• Journal of Digital Convergence
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• v.19 no.10
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• pp.501-508
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• 2021

The purpose of this study is to investigate the health belief, knowledge and performance of the infection control among nursing staffs in long term care hospital. Data from 146 nursing staff working at eight nursing hospitals in C city were collected for the period during September, 2020. Examining the infection control performance of the subjects, the general information showed that the ease of use of infection control personal protective equipment (β=-.198, p<.05), health belief (β=.124, p<.05), perceived susceptibility(β=.104, p<.05) which is a subgroup of health belief, perceived benefits(β=.111, p<.05) had an effect on infection control performance.

• Journal of the Korean Society of Safety
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• v.29 no.5
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• pp.104-109
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• 2014

More than 76% of occupational accidents occur in small and medium sized enterprises(SME) employing less than 50 workers, due to the lack of safety and health systems, and carelessness of workers and owners. Timely Technical Guidance(TTG) project of Korea Occupational Safety & Heath Agency(KOSHA) for SME was initiated to analyze and inform accident causes just after accidents occur. Improvement direction of TTG project is suggested through situation and performance analysis on TTG services conducted in 2012. KOSHA provided TTS services on 15,571 SMEs(suffering at least one accident in 2012), through which the working day losses from recurrence resulted in 19.0%p, 14.5%p and 31.3%p decreases in manufacturing, services and construction businesses, respectively.

• Korean Journal of Adult Nursing
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• v.25 no.1
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• pp.95-104
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• 2013

Purpose: The purpose of this study was to investigate the level of resilience, family support, anxiety and depression in patients with hematologic malignancy, and to determine modifiable psychosocial factors that affect their resilience. Methods: Data were collected from 104 patients undergoing curative therapy at 'S' hospital in Seoul. The data were collected from April to May, 2012. The questionnaires included Korean Version of Connor-Davidson Resilience Scale, Family Support Scale and Hospital Anxiety-Depression Scale. The data were analyzed using descriptive statistics, t-test, ANOVA, Pearson correlation and stepwise multiple regression. Results: Resilience had statistically significant correlation with family support (r=.43, p<.001), anxiety (r=-.49, p<.001) and depression (r=-.52, p<.001). Factors influencing resilience were depression, family support, anxiety and time since diagnosis with R-sq. value of 36%. Conclusion: The results of the study show that family support, anxiety and depression have important influences on resilience of patients with hematologic malignancy. Thus, family support needs to be reinforced when developing and implementing nursing intervention, and nurses need to intervene to reduce anxiety and depression of patients with hematologic malignancy.

• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.104-110
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• 2009

Phenylketonuria (PKU) is an inherited metabolic disorder caused by mutations in the phenylalanine catabolic enzyme, phenylalanine hydroxylase (PAH). The use of phenylalanine ammonia-lase (PAL) by oral and parenteral routes as a therapeutic drug for PKU has been severely limited due to inactivation by intestinal proteolysis and immune reactions. PEGylation was applied to PAL to reduce the degrees of antigenicity and proteolytic inactivation. Kinetic experiments with native PAL and pegylated PALs were performed, and pH stability, temperature stability, and protease susceptibility were evaluated. Enzyme linked immunosorbent assay (ELISA) was carried out to measure the immune complex between pegylated PALs and antiserum that had been extracted from a PAL-immunized mouse. Pegylated PAL, especially branched pegylated PAL (10 kDa, 1:32), was more active for phenylalanine and more stable in pancreatic proteases than native PAL. Native PAL was optimal at pH 8.5, corresponding to the average pH range of the small intestine; the same finding was noted for pegylated PALs. All linear and branched pegylated PALs had low reactivity with mouse antiserum, especially the 1:16 formulation with linear 5-kDa PEG and the 1:32 formulation with branched 10-kDa PEG. Therefore, we suggest the 1:32 formulation with branched 10-kDa PEG as the most promising formulation for enzyme replacement therapy.

• Mass Spectrometry Letters
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• v.3 no.4
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• pp.104-107
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• 2012

Mollugin isolated from Rubia cordifolia is known to have anti-inflammatory, anti-cancer, and anti-viral activities. In the present study, a cocktail probe assay and LC-MS/MS were used to investigate the modulating effect of mollugin on cytochrome P450 (CYP) enzymes in male ICR mice. After mollugin was orally administrated to mice at the 20, 40, or 80 mg/kg for 3 days, the activities of CYP in hepatic S-9 fractions were investigated. Unlike the selective inhibitory effect of mollugin on CYP1A2-catalyzed phenacetin O-deethylation in vitro, mollugin only significantly inhibited the activity of CYP2E1-catalyzed chlorzoxazone 6-hydroxylase in vivo. The activities of other CYPs were only slightly altered by mollugin. The results of this study suggest that mollugin might cause herb-drug interactions via the selective inhibition of CYP2E1 in vivo.

• Journal of muscle and joint health
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• v.25 no.2
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• pp.104-111
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• 2018

Purpose: The purpose of this study was to investigate the mediating effect of fatigue on the relationship between pain and sleep disturbance in patients with ankylosing spondylitis. Methods: The subjects of this study were 109 patients with ankylosing spondylitis who visited the rheumatology department in a university hospital. Subjects completed structured questionnaires measuring pain, sleep disturbance, and fatigue. Data were analyzed using t-test, Pearson's correlation coefficients, and 3-step regression analysis. Results: Pain was positively correlated with fatigue (r=.60, p<.001) and sleep disturbance (r=.45, p<.001). Fatigue was positively correlated with sleep disturbance (r=.55, p<.001) and had a mediating effect on the relationship between pain and sleep disturbance. Conclusion: The findings confirm that pain in patients with ankylosing spondylitis affects fatigue and its accumulation has a mediating effect on increasing the level of sleep disturbance. In clinical practice, education on symptom management for patients with ankylosing spondylitis needs to be provided for encouraging proper exercise and rest. Patient education should also include strategies to reduce fatigue and promote sleep in daily lives in addition to pain management.

• Journal of East-West Nursing Research
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• v.19 no.2
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• pp.104-113
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• 2013

Purpose: Due to the academic demands from a theory and practice-based educational program, nursing students often experience psychological burdens. The purpose of this study was to investigate the effect of mindfulness meditation programs on nursing students' perceived stress, depression, and self-efficacy. Methods: A quasi-experimental study with a non-equivalent control group pretest-posttest design was used. Participants were recruited from two nursing colleges. The sample consisted of an intervention group (n=29) that participated in a mindfulness meditation program and a control group (n=30). The experimental group participated in the program for 120 minutes a week for a total of 8 sessions. The data were collected prior and after the intervention using self-administered questionnaires. Data were analyzed using descriptive statistics, $X^2$-test, Fisher's exact probability test, and the t-test. Results: After the application of the mindfulness meditation program, the experimental group showed a significant difference in perceived stress(t=-10.33, p<.001), depression (t=-2.17, p=.035), and self-efficacy (t=2.57, p=.013) scores. However, there was no significant differrence in the control group. Conclusion: These findings provide a supportive evidence of mindfulness meditation program as a behavioral intervention to reduce stress, depression and increase self-efficacy among nursing students.

• Journal of Soil and Groundwater Environment
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• v.21 no.1
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• pp.104-110
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• 2016

The transport of silver nanoparticles (AgNPs) was investigated through a column packed with sand. A series of column experiments were carried out to evaluate the effect of ionic strength (IS), pH, electrolyte type and clay mineral on mobility of polyvinylpyrrolidone-coated silver nanoparticles (PVP-AgNPs). The deposition of PVP-AgNPs was increased with increasing solution ionic strength and decreasing pH. Furthermore, the depositon of PVP-AgNPs was affected by the electrolyte type (NaCl vs. NaNO₃) and was shown to be greater at NaNO₃ solution. Also, the transport of PVP-AgNPs was greatly increased after the pre-deposition of clay particles on sand. Our results suggest that various environmental factors can influence the mobility of PVP-AgNPs in soil-groundwater systems and should be carefully considered in assessing their environmental risks.

• Proceedings of the Korean Magnestics Society Conference
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• 2011.06a
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• pp.134-135
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• 2011

The fundamental properties of $Fe_3P$ intermetallic compound was investigated in terms of the FLAPW method within GGA. The FM state of $Fe_3P$ was found to be energetically more stable compared to the NM one. It is consistent with the experiment. In addition, the calculated magnetic moments of Fe atoms were calculated to be 2.367, 1.665, and 2.104 ${\mu}B$ for FeI, FeII, and FeIII atoms, respectively.

• Korean Journal of Pharmacognosy
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• v.11 no.2
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• pp.104-107
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• 1980

Mansam, the root of Codonopsis pilosula (Campanulaceae) has a action on blood metabolism. It has been known to possess anti leukemic effect by increasing of red blood cell, at same time, by decreasing white blood cell, with this connection, present study is aimed to clarify such potential anti leukenic effect by testing ethanol extract and chloroform extract against murine tumor model, lymphocytic leukemia P388. The data indicated that these extracts appeared to be inactive against this tumor line.