• Title/Summary/Keyword: parallel proximity

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Effects of Substance P on the Activities of Immune Cell (면역세포 활성에 대한 Substance P의 영향)

  • Kim, Hyung-Seop;Oh, Kwi-Ok;Lim, Chong-Deuk
    • Journal of Periodontal and Implant Science
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    • v.26 no.2
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    • pp.376-395
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    • 1996
  • The neuropeptide substance P(SP) has been recognized to modulate immune systems, with close proximity between peptidergic sensory nerve endings and immune cells. These include the macrophage and neutrophil activation, IL-2 production in T cell, augmentation of Ig synthesis, mast cell degranulation, $PGE_2$ and collagenase secretion in synoviocytes. In this study I examined SP-induced various biological activities such as antimicrobial action, cytokine production, and mast cell degranulation in the presence or absence of other inflammatory cell activators. Antimicrobial studies showed that undifferentiated HL-60 cells were not affected by SP. However, SP significantly enhanced antimicrobial action of TPA-treated or dbcAMP-treated HL-60 cells which had been differentiated into PMN or macrophage/monocyte. I could not find synergistic relationship between SP and LPS in parallel experiments of the above. SP did not induce IL-l production from murine macrophage cell line RAW264.7 whether costimulated with LPS or not. Mast cell degranulation was occured only when stimulated with high dose ($10^{-5}M$) of SP and the degree of this activation was slightly reduced by simultaneous application of $MIP-1{\alpha}$. In addition, CGRP which is known to be a common coexisting neuropeptide with SP within specific fibers did not augment the function of SP on mast cell degranulation. These results suggest that immunoregulatory activities of SP could be mediated through direct upregulation of various functions of immune cells and also upregulation of responsiveness of immune cells to other immune activators.

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Health monitoring of a new hysteretic damper subjected to earthquakes on a shaking table

  • Romo, L.;Benavent-Climent, A.;Morillas, L.;Escolano, D.;Gallego, A.
    • Earthquakes and Structures
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    • v.8 no.3
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    • pp.485-509
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    • 2015
  • This paper presents the experimental results obtained by applying frequency-domain structural health monitoring techniques to assess the damage suffered on a special type of damper called Web Plastifying Damper (WPD). The WPD is a hysteretic type energy dissipator recently developed for the passive control of structures subjected to earthquakes. It consists of several I-section steel segments connected in parallel. The energy is dissipated through plastic deformations of the web of the I-sections, which constitute the dissipative parts of the damper. WPDs were subjected to successive histories of dynamically-imposed cyclic deformations of increasing magnitude with the shaking table of the University of Granada. To assess the damage to the web of the I-section steel segments after each history of loading, a new damage index called Area Index of Damage (AID) was obtained from simple vibration tests. The vibration signals were acquired by means of piezoelectric sensors attached on the I-sections, and non-parametric statistical methods were applied to calculate AID in terms of changes in frequency response functions. The damage index AID was correlated with another energy-based damage index -ID- which past research has proven to accurately characterize the level of mechanical damage. The ID is rooted in the decomposition of the load-displacement curve experienced by the damper into the so-called skeleton and Bauschinger parts. ID predicts the level of damage and the proximity to failure of the damper accurately, but it requires costly instrumentation. The experiments reported in this paper demonstrate a good correlation between AID and ID in a realistic seismic loading scenario consisting of dynamically applied arbitrary cyclic loads. Based on this correlation, it is possible to estimate ID indirectly from the AID, which calls for much simpler and less expensive instrumentation.

Design of Broadband Microstrip Antenna for 2.5GHz with Inverted Parasite Patch and the Proximity Stub (근접 스터브와 뒤집힌 기생 패치를 이용한 2.5GHz용 광대역 마이크로스트립 안테나의 설계)

  • Cho, Ki-Ryang;Kim, Dae-Ik;Kim, Gun-Kyun
    • The Journal of the Korea institute of electronic communication sciences
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    • v.14 no.3
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    • pp.467-474
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    • 2019
  • In this paper, we studied a method for a broadband stacked patch antenna structure which is widely used for bandwidth improvement. The characteristics according to the distance between the two patches were analyzed and the impedance matching was optimized by connecting parallel open stubs to the main patch feed line. The shunt matching stub is inserted underneath the parasitic patch and so it does not require additional space, which enables the proposed antenna structure to be advantageous in miniaturizing antenna. The effects of the various parameters on the antenna performance are examined, and we introduced the design procedure for the proposed antenna to operate in the frequency range of 2.3~2.7GHz. Experimental results show that the bandwidth of the proposed antenna is about 480MHz with 2.27~2.75GHz bandwidth. And the antenna gain was 5.8dBi at 2.3GHz and 7.8dBi at 2.6GHz within the bandwidth.

A Survey on 5G Enabled Multi-Access Edge Computing for Smart Cities: Issues and Future Prospects

  • Tufail, Ali;Namoun, Abdallah;Alrehaili, Ahmed;Ali, Arshad
    • International Journal of Computer Science & Network Security
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    • v.21 no.6
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    • pp.107-118
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    • 2021
  • The deployment of 5G is in full swing, with a significant yearly growth in the data traffic expected to reach 26% by the year and data consumption to reach 122 EB per month by 2022 [10]. In parallel, the idea of smart cities has been implemented by various governments and private organizations. One of the main objectives of 5G deployment is to help develop and realize smart cities. 5G can support the enhanced data delivery requirements and the mass connection requirements of a smart city environment. However, for specific high-demanding applications like tactile Internet, transportation, and augmented reality, the cloud-based 5G infrastructure cannot deliver the required quality of services. We suggest using multi-access edge computing (MEC) technology for smart cities' environments to provide the necessary support. In cloud computing, the dependency on a central server for computation and storage adds extra cost in terms of higher latency. We present a few scenarios to demonstrate how the MEC, with its distributed architecture and closer proximity to the end nodes can significantly improve the quality of services by reducing the latency. This paper has surveyed the existing work in MEC for 5G and highlights various challenges and opportunities. Moreover, we propose a unique framework based on the use of MEC for 5G in a smart city environment. This framework works at multiple levels, where each level has its own defined functionalities. The proposed framework uses the MEC and introduces edge-sub levels to keep the computing infrastructure much closer to the end nodes.

An ESDA Tool for Time-series Spatial Association (지역분석을 위한 시계열 공간연관성 탐색도구)

  • Ahn Jae-Seong;Park Key-Ho;Lee Yang-Won
    • Spatial Information Research
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    • v.14 no.1 s.36
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    • pp.163-176
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    • 2006
  • The concept of 'spatial association' explains spatial distribution pattern of geographical phenomenon based on similarity with neighborhoods, as in the Tobler's Law of Geography: 'Everything is related to everything else, but near things are more related than distant things.' In this study, we develop a time-series exploratory analysis tool for discovering temporal patterns of spatial association by combining spatial statistics and geo-visualization, and thus present a possibility to support spatial decision-making process. As for the spatial proximity weight matrix indispensable to measuring global and local spatial association, we employ a variety of flexible weighting schemes using geometric characteristics of areal unit. In addition, we renovate the existing visualization methods for more effective understanding of the procedures and results of time-series analysis on spatial association: for instance, temporal parallel coordinate plot with box plot, animated map for spatial association, and 3D Moran scatterplot. The feasibility of our system is verified by time-series analysis experiments on the spatial association of land price fluctuation rate for all administrative units in Korea, $1995{\sim}2004$.

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Implant assisted removable partial denture using bilateral single implant-supported surveyed crown: a case report (양측성 단일 임플란트 지지 서베이드 크라운을 이용한 하악 임플 란트 보조 국소의치 수복 증례)

  • Seojune Choi;Hong Seok Moon;Jaeyoung Kim
    • The Journal of Korean Academy of Prosthodontics
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    • v.62 no.2
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    • pp.146-156
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    • 2024
  • Implant assisted removable partial denture (IARPD) has been practiced in various forms for a long time, and among them, implant surveyed crown RPD is gaining predictability as well as being considered as a treatment option for patients with anatomical and financial disadvantages. The position of implant could be divided as posterior placement or anterior placement according to the purpose of the treatment and should be planned in consider to the alveolar ridge of patient, anticipated prognosis of remaining teeth, and opposing dentition. This case report describes a treatment for mandibular Kennedy class I partial edentulous patient with two implant-supported surveyed crown and implant assisted removable partial denture. Given the difficulty of posterior placement in this patient and the prognosis of the residual teeth, the plan was to place two implants in close proximity to the residual teeth, which were placed in the planned position, angle, and depth using guided surgery. The process of fabricating the fixed prosthesis was carried out in parallel with the maxillary edentulous tooth arrangement process to increase predictability, and when fabricating the localized tooth, the implant was designed in a form that allows the patient to perform functional movements by preventing excessive loading as the last supporting tooth, and was fabricated through a secondary impression process. Each treatment procedure was proceeded as planned, with aesthetically and functionally satisfactory results for both patient and operator.

The Abuse and Invention of Tradition from Maintenance Process of Historic Site No.135 Buyeo Gungnamji Pond (사적 제135호 부여 궁남지의 정비과정으로 살펴본 전통의 남용과 발명)

  • Jung, Woo-Jin
    • Journal of the Korean Institute of Traditional Landscape Architecture
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    • v.35 no.2
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    • pp.26-44
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    • 2017
  • Regarded as Korea's traditional pond, Gungnamj Pond was surmised to be "Gungnamji" due to its geological positioning in the south of Hwajisan (花枝山) and relics of the Gwanbuk-ri (官北里) suspected of being components to the historical records of Muwang (武王)'s pond of The Chronicles of the Three States [三國史記] and Sabi Palace, respectively, yet was subjected to a restoration following a designation to national historic site. This study is focused on the distortion of authenticity identified in the course of the "Gungnamji Pond" restoration and the invention of tradition, whose summarized conclusions are as follows. 1. Once called Maraebangjuk (마래방죽), or Macheonji (馬川池) Pond, Gungnamji Pond was existent in the form of a low-level swamp of vast area encompassing 30,000 pyeong during the Japanese colonial period. Hong, Sa-jun, who played a leading role in the restoration of "Gungnamji Pond," said that even during the 1940s, the remains of the island and stone facilities suspected of being the relics of Gungnamji Pond of the Baekje period were found, and that the traces of forming a royal palace and garden were discovered on top of them. Hong, Sa-jun also expressed an opinion of establishing a parallel between "Gungnamji Pond" and "Maraebangjuk" in connection with a 'tale of Seodong [薯童說話]' in the aftermath of the detached palace of Hwajisan, which ultimately operated as a theoretical ground for the restoration of Gungnamj Pond. Assessing through Hong, Sa-jun's sketch, the form and scale of Maraebangjuk were visible, of which the form was in close proximity to that photographed during the Japanese colonial period. 2. The minimized restoration of Gungnamji Pond faced deterrence for the land redevelopment project implemented in the 1960s, and the remainder of the land size is an attestment. The fundamental problem manifest in the restoration of Gungnamji Pond numerously attempted from 1964 through 1967 was the failure of basing the restorative work in the archaeological facts yet in the perspective of the latest generations, ultimately yielding a replication of Hyangwonji Pond of Gyeongbok Palace. More specifically, the methodologies employed in setting an island and a pavilion within a pond, or bridging an island with a land evidenced as to how Gungnamji Pond was modeled after Hyangwonji Pond of Gyeongbok Palace. Furthermore, Chihyanggyo (醉香橋) Bridge referenced in the designing of the bridge was hardly conceived as a form indigenous to the Joseon Dynasty, whose motivation and idea of the misguided restoration design at the time all the more devaluated Gungnamji Pond. Such an utterly pure replication of the design widely known as an ingredient for the traditional landscape was purposive towards the aesthetic symbolism and preference retained by Gyeongbok Palace, which was intended to entitle Gungnamji Pond to a physical status of the value in par with that of Gyeongbok Palace. 3. For its detachment to the authenticity as a historical site since its origin, Gungnamji Pond represented distortions of the landscape beauty and tradition even through the restorative process. The restorative process for such a historical monument, devoid of constructive use and certain of distortion, maintains extreme intimacy with the nationalistic cultural policy promoted by the Park, Jeong-hee regime through the 1960s and 1970s. In the context of the "manipulated discussions of tradition," the Park's cultural policy transformed the citizens' recollection into an idealized form of the past, further magnifying it at best. Consequently, many of the historical sites emerged as fancy and grand as they possibly could beyond their status quo across the nation, and "Gungnamji Pond" was a victim to this monopolistic government-led cultural policy incrementally sweeping away with new buildings and structures instituted regardless of their original space, and hence, their value.