• Journal of Chest Surgery
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• v.43 no.5
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• pp.475-481
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• 2010

Background: We evaluated mid-term results of mitral annuloplasty using a flexible band and a completely rigid ring for mitral valve repair in patients with degenerative mitral regurgitation (MR). Material and Method: From January 2004 to September 2008, 71 patients (M:F=36:35, $55{\pm}13$ years) underwent mitral valve repair with mitral annuloplasty for degenerative MR. Ring annuloplasty was done using a Cosgrove-Edwards flexible band (Group I, n=43) or a Carpentier-Edwards classic ring (Group II, n=28). There were no differences in preoperative characteristics of the participants. Average duration of follow-up was 36 months (range: 2~69 mos). Result: There was no in-hospital mortality. Postoperative morbidity, which included atrial fibrillation (n=7) and low cardiac output syndrome (n=5) in groups I and II were similar. There was one late death in group II. The proportion exhibiting freedom from recurrent mitral regurgitation ($\geq$moderate) at 4 years in Groups I and II were, respectively, 94.5 and 91.8%, (p=0.695). Left ventricular ejection fraction decreased in the early postoperative period ($7{\pm}2$ days) and recovered by last follow-up ($25{\pm}16$ mos; p=0.002). The pattern was similar in groups I and II (p=0.905). Re-operation was performed in 3 patients (1 in Group I and 2 in Group II, p=0.316). Four-year event-free survival (free of adverse valve-related events) was 95.2% for Group I and 92.6% for Group II; this difference was not significant, p=0.646). Conclusion: The type of technique used in mitral annuloplasty to repair the mitral valve repair after degenerative MR did not affect mid-term clinical and functional results.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4331-4334
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• 2012

Aim and Background: The aim of the present study was to evaluate correlations between serum osteocalcin, osteoprotegerin and NTX (Cross-linked N-telopeptides of Type I Collagen) and urinary NTX in breast and lung cancer patients with bone metastases. These four markers are considered to have important roles in bone formation, resorption and metastases. Methods: Four markers were determined in the sera of 60 breast cancer and 21 lung cancer patients and healthy controls (n=30). Serum levels were studied using ELISA and EIA. Results: The median levels of serum osteoprotegerin (p<0.001) and osteocalcin (p=0.003) were higher in patients. Significant correlations were observed between the serum NTX-osteocalcin (r=0.431; p<0.001), serum NTX-osteoprotegerin (r=0.42; p=0.003) and serum NTX - urine NTX (r=0.255; p=0.022). Conclusion: We conclude that osteocalcin, osteoprotegerin and NTX are independent diagnostic tools. Due to the ease of urine collection, urine NTX may be applied routinely to allow early detection of bone metastases and indicate progression of the disease.

• Journal of Korean Academy of Nursing
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• v.40 no.5
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• pp.611-619
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• 2010

The purpose of this study was to examine the effects of exercise on muscle weight and Type I and II fiber cross-sectional area of affected and unaffected hindlimb muscles in rats with neuropathic pain induced by unilateral peripheral nerve injury. Methods: Neuropathic pain was induced by ligation and cutting of the left L5 spinal nerve. Adult male Sprague-Dawley rats were randomly assigned to one of two groups: The Pain+Exercise (PE) group (n=21) and the Sham+Exercise (SE) group (n=20). All rats had 28 sessions of treadmill exercise at grade 10 for 30 minutes, twice/day at 10 m/min for 14 days. Body weight, food intake and activity were measured every day. At 15 days all rats were anesthetized and soleus, plantaris and gastrocnemius muscles were dissected. Muscle weight and Type I, II fiber cross-sectional area of the dissected muscles were measured. Results: The PE group showed significant increases (p<.05), as compared to the SE group for body weight and total diet intake, muscle weight of the unaffected soleus and plantaris, and in Type I and II fiber cross-sectional area of unaffected three muscles and affected plantaris. Conclusion: Exercise for 14 days attenuates unaffected soleus, plantaris and gastrocnemius muscle atrophy in neuropathic pain model.

• Proceedings of the Korean Institute of Electrical and Electronic Material Engineers Conference
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• 2007.06a
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• pp.11-11
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• 2007

1차원 구조체인 반도체 나노선은 앙자제한효과 (quantum confinement effect) 등을 이용하여 고밀도/고효율의 소자 개발이 기대되고 있다. GaN는 상온에서 3.4 eV의 밴드갭 에너지를 갖는 III-V 족 반도체 재료로써 박막의 경우 광전자 소자로 폭넓게 응용되고 있다. 최근 GaN 나노선의 합성에 성공하면서 발광소자, 고효율의 태양전지, HEMT 등으로의 응용을 위한 많은 연구가 활발히 이루어지고 있다. 하지만, 아직까지 GaN 나노선의 전기적 특성을 제어하는 기술은 확립되지 않고 있다. 본 연구에서는 Vapor solid (VS)법을 이용하여 GaN 나노선을 합성하였으며, GaN 분말과 함께 $Mg_2N_3$ 분말을 첨가하여 (Ga,Mg)N 나노선을 성공적으로 합성하였다. 합성시에 GaN와 Mg 소스간의 거리 변화를 통해 Mg 도핑농도를 제어하고자 하였다. 이 같은 방법으로 합 된 (Ga,Mg)N 나노선의 Mg 도핑농도에 따른 결정학적 특성을 알아보고, (Ga,Mg)N 나노선을 이용하여 소자를 제작한 후 그 전기적 특성을 살펴보고자 한다. X-ray diffraction (XRD)과 high-resolution transmission electron microscopy (HRTEM), EDX를 이용하여 합성된 나노선의 결정학적 특성과 Mg의 도핑 농도를 확인하였다. Photo lithography와 e-beam lithography법을 이용하여 (Ga,Mg)N 나노선 field-effect transistor (FET)를 제작하고, channel current-drain voltage ($I_{ds}-V_{ds}$) 와 channel current-gate voltage ($I_{ds}-V_g$) 측정을 통해 (Ga,Mg)N 나노선이 도핑 농도에 따라 n형에서 p형으로 전기적 특성이 변화함을 확인하였다.

• Biomolecules & Therapeutics
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• v.28 no.5
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• pp.456-464
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• 2020

Mast cells (MCs) are systemically distributed and secrete several allergic mediators such as histamine and leukotrienes to cause type I hypersensitivity. Dasatinib is a type of anti-cancer agent and it has also been reported to inhibit human basophils. However, dasatinib has not been reported for its inhibitory effects on MCs or type I hypersensitivity in mice. In this study, we examined the inhibitory effect of dasatinib on MCs and MC-mediated allergic response in vitro and in vivo. In vitro, dasatinib inhibited the degranulation of MCs by antigen stimulation in a dose-dependent manner (IC₅₀, ~34 nM for RBL-2H3 cells; ~52 nM for BMMCs) without any cytotoxicity. It also suppressed the secretion of inflammatory cytokines IL-4 and TNF-α by antigen stimulation. Furthermore, dasatinib inhibited MC-mediated passive cutaneous anaphylaxis (PCA) in mice (ED₅₀, ~29 mg/kg). Notably, dasatinib significantly suppressed the degranulation of MCs in the ear tissue. As the mechanism of its effect, dasatinib inhibited the activation of Syk and Syk-mediated downstream signaling proteins, LAT, PLCγ1, and three typical MAP kinases (Erk1/2, JNK, and p38), which are essential for the activation of MCs. Interestingly, in vitro tyrosine kinase assay, dasatinib directly inhibited the activities of Lyn and Fyn, the upstream tyrosine kinases of Syk in MCs. Taken together, dasatinib suppresses MCs and PCA in vitro and in vivo through the inhibition of Lyn and Fyn Src-family kinases. Therefore, we suggest the possibility of repositioning the anti-cancer drug dasatinib as a treatment for various MC-mediated type I hypersensitive diseases.

• Journal of Sensor Science and Technology
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• v.4 no.1
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• pp.3-8
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• 1995

n-ITO/p-PSL heterojunction photodetector have been fabricated on the Si wafer by using ITO(indium tin oxide) and PSL(porous silicon layer). They were anodized selectively by using silicon nitride and Ni-Cr/Au and were passivated by using ITO as well as being isolated by using mesa structure. With white light from 0 to 3000 Lux, the photocurrent varied linearly with incident light intensity. The reverse characteristics of fabricated devices were very stable up to a bias voltage of -40V and dark current density was about $40nA/mm^{2}$. When the device was exposed by Xe lamp whose wavelength range from 400nm to 1100nm, the maximum photo responsivity was about 0.6A/W between 600 and 700nm. Variation of the characteristics of fabricated devices after 5 weeks was negligible.

• Journal of Korean Academy of Nursing
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• v.31 no.5
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• pp.835-845
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• 2001

This study was to identify the relationship between personality type, college admission SAT scores and GPA scores of student nurses. Method: The data was collected from 270 student nurses enrolled in a baccaleaureate program in Seoul. MBTI was used to identify students' personality and SAT score and GPA score were collected over 4 years. The collected data was analyzed by using SPSS Win. package. Result: 1. There were slightly more extrovert (E) type (54.4%) students than the introvert (I) type; more sensing (S) type (71.1%) than the intuitive (N) type. 2. The introvert type students had significantly higher SAT scores than those of the extrovert type (p=.002). 3. The judging type students had significantly higher GPA scores throughout their college years than the perceiving type. 4. There was no statistically significant relationship between SAT and GPA scores. SAT scores did not accurately predict students' academic achievement in college in this sample. Conclusion: The distribution of the personality types in the sample was different from the general population which may suggest that college admission criteria is biased toward certain personality type. Since different personality types process information and cope with the outside world differently, effective teaching strategies need to be considered for each class.

• Journal of the Korean Chemical Society
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• v.17 no.1
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• pp.60-66
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• 1973

When m-phenylenediamine (MPD) or m-aminophenol (MAP) was treated with formaldehyde(F), under $N_2$ stream, at the temperature $-5\sim0^{\circ}C$, addition condensation occurred and insoluble resins formed immediately. Under the same reaction conditions m-phenylenediamine, m-aminophenol and formaldehyde also easily copolycondensed and insoluble MPD-MAP-F type copolymer formed. MPD-MAP-F type copolycondensed resin was superior in both heat-resistant property and adsorptivity of Bromophenol Blue or Methylene Blue than the MPD-F and MAP-F type resins. From the result of TGA, under $N_2$stream, MPD-MAP-F resin showed about $40\%$ weight loss at $800^{\circ}C$, and this type of resin 1g adsorbed 308mg of Bromophenol Blue.

• Korean Journal of Human Ecology
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• v.24 no.5
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• pp.663-676
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• 2015

The purpose of this study was to examine whether any differences can be found in body comparison, body satisfaction, and appearance management behaviors according to the MBTI's typology among male and female adolescents in Gwangju and South Jeolla province, South Korea. It was conducted by a self-report survey of 534 male and female high school students in Gwangju and South Jeolla province. The collected survey data were analyzed by Means, Cronbach's ${\alpha}$, Factor analysis, and t-test using the SPSS/PC WIN 19.0 statistical program. The results were as follows: Introversion Type(I) teens tend to think a thinner body is closer to the ideal when compared to Extroversion type(E) students. They spend less time comparing their bodies with their peers. However, they usually have lower levels of body satisfaction and are more likely to be concerned about acne. Intuition Type(N) students tend to have a body figure that is a little plumper than Sensing Type(S) teens. They are inclined to try and lose weight and are concerned about acne. Sensing Type(S) students are more likely to compare their bodies with their peers than Intuition Type(N) teens. However, they are generally less satisfied with their bodies. Feeling Type(F) teens are more concerned with harmony and personal hygiene the Thinking Type(T) students. Judging Type (J) students generally want to be thinner than their current body type when compared with Perceiving Type(P) teens. When Judging Type(J) teens decide they need to be on a diet, they do their best to lose weight even if it means exercising and forgoing their favorite foods. These results indicate that it would be more effective to offer guidance to teens while taking into consideration their differences in terms of appearance management behaviors based on the MBTI Topology of Adolescents.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.20 no.9
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• pp.780-786
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• 2007

This paper describes the influence on partial discharge characteristics of defects at the model XLPE/EPDM interfaces of power cable joints. The defects of void and copper which could inadvertently be present at the joint interface. We measured ${\Phi}-n,\;{\Phi}-q$ patterns by a computer-aided partial discharge measuring system. Several parameters i, e, maximum discharge $q_{max}$ [pC], average discharge q [pC/cycle], and average angle of discharge ${\Theta}g$ [deg] were found to depend upon the defect type varying applied voltage. As the result of time evaluation, partial discharges are small different at copper defects, but is decreasing obviously about 20 minutes at void defect. It considered that difference of magnitude of total positive discharge of Q+ [pC] and total negative discharge of Q- [pC] is SPMD(swarming pulsive micro discharges).