• Biomolecules & Therapeutics
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• v.17 no.1
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• pp.1-11
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• 2009

Since the Committee for Proprietary Medicinal Products (CPMP) of the European Union issued in 1997 a "points to consider" document for the assessment of the potential for QT interval prolongation by non-cardiovascular agents to predict drug-induced torsades de pointes (TdP), the QT liability has become the critical safety issue in the development of pharmaceuticals. As TdP is usually linked to delayed cardiac repolarization, international guideline (ICH S7B) has advocated the standard repolarization assays such as in vitro IKr (hERG current) and in vivo QT interval, or in vitro APD (as a follow up) as the best biomarkers for predicting the TdP risk. However, the recent increasing evidence suggests that the currently used above biomarkers and/or assays are not fully predictive for TdP, but also does not address potential new druginduced TdP due to the selective disruption of hERG protein trafficking to the cell membrane or VT and/or VF with QT shortening. There is, therefore, an urgent need for other surrogate markers or assays that can predict the proarrhythmic potential of drug candidate. In this review, we provide an ideal pre-clinical strategy to predict the potentials of QT liability and lethal arrhythmia of the drug candidates with recent issues in this field in mind, not at the expense of discarding therapeutically innovative drugs.

• Korean Journal of Community Nutrition
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• v.13 no.2
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• pp.153-163
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• 2008

The objective of this research was to study the differences between urban and rural areas high school students in body image and dietary habits. The number of subjects in Seoul and Kyungkido were 902. Based on self-reported height and weight, there was no significant difference between the urban and rural students. However, the rate of obesity was significantly higher in males, whereas the rate of underweight was significantly higher in females, especially for urban females (p < 0.05). Their ideal body image ratio as skinny or slender-type was 91.6% (urban) and 95.7% (rural) for male category while 100% (urban) and 99.4% (rural) for females. Urban females had a strong preference for a skinny body (p < 0.05). Rural students were more highly interested in weight control than urban students were, but they appeared not to care their health. In addition, they had significantly lower levels of weight control knowledge and dietary attitude score (p < 0.001). Subjective assessment of body weight appeared to be more important in terms of body satisfaction, weight control knowledge and dietary attitude than actual measurement of body mass index. Significant test revealed that weight control knowledge was related to dietary attitude (p < 0.01). (p < 0.01).

• The Korean Journal of Food And Nutrition
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• v.31 no.5
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• pp.587-597
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• 2018

The quality characteristics of pudding products comprising of Korean Olbyossal (traditional steamed rice), added at different percentages, were examined to explore the application of Olbyossal to develop different types of processed food products. Five groups of pudding were produced containing 0%, 25%, 50%, 75%, and 100% of Olbyossal. Evaluation of their quality characteristics and antioxidant activities revealed that the control group (with no added Olbyossal) had the highest moisture content and pH (p<0.001). The sugar content and turbidity was highest in the 100% Olbyossal group and lowest in the control group (p<0.001). The salinity was lowest in the 100% Olbyossal group (p<0.001). In terms of color values, the L-value (p<0.001) and a-value were highest in the control group, while the b-value was highest in the 100% group (p<0.001). Texture properties revealed that hardness (p<0.001), springiness (p<0.01), and chewiness (p<0.001) decreased as the percentage of Olbyossal increased. Increase in adhesiveness was noted with an increase in the percentage of Olbyossal (p<0.01). Based on the sensory evaluation of Olbyossal pudding in terms of appearance (p<0.05), flavor (p<0.05), taste (p<0.01), texture (p<0.001), and overall quality (p<0.001), the 100% group showed the best results. Examination of Olbyossal pudding revealed that antioxidant activities, radical scavenging activities for DPPH and superoxide anion, and reducing power increased as the percentage of Olbyossal increased (p<0.001). Therefore, pudding containing 100% Olbyossal is considered as the ideal product with reference to the high level of preference and product quality.

• Journal of the Korean Chemical Society
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• v.67 no.2
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• pp.120-128
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• 2023

Osteoporosis is a disease that causes the weakening of bone by increasing porosity, which often results in fractures. Osteoporosis treatment measures include the use of Bisphosphonates and estrogen. However, these treatments cannot be used in the long term as these treatments have adverse side effects. Therefore, there is a need to identify better and safer treatment options. For this, 63 plant extracts were screened and among them, six extracts showed high anti-osteoclastic activity with low cytotoxicity. Of these six extracts, three extracts, Cudrania tricuspidata (P371), Ulmus davidiana var. japonica (P401), and Torilis japonica (P411), showed more than 50 percent osteoclast inhibition. While the remaining, Stewartia pseudocamellia extracts I and II (P370, P397) and Cuscuta chinensis (P418), showed moderate or between 40-50 percent osteoclast inhibition. Among all the extracts, Torilis japonica (P411) showed the highest inhibitory action against osteoclast development. Torilis japonica (P411) primary components include Kaempferol, Quercetin, and Luteolin, all proven to inhibit osteoclastogenesis. Stewartia pseudocamellia extracts I and II (P370 and P397) showed moderate or 44% osteoclast inhibition. Stewartia pseudocamellia extract II (P397) enhanced the growth of RAW 264.7 cells by 19%. Torilis japonica (P411) and Stewartia pseudocamellia extract II (P397) suppressed the expression of osteoclast-specific genes in RANKL-induced osteoclastogenesis in RAW 246.7 cells. Torilis japonica (P411) extracts even increased osteoblast-specific RUNX2 gene expression. This results provide that six extracts could be used as a potential treatment option for osteoporosis disease with the extracts of Torilis japonica (P411) and Stewartia pseudocamellia (P397) as an ideal candidates. However, the combination of the extract with higher osteoclastic inhibition and less toxic effects with further analysis should be recommended.

• Applied Biological Chemistry
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• v.18 no.4
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• pp.228-233
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• 1975

To determine the effect of anions on growth and major components of hot pepper fruit, various combinations of N, S and P concentration in culture media were employed. The results analyzed by using binary interaction method were 1. For the ideal condition for growth, the plant height was found by $75%\;NO_3^-+25%\;SO_4^{--}$ in NS group and $68.5%\;No_3^-+31.5%\;PO_4^{---}$ in NPgroup. The number of node was showed by $71%\;NO_3^-+29%\;SO_4^{--}$ and $75%\;NO_3^-+25%\;PO_4^{---}$. 2. The ideal condition for the maximum yield was by $77.5%\;No_3^-+22.5%\;SO_4^{--}$ and $72.5%\;NO_3^-+27.5%\;PO_4^{---}$. For matured fruit yield, $77%\;NO_3^-+23%\;SO_4^{--}$ and $73.5%\;NO_3^-+26.5%\;PO_4^{---}$ was found ideal. 3. There were no significant differences in the amount of free sugars and capsaicin between the treatments.

• Nutrition Research and Practice
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• v.4 no.6
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• pp.499-506
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• 2010

The study aimed to analyze the lifestyles, weight control behavior, dietary habits, and depression of female university students. The subjects were 532 students from 8 universities located in 4 provinces in Korea. According to percent ideal body weight, 33 (6.4%), 181 (34.0%), 283 (53.2%), 22 (4.1%) and 13 (2.5%) were severely underweight, underweight, normal, overweight and obese, respectively, based on self-reported height and weight. As much as 64.1 % and only 2.4%, respectively, overestimated and underestimated their body weight status. Six overweight subjects were excluded from overestimation group for the purpose of this study, resulting in overestimation group consisting of only underweight and normal weight subjects. Compared to those from the normal perception group, significantly more subjects from the overestimation group were currently smoking (P=0.017) and drank more often than once a week (P=0.015), without any significant differences in dietary habits. Despite similar BMIs, subjects who overestimated their own weight statuses had significantly higher weight dissatisfaction (P= 0.000), obesity stress (P= 0.000), obsession to lose weight (P = 0.007) and depression (P = 0.018). Also, more of them wanted to lose weight (P = 0.000), checked their body weights more often than once a week (P=0.025) and had dieting experiences using 'reducing meal size' (P=0.012), 'reducing snacks' (P=0.042) and 'taking prescribed pills' (P = 0.032), and presented 'for a wider range of clothes selection' as the reason for weight loss (P = 0.039), although none was actually overweight or obese. Unlike the case with overestimating one's own weight, being overweight was associated with less drinking 0.035) and exercising more often (P=0.001) and for longer (P=0.001) and healthier reasons for weight control (P=0.002), despite no differences in frequency of weighing and depression. The results showed that weight overestimation, independent of weight status, is associated with risky lifestyles, weight control behaviors, and mental conditions. Preventive interventions should focus not only on obesity, but also on body weight overestimation.

• Nutrition Research and Practice
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• v.5 no.1
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• pp.66-72
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• 2011

The purpose of this study was to assess the metabolic profile and nutrient intake data in Korean adolescents according to exercise regularity using the forth Korean National Health and Nutrition Examination Survey from 2008 data. A total of 834 Korean adolescents (440 boys, 394 girls) aged 12 to 18 years were classified into exercising male (EM), non-exercising male (NM), exercising female (EF), and non-exercising female (NF) groups. EM exhibited significantly higher weight (P<0.001), waist circumference (WC) (P<0.01) and body mass index (EMI) (P<0.001) than NM. EF showed significantly greater height (P<0.01), weight (P<0.001), we (P<0.001), and BMI (P<0.001) than NF. Although ratios of macronutrient intake were within the appropriate range in all groups, energy, riboflavin, vitamin e and calcium were assessed as in adequate by the nutritional adequacy ratio (NAR) in all groups. Moreover, EF and NF had inadequate intake of vitamin A and iron according to NAR, respectively. There were significant correlations between height and NAR protein (r=0.249, P<0.001), and mean adequacy ratio (MAR) (r=0.177, P<0.01), and between weight and NAR protein (r=0.180, P<0.01), and MAR(r=0.136, P<0.05) in EM. On the other hand, there were significant correlations between weight and NAR protein (r=0.270, P<0.01), we and NAR protein (r=0.271, P<0.01), and BMI and NAR protein (r=0.326, P<0.01) in NM. There were significant correlations height and NAR Fe (r=0.153, P<0.05) in EF. However, there were no significant correlations between metabolic factors and nutritional adequacy in NF. Although we noted no significant differences in MAR between the groups, the exercising groups showed higher MAR values than the non-exercising groups. Therefore, practicing of ideal dietary behaviors appears to be induced through physical activity and regular exercise in Korean adolescents.

• Korean Security Journal
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• no.16
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• pp.101-118
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• 2008

The subjects in this study were 500 students who were selected from a population that consisted of security majors who took courses in martial arts in four different four-year-course universities. After a survey was conducted, the answer sheets from 451 students were analyzed except 49 incomplete ones. The collected data were analyzed with SPSS Ver. 12.0 program. Frequency analysis, t-test and one-way ANOVA were utilized, and LSD and regression analysis were employed to make a post-hoc comparison. All the hypotheses formulated in this study were verified at the a=.05(Chronbach's alpha) level of significance. The findings of the study were as follows: First, as for relations between demographic characteristics and self- realization, the college students investigated were statistically different according to gender in three subvariables of self-realization that included ability development, ability display and attainment of ideal. Age and academic year made a significant difference to their ability development and attainment of ideal, and they differed statistically significantly in terms of ability development according to black lebel test. Second, concerning connections between the degree of martial-arts training and self-realization, training term, one of the subvariables of the degree of martial-arts training had a positive correlation to their ability development and attainment of ideal at the 5% level of significance, and training time was positively correlated to their ability development at the 5% level of significance. Third, training term, one of the subvariables of the degree of martial- arts training, had an impact on ability development, and that exerted a firsthand influence on attainment of ideal as well.

• Korean Journal of Mathematics
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• v.22 no.1
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• pp.181-206
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• 2014

Let $R={\bigoplus}_{\alpha{\in}\Gamma}R_{\alpha}$ be a graded integral domain graded by an arbitrary grading torsionless monoid ${\Gamma}$, and ⋆ be a semistar operation on R. In this paper we define and study the graded integral domain analogue of ⋆-Nagata and Kronecker function rings of R with respect to ⋆. We say that R is a graded Pr$\ddot{u}$fer ⋆-multiplication domain if each nonzero finitely generated homogeneous ideal of R is ⋆$_f$-invertible. Using ⋆-Nagata and Kronecker function rings, we give several different equivalent conditions for R to be a graded Pr$\ddot{u}$fer ⋆-multiplication domain. In particular we give new characterizations for a graded integral domain, to be a $P{\upsilon}MD$.

• Proceedings of the KIEE Conference
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• 1990.11a
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• pp.347-351
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• 1990

In this paper voltage source inverter(VSI)-fed induction motor vector control system is controlled by a derived model tracking controller. The system analysis is discussed from the viewpoints of ideal vector control, adoption of model tracking controller and derivation of linear model. Furthermore, the result is obtained by the model-tracking control compare with that of P-I, I-P control.