• Korean Journal of Radiology
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• 제25권1호
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• pp.74-85
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• 2024

Objective: Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology associated with venous sinus stenosis. This study aimed to develop a magnetic resonance venography (MRV)-based radiomics model for predicting a high trans-stenotic pressure gradient (TPG) in IIH patients diagnosed with venous sinus stenosis. Materials and Methods: This retrospective study included 105 IIH patients (median age [interquartile range], 35 years [27-42 years]; female:male, 82:23) who underwent MRV and catheter venography complemented by venous manometry. Contrast enhanced-MRV was conducted under 1.5 Tesla system, and the images were reconstructed using a standard algorithm. Shape features were derived from MRV images via the PyRadiomics package and selected by utilizing the least absolute shrinkage and selection operator (LASSO) method. A radiomics score for predicting high TPG (≥ 8 mmHg) in IIH patients was formulated using multivariable logistic regression; its discrimination performance was assessed using the area under the receiver operating characteristic curve (AUROC). A nomogram was constructed by incorporating the radiomics scores and clinical features. Results: Data from 105 patients were randomly divided into two distinct datasets for model training (n = 73; 50 and 23 with and without high TPG, respectively) and testing (n = 32; 22 and 10 with and without high TPG, respectively). Three informative shape features were identified in the training datasets: least axis length, sphericity, and maximum three-dimensional diameter. The radiomics score for predicting high TPG in IIH patients demonstrated an AUROC of 0.906 (95% confidence interval, 0.836-0.976) in the training dataset and 0.877 (95% confidence interval, 0.755-0.999) in the test dataset. The nomogram showed good calibration. Conclusion: Our study presents the feasibility of a novel model for predicting high TPG in IIH patients using radiomics analysis of noninvasive MRV-based shape features. This information may aid clinicians in identifying patients who may benefit from stenting.

• 대한전자공학회논문지SD
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• 제38권5호
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• pp.35-35
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• 2001

광대역 초고속 광변조기소자 패키지와 연계되는 주요 문제점인 die feature, pigtailing, suppression of RF package resonance, RF launcher approach, termination approach의 5가지 특성을 차례로 분석한 후 우수한 특성이 나올 수 있도록 소자를 패키징하였다. Microcoax에 의해 패키징된 변조기의 전기적 특성인 S21은 10㎓ 이상까지 -3㏈ 이상의 파워를 유지하였고, $S_{11}$은 18㎓까지 -l5㏈를 유지하였다. 10㎓까지 광파워는 최대값으로부터 3㏈ 이상 떨어지지 않았고 50km 전송실험 후 소광비는 약 10.6㏈, 지터 값은 3.2ps로 양호한 값을 나타내어 패키징을 원만히 해결해야만 변조기의 변조 능력은 10㎓ 이상이 됨을 알 수 있다.

• 한국전기전자재료학회:학술대회논문집
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• 한국전기전자재료학회 2001년도 하계학술대회 논문집
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• pp.543-546
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• 2001

So far, the design methods of quartz crystal resonator have been developed. Recently, as the electronic package and semiconductor modules become smaller, the need to minimize the sizes of crystal components grows larger. but Minimizing crystal plate sizes has limitations because its temperature-frequency characteristics is worse and unwanted resonances occur. so appropriate design of electrode size and crystal plates is necessary. In this palter, Two-dimensional governing equations for electroded piezoelectric crystal plates with general symmetry have been solved from deduced equations from three-dimensional equations of linear piezoelectricity in most cases. In practice, electroded piezoelectric crystal plates have three-dimensional geometry, so simplified 2-dimensional equations and 2-D modeling are insufficient for explaining its resonance modes and characteristics. So, three-dimensional FEM(finite element method) analysis is done and its effectiveness is verified from analyzing practical crystal resonator model.

• 한국소음진동공학회:학술대회논문집
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• 한국소음진동공학회 2012년도 추계학술대회 논문집
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• pp.476-481
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• 2012

A plant's generator system under operating condition has been suffered the vibration from the excitation force with 120Hz. The vibration is generated in the stator end windings. For analyze dynamic characteristics of the generator's stator, its finite element model were obtained using ANSYS software package for modal and harmonic analysis. we compare the analysis result with experimental data. The results show that the resonance frequency, which is related with second ecliptical mode on the stator end windings 129Hz. The experimental results are good agreement with the FEA model.

• 한국자기공명학회논문지
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• 제5권2호
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• pp.99-109
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• 2001

Authors investigated neuronal changes of local cellular metabolism in the cerebral lesions of Parkinsonian symptomatic side between before and after stereotactic neurosurgery by follow-up 1H magnetic resonance spectroscopy (MRS). Patients with Parkinson's disease (PD) (n = 15) and age-matched normal controls (n = 15) underwen MRS examinations using a stimulated echo acquisition mode (STEAM) pulse sequence that provided 2${\times}$2${\times}$2 ㎤ (8ml) volume of interest in the regions of substantia nigra, thalamus, and lentiform nucleus. Spectral parameters were 20 ms TE, 2000 ms TR, 128 averages,2500 Hz spectral width, and 2048 data points. Raw data were processed by the SAGE data analysis package (GE Medical Systems). Peak areas of N-acetylaspartate (NAA), creatine (Cr), choline-containing compounds (Cho), inositols (Ins), and the sum (Glx) of glutamate and GABA were calculated by means of fitting the spectrum to a summation of Lorentzian curves using Marquardt algorithm. After blindly processed, we evaluated neuronal alterations of observable metabolite ratios between before and after stereotactic neurosurgery using Pearson product-moment analysis (SPSS, Ver. 6.0). A significant reduction of NAA/Cho ratio was observed in the cerebral lesion in substantia nigra of PD patient related to the symptomatic side after neurosurgery (P : 0.03). In thalamus, NAA/Cho ratio was also significantly decreased in the cerebral lesion including the electrode-surgical region (P : 0.03). A significant reduction of NAA/Cho ratio in lentiform nucleus was not oberved, but tended toward significant reduction after neurosurgery (P = 0.08). In particular, remarkable lactate signal was noted from the surgical thalamic lesions of 6 among 8 patients and internal segments of globus pallidus of 6 among 7 patients, respectively. Significant metabolic alterations of NAA/Cho ratio might reflect functional changes of neuropathological processes in the lesion of substantia nigra, thalamus, and lentiform nucleus, and could be a valuable finding fur evaluation of Parkinson's disease after neurosurgery. Increase of lactate signals, being remarkable in surgical lesions, could be consistent with a common consequence of neurosurgical necrosis. Thus, IH MRS could be a useful modality to evaluate the diagnostic and prognostic implications fur Parkinsons disease after functional neurosurgery.

• Investigative Magnetic Resonance Imaging
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• 제4권2호
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• pp.128-135
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• 2000

목적 자기공명 스펙트럼 데이터의 처리 및 분석을 특정 workstation이 아닌 일반 PC의 windows 운영체제에서 동작할 수 있도록 GUI(Graphical User Interface)기반의 Spectroscopy 분석용 도구를 개발하였다. 대상 및 방법 S/W의 개발은 MATLAB(Mathwork사 미국)을 이용하여 PC의 window운영 체제에서 GUI 기반으로 동작하게 하였다. 시간 영역의 raw data와 주파수 영역의 spectrum data를 동시에 display할 수 있게 하였으며 Zero filling, 여러 종류의 filtering, 위상보정, FFT, peak area 측정 등의 기능을 갖추었다. 또한, 1.5T Gyroscan ACS-NT R6(Philips, Amsterdam, Netherland)의 $^1H$ Spectroscopy 패키지를 이용하여 정상인 뇌의 Parietal white matter, Basal ganglia, Occipital grey matter 영역에서 얻은 $^1$H MRS data를 정성 .정량적으로 분석하여 타 기종에서 얻어 발표된 $^1H$ MRS data와 비교분석하였다. 결과 : 본 연구에서 개발된 S/W를 이용하여 정상인 뇌에서 $^1H$ MRS data를 processing한 결과 NAA/Cr, Cho/Cr, MI/Cr 비율은 TE를 달리하였을 때, 유의수준 5%에서 Parietal white matter(PWM)의 NAA/Cr peak ratio를 제외하고 유의한 차이가 없었다. 그리고 기존에 발표된 문헌과 비교할 때 다른 MR장치의 NAA/Cr, Cho/Cr, MI/Cr 값들에 비해 평균값과 표준편차가 전반적으로 10-50%의 큰 값을 나타내었다. 결론 : 정상인 뇌에서 세 부위에 대하여 $^1H$ MRS를 얻고 이에 대한 정성.정량 분석을 함으로써 MRS를 임상적으로 적용하기 위한 준비를 하였으며 이러한 작업을 PC에서 독립적으로 수행함으로서 MRI system의 작업효율을 향상시킬 수 있었다. 그리고 서로 다른 기종간에는 유의한 차이가 있으므로 정상인에 대한 MRS database를 구축한 후에 $^1H$ MRS를 임상에 적용해야 함을 알 수 있었다.

• Investigative Magnetic Resonance Imaging
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• 제13권1호
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• pp.63-73
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• 2009

배경: 두개강내 용적에 대한 수동과 자동 측정법이 여성 주요 우울증 환자의 해마의 용적측정술과 modulated voxel-based morphometry (mVBM)의 결과에 미치는 영향을 알아보고자 한다. 방법: 21명의 여성 주요 우울증 환자와 성별, 나이의 분포가 비슷한 20명의 여성 정상인을 연구대상에 포함시켰다. 해마와 두개강내 용적은 수동으로 측정하였고, FreeSurfer 프로그램을 이용하여 두개강내 용적을 자동으로 측정하였다. 또한 회색질과 백색질의 부피도 SPM을 이용하여 자동으로 측정하였다. 결과: 수동으로 측정한 두개강의 용적을 통제변인으로 하여 분석한 통계분석의 결과가 FreeSurfer에 의해 측정된 두개강내 용적이나 뇌실질의 용적을 통제변인으로 한 통계분석의 결과보다 우울증 환자의 해마부피 감소와 mVBM 분석의 국조적 부피감소를 보다 민감하게 보여주었다. 수동적인 방법과 FreeSurfer에 의해 측정된 두개강내 용적은 정상인에서는 차이가 없었지만 (p = 0.696), 우울증 환자의 두개강 부피는 FreeSurfer를 이용해 측정한 두 개강의 부피가 더 작았다 (p = 0.000002). 우울증 환자의 전체 회색질의 부피는 수동으로 측정한 두개강의 용적을 통제변인으로 적용하였을 때 정상인의 회색질의 부피보다 작았고 (p = 0.000002), 해마의 부피도 수동으로 측정한 두 개 강의 부피를 통제변인으로 통계처리를 했을 때는 우울증환자의 해마가 뚜렷한 위축을 보였지만 (오른쪽, p = 0.014; 왼쪽, p = 0.004), 다른 측정법을 통제변인으로 했을 때는 유의하지 않았다 (p > 0.05). mVBM 분석에서는 수동으로 측정한 두개강의 부피를 통제변인으로 사용했을 때만 다중비교교정 후에 유의한 결과를 보였다 (FDR p < 0.05). 결론: 수동적인 방법으로 측정한 두개강의 용적이 FreeSurfer에 의해 자동으로 측정된 두개강의 용적이나 뇌실질의 부피보다 해마용적측정술과 mVBM 의 결과에 있어서 더 효율적으로 우울증이 있는 그룹과 없는 그룹의 차이를 보여주는 것에 민감한 결과를 보였다.

• 대한방사선기술학회지:방사선기술과학
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• 제33권1호
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• pp.45-50
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• 2010

본 연구는 T2고속스핀에코 3.0T 자기공명영상에서 지방조직 소거기법인 SPAIR와 STIR기법의 임상적 유용성에 관한 비교연구를 시행하였다. SPAIR와 STIR 프로토콜을 사용하여 뇌의 축방향 영상(20개), 요추의 시상단면영상(20개), 고관절의 관상단면영상(17개), 무릎관절의 축방향 영상(25개)을 획득하였다. 검사부위별로 지방억제기법의 지방소거능력과 화질을 파악하기위해 지방조직의 신호강도와 불균일성을 측정하였다. 지방조직에서 불균일치는 측정된 지방 신호의 평균치(mean)에 대한 표준편차(SD)로서 그 산출은 SD/mean으로 계산하였다. 수집된 자료는 SPSS(Statistical Package for the Social Science) WIN 13.0 프로그램을 이용하여 분석한 결과 다음과 같은 결론을 얻었다. 첫째, 뇌 검사는 SPAIR가 STIR보다 지방억제능력과 화질면에서 우수한 결과를 나타냈으며, 둘째, 요추, 고관절, 무릎관절 검사는 지방의 신호억제능력은 STIR가 우수하고, 화질면에서는 SPAIR가 우수한 결과를 나타냈다.

• Korean Journal of Radiology
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• 제24권8호
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• pp.784-794
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• 2023

Objective: To determine whether dynamic susceptibility contrast-enhanced (DSC) perfusion magnetic resonance imaging (MRI) can be used to evaluate posterior cerebral circulation in pediatric patients with moyamoya disease (MMD) who underwent anterior revascularization. Materials and Methods: This study retrospectively included 73 patients with MMD who underwent DSC perfusion MRI (age, 12.2 ± 6.1 years) between January 2016 and December 2020, owing to recent-onset clinical symptoms during the follow-up period after completion of anterior revascularization. DSC perfusion images were analyzed using a dedicated software package (NordicICE; Nordic NeuroLab) for the middle cerebral artery (MCA), posterior cerebral artery (PCA), and posterior border zone between the two regions (PCA-MCA). Patients were divided into two groups; the PCA stenosis group included 30 patients with newly confirmed PCA involvement, while the no PCA stenosis group included 43 patients without PCA involvement. The relationship between DSC perfusion parameters and PCA stenosis, as well as the performance of the parameters in discriminating between groups, were analyzed. Results: In the PCA stenosis group, the mean follow-up duration was 5.3 years after anterior revascularization, and visual disturbances were a common symptom. Normalized cerebral blood volume was increased, and both the normalized time-topeak (nTTP) and mean transit time values were significantly delayed in the PCA stenosis group compared with those in the no PCA stenosis group in the PCA and PCA-MCA border zones. TTP_PCA (odds ratio [OR] = 6.745; 95% confidence interval [CI] = 2.665-17.074; P < 0.001) and CBV_PCA-MCA (OR = 1.567; 95% CI = 1.021-2.406; P = 0.040) were independently associated with PCA stenosis. TTP_PCA showed the highest receiver operating characteristic curve area in discriminating for PCA stenosis (0.895; 95% CI = 0.803-0.986). Conclusion: nTTP can be used to effectively diagnose PCA stenosis. Therefore, DSC perfusion MRI may be a valuable tool for monitoring PCA stenosis in patients with MMD.

• ETRI Journal
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• 제26권6호
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• pp.589-596
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• 2004

Packaging technologies for a broadband and narrowband modulator with a traveling wave electro-absorption modulator (TWEAM) device were developed. In developing a broadband modulator, the effects of the device and packaging designs on the broadband performance were investigated. The optimized designs were obtained through a simulation with the result that we developed a broadband modulator with a 3 dB bandwidth of 38 GHz in the electrical-to-optical (E/O) response, an electrical return loss of less than -10 dB at up to 26 GHz, an rms jitter of 1.832 ps, and an extinction ratio of 5.38 dB in a 40 Gbps non-return to zero (NRZ) eye diagram. For analog application, the effect of the RF termination scheme on the fractional bandwidth was studied. The microstrip line with a double stub as a matching circuit and a laser trimming process were used to obtain an $S_{11}$ of -34.58 dB at 40 GHz and 2.9 GHz bandwidth of less than -15 dB.