• Archives of Pharmacal Research
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• 제13권2호
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• pp.151-160
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• 1990

In order to develop a controlled-release oral drug delivery system (DDS) which sustains the plasma acetaminophen (AAP) concentration for a certain period of time, microporous membrane-coated tablets were prepared and evaluated in vitro. Firstly, highly water-soluble core tablet of AAP were prepared with various formulations by wet granulation and compression technique. Then the core tablets were coated with polyvinychloride (PVC) in which micronized sucrose particles were dispersed. Effect of formula compositions of core tablets and coating suspensions on the pharmaceutical characteristics such as drug release kinetics and membrane stability of the coated tablets was investigated in vitro. AAP was released from the coated tablets as a zero-order rate in a pH-independent manner. This independency of AAP release to pH change from 1.2 to 7.2 is favorable for the controlled oral drug delivery, since it will produce a constant drug release in the stomach and intestine regardless of the pH change in the GI tract. Drug release could be extended upto 10 h according to the coating condition. The release rate could be controlled by changing the formula compositions of the core tablets and coating suspensions, coat weight per each tablet, and especially PVC/sucrose ratio and particle size of the sucrose in the coating suspension. The coated tablets prepared in this study had a fairly good pharmaceutical characteristics in vitro, however, overall evaluation of the coated tablet should await in vivo absorption study in man.

• Archives of Pharmacal Research
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• 제8권1호
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• pp.7-14
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• 1985

Membrane-coated tablet of isonicotinic acid hydrazide (INAH) which releases INAH at the zero-order kinetics was deveoped. It consisted of a soluble tablet core surrounded by a porous membrane which controls the diffusion rate. Tablet cores were prepared by compressing granules of INAH and polyvinyl chloride (PVC) dissolved in methyl ethyl ketone in which micronized sucrose were suspended. Diffusion rate of INAH from the tablet through the membrane was constant until the loaded INAH in the core was almost released. The rate was independent of pH of the dissolution medium. Water-soluble sucrose particles behaved as a poreproducing material in the water-insoluble PVC film coat. The pH independency of the rate was probably due to the high solubility of INAH in the water of wide pH range. The diffusion rate of INAH could be controlled by chnaging the composition of the membrane or the coat weight. This membrane-coated INAH tablet seemed to be a powerful candidate for the controlled release drug delivery system (DDS) of INAH or other highly watersoluble drugs.

• 한국강구조학회 논문집
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• 제24권1호
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• pp.23-34
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• 2012

본 연구에서는 인장강도 800MPa급 고강도강재(HSA800)의 단주 중심압축실험과 편심압축실험을 통해 균등압축과 휨-압축 부재의 강도를 평가하여 현행 강구조기준(KBC2009, AISC2005)의 적용성 여부를 검토하였다. 또한 잔류응력의 계측을 통하여 강재 항복강도와 잔류응력과의 상관성 여부도 검토하였다. 고강도강재와 일반강재의 국부좌굴 거동 차이의 여부를 확인하기 위하여 중심압축실험에 SM490 강재로 제작된 비교실험체도 포함시켰다. 강도로 무차원화한 판폭두께비와 판 단부의 지지조건을 주요변수로 하여 실험을 실시하였다. 편심압축실험은 HSA800 강재만을 대상으로 하였으며, 휨-압축의 조합력을 받는 부재의 P-M 상관관계를 알아보기 위해 가력 편심거리를 조정하여 다양한 P-M 조합에 대해 강도평가 실험을 수행하였다. 잔류응력은 중심압축실험에 사용된 H형단면 실험체를 대상으로 비파괴실험법인 압입법에 의해 가력 이전에 그 크기와 분포를 측정하였다. 실험결과 중심압축을 받는 모든 HSA800 단주는 판 단부의 지지조건 및 판폭두께비 조건에 따른 현행 강구조기준의 설계강도를 충분히 발휘하였다. 편심압축을 받는 실험체 역시 현행 설계기준의 P-M 상관관계를 충분히 안전측으로 충족하였다. 본 연구에서도 잔류응력의 크기는 강재의 항복강도와 무관하다는 선행연구결과와 합치하는 잔류응력 측정값이 얻어졌다.