conclusions: Systemic morphine and memantine have an antinociceptive effect on the vincristine-induced peripheral neuropathy model in rats. These results suggest morphine and memantine may be an alternative approach for the treatment of vincristine-induced peripheral neuropathic pain.

• The Korean Journal of Pain
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• v.31 no.3
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• pp.183-190
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• 2018

Background: Vitamin B12 deficiency has been associated with peripheral neuropathy, loss of sensation in the peripheral nerves, and weakness in the lower extremities. Methylcobalamin is the most effective analogue of vitamin B12 used to treat or prevent the complications associated with vitamin B12 deficiency. The current study aimed to compare the serum cobalamin levels after administration of two different regimes of methylcobalamin in peripheral neuropathy patients. Methods: The present study was a prospective, randomized, comparative study. The study consisted of two parallel groups, group A (methylcobalamin $500{\mu}g$ injection intramuscularly three times a week) and group B (methylcobalamin $1500{\mu}g$ injection intramuscularly once a week). A control group of healthy volunteers was also included. Results: A total of 24 patients (12 in each group) were included in the study. Five healthy volunteers were also included as a control in each group. At the end of treatment, serum cobalamin levels were significantly (P = 0.028) higher in group A ($1892.08{\pm}234.50$) as compared with group B ($1438.5{\pm}460.32$). The serum cobalamin levels in Group A healthy volunteers were also two times higher than that of group B (P = 0.056). Both the LANSS scale and DN4 questionnaire reported similar results at end of treatment. Conclusions: The $500{\mu}g$ methylcobalamin thrice weekly regime is more effective in increasing the serum cobalamin levels as compared to the $1500{\mu}g$ methylcobalamin once weekly regime.

• Journal of Korean Neurosurgical Society
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• v.58 no.6
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• pp.504-507
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• 2015

Objective : Our aim was to evaluate the histopathological effects of tissue adhesives on peripheral nerve regeneration after experimental sciatic nerve transection in rats and to search whether these tissue adhesives may possess a therapeutic potential in peripheral nerve injuries. Methods : This experimental study was performed using 42 female Wistar-Albino rats distributed in 6 groups subsequent to transection of right sciatic nerves. Group I underwent external circumferential neurolysis; Group II received suture repair; Group III had local polymeric hydrogel based tissue adhesive administration; Group IV received suture repair and polymeric hydrogel based tissue adhesive application together; Group V had gelatin based tissue adhesive application and Group VI had suture repair and gelatin based tissue adhesive together. After a 6-week follow-up period, biopsies were obtained from site of neural injury and groups were compared with respect to histopathological scoring based on inflammatory, degenerative, necrotic and fibrotic changes. Results : There were remarkable differences between control group and study groups with respect to inflammation (p=0.001), degeneration (p=0.002), necrosis (p=0.007), fibrosis (p<0.001) and vascularity (p=0.001). Histopathological scores were similar between study groups and the only noteworthy difference was that Group V displayed a lower score for necrosis and higher score in terms of vascularization. Conclusion : Our results imply that tissue adhesives can be useful in repair of peripheral nerve injuries by decreasing the surgical trauma and shortening the duration of intervention. Results with gelatin based tissue adhesive are especially promising since more intense vascularity was observed in tissue after application. However, trials on larger series with longer durations of follow-up are essential for reaching more reliable conclusions.

• The Korean Journal of Physiology and Pharmacology
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• v.18 no.6
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• pp.489-495
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• 2014

Protease-activated receptor (PAR)-2 is expressed in endothelial cells and vascular smooth muscle cells. It plays a crucial role in regulating blood pressure via the modulation of peripheral vascular tone. Although some reports have suggested involvement of a neurogenic mechanism in PAR-2-induced hypotension, the accurate mechanism remains to be elucidated. To examine this possibility, we investigated the effect of PAR-2 activation on smooth muscle contraction evoked by electrical field stimulation (EFS) in the superior mesenteric artery. In the present study, PAR-2 agonists suppressed neurogenic contractions evoked by EFS in endothelium-denuded superior mesenteric arterial strips but did not affect contraction elicited by the external application of noradrenaline (NA). However, thrombin, a potent PAR-1 agonist, had no effect on EFS-evoked contraction. Additionally, ${\omega}$-conotoxin GVIA (CgTx), a selective N-type $Ca^{2+}$ channel ($I_{Ca-N}$) blocker, significantly inhibited EFS-evoked contraction, and this blockade almost completely occluded the suppression of EFS-evoked contraction by PAR-2 agonists. Finally, PAR-2 agonists suppressed the EFS-evoked overflow of NA in endothelium-denuded rat superior mesenteric arterial strips and this suppression was nearly completely occluded by ${\omega}$-CgTx. These results suggest that activation of PAR-2 may suppress peripheral sympathetic outflow by modulating activity of $I_{Ca-N}$ which are located in peripheral sympathetic nerve terminals, which results in PAR-2-induced hypotension.

• Korean Journal of Cognitive Science
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• v.21 no.1
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• pp.25-45
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• 2010

If color and motion direction of random dots in the central region was combined in opposite fashions with those of random dots in the peripheral region, the color of dots with a particular direction in the peripheral region is perceived as that of dots in the central region, known as color-motion mis-binding phenomenon. In the present study, it is investigated whether mis-binding would happen even if the central and peripheral region do not have a common three-dimensional surface. In the first experiment, the dots in the peripheral were presented in a different depth plane with use of binocular disparity, and in the second experiment the disparity of dots in the peripheral region was randomly selected from a given range. The results showed that the magnitude of mis-binding was weakened, but not completely disappeared even when two regions did not have a common 3D surface. These results indicate that the surface information from motion and stereodepth may influence in the process of color-motion mis-binding.

• Journal of Acupuncture Research
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• v.29 no.5
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• pp.31-37
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• 2012

Objectives : The purpose of this study is to evaluate the effect of BUM pharmacopuncture and Soyeom pharmacopuncture on postauricular pain accompanied peripheral facial paralysis. Methods : We observed 31 peripheral facial paralysis patients with postauricular pain at Oriental Hospital of Semyung University from Jan. 1st, 2010 to Feb. 29th, 2012. One group(group A) was treated BUM Pharmacopuncture in the posterior ear with general oriental medical treatment and the other(group B) was treated Soyeom pharmacopuncture in the posterior ear with general oriental medical treatment. Results : 1. Postauricular pain was significantly decreased in each group but no significant difference between two groups. 2. Facial paralysis was significantly improved in each group and significant difference in group B. Conclusions : In peripheral facial paralysis patients with postauricular pain, both BUM pharmacopuncture and Soyeom pharmacopuncture were effective on postauricular pain.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2015.05a
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• pp.606-608
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• 2015

In order to bear a relationship between the devices in the IoT environment whereby the task of navigating the device and relationship should be preceded before. The new device transmits a search signal in order to find a device and a peripheral device that receives this will determine the distance information of the device and determines the intensity of the transmitted signal. M2M (Machine to Machine) method has been used in conventional sends the search signal to all of the peripheral devices in a single device, a peripheral device that is greater the search time becomes long, a problem that a loss of information, the more devices that are far there is. In this paper, a method to compensate for problems of existing methods of M2M devices and new shortening of the search time when the search for the peripheral device, an algorithm to reduce the information loss of time to send and receive signals from the navigation device and away proposals were discussed and used in the field.