• 한국소음진동공학회논문집
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• 제22권1호
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• pp.22-28
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• 2012

While a dash panel component, close to passengers, plays a very important role to protect heat and noise from a power train, it is also a main path that transfers vibration energy and eventually radiates acoustic noise into the cavity. Therefore, it is important to provide optimal design schemes incorporating sound packages such as a dash isolation pad and a floor carpet, as well as structures. The present study is the extension of the previous investigation how design variables affect sound radiation, which was carried out using the simple plate and framed system. A novel FE-SEA hybrid simulation model is used for this study. The system taken into account is a dash panel component of a sedan vehicle, which includes front pillars, front side members, a dash panel and corresponding sound packages. Design variables such as panel thicknesses and sound packages are investigated how they are related to two main NVH indexes, sound radiation power(i.e. structure-borne) and sound transmission loss(i.e. air borne). In the viewpoint of obtaining better NVH performance, it is shown that these two indexes do not always result in same tendencies of improvement, which suggests that they should be dealt with independently and are also dependent on frequency regions.

• Molecular & Cellular Toxicology
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• 제4권2호
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• pp.144-149
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• 2008

Despite versatile activity (cancericidal, antimicrobial, hypoxia inducible factor (HIF) inhibition, immune deactivation of DNA bis-intercalation agent, echinomycin, its specific mechanism has been elusive. Of these novel mechanisms, we reported that using human colon cancer cells (HT-29), apoptotic machinery induced by echinomycin might be dependent of caspase-3 pathway. Despite a partial enlightenment of prototypic signal path triggered by echinomycin, the role of Bcl-2 in this signaling pathway is unclear. To address this issue, we explored whether or not echinomycin would overcome the anti-apoptotic impact of Bcl-2 in HT-29 cells by the controlled Bcl-2 overexpression. Prior to this proof, we confirmed that echinomycin induces mitochondrial depolarization, then triggering the mitochondrial pathway of apoptosis with an involvement of upstream cas-pases-3. Transiently transfection with inactive Bax-DNA failed to prevent echinomycin-induced apoptosis in HT-29 cells. To dissect the role of Bcl-2 in echinomycin-induced apoptosis, HT-29 cells were transiently transfected with Bcl-2 DNA for overexpression and then treated with echinomycin for 24h. Combined analyses of DNA fragmentation and flow cytometric analysis clearly verified that echinomycin-induced apoptosis was drastically attenuated by Bcl-2 overexpression, whereas a control vector rarely affected echinomycin-induced apoptosis. Collectively, these data verify that Bcl-2 regulates echinomycin-induced apoptosis in HT-29 cells. To my knowledge, this is the first evidence that of diverse, structured minor groove binders (MGB), the prototypic echinomycin might control the apoptotic signaling via Bcl-2-mitochondrial pathway.

• Journal of Communications and Networks
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• 제12권5호
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• pp.433-441
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• 2010

Multihop transmission is a promising technique that helps in achieving broader coverage (excellent network connectivity) and preventing the impairment of wireless channels. This paper proposes a cluster-based multihop wireless network that makes use of the advantages of multihop relaying, i.e., path loss gain, and partial relay selection in each hop, i.e., spatial diversity. In this partial relay selection, the node with the maximum instantaneous channel gain will serve as the sender for the next hop. With the proposed protocol, the transmit power and spectral efficiency can be improved over those in the case of direct transmission and conventional multihop transmission. Moreover, at a high signal-to-noise ratio (SNR), the performance of the system with at least two nodes in each cluster is dependent only on the last hop and not on any of the intermediate hops. For a practically feasible decode-and-forward relay strategy, a compact expression for the probability density function of the end-to-end SNR at the destination is derived. This expression is then used to derive closed-form expressions for the outage probability, average symbol error rate, and average bit error rate for M-ary square quadrature amplitude modulation as well as to determine the spectral efficiency of the system. In addition, the probability of SNR gain over direct transmission is investigated for different environments. The mathematical analysis is verified by various simulation results for demonstrating the accuracy of the theoretical approach.

• Toxicological Research
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• 제16권4호
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• pp.317-323
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• 2000

The immunosuppressive effects of thirty nine chemicals chosen by their potential toxicity were evaluated using a three-step testing method. The immunotoxicity test method developed in this study consisted of three simple assays of lymphoproliferation, mixed leukocyte response, and interleukin (IL)-2 production. The first step was mitogen-induced proliferation assay. Ten chemicals showed the inhibitory effects on the mitogen (lipopolysaccharide or concanavalin A)-induced proliferation in dose-dependent manners. The second step was mixed lymphocyte response. This step crosschecked the growth-suppressive effects detected at the first step. All of 10 chemicals, which showed suppression of lymphoproliferation, also exhibited the suppressive effects on the mixed lymphocyte response in the similar range of chemical concentration. The third step was planned to determine whether or not this growth suppression was mediated through an early activation of T-cell, which could be represented with IL-2 production. Six out of 10 chemicals decreased the interleukin-2 production in the similar concentration range used in the step 1 and 2. These results suggest that those 6 chemicals might have their targets on the signal transduction path-way toward the IL-2 production. In the meantime the other 4 chemicals might have their targets after the IL-2 production signal. Taken all together, the three-step test would be simple, fast, and efficient to deter-mine whether or not the chemical has immunosuppressive effects.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제23권3호
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• pp.141-147
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• 2017

국내에서 개발 중인 장비의 기술 유출 방지와 국내 환경에 맞는 적외선 신호 분석 S/W 개발에 대한 요구가 있어 왔다. 본 논문에서는 적외선 영상을 생성하기 위한 적외선 신호 분석 S/W에 대한 구성과 특정 파장대역의 적외선 영상 생성 방법 및 분석 방법에 대해 나타내었다. 개발된 적외선 신호 분석 S/W는 표면온도 해석 결과와 물체의 자체방사 성분 및 반사성분 그리고 대기경로 복사성분을 통해 적외선 영상을 생성하도록 구성되어 있다. 대부분의 상용 S/W에는 복사 대비값 및 탐지거리 또는 탐지율 분석 기능이 포함되어 있지 않지만 개발된 S/W에는 생성된 적외선 영상을 이용하여 위협도 분석할 수 있는 기술을 포함하고 있다.

• Advances in concrete construction
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• 제6권3호
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• pp.245-268
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• 2018

The numerical investigations have been carried out on deep beam with opening subjected to static monotonic loading to demonstrate the accuracy and effectiveness of the finite element based numerical models. The simulations were carried out through finite element program ABAQUS/CAE and the results thus obtained were validated with the experiments available in literature. Six simply supported beams were modelled with two square openings of 200 and 250 mm sides considered as opening at centre, top and bottom of the beam. In order to define the material behaviour of concrete and reinforcing steel bar the Concrete Damaged Plasticity model and Johnson-Cook material parameters available in literature were employed. The numerical results were compared with the experiments in terms of ultimate failure load, displacement and von-Mises stresses. In addition to that, seventeen beams were simulated under static loading for studying the effect of opening location, size and shape of the opening and depth, span and shear span to depth ratio of the deep beam. In general, the numerical results accurately predicted the pattern of deformation and displacement and found in good agreement with the experiments. It was concluded that the structural response of deep beam was primarily dependent on the degree of interruption of the natural load path. An increase in opening size from 200 to 250 mm size resulted in an average shear strength reduction of 35%. The deep beams having circular openings undergo lesser deflection and thus they are preferable than square openings. An increase in depth from 500 mm to 550 mm resulted in 78% reduced deflection.

• 한국지역지리학회지
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• 제13권1호
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• pp.82-103
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• 2007

신자유주의는 국가 개입을 통해 작동하는 경로의존적, 혼종적, 모순적 프로젝트로 이해된다. 신자유주의 하에서 실제 국가의 개입은 그 힘이 약화되었다기보다는 전략이 변화했다고 할 수 있으며, 이는 특히 도시공간의 재구성을 위한 신자유주의적 정책들에서 잘 나타난다. 이러한 점에서 이 논문은 발전국가로 특징지워지는 한국에서 신자유주의의 도입과정과 이에 따른 도시정책의 특성 변화를 고찰하고자 한다. 이를 위해 이 논문은 우선 1960년대 이후 국가주도적, 수출지향적 경제개발을 주도한 발전국가 및 그 공간정책의 특성을 살펴보고, 1980년대 후반 이후 신자유주의의 전개과정을 두 단계, 즉 1980년대 후반에서 1997년 경제위기 이전(1단계)과 그 이후 현재까지(2단계)로 구분하여 고찰하고자 한다. 특히 이러한 신자유주의화 과정은 기존 발전주의와 상호 중첩적, 혼종적으로 결합되어 있으며, 이러한 성향은 공간정책의 변화과정에 반영되고 있다고 주장한다. 끝으로 국가와 시장 간 결합(즉 발전주의적 신자유주의)은 다양한 유형으로 전개될 수 있지만, 국가의 발전 전망과 공간정책은 산업(자본)중심이 아니라 복지(인간)중심이어야 한다는 점이 강조된다.

• 정보처리학회논문지D
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• 제11D권5호
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• pp.1021-1030
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• 2004

데이터 중심의 XML 문서를 관계형 데이터베이스에 저장하고 관리할 경우에 XML 스키마로부터 관계형 스키마를 추출하는 것이 보다 시급한 일이다. 또한 생성된 테이블에 XML 문서를 분할하여 저장할 경우에 많은 널 값을 초래하거나 조인 비용의 증가를 가져오기 때문에 이에 대한 해결책이 필요하다. 이 논문에서는 XML 스키마로부터 관계형 스키마를 생성하는 Schema Hybrid Inlining 기법을 제안하였다. 제안된 기법은 XML 스키마 그래프를 바탕으로 관계형 스키마를 생성하게 되는데, 기존의 Inlining 방식을 확장하여 출현 지시자와 진입 차수에서의 테이블 생성 방법을 휴리스틱하게 매뉴얼 처리를 하며, 유도 관계에서 최종 노드인 조상 노드는 새로운 테이블을 생성한다. 또한 DTD 종속적인 저장 방식의 단점인 조인 연산 비용을 줄이기 위하여 중복을 활용한 분할 저장과 구조적 검색 기법을 개선한 관계 경로 요소 정보를 이용하였다.

• 약학회지
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• 제49권4호
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• pp.347-354
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• 2005

Lipopolysaccharide (LPS) induces synthesis of several inflammatory cytokines and nitric oxide (NO). NO in brain is involved not only in the regulation of important metabolic pathways via intracellular cyclic GMP-dependent path­ways, but also in neurotoxic damage by reacting with superoxide ion leading to form peroxynitrite radical. Oxidative stress has suggested to be related to the inhibition of NO synthase/cyclic GMP pathway. OQ21 is a new fluorinated quinone compound that is recently known to have inhibitory effects on both NO synthase (NOS) and guanylyl cyclase (GC). In this study, we examined effects of OQ21, other known NOS or GC inhibitors, or an antioxidant, melatonin, on the oxidative stress produced by LPS in rat brain. Oxidative stress was observed by using the 2',7'-dichlorofluorescin diacetate to measure intra-cellular reactive oxygen species (ROS) production and by measuring the formation of thiobarbituric acid reactive substances to measure lipid peroxidation. LPS induced significant increase in both ROS produdction and lipid peroxidation in all brain regions tested (striatum, hippocampus and cortex), which were dissected 6hr after intraperitoneal administration of LPS to rats. Direct striatal injection of two NOS inhibitors, N-nitro-L-arginine methyl ester and diphenyleneiodonium, or a GC inhibitor, IH-[1,2,4]oxadiazolo[4,3-a]quinoxaline-l-one, produced no significant ROS increase. However, OQ21 enhanced ROS formation in striatal tissues from LPS-treated rats. Melatonin decreased LPS-induced ROS formation and decreased ROS formation increased by OQ21 in striatum of LPS-treated rats.

• 대한본초학회지
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• 제31권1호
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• pp.25-31
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• 2016

Objectives : The present study was conducted to evaluate protective effects of Combined Extract of young persimmon fruit and citrus peel (PCM) in Reflux Esophagitis(RE) rats.Methods : Twenty-four Sprague-Dawley (SD) rats were divided four groups and each group had six rats ; Normal group, RE control group, RE group treated PCM 50 ,100 mg/kg body weight group. Reflux esophagitis was induced that tied the pylorus and fundus in SD rats stomach. PCM was administered at 50, 100 mg/kg body weight 2 hrs prior to induction of RE. After 6 hrs, the effects of PCM treated rats were compared with those of normal and control rats. We have performed an analysis such as pH of stomach secretion, oxidative stress biomarkers in serum, and western blot.Results : The increased esophageal mucosa damage by RE was markedly improved by PCM treatment in a dose-dependent manner. Also, the administration of PCM decreased the elevated serum reactive oxygen species (ROS) and peroxynitrite (ONOO^-) in serum. The protein expressions of anti oxidant such as SOD, catalase, GPx exhibited down-regulation by PCM treatment in tissues. And, PCM effectively reduce inflammatory cytokines such as inflammation-related proteins cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), Tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) in RE rats. In addition, NFκB and p-IκBɑ were decreased in PCM-adiministrated RE rats. But there was no difference on stomach secretion pH between reflux esophagitis rats and PCM administration rat group.Conclusions : In conclusion, administration of PCM (50, 100 mg/kg body weight) made esophagus have less inflammation and injury by decreased NFκB path way. These findings suggest that PCM could have Improving effects on reflux esophagitis.