• 대한두경부종양학회지
• /
• 제16권2호
• /
• pp.212-215
• /
• 2000

Background and Objective: Kikuchi's disease(KD) is an idiopathic, self-limited lymphadenopathy that was described as a distinctive type of necrotizing lymphadenitis affecting primarily cervical lymph nodes of young adults independently by Kikuchi and Fujimoto et al at first in 1972. The purpose of this study is a knowledge about clinicopathologic findings, many laboratory tests and differentiation of KD from other lymphadenitis due to lymphoma, systemic lupus erythematosus(SLE) and many viral disease. Materials and Methods: Thirty-four case of KD collected at Chonnam University Hospital in Kwang-Ju from 1992 through 2000 were evaluated with retrospective chart review. Results: The patients were consisted of 11 men and 23 women. All patients had tender or nontender cervical mass and fever was the most common associated symptom. The others was pain, weight loss, chills, cold sweating and headache et al. Multiple bilateral involvement of cervical lymphnodes was 25 cases(74%) and solitary involvement was 9 cases(26%). In laboratory tests, leukopenia was 12 cases(75%), elevated ESR 5 cases (34%) and elevated LDH 11 cases(69%). Conclusion: KD is necessary to differentiate from lymphoma and SLE, because of the different of therapeutic modality and prognosis. The diagnosis is established on the basis of histopathologic studies with excisional biopsy of lymph node.

• Journal of Gastric Cancer
• /
• 제23권3호
• /
• pp.388-399
• /
• 2023

Gastric cancer remains a significant global health concern, coercing the need for advancements in imaging techniques for ensuring accurate diagnosis and effective treatment planning. Artificial intelligence (AI) has emerged as a potent tool for gastric-cancer imaging, particularly for diagnostic imaging and body morphometry. This review article offers a comprehensive overview of the recent developments and applications of AI in gastric cancer imaging. We investigated the role of AI imaging in gastric cancer diagnosis and staging, showcasing its potential to enhance the accuracy and efficiency of these crucial aspects of patient management. Additionally, we explored the application of AI body morphometry specifically for assessing the clinical impact of gastrectomy. This aspect of AI utilization holds significant promise for understanding postoperative changes and optimizing patient outcomes. Furthermore, we examine the current state of AI techniques for the prognosis of patients with gastric cancer. These prognostic models leverage AI algorithms to predict long-term survival outcomes and assist clinicians in making informed treatment decisions. However, the implementation of AI techniques for gastric cancer imaging has several limitations. As AI continues to evolve, we hope to witness the translation of cutting-edge technologies into routine clinical practice, ultimately improving patient care and outcomes in the fight against gastric cancer.

• Asian Spine Journal
• /
• 제12권6호
• /
• pp.1117-1122
• /
• 2018

Study Design: Prospective study. Purpose: To assess the prevalence of periodontoid calcification and its associations with acute cervical pain. Overview of Literature: Calcium pyrophosphate dihydrate (CPPD) deposition disease is a common rheumatological disorder that occurs especially in elderly patients. Although CPPD crystals induce acute arthritis, these crystals are not usually symptomatic. Calcification surrounding the odontoid process (periodontoid calcification) has been reported to induce inflammation, resulting in acute neck pain. This disease is called crowned dens syndrome. Whether calcification induces inflammation or whether the crystals are symptomatic remains unclear. Methods: The prevalence of periodontoid calcification at the atlas transverse ligament was examined by computed tomography of the upper cervical spine in patients suspected of brain disease but no cervical pain (control group, n=296), patients with pseudogout of the peripheral joints but no cervical pain (arthritis group, n=41), and patients with acute neck pain (neck pain group, n=22). Next, the correlation between the prevalence of periodontoid calcification and symptoms was analyzed. Results: In the control group, 40 patients (13.5%) showed periodontoid calcification with no significant difference in the prevalence with gender. The prevalence of calcification increased significantly with age (p=0.002). In the arthritis group, 26 patients (63.4%) reported periodontoid calcification. In the neck pain group, 14 patients (63.6%) reported periodontoid calcification. Multiple logistic regression analysis by age and group revealed that higher age, inclusion in the arthritis group, and inclusion in the neck pain group significantly affected the prevalence of calcification. Conclusions: Our results cumulatively suggest that periodontoid calcification is an aging-related reaction and that calcification per se does not always cause neck pain. Periodontoid calcification was observed more frequently in patients with pseudogout of the peripheral joints and in those with acute neck pain than in asymptomatic control patients.

• Childhood Kidney Diseases
• /
• 제21권1호
• /
• pp.8-14
• /
• 2017

Purpose: To classify the results of renal biopsy in pediatric patients and to compare pathological findings with clinical features. Methods: This study included data of 318 children who underwent renal biopsy at our hospital between December 1987 and November 2014. Biopsy specimens were examined histopathologically using light, immunofluorescence, and electron microscopy. Results: Asymptomatic urinary abnormalities was the most common clinical diagnosis (35.9%), followed by nephrotic syndrome (29.3%), and acute glomerulonephritis (18.0%). Glomerular disease was identified in 98.1% of the renal biopsy specimens. The most common primary cause of glomerulonephritis was IgA nephropathy, with gross hematuria in 61.9% of the patients, hypertension in 14.2%, proteinuria >1.0 gm/24-hr in 33.3%, and impaired renal function in 3.6% patients. Conclusion: The most common clinical diagnosis was asymptomatic urinary abnormalities, with primary glomerular disease being the most common renal biopsy finding, and IgA nephropathy the most common histopathological lesion. This study provides a 27-year overview of pediatric renal disease at our center and underlines the importance of renal biopsy for accurate diagnosis and proper management.

• Molecules and Cells
• /
• 제46권10호
• /
• pp.579-588
• /
• 2023

Sarcomas are rare and heterogeneous mesenchymal neoplasms originating from the bone or soft tissues, which pose significant treatment challenges. The current standard treatment for sarcomas consists of surgical resection, often combined with chemo- and radiotherapy; however, local recurrence and metastasis remain significant concerns. Although immunotherapy has demonstrated promise in improving long-term survival rates for certain cancers, sarcomas are generally considered to be relatively less immunogenic than other tumors, presenting substantial challenges for effective immunotherapy. In this review, we examine the possible opportunities for sarcoma immunotherapy, noting cancer testis antigens expressed in sarcomas. We then cover the current status of immunotherapies in sarcomas, including progress in cancer vaccines, immune checkpoint inhibitors, and adoptive cellular therapy and their potential in combating these tumors. Furthermore, we discuss the limitations of immunotherapies in sarcomas, including a low tumor mutation burden and immunosuppressive tumor microenvironment, and explore potential strategies to tackle the immunosuppressive barriers in therapeutic interventions, shedding light on the development of effective and personalized treatments for sarcomas. Overall, this review provides a comprehensive overview of the current status and potential of immunotherapies in sarcoma treatment, highlighting the challenges and opportunities for developing effective therapies to improve the outcomes of patients with these rare malignancies.

• Journal of Preventive Medicine and Public Health
• /
• 제26권4호
• /
• pp.508-533
• /
• 1993

지금까지 우리나라의 국민들의 예방행태와 질병행태, 그리고 환자역할에 대하여 기존에 발표된 자료를 중심으로 재해석을 기하여 보았다. 물론 이 발표에서 사용된 자료들이 정확하며 타당한 자료인가에 대해서는 반드시 그렇다라고 답변할 수는 없다. 다만 우리나라에서의 건강관련행태를 설명하기 위해서는 자료의 한계라는 현실을 감안하지 않을 수 없다는 사실을 이해해주기 바란다. 우리나라국민들의 건강행태는 과거에 비해 상당히 변화하고 있으나 계층간의 행태의 차이, 변화의 원인 등에 대해서는 아직 연구가 미흡하다. 지금까지 이루어진 행태연구들이 정합적인 모형을 사용하고 있다고 보기 어려운 것이 그 원인의 하나 일 것이다. 새로이 개발된 모형들을 적용하기 위한 노력이 필요하며, 사용되는 변수의 타당성에 대한 연구도 필요하다. 행태와 관련된 연구에서 사용되는 변수들이 사회문화의 산물이라는 사실을 생각하면 우리나름대로의 변수정의가 있어야 한다는 것은 지극히 당연하다 하겠다. 끝으로 행태를 연구함에 있어 인간의 의식은 사회구조의 산물이라는 사실을 명심할 필요가 있다. 루카치는 자본주의 사회에서는 노동자의 계급의식 역시 자본주의 구조의 산물일 수 있다 하였다. 이런 의미에서 지식, 태도, 행태 등에 대한 연구는 사회구조의 총체성에 대한 인식을 요구한다. 만일 그렇지 않은 경우에는 행태연구를 통한 결과가 희생자비난의 논리로 악순환할 가능성이 높기 때문이다.

• 수면정신생리
• /
• 제26권1호
• /
• pp.5-15
• /
• 2019

일주기 유형의 차이는 다양한 관점에서 이해되어야 한다. 기존 연구결과들에 따르면 일주기 유형 중 아침형이 몇몇 정신장애의 보호요인인 반면 저녁형은 위험 요인으로 나타났다. 일반적으로 아침형에서 나타나는 습관들은 저녁형보다 더 건강하다. 성인의 생활양식을 형성하는 과정에 있는 청소년 시기와 생활습관과 관련된 건강 문제가 잦아지는 노년기에 일주기 유형의 중요성이 더욱 크다고 볼 수 있다. 따라서 일주기 유형을 생물-심리-사회적 건강 모델에 포함시켜 보다 효율적인 예방 및 치료적 접근을 설계하는 것이 중요하겠다. 정신장애 치료에서도 일주기 리듬을 고려해야 한다. 일반적으로 취침-기상, 식사, 그리고 일상 활동을 규칙적인 아침형 패턴으로 변화시키는 것이 도움이 될 수 있다. 광치료(light therapy)와 멜라토닌 주입(melatonin administration)과 같은 전략들도 정신장애의 치료 및 재발 방지에 효과적일 수 있다. 일주기 유형 기저의 유전학을 이해하는 것 또한 어떤 사람이 특정한 생활 양식이나 정신장애에 취약한지 구별하는데 도움이 될 수 있다.

• 대한한의학원전학회지
• /
• 제22권4호
• /
• pp.199-211
• /
• 2009

The concept of Myeongmun(命門) could be found in early medical texts such as "Naegyeong (內經)" and "Nan-gyeong(難經)", but the real idea about Myeongmun(命門) had mainly originated from "Nan-gyeong", in successive medical research. The concept of Myeongmun in "Nan-gyeong" could be read as an organ without form, and under the influence of Taoism theory, the concept of Myeongmun could also be understood as Danjeon(丹田). The theory about Danjeon in Taoism theory affected the concept of Myeongmun in medical theory to be closely related with the concept of Hwa(火), especially Sanghwa(相火). Through the theoretical development of Myeongmun and Sanghwa, the concept of Sanghwa could have been understood as a kind of Hwa(火) in human body, and the theoretical development like this had appeared from the time of Geumwon(金元) dynasty, when many medical doctors had experienced the Naedan(內丹) theory of Taoism. Under the influence of Taoism theory, from the time of the Geumwon dynasty to Myeong(明) dynasty, efforts to explain the concept of Myeongmun and Sanghwa in the human body made various meaningful theoretical products, which was not well-known within medical theories of ancient times. We need to recognize the differences in the understanding of the concept of Myeongmun and Sanghwa among each medical doctors, especially among those that showed opposite views. This study is based on the opinion that the difference in the understanding of the concept of Myeongmun and Sang-hwa among each medical doctors had been mainly due to the difference of understanding and analyzing the Taoism theory as the origin of the Myeongmun and Sanghwa theory in medicine. Regarding this, this study will take an overview of the successive development of Myeongmun and Sang-hwa theory in medicine, and will also look into the concept of Danjeon and Sanghwa in Taoism theory, which will allow better understanding of the progress of development of the Myeongmun and Sanghwa theory.

• 대한치과교정학회지
• /
• 제47권6호
• /
• pp.401-413
• /
• 2017

Objective: The aim of this systematic review was to assess the occlusal outcome and duration of fixed orthodontic therapy from clinical trials in humans with the Objective Grading System (OGS) proposed by the American Board of Orthodontics. Methods: Nine databases were searched up to October 2016 for prospective/retrospective clinical trials assessing the outcomes of orthodontic therapy with fixed appliances. After duplicate study selection, data extraction, and risk of bias assessment according to the Cochrane guidelines, random-effects meta-analyses of the mean OGS score and treatment duration were performed and 95% confidence intervals (CIs) were calculated. Results: A total of 34 relevant clinical trials including 6,207 patients (40% male, 60% female; average age, 18.4 years) were identified. The average OGS score after treatment was 27.9 points (95% CI, 25.3-30.6 points), while the average treatment duration was 24.9 months (95% CI, 24.6-25.1 months). There was no significant association between occlusal outcome and treatment duration, while considerable heterogeneity was identified. In addition, orthodontic treatment involving extraction of four premolars appeared to have an important effect on both outcomes and duration of treatment. Finally, only 10 (39%) of the identified studies matched compared groups by initial malocclusion severity, although meta-epidemiological evidence suggested that matching may have significantly influenced their results. Conclusions: The findings from this systematic review suggest that the occlusal outcomes of fixed appliance treatment vary considerably, with no significant association between treatment outcomes and duration. Prospective matched clinical studies that use the OGS tool are needed to compare the effectiveness of orthodontic appliances.

• Archives of Plastic Surgery
• /
• 제39권6호
• /
• pp.606-611
• /
• 2012

Background Facial fractures are infrequent in children and adolescents and have different clinical features from those in adults. The low incidence in children and adolescents reflects the flexibility and underdevelopment of their facial skeletons, as well as their more protected environments. Only a few reports have reviewed such patients in Korea. The authors performed a retrospective study to analyze the characteristics of facial fractures in the Korean pediatric population. Methods We conducted a retrospective review on a series of 741 patients, aged <18 years, with facial fractures who had been treated at our hospital between 2006 and 2010. The following parameters were evaluated: age, sex, cause, location and type of fractures, associated injuries, treatment and complications. Results A total of 741 consecutive patients met the inclusion criteria. The ratio of boys to girls was 5.7:1. Facial fractures most commonly occurred in patients between 13 and 15 years of age (36.3%). The most common causes of injury was violence. The nasal fracture was the most common type of fracture (69%) and the blowout fracture was the second most common (20%). Associated injuries occurred in 156 patients (21%). Conclusions The incidence of pediatric facial fractures caused by violence is high in Korea. Our results show that as age increases, etiological factors and fracture patterns gradually shift towards those found in adults. This study provides an overview of facial fractures in these age groups that helps illustrate the trends and characteristics of the fractures and may be helpful in further evaluation and management.