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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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The role of immunomodulatory metabolites in shaping the inflammatory response of macrophages

  • Doyoung, Park (Department of Biochemistry, College of Natural Sciences, Chungnam National University) ;
  • Gyumin, Lim (Department of Biochemistry, College of Natural Sciences, Chungnam National University) ;
  • Sung-Jin, Yoon (Environmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB)) ;
  • Hyon-Seung, Yi (Department of Internal Medicine and Laboratory of Endocrinology and Immune System, Chungnam National University College of Medicine) ;
  • Dong Wook, Choi (Department of Biochemistry, College of Natural Sciences, Chungnam National University)
  • Received : 2022.08.09
  • Accepted : 2022.09.20
  • Published : 2022.11.30
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Abstract

Macrophage activation has long been implicated in a myriad of human pathophysiology, particularly in the context of the dysregulated capacities of an unleashing intracellular or/and extracellular inflammatory response. A growing number of studies have functionally coupled the macrophages' inflammatory capacities with dynamic metabolic reprogramming which occurs during activation, albeit the results have been mostly interpreted through classic metabolism point of view; macrophages take advantage of the rewired metabolism as a source of energy and for biosynthetic precursors. However, a specific subset of metabolic products, namely immune-modulatory metabolites, has recently emerged as significant regulatory signals which control inflammatory responses in macrophages and the relevant extracellular milieu. In this review, we introduce recently highlighted immuno-modulatory metabolites, with the aim of understanding their physiological and pathological relevance in the macrophage inflammatory response.

Keywords

Acknowledgement

This study was supported by a research funding of Chungnam National University.

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