• Proceedings of the KSR Conference
• /
• 2010.06a
• /
• pp.1975-1981
• /
• 2010

In this study, the patent trends for noise barrier and noise reducing device have been analyzed, for the development of adaptive noise barrier according to the transmission characteristics of railway noise. Using patent search engine, keyword searching for patents after 1980 in Korea was performed. The first 667 patents details were reviewed for the extraction core(ie, key) patents. From this review, finally 70 patents were built as DB. From this analysis of core patents, system requirements for development of noise reducing device were obtained.

• The Journal of Engineering Geology
• /
• v.28 no.3
• /
• pp.431-441
• /
• 2018

To set up the future research and development direction for Auger bit, this study analyzed publicized patent trends of Deep Cement Mixing method (DCM) in Korea, USA, Japan, and Europe. DCM method was firstly classified into wing shapes and the number of rods according to the technical scope, and secondly, classified into 8 types according to type of screw and rotation axial. A total of 2,815 patents were searched and 448 validated patents were selected through de-duplication and filtering. As a result of the analysis of the portfolio through the number of patents and growth stages, it was selected as the core technology that auger is deemed to have high growth potential and if there is a patent similar to core technology through a patent barrier analysis, the basic data is suggested to develop the design around and differentiated technologies.

• Journal of Technology Innovation
• /
• v.20 no.2
• /
• pp.135-159
• /
• 2012

To the analysis and discussion whether to conceptualization between the basis and LCM(Life cycle management) of patentability decisions and evergreening through research on patent application strategies and litigation cases. The Stakeholders have said that the LCM and evergreening strategies are an innovative effort to develop new pharmaceuticals, while others say that it is an effort to block generic pharmaceuticals from entering the market and permanently dominate the market by generic pharmaceuticals manufacturers or health economic perspectives. To achieve the goal of research, to discuss for conceptualization LCM and Evergreening strategies through patent application strategies for 14 pharmaceuticals for APIs and case studies for litigations. As a results, the LCM is getting patent rights for the results of research at the initial R&D stage and as such this shall be regarded as part of an effort for technology innovation. However, Evergreening is granting patent rights for the results by making high permission barrier to prevent the market entry of generic pharmaceuticals in the late development period during the pharmaceuticals development process or after their launch. This may lead to the problem of getting weak in health economic aspects and consumer welfare aspects by lowering the market accessibility of cheap generic pharmaceuticals.

• Journal of the Korean Society of Environmental Restoration Technology
• /
• v.20 no.6
• /
• pp.161-180
• /
• 2017

As the competition for securing cross-border biological sovereignty becomes intensified due to the adoption of the Nagoya Protocol, this study analyzed patent trends only for freshwater plants in order to secure national biological sovereignty. As a result, freshwater plants include a total of 68 genera and 128 species, and a total of 60 genera and 3,256 patents were surveyed. Among them, iris was the most industrialized, 14.71% followed by angelica(8.48%) and Mentha(6.94%). However, unconfirmed eight genera (Aneilema, Artemisia Cabomba, Nymphoides, Pistia stratiotes L., Pseudoraphis Griff., Ruppia) are not patented freshwater plants and it is expected that patent entry is high and barrier is low in the future. Based on patent results, Cooperative Patent Classification analysis was carried out and as a result, a total of 15 industry sectors were derived. And biopharmaceutical(30.24%) was found to be the most industrialized industry sector followed by agricultural chemistry (28.89%), biochemical industry (16.25%). In the biomedical industry, angelica(17.74%) was the most used and Iris (9.55%), Sium(20.56%) and angelica (20.48%) were found to be the most used in agricultural chemistry, biochemical industry and bio food industry, respectively. The analysis of detailed industry fields for 15 industry sectors showed that medicines of unknown structure containing substances from plants (37.77%), raw materials (46.57%) such as insect repellants, attracting agents and preparation of peptides(16.82%) with more than 21 amino acids were most frequently used in biopharmaceutical, agricultural chemistry and biochemical industry, respectively. This study is of significance as a basic data to know which freshwater plants are used in which field in order to secure biological sovereignty and patent analysis is considered necessary to continuously secure the biological sovereignty for freshwater plants.

• Proceedings of the Korean Powder Metallurgy Institute Conference
• /
• 2006.09b
• /
• pp.1142-1143
• /
• 2006

Kinik Company pioneered diamond pad conditioners protected by DLC barrier ($DiaShield^{(R)}$ Coating) back in 1999 (Sung & Lin, US Patent 6,368,198). Kink also evaluated Cermet Composite Coating (CCC or $C^3$, patent pending) with a composition that grades from a metallic (e.g. stainless steel) interlayer to a ceramic (e.g. $Al_2O_3$ or SiC) exterior. The metallic interlayer can form metallurgical bond with metallic matrix on the diamond pad conditioner. The ceramic exterior is both wear and corrosion resistant. The gradational design of $C^3$ coating will assure its strong adherence to the substrate because there is no weak boundary between coating and substrate.

• The Journal of Engineering Geology
• /
• v.23 no.2
• /
• pp.127-136
• /
• 2013

We analyzed the patent trends for whole drilling bits to reveal the main R&D directions, focusing on patents applied for and registered in Korea, the USA, Japan, and Europe. The technology was classified into two groups as a primary classification step (reaming systems and fixed systems), and into seven groups as a secondary classification step (sliding, odex, horizontal pivot, vertical pivot, concentric, eccentric, and etc.). A total of 33,614 patents were retrieved and 870 patents were selected for final effective analysis by data deduplication and filtering. A portfolio analysis using the correlation between the number of patents and the applicants for each patents revealed a sliding system as the key technology with greatest growth potential. From an analysis of the barriers to patents being granted, we emphasize the need to avoid similar topics existing patents or patent applications and to develop differential technology.

• Korean Journal of Oriental Medicine
• /
• v.13 no.1 s.19
• /
• pp.101-107
• /
• 2007

Aims: We have examined and analyzed trends of acupuncture related patents to understand the status of acupuncture technology and research trends of acupuncture in major countries including Korea, the United States, European Union and Japan. Methods: To analyze the patents, we searched and analyzed the total of 1,048 on-line DB based patents under time limit of July, 2006. Results: According to the search results, Korea is mostly superior compared to the others in number of domestic patents. However, Korea patents is inferior in number of international patents and leave much to be desired in industrial applications because of low patents barrier of personal patents and the absence of prospective clients. In addition, in this study, we show an index of international competitiveness and preliminary data of necessity of international cooperation in a field of acupuncture researches. Conclusion: These data suggest that Korea has strong possibility to recover competitiveness for guaranteeing valuable patents, if there are international cooperation and intensive managements of industries in advanced country markets.

• Journal of Soil and Groundwater Environment
• /
• v.17 no.3
• /
• pp.59-75
• /
• 2012

It is getting difficult to manage water resources in South Korea because more than half of annual precipitation is concentrated in the summer season and its intensity is getting severe due to global warming and climate change. Artificial recharge schemes can be a useful method to manage water resources in Korea adapting to climate change. Patent analysis enables us to prevent overlapping investment and to find out unoccupied technology. In this study, international patent trends and barriers of artificial recharge technology are analysed for patents of Korea, Japan, the United States and Europe. The four artificial recharge methods such as well recharge, surface infiltration, bank filtration and underground structures are classified as main class and the nine sub-technologies such as water intake, water treatment, injection wells, monitoring of groundwater flow, groundwater pumping, surface infiltration/soil aquifer treatment, radial collection well, iron/manganese treatment, and underground subsurface dam are classified as intermediate class. Water intake techniques are subdivided into five classifications. Total 1,281 of patents, searched by WIPS DB tool and selected after removing noisy patents, are analyzed quantitatively to evaluate application trends by year, applicant, country for each classified technologies and analyzed qualitatively to find out occupied and unoccupied technologies. It is expected that upcoming research and development project could be performed efficiently in that an avoidance plan for the similar patents and differentiation plan for the advancing patents are set up based on the quantitative and qualitative analysis results from this research.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.10
• /
• pp.4331-4338
• /
• 2014

$N^1$-(2, 5-dimethoxyphenyl)-$N^8$-hydroxyoctanediamide (N25) is a novel SAHA cap derivative of HDACi, with a patent (No. CN 103159646). This invention is a hydroxamic acid compound with a structural formula of $RNHCO(CH_2)6CONHOH$ (wherein R=2, 5dimethoxyaniline), a pharmaceutically acceptable salt which is soluble. In the present study, we investigated the effects of N25 with regard to drug distribution and molecular docking, and anti-proliferation, apoptosis, cell cycling, and $LD_{50}$. First, we designed a molecular approach for modeling selected SAHA derivatives based on available structural information regarding human HDAC8 in complex with SAHA (PDB code 1T69). N25 was found to be stabilized by direct interaction with the HDAC8. Anti-proliferative activity was observed in human glioma U251, U87, T98G cells and human lung cancer H460, A549, H1299 cells at moderate concentrations ($0.5-30{\mu}M$). Compared with SAHA, N25 displayed an increased antitumor activity in U251 and H460 cells. We further analyzed cell death mechanisms activated by N25 in U251 and H460 cells. N25 significantly increased acetylation of Histone 3 and inhibited HDAC4. On RT-PCR analysis, N25 increased the mRNA levels of p21, however, decreased the levels of p53. These resulted in promotion of apoptosis, inducing G0/G1 arrest in U251 cells and G2/M arrest in H460 cells in a time-dependent and dose-dependent manner. In addition, N25 was able to distribute to brain tissue through the blood-brain barrier of mice ($LD_{50}$: 240.840mg/kg). In conclusion, our findings demonstrate that N25 will provide an invaluable tool to investigate the molecular mechanism with potential chemotherapeutic value in several malignancies, especially human glioma.