• 한국정보디스플레이학회:학술대회논문집
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• 한국정보디스플레이학회 2006년도 6th International Meeting on Information Display
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• pp.1299-1301
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• 2006

A visual display is formed by picture elements, which are optically coupled to optical pathways through which light is supplied from light sources. Light sources, controlled by control hardware, transmit light to the optical pathways by scanning light from the light sources to different optical pathways. The light sources and the optical pathways are mutually oriented so that light from the light sources can be canned to different optical pathways to form the displayed image. Light sources can be mounted to a rotating mounting that rotates past static pathways that transmit coupled light to the waveguide screen.

• 한국주거학회논문집
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• 제26권2호
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• pp.39-46
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• 2015

The 'pathways' in the Deteriorated Residential Area is the valuable place which represents the history of the community. The 'pathways' is the physical boundary which connects individual environment of private residential area to public environment and which has value as a medium for the definite site for regeneration of Deteriorated Residential Area. Thus, the 'pathways' is considered as the perfect material for the public design for spatial culture to regenerate the Deteriorated Residential Area. However, the most of the public design projects utilize the 'pathways' fragmentarily, there are few systematic studies based on the attribute of the Deteriorated Residential Area. The purpose of this study is the consideration on the attributes of the 'pathways', the detection of the spatial characteristics to find application of the 'pathways', and the cultivation of the baseline data for further research for the spatial nature of the Deteriorated Residential Area. For this study, theoretical consideration is practiced in advance to analyze the meaning of the 'pathways' and Deteriorated Residential Area, the case research is performed using design elements as the analytic frame, and the approach is inferred for systematic public design based on the above result. The objects of case research were chosen among the latest projects implemented in the Deteriorated Residential Area whose subject was 'pathways' and which showed successful result. The characteristics of them were investigated and the details were examined through the homepages of the projects, the reports related to the projects, research material, and interview with the people involved. And to conclude, 'pathways' represents the composition of contents, the space of movement, the formation of community, the landscape design, and the participatory design in the Deteriorated Residential Area. The 'pathways' also finds the proper secondary cultural material for the spatial characteristics and can create the space for the various movements, stay, and communication using the characteristics of movements. The narrow and closed space should be utilized actively to be altered into beautiful space and the Deteriorated Residential Area should be regenerated into coexistent design where people share their lives through sharing spaces.

• Nuclear Engineering and Technology
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• 제53권9호
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• pp.2878-2887
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• 2021

As the amount of fission product released from ISLOCA was overestimated because of conservative assumptions in the past, several studies have been recently conducted to evaluate the actual release amount. Among several pathways for the ISLOCA, most studies were focused on the pathway with the highest possibility. However, different ISLOCA pathways may have different fission product release characteristics. In this study, fission product behavior was analyzed for various pathways at the Westinghouse two-loop plant using MELCOR. Four pathways are considered: the pipes from a cold leg, from a downcomer, from a hot leg to the outlet of RHR heat exchanger, and the pipe from the hot leg to the inlet of RHR pump (Pathway 1-4). According to the analysis results, cladding fails at around 2.5 h in Pathways 1 and 2, and on the other hand, about 3.3 h in Pathways 3 and 4 because the ISLOCA pathways affect the safety injection flow path. While the release amount of cesium and iodine ranges between 20 and 26% in Pathways 1 to 3, Pathway 4 allows only 5% to the environment because the break location is submerged. Also, as more than 90% of cesium released to the environment passes through the personnel door, reinforcing the pressure capacity of the doors would be a significant factor in the accident management of the ISLOCA.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.373-378
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• 2005

The diagrammatic language for pathways is widely used for representing systems knowledge as a network of causal relations. Biologists infer and hypothesize with pathways to design experiments and verify models, and to identify potential drug targets. Although there have been many approaches to formalize pathways to simulate a system, reasoning with incomplete and high level knowledge has not been possible. We present a qualitative formalization of a pathway language with incomplete causal descriptions and its translation into propositional temporal logic to automate the reasoning process. Such automation accelerates the identification of drug targets in pathways.

• Asian Pacific Journal of Cancer Prevention
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• 제16권8호
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• pp.3543-3549
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• 2015

Background: Bladder cancer is one of the most common cancers worldwide. Gene expression profiling using microarray technologies improves the understanding of cancer biology. The aim of this study was to determine the gene expression profile in Egyptian bladder cancer patients. Materials and Methods: Samples from 29 human bladder cancers and adjacent non-neoplastic tissues were analyzed by cDNA microarray, with hierarchical clustering and multidimensional analysis. Results: Five hundred and sixteen genes were differentially expressed of which SOS1, HDAC2, PLXNC1, GTSE1, ULK2, IRS2, ABCA12, TOP3A, HES1, and SRP68 genes were involved in 33 different pathways. The most frequently detected genes were: SOS1 in 20 different pathways; HDAC2 in 5 different pathways; IRS2 in 3 different pathways. There were 388 down-regulated genes. PLCB2 was involved in 11 different pathways, MDM2 in 9 pathways, FZD4 in 5 pathways, p15 and FGF12 in 4 pathways, POLE2 in 3 pathways, and MCM4 and POLR2E in 2 pathways. Thirty genes showed significant differences between transitional cell cancer (TCC) and squamous cell cancer (SCC) samples. Unsupervised cluster analysis of DNA microarray data revealed a clear distinction between low and high grade tumors. In addition 26 genes showed significant differences between low and high tumor stages, including fragile histidine triad, Ras and sialyltransferase 8 (alpha) and 16 showed significant differences between low and high tumor grades, like methionine adenosyl transferase II, beta. Conclusions: The present study identified some genes, that can be used as molecular biomarkers or target genes in Egyptian bladder cancer patients.

• 대한한의학원전학회지
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• 제23권5호
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• pp.95-101
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• 2010

This article is about diverse meanings, directions and related parts on pathways of meridians on face mentioned in "Yeongchoo Kyeongmaek". In this article, I focus on finding right positions of pathways and right names of what is related with pathways. In methods, I found out names of face part related with pathways of meridians in "Kyeongmaek" and compared with other names. As a result, I suggest that we have to make a fine definition about erms describing pathways of meridians instead of meridian points and broad names on face.

• Korean Journal of Acupuncture
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• 제26권4호
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• pp.89-105
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• 2009

Objectives : Hyun-Ga therapy, a creative method that involves meridian pathways for isometric exercise, has displayed the possibility of treating and alleviating idiopathic scoliosis in terms of theory. The researcher explored current research trends and introduced Hyun-Ga therapy in which meridian pathways theory is applied. Methods : We examined theses and books of oriental or western medicine that cover idiopathic scoliosis. By doing these, we looked into the role of Hyun-Ga therapy towards the prevention and treatment of idiopathic scoliosis, and gained the following results. Results and Conclusions : Hyun-Ga therapy, the manual technique that has introduced the concept of silence and movement into rectifying the body through isometric exercise on meridian pathways in the limbs, can be practiced more easily than other conventional manual techniques. Hyun-Ga therapy based on meridian pathways theory is highly evaluated for its clinical insight on the structural and functional roles of meridian pathways. The theory of Hyun-Ga therapy, however, needs to be supported by more objective and sufficient complementary data. For this, continuing research and analysis are required in the future.

• Genes and Genomics
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• 제40권12호
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• pp.1339-1349
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• 2018

Cerebral palsy (CP) is a non-progressive neurological disease, of which susceptibility is linked to genetic and environmental risk factors. More and more studies have shown that CP might be caused by multiple genetic factors, similar to other neurodevelopmental disorders. Due to the high genetic heterogeneity of CP, we focused on investigating related molecular pathways. Ten children with CP were collected for whole-exome sequencing by next-generation sequencing (NGS) technology. Customized processes were used to identify potential pathogenic pathways and variants. Three pathways (axon guidance, transmission across chemical synapses, protein-protein interactions at synapses) with twenty-three genes were identified to be highly correlated with CP. This study showed that the three pathways associated with CP might be the molecular mechanism of pathogenesis. These findings could provide useful clues for developing pathway-based pharmacotherapies. Further studies are required to confirm potential roles for these pathways in the pathogenesis of CP.

• 생명과학회지
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• 제32권3호
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• pp.249-255
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• 2022

대사는 생존과 번식에 필수적이다. 2020년에 업그레이드된 COG (cluster of orthologous proteins) 데이터베이스에는 "pathways" 항목이 있다. 본 연구에서는 COG pathways를 이용하여 1,309개의 원핵생물의 대사 경로를 분석하였다. 63개의 대사경로와 관련된 822개의 COG가 있었고, 각 분류단위의 대사관련 COG의 평균은 200.50개(phylum Mollicutes)에서 527.07개(phylum Cyanobacteria)의 사이였다. MPCR을 대사경로구성율(하나의 게놈에 존재하는 COG 수 / 각 대사 경로를 구성하는 COG의 총 수)로 정의하였다. MPCR이 100%인 대사경로의 수는 원핵생물에 따라 0에서 26의 범위였다. 다수의 원핵생물에서 100% MPCR인 대사경로는 세포벽 합성과 관련된 murein biosynthesis (922종), glycine cleavage (918종), ribosome 30S subunits (903종) 등이었다. MPCR이 0%인 대사경로(종의 수)는 photosystem I (1,263종), A/V (archaea/vacuolar)-type ATP synthase (1,028종) 및 Na⁺-translocation NADH dehydrogenase (976종) 등이었다. 원핵생물에 따라 3~49개의 대사경로를 전혀 수행할 수 없었다. MPCR의 보존성이 높은 대사경로의 순서는 ribosome 30S subunit (1,309종의 96.1%), murein biosynthesis (86.8%), arginine biosynthesis (80.4%), serine biosynthesis (80.3%) 및 aminoacyl-tRNA synthetases (82.2%) 등이었다. 단백질과 세포벽 합성이 원핵생물에서 중요한 대사경로인 것을 알 수 있었다. 본 연구의 결과와 원핵생물 사이의 대사경로와 관련된 COG는 항생제 및 인공세포의 개발 등에 활용될 수 있을 것이다.

• Genomics & Informatics
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• 제6권4호
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• pp.210-222
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• 2008

Due to the polygenic nature of cancer, it is believed that breast cancer is caused by the perturbation of multiple genes and their complex interactions, which contribute to the wide aspects of disease phenotypes. A systems biology approach for the identification of subnetworks of interconnected genes as functional modules is required to understand the complex nature of diseases such as breast cancer. In this study, we apply a 3-step strategy for the interpretation of microarray data, focusing on identifying significantly perturbed metabolic pathways rather than analyzing a large amount of overexpressed and underexpressed individual genes. The selected pathways are considered to be dysregulated functional modules that putatively contribute to the progression of disease. The subnetwork of protein-protein interactions for these dysregulated pathways are constructed for further detailed analysis. We evaluated the method by analyzing microarray datasets of breast cancer tissues; i.e., normal and invasive breast cancer tissues. Using the strategy of microarray analysis, we selected several significantly perturbed pathways that are implicated in the regulation of progression of breast cancers, including the extracellular matrix-receptor interaction pathway and the focal adhesion pathway. Moreover, these selected pathways include several known breast cancer-related genes. It is concluded from this study that the present strategy is capable of selecting interesting perturbed pathways that putatively play a role in the progression of breast cancer and provides an improved interpretability of networks of protein-protein interactions.