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The Effect of Seasoning on the Intestinal Absorption -Absorption by Passive Transport and the Effect of Red Pepper- (조미료가 창자 운동과 흡수기능에 미치는 영향 -소장의 피동적 흡수에 대한 고추의 영향-)

  • Shin, Dong-Hoon;Kim, Joong-Soo;Koh, Jae-Pyong;Ahn, Seung-Woon
    • The Korean Journal of Physiology
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    • v.7 no.1
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    • pp.23-31
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    • 1973
  • Numerous factors concern with the absorption of substances through the membrane of the gastrointestinal tract. To simplify the experimental condition, present work has been restricted to observe the disappearance rate of substance from the intestinal loop which was made in the jejunum, 70 cm apart from the pylorus of the adult rabbit. The purpose of the study is to clarify the absorption of urea through the jejunal wall is solely attributable to the concentration difference between the luminal fluid and plasma, and to observe the effect of adding red pepper upon the rate of absorption. The rabbits were anesthetized with nembutal, 35mg/kg I.V. Jejunal loop was made by ligating at 2 spots, 70 cm and 80cm apart from the pylorus. After rinsing with normal saline solution through the polyethylene tubing inserted from the end of the loop, 8 ml of test solution was placed through the same tubing. The test solution contained 200 mg% of urea and 150mg% of polyethylene glycol(M.W. 4,000) in normal saline solution. Right after placing the test solution the first specimen was taken through the tubing, and successive samplings were performed at 5, 10, 20, and 30 minutes. Logarithm of the difference of urea concentration between the luminal fluid and plasma was plotted against time elapsed after the onset of the experiment. If straight line is revealed, it would verify the nature of transport mechanism as diffusion, obeying the Fick's principle. The concentration of polyethylene glycol (PEG) was also measured in order to examine the change in the volume. PEG was used as the marker substance because it is not absorbable in the intestinal tract. Consequently the concentration of PEG relates inversely to the volume of the loop. Instantaneous concentration of urea in the loop times the volume will give the amount of urea remaining in the luminal fluid. The change in the amount of any substance is directly relate to the volume of the compartment and differs from the change in the concentration which is independent of the volume. After completion of the experiment without red pepper, it was added in the test solution and was centrifuged after thorough mixing. Supernatant of the mixture was placed in the loop and similar sampling were performed with the same time intervals that of previous run in order to observe the effects of the red pepper on the passive transport of the water soluble small substance, urea. The results obtained were as follows: 1. Logarithm of the concentration difference of urea between the luminal fluid and plasma was diminished exponentially as time elapsed. The decay constant in the experiment without red pepper was 0.0563/min. By adding red pepper in the test solution as much as the concentration rose to 4,000 mg% and 8,000 mg%, the decay constants were lowered to 0.0493/min and to 0.0506/min, respectively. The time interval by which the concentration difference dropped to one half of the initial value was prolonged. Without red pepper the half concentration time was 13.30 minutes, and by adding extract of red pepper, 15.31 minutes and 15.71 minutes were revealed. 2. The profile of the diminishing rate of tile amount of urea was quite different from that of the concentration because of the change in the volume of the loop during the observed period. 3. By adding the extract of red pepper, it slowed down the rate of absorption of urea in the intestinal loop, suggesting an increase in the diffusional barrier. 4. Larger dosage of red pepper brought an increase in the secretion of intestinal fluid with concomitant expansion of the luminal volume, and the retardation of the absorption of urea was noticed. This effect was largely dependent on the sensitivity of the individual animal to the red pepper, extract. The amount of urea remained after 10 minutes interval was 55.5% of the initial amount in the experiment without red pepper. On the other hand it was not consistent after administration of red pepper, showing 50.6% and 66.5% of the initial figures by adding 400 mg and 800 mg of red pepper in the test solution, respectively. It was postulated that symptom of diarrhea often encountered by taking a hot (red pepper) food might be attributable to the increase of secretion and the retardation of absorption in the intestinal tract.

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Controller with Voltage-Compensated Driver for Lighting Passive Matrix Organic Light Emitting Diodes Panels

  • Juan, Chang Jung;Tsai, Ming Jong
    • 한국정보디스플레이학회:학술대회논문집
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    • 2004.08a
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    • pp.673-675
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    • 2004
  • This study proposes controller with voltage-compensated drivers for producing gray-scaled pictures on passive matrix organic light emitting diodes (PMOLEDs) panels. The controller includes voltage type drivers so the output impedance of the driver is far less than that of the current-type driver. Its low output impedance provides better electron-optical properties than those of traditional current drivers. A free running clock and a group of counters are applied to the gray-scaled function so that phase lock loop (PLL) circuit can be reduced in the controller. A pre-charge function is used to enhance performance of the luminance of an active OLED pixel. As a result, distribution of the low gray level portion is achieved linear relationship with input data. In this work, the digital part of the proposed controller is implemented using FPGA chips, and analog parts are combined with a digital-analog converter (DAC) and analog switches. A still image is displayed on a $48^{\ast}64$ PMOLEDs panel to assess the luminance performance fir the controller. Based on its cost requirement and luminance performance, the controller is qualified to join the market for driving PMOLEDs panels.

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Vibration isolation with smart fluid dampers: a benchmarking study

  • Batterbee, D.C.;Sims, N.D.
    • Smart Structures and Systems
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    • v.1 no.3
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    • pp.235-256
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    • 2005
  • The non-linear behaviour of electrorheological (ER) and magnetorheological (MR) dampers makes it difficult to design effective control strategies, and as a consequence a wide range of control systems have been proposed in the literature. These previous studies have not always compared the performance to equivalent passive systems, alternative control designs, or idealised active systems. As a result it is often impossible to compare the performance of different smart damper control strategies. This article provides some insight into the relative performance of two MR damper control strategies: on/off control and feedback linearisation. The performance of both strategies is benchmarked against ideal passive, semi-active and fully active damping. The study relies upon a previously developed model of an MR damper, which in this work is validated experimentally under closed-loop conditions with a broadband mechanical excitation. Two vibration isolation case studies are investigated: a single-degree-of-freedom mass-isolator, and a two-degree-of-freedom system that represents a vehicle suspension system. In both cases, a variety of broadband mechanical excitations are used and the results analysed in the frequency domain. It is shown that although on/off control is more straightforward to implement, its performance is worse than the feedback linearisation strategy, and can be extremely sensitive to the excitation conditions.

Modeling and Feedback Control of LLC Resonant Converters at High Switching Frequency

  • Park, Hwa-Pyeong;Jung, Jee-Hoon
    • Journal of Power Electronics
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    • v.16 no.3
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    • pp.849-860
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    • 2016
  • The high-switching-frequency operation of power converters can achieve high power density through size reduction of passive components, such as capacitors, inductors, and transformers. However, a small-output capacitor that has small capacitance and low effective series resistance changes the small-signal model of the converter power stage. Such a capacitor can make the converter unstable by increasing the crossover frequency in the transfer function of the small-signal model. In this paper, the design and implementation of a high-frequency LLC resonant converter are presented to verify the power density enhancement achieved by decreasing the size of passive components. The effect of small output capacitance is analyzed for stability by using a proper small-signal model of the LLC resonant converter. Finally, proper design methods of a feedback compensator are proposed to obtain a sufficient phase margin in the Bode plot of the loop gain of the converter for stable operation at 500 kHz switching frequency. A theoretical approach using MATLAB, a simulation approach using PSIM, and experimental results are presented to show the validity of the proposed analysis and design methods with 100 and 500 kHz prototype converters.

Risk and Sensitivity Analysis during the Low Power and Shutdown Operation of the 1,500MW Advanced Power Reactor (1,500MW대형원전 정지/저출력 안전성향상을 위한 설계개선안 및 민감도 분석)

  • Moon, Ho Rim;Han, Deok Sung;Kim, Jae Kab;Lee, Sang Won;Lim, Hak Kyu
    • Transactions of the Korean Society of Pressure Vessels and Piping
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    • v.15 no.1
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    • pp.33-39
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    • 2019
  • An 1,500MW advanced power reactor required the standard design approval by a Korean regulatory body in 2014. The reactor has been designed to have a 4-train independent safety concept and a passive auxiliary feedwater system (PAFS). The full power risk or core damage frequency (CDF) of 1,500MW advanced power reactor has been reduced more than that of APR1400. However, the risk during the low power and shutdown (LPSD) operation should be reduced because CDF of LPSD is about 4.7 times higher than that of internal full power. The purpose of paper is to analysis design alternatives to reduce risk during the LPSD. This paper suggests design alternatives to reduce risk and presents sensitivity analysis results.

Folded Loop Antennas for RFID Appilication (RFID 응용을 위한 폴디드-루프 안테나)

  • Choi, Tea-Il
    • The Journal of the Korea institute of electronic communication sciences
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    • v.2 no.4
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    • pp.199-202
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    • 2007
  • In this paper, we examined the operating principle of a passive tag antenna for RFID system in UHF band. Based on the study, we proposed a novel RFID tag antenna which adopts the inductively coupled feeding structure to match antenna impedance to a capacitively loaded commercial tag chip. The proposed tag antenna consists of microstrip lines on a thin PET substrate for low-cost fabrication. The detail structure of the tag antenna were optimized using a full electromagnetic wave simulator of IE3D in conjunction with a Pareto genetic algorithm, and the size of the tag antenna can be reduced up to kr=0.27(2 cm2). We built some sample antennas and measured the antenna characteristics such as a return loss, an efficiency, and radiation patterns. The readable range of the tag antenna with a commercial RFID system showed about 1 to 3 m.

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Analysis of PLL Phase Noise Effect for High Data-rate Underwater Communications

  • Lee, Chong-Hyun;Bae, Jin-Ho;Hwang, Chang-Ku;Lee, Seung-Wook;Shin, Jung-Chae
    • International Journal of Ocean System Engineering
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    • v.1 no.4
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    • pp.205-210
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    • 2011
  • High data-rate underwater communications is demanded. This demand imposes stringent requirements on underwater communication equipment of phase-locked-loop (PLL). Phase noise in PLL is unwanted and unavoidable. In this paper, we investigate the PLL phase noise effect on high order QAM for underwater communication systems. The phase noise model using power spectral density is adopted for performance evaluation. The phase noise components considered in PLL are reference oscillator, voltage controlled oscillator (VCO), filter and divider. The filters in PLL noise are assumed to be second order active and passive low pass filters. Through simulation, we analyze the phase noise characteristics of the four components and then investigate the performance improvement factor of each component. Consequently, we derive specifications of VCO, phase detector, divider to meet performance requirement of high data-rate communication using QAM under phase noise influence.

Development of a methodology for damping of tall buildings motion using TLCD devices

  • Diana, Giorgio;Resta, Ferruccio;Sabato, Diego;Tomasini, Gisella
    • Wind and Structures
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    • v.17 no.6
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    • pp.629-646
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    • 2013
  • One of the most common solutions adopted to reduce vibrations of skyscrapers due to wind or earthquake action is to add external damping devices to these structures, such as a TMD (Tuned Mass Damper) or TLCD (Tuned Liquid Column Damper). It is well known that a TLCD device introduces on the structure a nonlinear damping force whose effect decreases when the amplitude of its motion increases. The main objective of this paper is to describe a Hardware-in-the-Loop test able to validate the effectiveness of the TLCD by simulating the real behavior of a tower subjected to the combined action of wind and a TLCD, considering also the nonlinear effects associated with the damping device behavior. Within this test procedure a scaled TLCD physical model represents the hardware component while the building dynamics are reproduced using a numerical model based on a modal approach. Thanks to the Politecnico di Milano wind tunnel, wind forces acting on the building were calculated from the pressure distributions measured on a scale model. In addition, in the first part of the paper, a new method for evaluating the dissipating characteristics of a TLCD based on an energy approach is presented. This new methodology allows direct linking of the TLCD to be directly linked to the increased damping acting on the structure, facilitating the preliminary design of these devices.

A Low Noise Low Power Capacitive Instrument Amplifier for Bio-Potential Detection (생체 신호 측정용 저 잡음 저 전력 용량성 계측 증폭기)

  • Park, Chang-Bum;Jung, Jun-Mo;Lim, Shin-Il
    • Journal of Sensor Science and Technology
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    • v.26 no.5
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    • pp.342-347
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    • 2017
  • We present a precision instrument amplifier (IA) designed for bio-potential acquisition. The proposed IA employs a capacitively coupled instrument amplifier (CCIA) structure to achieve a rail-to-rail input common-mode range and low gain error. A positive feedback loop is applied to boost the input impedance. Also, DC servo loop (DSL) with pseudo resistors is adopted to suppress electrode offset for bio-potential sensing. The proposed amplifier was designed in a $0.18{\mu}m$ CMOS technology with 1.8V supply voltage. Simulation results show the integrated noise of $1.276{\mu}Vrms$ in a frequency range from 0.01 Hz to 1 KHz, 65dB SNR, 118dB CMRR, and $58M{\Omega}$ input impedance respectively. The total current of IA is $38{\mu}A$. It occupies $740{\mu}m$ by $1300{\mu}m$ including the passive on-chip low pass filter.

Loop Suture Technique for Flexor Digitorum Profundus Tendon Repair in the Insertion Site (고리 봉합법을 이용한 심부 수지 굴건 종지부에서의 건봉합)

  • Lee, Kyu-Cheol;Lee, Dong-Chul;Kim, Jin-Soo;Ki, Sae-Hwi;Roh, Si-Young;Yang, Jae-Won
    • Archives of Plastic Surgery
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    • v.37 no.5
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    • pp.650-658
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    • 2010
  • Purpose: In the case of repair for far distal parts of FDP (Flexor digitorum profundus) division, the method of either pull-out suture or fixation of tendon to the distal phalanx is preferred. In this paper, the results of a modified loop suture technique used for the complete division of FDP from both zone 1a and distal parts of zone 1b in Moiemen classification are presented. Methods: From July 2006 to July 2009, the modified loop suture technique was used for the 10 cases of FDP in complete division from zone 1a and distal parts of zone 1b, especially where insertion sites were less than 1 cm apart from a tendon of a stump. In a suture technique, a loop is applied to each distal and proximal parts of tendon respectively. Core suture of 2-strand and epitendinous suture are done with PDS 4-0. Out of 10 patients, the study was done on 6 patients who were available for the followup. The average age of the patients was 49.1 years (in the range from 26 to 67). 5 males and 1 female patients were involved in this study. There were 3 cases with zone 1a and distal parts of zone 1b. The average distance to the distal tendon end was 0.6 cm. There were 5 cases underwent microsurgical repair where both artery and nerve divided. One case of only tendon displacement was presented. The dorsal protective splint was kept for 5 weeks on average. The results of the following tests were measured: active & passive range of motion, grip strength test, key pinch and pulp pinch test. Results: The follow-up period on average was 11 months, in the range from 2 to 20 months. There was no case of re-rupture, but tenolysis was performed in 1 cases. In all 6 cases, the average active range of motion of distal interphalangeal joint was 50.8 degree. The grip strength (ipsilateral/contralateral) was measured as 88.7% and the pulp pinch test was 79.2% as those of contralateral side. Flexion contracture was presented in 2 cases (15 degree on average) and there was no quadrigia effect found. Conclusion: Despite short length of tendon from the insertion site in FDS rupture in zone 1a and distal parts of zone 1b, sufficient functional recovery could be expected with the tendon to tendon repair using the modified loop suture technique.