• Communications for Statistical Applications and Methods
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• v.18 no.5
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• pp.581-594
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• 2011

The traditional method of 3+3 standard design and model-based Bayesian continual reassessment method (CRM) are commonly used in Phase I clinical trials to identify the maximal tolerated dose(MTD) of a new drug. In this paper we review clinical examples of Phase I trials that were carried out in patients with refractory or relapsed leukemia and myelodysplastic syndrome. The recently proposed 3+1+1 design and rolling-6 design can shorten the trial duration, when a very slow accrual of patients with a simple 3+3 standard design may result in the untimely termination of trials. Too conservative approaches in determining the dose levels in Phase I clinical trials can leave clinical investigators unable to accurately determine the MTD. When determining future patient doses, the designs that use a time-to-event CRM can cooperate late toxicities by accounting for the proportion of the observation period of each enrolled patient. With the CRM design, simulations under different scenarios during the trial are important in detecting the under- or over-estimation of the initial estimate of the dose-limiting toxicity rate for each dose level. We present the advantages and drawbacks of the designs used in Phase I clinical trials for leukemia patients.

• Korean Journal of Soil Science and Fertilizer
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• v.38 no.5
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• pp.253-258
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• 2005

It is necessary to determine a nitrogen supplying capacity (NSC) of soil for sustainable agriculture. NSC has been decided by directly detecting N mineralization potential (NMP) and inorganic nitrogen or by indirectly approximating from organic matter and chemical properties of soil. NMP is best method for NSC but it takes long period. A study was conducted to find a short-term incubation method using pepsin through 1) determining NMP of 3 upland and 3 paddy soils, 2) establishing analytical condition of pepsin digestion by comparing to NMP, 3) validating with relations to N requirements for maximum yield of rice. NMPs of 6 soils were ranges from $63mg\;N\;kg^{-1}$ to $156mg\;N\;kg^{-1}$. The pepsin digestion method of soil nitrogen was established by determining amino nitrogen from digesting 5 g of soil for 30 minutes by 0.02% pepsin. This method was so highly correlated with a maximum rate of nitrogen fertilizer that it could be used for determining NSC in paddy soil.

• Journal of Environmental Health Sciences
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• v.21 no.3
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• pp.38-47
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• 1995

The Bioconcentration factor (BCF) is used as an important criterion in the risk assessment of environmental contaminants. Also it can be used as indicator of biomagnification of environmentally hazardous chemicals through food-chain as well as a tool for ranking the bioconcentration potential of the chemicals in the environment. This paper reports the measured BCF value on Chlorothalonil in Carassius auratus(goldfish), under steady state, and examined correlation between the BCF value and the partition coefficient or acute toxicity or physicochemical properties. Carassius auratus(goldfish) was chosen as test organism and test period were 3-day, 5-day. Experimental concentrations were 0.005, 0.01 and 0.05 ppm. Chlorothalonil in fish tissue and in test water were extracted with n-hexane and acetonitrile. GC-ECD was used to detecting and quantitating of Chlorothalonil. Partition coefficient was determined by stir-flask method. $LC_{50}$ was determined on Chlorothalonil. Carbaryl and BPMC. The obtained results were as follows. 1. It was possible to determine short term BCFs of Chlorothalonil through relatively simple procedure in environmental concentrations. 2. $BF_3$ of Chlorothalonil in concentration of 0.005, 0.01 and 0.05 ppm were 2.1866$\pm$0.23446, 3.5269$\pm$0.23517, 10.2045$\pm$0.18053 and BCFs were 6.6543$\pm$0.55257, 6.9774$\pm$0.02500, 23.4576$\pm$2.06884, respectively. 3. Chlorothalonil concentration in fish extract and BCFs of Chlorothalonil were increased as increasing test concentration and prolonging test period. 4. Fate of test-water concentration on Chlorothalonil was greater than that of control-water con-centration. It is considered that greater fate of test-water concentration on Chlorothalonil is due to hydrolyzing nitrile group under the mild condition and substituting chloro group by some aromatic compounds in test water. 5. Determined logP of Chlorothalonil was 2.80. And determined $LC_{50}$ of Chlorothalonil in time of 24, 48, 72 and 96 hr were 0.1684, 0.1402, 0.1400, 0.1352(mg/l) respectively. And $LC_{50}$ of Carbaryl in above times were 19.918, 18.635, 18.466, 18.12(mg/l) respectively. $LC_{50}$ of BPMC were 10.248, 9.166, 9.087, 8.921(mg/l) respectively. 6. It is suggested that the BCF of Carbamates depend on partition coefficients. But BCF of Chlorothalonil, organochlorine pesticide, would be strongly influenced by steric, electronic effect of substituents than partition coefficient.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.11B
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• pp.750-757
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• 2005

This paper reports on the study of P2P traffic behaviors in a high-speed campus network under a simple firewall which drops packets with default port numbers for the well-blown P2P applications. Among several ways of detecting P2P traffic, the easiest method is to filter out packets with the default port number of each P2P application. After deploying the port-based firewall against P2P-traffic, it is expected that the amount of P2P traffic will be decreased. However, during the eight-month measurement period, three new commercial P2P applications have been identified and their traffic usages have reached up to $30/5.6\%$ of the total outbound/inbound traffic volumes at the end of the measurement period. In addition, the most famous P2P application, eDonkey, has adapted and has escaped detection through port hopping. The measurement result shows that the amount of eDonkey traffic is around $6.7/4.0\%$ of the total outbound/inbound traffic volume. From the measurement results, it is observed that the port-based firewall is not effective to limit the usage of P2P applications and that the P2P traffic is steadily growing due to not only the evolution of existing P2P applications such as port hopping but also appearances of new P2P applications.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.4
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• pp.201-209
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• 2012

The point-based complex event processing handled an instantaneous event by using one time stamp in each event. However, the activity period of the event plays the important role in the field which is the same as the finance, multimedia, medicine, and meteorology. The point-based event is insufficient for expressing the complex temporal relationship in this field. In the application field of the real-time world, the event has the period. The events more than two kinds can be temporally overlapped. In addition, one event can include the other event. The relation about the events of kind of these can not be successive like the point-based event. This thesis designs and implements the method detecting the patterns of the complex event by using the interval-based events. The interval-based events can express the overlapping relation between events. Furthermore, it can include the others. By using the end point of beginning and end point of the termination, the operator of interval-based events shows the interval-based events. It expresses the sequence of the interval-based events and can detect the complex event patterns. This thesis proposes the algorithm using the active instance stack in order to raise efficiency of detection of the complex event patterns. When comprising the event sequence, this thesis applies the window push down technique in order to reduce the number of intermediate results. It raises the utility factor of the running time and memory.

• Korean Journal of Clinical Laboratory Science
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• v.51 no.4
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• pp.428-435
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• 2019

The rapid increase and dissemination of carbapene mases, such as Klebsiella pneumoniae carbapenemase (KPC), has become a major problem within the field of healthcare-related infection. There are few antibiotics to treat carbapenem-resistant Enterobacteriaceae (CRE) infections, so the identification of resistant bacterial mechanisms is critical to initiate infection control and conduct epidemiological research. A rapid and effective method for detecting KPC-producing bacteria is needed to avoid therapeutic failures and introduce measures to prevent and control the dissemination of these multi-resistant bacteria. During the study period, 31 isolates (seven isolates of Acinetobacter spp., six isolates of Morganella morganii, five isolates of Pseudomonas aeruginosa, five isolates of Proteus mirabilis, one isolate of Proteus vulgaris, two isolates of Enterobacter cloacae, one isolate of Enterobacter aerogenes, one isolate of Klebsiella pneumoniae, one isolate of Klebsiella oxytoca, one isolate of Serratia marcescens and one isolate of Escherichia coli) were identified by the VITEK. Gram negative rod bacteria were the most frequently isolated from urine (35.5%), blood (19.4%), sputum (16.1%), pus (9.7%), ascitic fluid (9.7%), tracheal aspirates (6.5%) and bile juice (3.2%). Analysis using the PCR method identified the bla_KPC gene in the K. oxytoca1 strain, but the bla_IMP, bla_VIM and bla_OXA-48 genes are not amplified. In conclusion, diagnosis using the PCR method can accurately and quickly diagnose KPC, thus establishing quick preventive measures to prevent the spread of KPC in hospitals.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.156-156
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• 2017

Most crop damages have been occurred by vermin(e.g., wild birds and herbivores) during the period between seeding and the cotyledon level. In this study, to minimize the damage by vermin and acquire the benefits such as protection against weeds and maintenance of water content in soil, immediately vinyl mulching after seeding was devised. Vinyl mulching has been generally covered with black color vinyl, that crop seeding locations cannot be detected by visible light range. Before punching vinyl, non-contact and non-destructive methods that can continuously determine the locations are necessary. In this study, a crop position detection method was studied that uses infrared thermal image sensor to determine the cotyledon position under vinyl mulch. The moving system for acquiring image arrays has been developed for continuously detecting crop locations under plastic mulching on the field. A sliding mechanical device was developed to move the sensor, which were arranged in the form of a linear array, perpendicular to the array using a micro-controller integrated with a stepping motor. The experiments were conducted while moving 4.00 cm/s speed of the IR sensor by the rotational speed of the stepping motor based on a digital pulse width modulation signal from the micro-controller. The acquired images were calibrated with the spatial image correlation. The collected data were processed using moving averaging on interpolation to determine the frame where the variance was the smallest in resolution units of 1.02 cm. For this study, the spline method was relatively faster than the other polynomial interpolation methods, because it has a lower maximum order of formulation when using a system such as the tridiagonal linear equation system which provided the capability of real-time processing. The temperature distribution corresponding to the distance between the crops was 10 cm, and the more clearly the leaf pattern of the crop was visually confirmed. The frequency difference was decreased, as the number of overlapped pixels was increased. Also the wave pattern of points where the crops were recognized were reduced.

• Journal of the Korean Institute of Telematics and Electronics C
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• v.35C no.10
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• pp.1-11
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• 1998

This paper presents a new implementation method of the pulsed NMR(nuclear magnetic resonance) apparatus, which contains a single coil in a magnet console, to detect a NMR signal. Applying an RF magnetic field of 5MHz to the magnet console which is designed to have Larmor frequency of 5MHz for hydrogen atom, the hydrogen NMR signal was obtained from the glycerin which was put in the magnet console as a sample. The DC magnetic field in the magnet console was implemented with a permanent magnet of 1168 gauss and the RF magnetic field was generated appling an RF signal with the frequency of 5MHz and the current magnitude of 8A to a coil of 5.73${\mu}$H. The magnitude of the NMR signal was maximum when the RF magnetic field was generated for 2.8 ${\mu}$sec, and the period of generating the RF magnetic field was designed to 100msec for detecting the NMR signal repeatedly. The NMR signal, radiated from the sample in the magnetic console, was appeared as an amplitude-modulated signal with a frequency equal to the Larmor frequency. The signal, induced in the coil, was amplified in the tx/rx separation circuit, preamplifier and intermediate amplifier by a factor of 20.7dB, 36dB and 40dB, respectively, and the signal was detected by a synchronous detection circuits, then the NMR signal was obtained.

• Korean Journal of Remote Sensing
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• v.21 no.4
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• pp.273-285
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• 2005

This study has investigated the suitable wavelength for detecting biomass burning aerosols. We have performed the analysis of the wavelength at 380nm in near-UV, 400nm, 412nm, 460nm, and 490nm in visible, and 2100nm in shortwave infrared regions from the Global Imager measurements. It is well known that the UV bands have the advantage of the aerosols retrieval due to the low surface reflectance and a weak effect of Bidirectional Reflectivity Distribution Function. However, the pure surface reflectances of shortwave visible bands, except 412nm, are as low as that of 380nm in near-UV over northeast Asia. In order to detect the aerosol signal, we have retrieved the aerosol reflectance as a function of wavelength based on the surface reflectivity contrast method for the period of May 2003. It is interesting that the retrieved aerosol reflectance with 460nm is slightly more sensitive than that with 380nm. Additionally, we have applied the TOMS aerosol index method to determine the best pair for biomass burning aerosols and found that the pair of 380 and 460nm results in the best signal for retrieving aerosols.

• The Korean Journal of Pesticide Science
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• v.7 no.3
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• pp.159-168
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• 2003

With microtiter plate, the assay method was developed for detecting the fungicidal activity of new compounds against spore germination, spore adhesion and mycelial growth of Colletotrichum sp. JC24 cal1Sing red pepper anthracnose. Also, the effects of some commercialized fungicides on fungal development like above mentioned were investigated by measuring the optical density of mycelia grown into wells of microtiter plate. For the standardization of assay method, some factors, such as the treatment of MTT and/or propanol, inodulum density and incubation period, affecting on mycelial optical density were investigated. For obtaining precise and consistent mycelial optical density, it was necessary the treatment of MTT for 12 hrs and propanol for 1 hr. inoculum density adjusted to $1\times10^5$ spores/mL and incubation period for 36 hrs at $25^{\circ}C$. For fungicidal activities, 6 protective fungicides, 6 ones inhibiting sterol biosynthesis, and one inhibiting respiration were used in this study. While mancozeb, chlorothalonil and dithianon among 6 protective fungicides inhibited strongly spore germination, adhesion, and mycelial growth at $6.25{\mu}g/mL$, propineb, iminoctadine and fluazinam inhibited intermediately spore germination and mycelial growth at $100{\mu}g/mL$. Washing above 3 fungicides with new PD broth, their activity against spore adhesion decreased. With hexaconazole, tebuconazole and myclobutanil, the tendency of the activity against fungal differentiation of the early infection stage was similar to the latter group of protective fungicides, showing the decrease of the inhibitory activity against spore adhesion by washing 2 hrs after incubation. However, kresoxim-methyl inhibited spore adhesion distinctly, depending on the applied concentrations. Based on these results, it might be able to assess the fungicidal activity of many compounds against spore germination, adhesion and mycelial growth by the use of microtiter plate in vitro. Using the assay developed in this report, it was possible to investigate the inhibitory activity of some commercialized fungicides, too.