• 혜화의학회지
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• 제9권1호
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• pp.379-386
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• 2000

1. There two parts of alcohol's metabolic system the first one is alcoholdehydrogenase(ADH), and second is microsomal ethanol oxidizing system(MEOS). 2. Alcoholic cirrhosis(fibrosis) leads from cytotoxin, malnutrition, and immunue reaction. 3. In the Oriental medical point of view alcohol has strong heat and toxin, which can cause judal, ju-ka, ju-beack, ju-juck, and ko-chang in other words these means that it can cause hepatasis, fatty liver, fibrosis, and liver cirrhosis. 4. About the Liver cirrhosis(fibrosis) pathological system, in the oriental medical point of view, it effects the liver, kidney and spleen which causes Uy-heulGin-guk(瘀血 積), seup-yeul ne-oun(濕熱內蘊), and in the long term it can cause kansinyumhu(肝腎陰虛), kanbeyumhu(肝脾陰虛). Because of the expand of alcohol liver disease, in the future there must be more studies about these disease in Oriental medicine point of view.

• 동의생리병리학회지
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• 제24권5호
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• pp.784-789
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• 2010

Syndrome of asthenia of spleen gi usually caused by improper diet, overstrain, emotional upsets, followed by syndrome of sinking of splenic gi. There are several pathologic categories of splenic gi deficiency syndrome. These include failure to nourish the body, failure to astringe liquid substances, failure of splenic gi to rise, gi stagnation in which gi can't disperse normally, failure of transportation. In the splenic gi deficient situation, body fluid is usually stagnated because the rest of the water absorbed from the food is transported to every part of the body by the action of splenic gi. In addition, there is abnormal sinking of clear gi, followed by fever due to gi deficiency. Bojungikgi-tang is composed of restoratives which are invigorating splenic gi and herbs which uplift splenic gi. It is mainly applicable to splenic gi deficiency syndrome accompanied by gi stagnation and fluid accumulation.

• 동의생리병리학회지
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• 제26권1호
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• pp.10-18
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• 2012

In this paper, to find out how different the treatment of special individuals named 'old people' is with that of ordinary cases, Dongeuibogam(東醫寶鑑) was chosen as the study material and some parts in it where the symptoms of old people in the same disease category were treated in different ways were excerpted to analyze the tendency of pathological symptoms and prescriptions in the physiological perspective. As the result of analysis on the parts in Dongeuibogam(東醫寶鑑) where the old people were treated in different ways, it turned out that 65 prescriptions were used in 24 pathological symptoms. The 24 symptoms are included mainly in chapters of 'inner view(內景)' and 'outer form(外形)'. They are including the pathological symptoms which had been presented as general geriatric symptoms and also seems to have added other symptoms which should be clinically reflected in the specialty of treatment for geriatric diseases. The 65 prescriptions are also recorded mainly in chapters of 'inner view(內景)' and 'outer form(外形)'. The herbs used for them were sweet and warm herbs such as Rehmannia glutinosa (Gaertner) Libosch(熟地黃), Angelica gigas Nakai(當歸), Panax ginseng C. A. Mey(人蔘) and Atractylodes macrocephala Koidz(白朮) that can support the essence blood of liver and kidney and the energy of spleen, lung and stomach. Those herbs could be added or subtracted according to the symptom. It seems to have resulted from the treatment method that old people was applied to old people in consideration of their physiological features. When the 24 symptoms and 65 prescriptions for geriatric diseases different from ordinary ones in Dongeuibogam(東醫寶鑑) were considered in the physiological view point, it could be seen that each pathological symptom was manifested as a exhaustion of kidney qi(腎氣枯渴) which was a characteristic physiologic state of old people. Through this, it could be seen that the use of prescriptions was also made to mitigate the body fluid deficiency(津液不足), the kidney yin inner heat(腎陰內熱), the heart spirit void and loss(心神虛損), the kidney yang deficiency(腎陽不足), the spleen failing in transportation(脾失健運), the spleen yang deficiency(脾陽不足), the liver fire inner movement(肝火內動) and the lung energy void and loss(肺氣虛寒).

• 대한의용생체공학회:의공학회지
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• 제16권2호
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• pp.149-156
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• 1995

동맥전단부를 연구할수있는 새로운 실험방법과 기계역학적 분석방법을 제시하였다. 지금까지동맥역학적 연구는 대부분이 동맥의 길이방향과 원주방향에 대한것이 이였다. 두께방향의 변형은 포아손비라든지 비압축성가정으로 이론적으로 결정되었다. 또한 두께에 걸친 변형의 변화도 무시되었다. 그러나 병리학적인 의미에서 동맥의 두께에 걸친 변형도와 변형의 분포는 중요한 의미를 가진다. 그러므로 본연구에서 제안된 실험방법과 장치는 두께전반에 걸친 변형을 측정할수 있게 했다. 또한 전단부의 부위별 변형도의 관찰이 가능하고 병리적인 동맥경화증에 대한 현상과 역학적현상을 상관시킬 수 있음에 중요한 의미를 들 수 있다.

• 혜화의학회지
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• 제9권1호
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• pp.661-689
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• 2000

We came to the conculsion after considering all of information from many kinds of books on the cause, pathogenesis and treatment of Flaccidity-syndrome. The results were as follows : 1. Flaccidity-syndrome means limb-relaxation due to muscle atony that isn't able to constraction. It's begun as mild degree from extremities, in some cases ended to quadriplegia or expire. 2. Cause factor and pathogenesis of Flaccidity-syndrome is various. After Lung fluid consuption caused by heat-evil was refered in The Yellow Emperor's Canon of Internal Medicine. They were refered as cause factor that Main channel asthenia, excess of sexual intercourse, wetness-evil, heat-evil gets into the interior, asthenia of the spleen and stomach. Since Ming Dynasty, It's classified to wetness-heat evil, wetness-phlegm, deficiency of vital energy, deficiency of blood, deficiency of yin, blood stasis and indygestion, etc. 3. In the view of treatment of Flaccidity-syndrome, Yangming was selected in The Yellow Emperor's Canon of Internal Medicine, and it's been mean to clear away wetness-heat evil located at Yangming. In the method of acupuncture it was same on the base, and many skills have been used that electronic acupuncture, point-injection theraphy, acupuncture point block, catgut implantaion at acupuncture point, cutaneous acupuncture, auriculo-acupuncture and head acupuncture by the through post generation. 4. Flaccidity-syndrome was defined to weak, disuse and non-pain. Beacause it was non-pain, so medicine to expel wind-evil was prevented to use. But through post generation Flaccidity-syndrome has been treated that is able to cause pain or numness as arthralgia-syndrome. Therefore there is tendency that medicine to expel wind-evil is capable within pathological basement of Flaccidity-syndrome in recent. 5. In the view of west-medicine, Flaccidity-syndrome is diplegia or quadriplegia with sensory disorder, muscle atropy in some cases. And there are spinal disease, peripheral nerve disease, muscular disease, nerve-muscle copula disease. The symptoms are able to amyotomia, numness, sensory disorder, pain.

• BMB Reports
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• 제55권11호
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• pp.519-527
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• 2022

Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages' inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.

• Journal of Mechanical Science and Technology
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• 제17권7호
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• pp.1016-1025
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• 2003

The rupture of blood vessels in the human brain results in serious pathological and medical problems. In particular, brain hemorrhage and hematomas resulting from impact to the head are a major cause of death. As such, investigating the tensile behavior and rupture of blood vessels in the brain is very important from a medical point of view. In the present study, the tensile characteristics of the blood vessels in the human brain were analyzed using a quasi-static uniaxial tensile test, and the properties of the arteries and veins compared. In addition, to compare the tensile behavior and demonstrate the validity of the experimental results, blood vessels from the legs of pigs were also tested and analyzed. The overall results were in accordance with the histological structures and previous medical reports.

• 동의생리병리학회지
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• 제25권5호
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• pp.773-776
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• 2011

This study was focused on a certain clinical symptom, which could applicated by Pyeongwi-san, and the radical treatment. Pyeongwi-san is applicable to dampness retention in the spleen and stomach, accompanied by abdominal fullness, anorexia, nausea and regurgitation. Main action of Pyeongwi-san is to dry dampness, invigorate the spleen, promote the flow of gi, and regulate the stomach. The herbal remedy drying dampness like Pyeongwi-san however, is just indicatio symptomatica therefore radical treatment must be used together. Jeunginmaegchi, a medical book written by Gyeong-Myeong Jin, who was lived in Myeong dynasty. This book contains many clinical applicable symptoms and constituents derived from Pyeongwi-san. The herbal prescriptions composing Pyeongwi-san is composed of Changchul, Hubak, Jinpi, Gamcho. The major action of these herbs is drying dampness. Therefore, it shoud be seriously consider that curative therapy must eliminate the cause of endogenous dampness.

• Journal of Information Processing Systems
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• 제15권5호
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• pp.1068-1081
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• 2019

Signal complexity is one point of view to analyze the biological signal. It arises as a result of the physiological signal produced by biological systems. Signal complexity can be used as a method in extracting the feature for a biological signal to differentiate a pathological signal from a normal signal. In this research, Hjorth descriptors, one of the signal complexity measurement techniques, were measured on signal sub-band as the features for lung sounds classification. Lung sound signal was decomposed using two wavelet analyses: discrete wavelet transform (DWT) and wavelet packet decomposition (WPD). Meanwhile, multi-layer perceptron and N-fold cross-validation were used in the classification stage. Using DWT, the highest accuracy was obtained at 97.98%, while using WPD, the highest one was found at 98.99%. This result was found better than the multi-scale Hjorth descriptor as in previous studies.

• 대한한의학원전학회지
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• 제24권1호
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• pp.73-84
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• 2011

In the pathological theory of Oriental medicine, the concept of Ul(鬱) largely comprises the two meanings as follows. One is the concept used as the meaning of pathological state originated from stasis in Qi-Xie(氣血) or the function of internal organs. The other is the concept used as the meaning of Ul-disease(鬱病), which is a group of symptom that is mostly characterized by stasis in function of Qi system. The concept of Ul in the medical classics was originated from "Neijing(內經)", and in this book it was depicted as five-Ul(五鬱). Since the concept of Ul was depicted in "Neijing", many relevant theory about it had been developed on the basis of the theory in "Neijing", and in the theoretical development like this, the concept of Ul had become a little bit complicated. With regard to the historical change like this, this study is going to focus on some argument in Ming(明) dynasty, which asserted the existence of deficiency[虛證] in Ul that had opposed the general thought of that time usually recognizing the concept of Ul as [實證]. In this point of view, this study regards Zhang-zihe(張子和) as a doctor who had made an important role in the theoretical development of Ul after "Neijing", and will newly analyze the theoretical development of Ul on the basis of the Zhang-zihe's Ul theory, which is seemed to have played the main role in the formation of concept of Ul as excessive state[實證].