• Asian Pacific Journal of Cancer Prevention
• /
• v.13 no.6
• /
• pp.2979-2984
• /
• 2012

Recent studies have indicated a link between levels of cyclooxygenase-2 (COX-2) and development of the multidrug resistance (MDR) phenotype. The ATP-binding cassette sub-family G member 2 (ABCG2) is a major MDR-related transporter protein that is frequently overexpressed in cancer patients. In this study, we aimed to evaluate any positive correlation between COX-2 and ABCG2 gene expression using the COX-2 inducer 12-O-tetradecanoylphorbol-13-acetate (TPA) in human breast cancer cell lines. ABCG2 mRNA and protein expression was studied using real-time RT-PCR and flow cytometry, respectively. A significant increase of COX-2 mRNA expression (up to 11-fold by 4 h) was induced by TPA in MDA-MB-231 cells, this induction effect being lower in MCF-7 cells. TPA caused a considerable increase up to 9-fold in ABCG2 mRNA expression in parental MCF-7 cells, while it caused a small enhancement in ABCG2 expression up to 67 % by 4 h followed by a time-dependent decrease in ABCG2 mRNA expression in MDA-MB-231 cells. TPA treatment resulted in a slight increase of ABCG2 protein expression in MCF-7 cells, while a time-dependent decrease in ABCG2 protein expression was occurred in MDA-MB-231 cells. In conclusion, based on the observed effects of TPA in MDA-Mb-231 cells, it is proposed that TPA up-regulates ABCG2 expression in the drug sensitive MCF-7 breast cancer cell line through COX-2 unrelated pathways.

• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.12
• /
• pp.4815-4821
• /
• 2014

Background: This study aimed to examine the relationship between respiratory health of Malaysian adolescents with secondhand smoke (SHS) exposure and smoke-free legislation (SFL) implementation. Materials and Methods: A total of 898 students from 21 schools across comprehensive- and partial-SFL states were recruited. SHS exposures and respiratory symptoms were assessed via questionnaire. Prenatal and postnatal SHS exposure information was obtained from parental-completed questionnaire. Results: The prevalence of respiratory symptoms was: 11.9% ever wheeze, 5.6% current wheeze, 22.3% exercise-induced wheeze, 12.4% nocturnal cough, and 13.1% self-reported asthma. SHS exposure was most frequently reported in restaurants. Hierarchical logistic regression indicates living in a comprehensive-SFL state was not associated with a lower risk of reporting asthma symptoms. SHS exposure in public transport was linked to increased risk for wheeze (Adjusted Odds Ratio (AOR) 16.6; 95%confidence interval (CI), 2.69-101.7) and current wheezing (AOR 24.6; 95%CI, 3.53-171.8). Conclusions: Adolescents continue to be exposed to SHS in a range of public venues in both comprehensive- and partial-SFL states. Respiratory symptoms are common among those reporting SHS exposure on public transportation. Non-compliance with SFL appears to be frequent in many venues across Malaysia and enforcement should be given priority in order to reduce exposure.

• Journal of Nutrition and Health
• /
• v.34 no.2
• /
• pp.198-212
• /
• 2001

This study was designed to compare the prevalence rate of obesity, food attitude, food frequency and food habits between children in Kangnung and Seoul areas. 1,005 children aged 9-12 were included in this study. They were composed of 343 children living in Kangnung from one elementary school, and 662 children in Seoul from two elementary schools. The body weight, height, waist and hip circumferences of children were measured and food frequency scores of Korean and Western foods were examined by questionnaire. And questionnaires about food attitude, food habits and life style were administered to the mother of each child. There was no significant difference in body weight and obesity index among three groups(one school of Kangnung area and two schools of Seoul area). The male children\`s prevalence rates of obesity in Kangnung and two schools(A, B) of Seoul were 10.3%, 10.3% and 7.3%, respectively. Female children\`s prevalence rate were 5.4%, 4.7%, and 6.3%, respectively. Children in Seoul turned out to more frequently eat such Korean foods like pulkogi, kalbi and fried rice and such western foods like butter, margarine, hamburger, pizza, and fried chicken. Children in Seoul had more tendency to eat regularly and spent less time in sleeping and watching TV and more time in exercise than the respondents in Kangnung. The obesity index of parents had a significantly positive correlation with that of children. These results suggest that children in Seoul have tendency to eat high-energy food frequently and to have more energy expenditure than children in Kangnung. In conclusion, further studies on the evaluation of energy intake and energy expenditure of obese and normal children different in area should be conducted. (Korean J Nutrition 34(1) : 198∼212, 2001)

• Korean Journal of Childcare and Education
• /
• v.11 no.6
• /
• pp.79-96
• /
• 2015

The purpose of this study was to investigate the structural relationships between preschooler's temperament, externalizing behavior problems and mother's parenting competency. The 5th Panel Study of Korean Children by Korea Institute of Child Care and Education were analyzed in this study by using the structural model. The major findings are as follows, First, preschoolers' emotionality temperament were found to have a negative effect on mothers' parenting competency. Preschoolers' activity and sociability temperament had a positive influence on mothers' parenting competency. Second, preschoolers's emotionality temperament also had a direct impact on their externalizing problems behavior, otherwise preschoolers's activity and sociability temperament were unrelated to that. Third, mothers' parenting competency had a negative influence on preschoolers' externalizing problems behavior. Finally, mothers' parenting competency had mediating effects between preschoolers' temperament and their externalizing problems behavior. These findings suggest that parental education should be concerned about parenting competency based on the understanding of preschooler's temperament.

• Journal of Environmental Science International
• /
• v.6 no.1
• /
• pp.45-52
• /
• 1997

Methyl methanesulfonate (MMS) was fed to Drosophila melnogaster in order to investigate its toxic capability at developmental and adult stages, and the hereditary effect of toxicity and the potency for induction of sex-linked lethal mutation during the slyer-matogenesis by the means of an attached-X method. In the control group, the egg to adult viability of D. melnogaster was 95.2%, while 3. 5mM and 5.0mM treated groups were 90.0% and 84.1%, respectively. In the case of their progenies (Fl), the viability was 96.9% in the control group, while 3.5mM and 5.0mM treated groups were 54.5% and 1.6%, respectively. Therefore, these differences between two generations show significant physiological toxic effects in the next generation. In the parental generation, the developmental time was calculated 11.05 days in the control group, 12.43 days In 3.5%mM treated group, and 13.23 days in 5.0mM. In the case of Fl it was estimated 10.35 days in the control group, and 11.43 days In 3.5mM treated group. Compared with the control groups In two generations, the developmental time generally delayed as the dose of MMS increased. As to the sex-ratio, there was no differences between the control and MMS treated groups. The toxic values of adult stage showed which increased the frequency of mortality with MMS concentrations. The mortality at 120hr In the control group was 1.67% and it in 0.5mM MMS treated group 3.33%. In 2.5mM MMS treated group, it was 33.3% at 72hr, and it 95% at 120hr The increase of the morality was shown from 72hr in 4.0mM treated group which was 100% at 96hr. There was the concentration-dependent induction of sex-linked lethal mutation during the spermatogenesis by means of an attached-X method, MMS had more pronounced effect in sperm and spermaid stages in D. melnogaster.

• Journal of The Korean Association For Science Education
• /
• v.21 no.5
• /
• pp.893-905
• /
• 2001

Korean students ranked the 3rd out of 32 participating countries in the first cycle of PISA(Programme for International Student Assessment) science field, which assessed 15-years-old students' scientific literacy. PISA developed several variables such as parents' socio-economic status, parents' educational attainment, family wealth, and cultural possession, to investigate the effects of background variables on scientific literacy. On the other hand, motivation and engagement in science study were not given much attention, partly because science was the minor area in the first cycle of PISA. Therefore, PISA Korea developed a series of variables to collect data on students' learning motives and out-of-school activities in science as a national option. The results are as followings. First, Korea was found to be one of the PISA participating countries with the scientific literacy achievement least influenced by parents' socio-economic status, family wealth, and parents' cultural possession. Second, the degree of achievement in scientific literacy according to parents' educational attainment was in a positive correlation, similar to the overall tendency of PISA. Third, the most crucial learning motive for Korean students was their desire to develop scientific thinking abilities or obtain science knowledge. On the other hand, choosing jobs in the field of science or parental expectation was the least important learning motive. In particular, the motive for scientific learning was found to have a positive relationship with the degree of scientific literacy achievement. Therefore, the higher the students achievement, the stronger the motive for scientific learning in order to develop their ability to think scientifically or acquire science knowledge. Fourth, Korean students were shown to participate very little in out-of-school scientific activities other than watching TV programs related to science. Whatever the activities may be, the more actively involved students are in out-of-school scientific activities, the higher their scientific literacy achievement. Fifth, Korean girls were rather passive compared to boys in all areas, including science learning motive and out-of-school scientific activities. The gender difference was especially more pronounced in out-of-school scientific activities with wider gaps in such activities as reading scientific books or articles and visiting science-related web sites.

• Journal of the Korea Convergence Society
• /
• v.11 no.11
• /
• pp.147-154
• /
• 2020

The purpose of this study is to analyze how parents' income, goal, expectancy, and value affect their parents' child supporting behavior, and to understand the behavior of parents supporting their children of elite athletes. For this, the influence relations of parental supporting cost/time according to income, children's achievement level, parents' sports parenting objective, achievement expectancy, and task value were analyzed through simple regression analysis and hierarchical regression analysis. As a result of the study, income and identity objective had an effect on supporting time. Income affected the supporting cost. Achievement expectancy had a moderating effect of income on supporting cost, and usefulness value had a moderating effect on income and relational objective. It is significant that it provided a quantitative basis for understanding parents' child supporting behavior.

• Survey Research
• /
• v.11 no.3
• /
• pp.81-101
• /
• 2010

The purposes of the present study were to investigate the effects of individual, family, and school factors on the onset of adolescents' violence behaviors. For these goals, we applied discrete-time survival analysis to the Korean Youth Panel Survey. According to the estimated hazard function, the likelihood of onset of adolescents' violence behavior was low during elementary school years and increasing sharply from middle school years. Results showed that gender, self-esteem, aggressiveness, broken home, parental abuse, and the number of delinquent friends were significant determinants of the onset of adolescents' violence behaviors. Findings from this study suggest the need to focus on the significant determinants and consider various prevention programs.

• Child Health Nursing Research
• /
• v.22 no.4
• /
• pp.379-389
• /
• 2016

Purpose: A longitudinal study was conducted to explore flora colonization and oral glucose high-risk newborns during the first 7 days after birth. Methods: Oral secretions of hospitalized newborns were obtained for microbial cultures and glucose test at days 1-7 after birth. Results: Among the total 112 newborns, 40% were girls and 73% were premature. Mean gestational age was $34.4{\pm}3.2$ weeks and weight was $2,266{\pm}697.5$ grams. The most common flora included Streptococcus (28.2%), Methicillin-resistant Staphylococcus aureus (MRSA, 10.9%), Staphylococcus (6.0%) and Coagulase-Negative Staphylococcus (CNS, 4.0%). The average oral glucose level was $29.2{\pm}23.0mg/dL{\sim}58.2{\pm}39.5mg/dL$. Newborns with higher oral glucose than serum (crude odds ratio [ORc] =1.75; 95% confidence interval [CI] =1.03-2.97), phototherapy (ORc=3.30; 95% CI=2.29-4.76) and prone position (ORc= 2.04; 95% CI=1.13-3.69) were more likely to be colonized. Having oral tubes (ORc=0.42; 95% CI=0.29-0.59), parental nutrition (ORc=0.21; 95% CI=0.13-0.32) and antibiotics (ORc=0.51; 95% CI=0.36-0.73) had protective effects. For oral glucose statistical significances existed on time effect among newborns with Streptococcus (F=9.78, p=.024), MRSA (F=7.60, p=.037) or CNS (F=11.15, p=.019) and interaction between time and colonization among newborns with all of four flora (F=2.73, p=.029) or colonization with only Staphylococcus (F=2.91, p=.034). Conclusion: High-risk newborns develop flora colonization at an early period of life. Their clinical features were associated with types and time of oral flora colonization. They need close monitoring and multifaceted intervention to improve oral environment and infection control.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
• /
• v.2 no.1
• /
• pp.3-10
• /
• 1991

Test situations are relatively specific and are experienced by everyone. The major purposes of this overview are to review the current concepts and theories of test anxiety and based on this review to suggest future directions in test anxiety theory and research. Test anxiety can be explained in terms of drive-oriented approach. trait-state anxiety theory, cognitive theory, cognitive and emotional approach, and psychodynamic theory. Usually, high test-anxious students keep the following characteristics : 1) The test situation is seen as difficult, challenging and threatening. 2) The individual sees himself as ineffective, and inadequate in handling the task at hand. 3) The individual focuses on undesirable consequences of personal inadequacy. 4) Self-deprecatory preoccupations are strong and interfere or compete with task-relevant cognitive activity. 5) The individual expects and anticipates failure and loss of regard by others. Future directions in test anxiety research should be focused to elucidate the nature and construct of test anxiety and the etiological factors of test anxiety by conducting research on the relationship between parental or social attitude and test anxiety. The effects of test anxiety on memory, attention, and cue utilization should be performed to elucidate the relationship between test anxiety and performance.