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Enhancement of Skin Permeation of Wrinkle Improvement Peptides GHKs Using Liposomes Containing Skin Penetrating Peptides (피부 투과 펩티드가 함유된 리포좀을 이용한 주름 개선 펩티드 GHKs의 피부 흡수 증진)

  • Park, Su In;An, Gyu Min;Kim, Min Gi;Heo, Soo Hyeon;Shin, Moon Sam
    • Journal of the Korean Applied Science and Technology
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    • v.36 no.3
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    • pp.853-865
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    • 2019
  • In this study, the skin permeability was measured by adding skin penetrating peptides, arginine oligomers R4(tetra-D-arginine), R6(hexa-D-arginine) to little skin-permeable wrinkle improvement peptides GHK, GHK-Cu, and Pal-GHK liposomes, and the results were analyzed by the following six cases. (1) In cases where only wrinkle improvement peptides GHK, GHK-Cu, and Pal-GHK were contained liposomes; the final cumulative permeations in 24 hours were 6.05%, 7.4%, and 8.83% respectively. (2) In cases where arginine oligomers R4, R6 were added to GHK liposomes; the final cumulative permeations in 24 hours were 13.63% and 7.68%. (3) In cases where R4, R6 were added to GHK-Cu liposomes; the final cumulative permeations in 24 hours were 15.46% and 8.64%. (4) In cases where R4, R6 were added to Pal-GHK liposomes; the final cumulative permeations in 24 hours were 16.9% and 10.67%. (5) In cases where R4 were added to GHK, GHK-Cu, and Pal-GHK liposomes; the final cumulative permeations in 24 hours were 13.63%, 15.46%, and 16.9% respectively. (6) In cases where R6 were added to GHK, GHK-Cu, and Pal-GHK liposomes; the final cumulative permeations in 24 hours were 7.68%, 8.64%, and 10.67% respectively. This experiment showed that skin absorption of GHK was increased by copper ion (Cu2+) and palmitic acid and skin absorption of wrinkle improvement peptides was enhanced by cell penetrating peptides, and R4 showed higher effect than R6 in GHK, GHK-Cu and Pal-GHK. Through this process, we propose broad use and application in wrinkle improvement functional cosmetics by presenting the optimal conditions for increasing skin absorption of GHK, GHK-Cu, thus maximizing its efficacy.

On the Selection of Hydraulic System for Hatch Cover (Hatch Cover의 유압장치의 선정에 관한 연구)

  • Kim, Hyeong-Su
    • 한국기계연구소 소보
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    • s.14
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    • pp.157-168
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    • 1985
  • In cargo vessels, hatch covers are used to prevent sea water from penetrating into the cargo hold and to keep the vessels buoyant. And also they can be used as cargo loading devices as in container ships. In this paper, hatch covers are classified according to their operation method and their characteristics are briefly demonstrated. Systematic description on the scantling of the hatch cover panel and how to determine the capacity of the hydraulic power system fir folding hatch cover panels are also presented. The hydraulic power system is selected from the result of dynamic analysis of the movements of the hatch cover panels when stored on the upper deck. The hatch coaming height is determined as shortly as the hydraulic cylinders can be installed. This study deals with the hatch cover system of the medium sized multi-purpose cargo vessel, but the results of this study can be applied to large-sized cargo vessels with a slight change of the input data in the calculations. Further research on the high pressure pump, hydraulic cleating system and hydraulic piping will realize domestic production of the whole hatch cover system which have been supplied from foreign makers until now

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다중 방책 연구

  • Jo Deok-Un;Lee Sang-Yong
    • Journal of the military operations research society of Korea
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    • v.11 no.2
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    • pp.6-14
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    • 1985
  • The layered multi-barrier defense situation against penetrating enemy threat is analytically modeled towards minimizing the penetration probability. Each layer is characterized by probability of detection and probability of kill given detection. The two capabilities are assumed independent. Detection in a layer, however, affects detection performance in subsequent layers. The following three models were formulated and investigated: (1) 'Model A' permits increase of detection performance in only the next barrier, (2) 'Model B' permits the increase in all subsequent barriers linearly, and (3) 'Model C' expresses the increase in an asymptotic exponential way. The best and the worst barrier combinations are determined through model exercise and model performances are compared through sensitivity analysis for the 'intensification factor.'

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Grand Penetrating Radar using Ultra Wideband Impulse Waveform for Nondestructive Testing of Underground Objects (초광대역 기술을 이용한 고해상도 비파괴 진단용 지반 탐사 영상 레이더 개발)

  • Park, Young-Jin;Kim, Kwan-Ho;Park, Hae-Soo
    • Proceedings of the KIEE Conference
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    • 2004.07c
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    • pp.2070-2072
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    • 2004
  • 극 초단의 임펄스를 사용하여 지중 매설물을 탐색하기 위한 지반탐사 영상 레이더를 개발하였다. 개발된 지반 탐사 레이더는 Gaussian 임펄스, 임펄스 송수신을 위한 초 광대역 소형 모노폴 안테나, 수신 신호 저장을 위한 고속 A/D로 구성된다. 탐지 깊이와 시스템의 크기를 고려하여 임펄스 발생기 및 초광대역 안테나가 설계되었다. 지중 매설물의 영상화를 위해 여러 가지 이미지 기법이 사용되었다. 발표에서는 구현된 시스템의 시제품을 소개하고, 개발된 시제품을 사용하여 가상의 모래 시험장에서 측정된 결과를 보일 것이다.

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A Cervical Stab Wound Near Vertebral Artery : A Case Report (척추동맥에 근접한 경부 자창 1례)

  • Joo, Young-Roon;Kim, Jong-Roon;Kim, Min-Sik;Sun, Dong-Il
    • Korean Journal of Bronchoesophagology
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    • v.13 no.2
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    • pp.57-60
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    • 2007
  • The management of penetrating zone II neck injuries without hard signs of vascular injury has been controversial. The controversy lies between mandatory exploration and a selective approach to the management of theses injuries. Authors that advocate mandatory exploration state its low complication rate and high sensitivity in support of this approach. Surgeons in support of selective management argue selective management has comparable efficacy with lower morbidity in comparison with mandatory exploration. Recently we experienced a case of stab wound near vertebral artery and operatively explored, therefore we report a case along with review of literature.

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Experimental Studies on Eye Injury Risks by Different BB Pellet Materials (BB Pellet 재질에 따른 안구 손상 위험성에 관한 실험적 연구)

  • Kim, Hyung-Suk;Park, Dal-Jae
    • Journal of the Korean Society of Safety
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    • v.27 no.2
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    • pp.20-24
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    • 2012
  • Experimental studies were performed to investigate the eye injury risks by different BB pellet materials. Four different BB pellet materials were used: plastic (P), silicon (S), rubber (R) and plastic covered with silicon (SR). The BB pellet images penetrating into the gelatine simulant were recorded by a high-speed video camera. The results obtained from the different pellet materials were discussed in terms of impact velocity and penetration depth; threshold velocity and projectile sectional density; eye injury risks by normalized energies. It was found that the P pellets caused higher impact velocity while the lower was SR pellets. The penetration depth and threshold velocity of the pellets were dependent on the impact velocity of the pellets, and the P pellets resulted in the higher eye injury risk while the lower was SP.

Shock Reflection and Penetration Impinging into a Vortex (I) - Experimental Model- (와동에 입사하는 충격파의 반사 및 투과(I))

  • Jang, Se-Myeong;Jang, Geun-Sik
    • Transactions of the Korean Society of Mechanical Engineers B
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    • v.26 no.9
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    • pp.1311-1318
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    • 2002
  • An experimental model is investigated in this paper using the experimental method with a shock tube and the numerical technique. The shock-vortex interaction generated by this model is visualized with various methods: holographic interferometry, shodowgraphy, and numerical computation. In terms of shock dynamics, there are two meaningful physics in the present problem. They are reflective wave from the slip layer at the vortex edge and transmitted shock penetrating the vortex core. The discussion in this study is mainly focused on the two kinds of waves contributing to the quadrupolar pressure distribution around the vortex center during the interaction.

Common-Mode Current on a Wire through a Corrugated Aperture

  • Park, Hyun-Ho;Lee, Jae-Wook;Kwon, Jong-Hwa;Lee, Hyung-Soo
    • ETRI Journal
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    • v.24 no.6
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    • pp.429-434
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    • 2002
  • This paper investigates the effect of a corrugated aperture on a common-mode current traveling along a penetrating wire. Computational results illustrate that the corrugated aperture acts as a filter, significantly reducing the common-mode current on the wire. This effect causes a reduction of radiated emission from cables passing through apertures on shielding enclosures. To predict and analyze the characteristics of the common-mode current on a straight wire passing through a corrugated aperture with cylindrical symmetry, the finite-difference time-domain (FDTD) method is applied.

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Pulse Radar Signal Processing Algorithm for Vehicle Detection (차량검지 시스템을 위한 펄스레이더 신호처리 알고리즘)

  • 고기원;우광준
    • Journal of the Institute of Electronics Engineers of Korea SC
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    • v.41 no.5
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    • pp.9-18
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    • 2004
  • This paper presents a vehicle detecting algorithm using microwave system signals. The Proposed algerian decides the breakpoint of signals using the likelihood criteria. The decided signals are segmented and simplified. The proposed searching algorithm uses the Euclid distance from the weighted signal data. We tested the proposed algorithm to compare with the segmentation which is a method using smoothing and edge detection. We confirm that the proposed algorithm is very useful for detecting vehicles by field test.

Application of 3D ADI-FDTD Method for GPR System Simulation (GPR 시스템 시뮬레이션을 위한 3차원 ADI-FDTD 기법의 적용)

  • Jeon Won Sok;Yeo Woonsik;Yun Seung Hyun;Kim Hyeongdong
    • Proceedings of the IEEK Conference
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    • 2004.06a
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    • pp.131-134
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    • 2004
  • This paper has been studied a ADI-FDTD(Alternating Direction Implicit Finite Difference Time Domain ) algorithm using an alternating Direction time-stepping scheme for GPR( Ground-Penetrating Radar ) system simulation. We did the numerical formulations for three-dimensional ADI-FDTD algorithm and PML(Perfect Matched Layer), and made an simple experiment on a arbitrary cube with programed algorithms. And then we compared its computed results with those of conventional FDTD.

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