• 제목/요약/키워드: outcome measure

검색결과 505건 처리시간 0.031초

아토피 피부염의 한약 치료에 대한 무작위대조군연구 중심의 연구 동향 - CNKI를 중심으로 (Research Trends of Randomized Controlled Trials on Herbal Medicine Treatment for Atopic Dermatitis-Focusing on CNKI)

  • 양금진;조은희;강수진;홍지은;심유화;이주현;박민철
    • 동의생리병리학회지
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    • 제34권2호
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    • pp.102-116
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    • 2020
  • The purpose of this study was to analyze the research trends of randomized controlled trials on herbal medicine treatment for atopic dermatitis in China for the last 5 years. We searched for randomized controlled trials with the intervention of herbal medicine for the treatment of atopic dermatitis in the CNKI (China National Knowledge Infrastructure) from January 2014 to December 2018. For the screening of the paper, we used '特应性皮炎' and '异位性皮炎' which mean atopic dermatitis and search was limited to three areas within Medicine & Public Health: Traditional Chinese Medicine, Traditional Chinese Medicinal Herbs, Combination of Traditional Chinese Medicine with Western Medicine. Among the 136 searched studies, we selected a total of 34 studies and analyzed a year of publication, subject characteristics, study design and intervention, prescribed herbal medicine and herbs, pattern identification, evaluation criteria, and outcomes. Longmu decoction (龍牡湯) and Polia Sclerotium (茯笭) was the most frequently prescribed medicine and herb. The most commonly used pattern identification was Blood deficiency and Wind-dryness (血虛風燥), and among them, the most frequently prescribed herb is Rehmanniae Radix (生地黃). In most studies using the total effectiveness and SCORAD index as an outcome measure, the herbal medicine treatment group showed statistically better results than the control group. As a result of the safety assessment, the herbal medicine treatment group was reported having significantly fewer side effects compared to the control group. Hence, it was confirmed that the intervention including herbal medicine had a significant effect on atopic dermatitis. This study would be able to provide the basis of clinical research on atopic dermatitis and applied to the treatment of atopic dermatitis.

치과의료기관 방문시 불만처리서비스에 대한 의료소비자의 평가 (Client Services Evaluation in Dentistry Sector)

  • 한지형;김진
    • 한국치위생학회지
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    • 제3권2호
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    • pp.209-220
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    • 2003
  • The purpose of this study was to examine how clients who visited dental institutions perceived client services, what sorts of client services were provided to them and to what extent they were satisfied with them. It's ultimately meant to seek ways to enhance and enlarge client services. A survey was conducted on 379 residents who used dental institutions in Seoul and Gyeonggi provinces, and the findings of this study were as follows: 1. 64.6 percent of the people investigated weren't aware of client services, and 33.0 percent viewed them as part of medical services. 77.5 percent had grievances about dental institutions they'd ever used. 2. The biggest complaint was that the dental treatments they received weren't covered by the dental insurance. As for how to solve their grievances, the largest group of them told the employees of the dental institutions about their complaints or didn't use them again. When asked whether the dental institutions took any steps to get rid of their grievances, the greatest group replied they had no idea. and the second largest group answered they took no measure. 3. By age and educational level, those who were in their 60s and up and stopped at elementary school were best cognizant of client services. Among client service variables, they were most satisfied with how the employees handled their complaints, and as to overall satisfaction, their willingness to revisit ranked highest. 4. Concerning connections among client service awareness, service variables and overall satisfaction level, their awareness of client services had a positive correlational relationship with every service variable and satisfaction level. Among the service variables, prompt client services and employee attitude were positively correlated to overall satisfaction level, but service procedure, facilities and information services exercised little impact on that. 5. As for what factors affected their content with client services, their client service awareness was identified as one of the important factors to influence their use of dental institutions, the outcome of their visit and their willingness to revisit. The above-mentioned findings suggested that dental institutions should strengthen publicity activities to inform people of client services, and encourage them to express their grievances. In addition, they should take an immediate action to remove their complaints, and try to get a successful feedback to offer higher-quality medical services and customer-oriented services.

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일 지역 대학생의 피로와 건강증진 생활양식과의 관계분석 (The correlation analysis between fatigue and health promoting life style among a rural college students)

  • 장희정
    • 기본간호학회지
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    • 제6권3호
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    • pp.477-492
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    • 1999
  • The disease patterns among the Korean was shifted from acute and infectious diseases to chronic diseases. According to the these disease patterns trends, people have concerned about the health promotion and health behaviors. Pender's(1996) revised health promotion model(HPM) is consist of three categories; Individual characteristics and experiences, Behavior-specific cognitions and affect, behavioral outcome. Of these categories, individual characteristics and experiences, this category of variables is considered to be of biological, psychological and socio-cultural personal factors, especially, individual fatigue. Futhermore. these variables constitute a critical core for nursing intervention, as they are subject to modification through nursing actions. But there is no few the research of the relationship between the fatigue and health promotion. Therefore, the purpose of this study is to investigate the correlation between the fatigue and health promoting life style among a rural college students. Additionally, this descriptive correlational study identified the relation of demographic factors and fatigue, health promoting life style. From June 20 to 26, 1998, a convenience sample of 270 college students completed the questionnaire of the fatigue and health promoting life style profile which were developed by the Yoshitake(1978) and Walker, et al.(1987), respectively. The descriptive correlational statistics, mean, t-test, ANONA, Pearson correlation coefficient were used to analyze the data gathered with SAS pc+ program. The results were as it follows: 1. The average fatigue score of the subjects was $64.93{\pm}12.89$. Fatigue scores by subcategory were physical symptoms($23.5{\pm}4.87$). psychological symptoms($22.11{\pm}4.66$) and neuro-sensory symptoms($19.32{\pm}5.14$). With the respect to the demographic characteristics of the subjects, there were statistically significant differences between the demographic factors and fatigue, especially, sex(t==3.69 p<0.01), major(t=-2.89 p<0.01). the experience of family illness(t=2.76 p<0.01). 2. The average health promoting life style item score of the subjects was $2.33{\pm}0.33$. In the subcategories, the highest degree of performance was self-actualization(2.94), following interpersonal support(2.81). stress management(2.33), exercise(2.20), nutrition(2.10), and the lowest degree was health responsibility(1.73). There were the significant differences on the learning of health education(t=2.00 p<0.01). religion(F=3.01, p<0.05), circle activity(t=2.07, p<0.05), nutrition control(t=5.25, p<0.01) of demographical factors with the health promoting life style. 3. The correlation between the fatigue and health promoting life style made statistically no significance(r=-0.09731, p>0.05). But there was negative significant relationship between health promoting life style and psychological symptom as a fatigue subcategory(r=-0.15721, p<0.05). The self-actualization showed negative significant correlation with all fatigue subcategory. The health responsibility showed significant relationship with total fatigue(r=0.13050. p<0.05). For further research, it suggests to replicate the correlational and causal study between the fatigue and the health promoting life style using the another fatigue scale which is able to measure the subjective and objective fatigue degree. And it needs to develop the nursing intervention program for maintaining and promoting the health behavior as well as for decreasing the college students's fatigue.

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특허의 가치에 대한 시장의 평가 (Market Evaluation of the Value of Patent)

  • 연태훈
    • KDI Journal of Economic Policy
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    • 제26권2호
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    • pp.63-104
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    • 2004
  • 연구개발활동, 그리고 그 성과물인 지적재산이 가져오는 경제적 효과는 오래전부터 경제학자들에게 매력적인 연구분야로 인식되어 왔다. 그러나 우리나라의 경우에는 가용 자료의 부족 등의 이유로 이 분야의 연구가 그다지 활발히 이루어지지 못하였다. 이러한 문제인식하에 본 연구는 지적재산의 대표적 형태라고 할 수 있는 '특허'가 우리나라 상장기업들의 시장가치에 미친 영향을 분석해보고자 시도하였으며, 가능한 한 다양한 각도에서 문제에 접근하기 위하여 사건연구와 패널분석의 두 가지 분석기법을 병행하였다. 먼저, 특허취득 공시에 대한 일별주가의 반응을 사건연구기법을 통해 분석한 결과, 기업의 특허취득이 가지는 경제적 가치가 상당히 높은 것으로 파악되었다. 특허공시가 시장에 유의한 주가상승 신호를 주는 것으로 파악되었으며, 이러한 효과는 비교적 오랜 기간에 걸쳐서 유지되는 것으로 나타났다. 또한 증권거래소 상장기업들의 연간 패널자료를 토대로 분석한 결과 역시 특허취득이 누적적으로 기업의 시장가치에 유의하고 긍정적인 영향을 미치는 것으로 나타났다. 본 연구에서 행해진 분석들은 우리나라의 특허제도가 가지는 유효성을 지지하는 결과로 해석할 수 있다. 그러나 이러한 연구결과가 현행 특허제도의 최적성을 지지하는 것은 아니며, 특허제도가 경제에 미치는 파급효과를 극대화하기 위해서는 추후 보다 심도 깊은 경제학적 분석들이 활발히 이루어져야 할 것이다.

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연질 골에서 두 종류의 테이퍼 형태 임플란트의 초기 안정성에 관한 실험실적 연구 (In Vitro Study on the Initial Stability of Two Tapered Dental Implant Systems in Poor Bone Quality)

  • 김덕래;김명주;권호범;이석형;임영준
    • 구강회복응용과학지
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    • 제25권4호
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    • pp.391-401
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    • 2009
  • 임플란트의 성공은 식립 후의 초기 안정성 (Initial stability)의 결과가 중요한 영향을 준다. 이 연구의 목적은 연질 골에서 두 종류의 테이퍼 형태 임플란트가 임플란트의 디자인과 self-tapping blade의 유무에 따라서 초기 안정성에 주는 영향을 알아보는 것이다. Self-tapping blade를 가지고 있는 것과 가지고 있지 않은 두 종류의 테이퍼 형태 임플란트가 사용되었다. Solid Rigid Polyurethane Form으로 연질 골 상태인 D4 골 모형을 재현하였다. 임플란트 고정체를 식립하면서 초기 안정성 값을 기록하고, 식립 직후 implant stability quotient (ISQ)을 측정하여 Resonance frequency Analysis (RFA)를 평가하였다. 마지막으로 임플란트가 식립된 모형골을 만능 시험기에 부착하여 장축 방향으로의 pull-out force를 측정하였다. 초기 안정성 값과 최대 pull-out torque 값은 non self-tapping implants가 self-tapping group에 비하여 통계학적으로 유의하게 큰 평균값을 나타냈다 (P = 0.008). 공진 주파수 분석 결과인 ISQ 값은 거의 비슷한 평균값을 보였으면 통계학적으로 차이가 없었다. 각 임플란트 시스템에서 식립 토크와 pull-out 최대 토크 그리고 공진 주파수 간에는 상관관계를 나타내지 않았다. Non self-tapping 임플란트의 높은 식립 토크는 임상적으로 우수한 초기 안정성을 의미한다. 결론적으로 연질 골에서 self-tapping blade가 없는 임플란트가 있는 것 보다 더 우수한 초기 안정성을 보였다.

레이저 다이오드를 이용한 고형암 치료를 위한 간질성 광역학 치료법 개발 (Interstitial Photodynamic Therapy (PDT) Set-up for Treating Solid Tumor Using Laser Diode)

  • 김종기;김기홍
    • 한국의학물리학회지:의학물리
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    • 제16권2호
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    • pp.104-109
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    • 2005
  • 암치료에 사용되고 있는 광역학 치료는 환자에게 광민감제를 투여하고 다이오드 레이저(630 nm)를 조사하여 생성되는 단일상태 산소와 자유 라디칼에 의해 암조직을 괴사시키는 치료방법이다. 현재 광역학 치료의 문제점은 부피가 큰 종양이나 고형암에서는 빛이 종양전체를 투과할 수 없으므로 광역학 치료의 효과가 떨어지는 것이다. 따라서 이 문제를 해결하기 위하여 간질성 광역학 치료법을 개발하고자 한다. 생체조직내의 정확한 광선량 측정이 간질성광역학치료의 효과에 매우 중요한 영향을 주므로, 실험 연구에 사용된 계수는 실제 생체조직의 광학 계수이다. 생체조직 대부분은 가시광선영역에서 큰 산란계수를 가지며, 투과 깊이에 많은 영향을 미치는 것으로 확인되었다. 가시영역에서의 인체조직의 투과깊이는 약 $15\~20mm$이었다. 몬테칼로 시뮬레이션(Monte Carlo simulation)을 이용하여 생체조직내의 광전파, 광선량, 에너지율, 투과깊이를 잘 측정할 수 있음을 알았다. 그리고 이 시뮬레이션 결과를 가지고 고형암에 간질성 광역학 치료를 하여 치료효과를 확인하였다.

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Genetic Variants of NBS1 Predict Clinical Outcome of Platinum-based Chemotherapy in Advanced Non-small Cell Lung Cancer in Chinese

  • Xu, Jia-Li;Hu, Ling-Min;Huang, Ming-De;Zhao, Wan;Yin, Yong-Mei;Hu, Zhi-Bin;Ma, Hong-Xia;Shen, Hong-Bing;Shu, Yong-Qian
    • Asian Pacific Journal of Cancer Prevention
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    • 제13권3호
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    • pp.851-856
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    • 2012
  • Objective: NBS1 plays a key role in the repair of DNA double-strand break (DSB). We conducted this study to investigate the effect of two critical polymorphisms (rs1805794 and rs13312840) in NBS1 on treatment response and prognosis of advanced non-small cell lung cancer (NSCLC) patients with platinum-based chemotherapy. Methods: Using TaqMan methods, we genotyped the two polymorphisms in 147 NSCLC patients. Odds ratios (ORs) and their 95% confidential intervals (CIs) were calculated as a measure of difference in the response rate of platinum-based chemotherapy using logistic regression analysis. The Kaplan-Meier and log-rank tests were used to assess the differences in progression-free survival (PFS) and overall survival (OS). Cox proportional hazards model was applied to assess the hazard ratios (HRs) for PFS and OS. Results: Neither of the two polymorphisms was significantly associated with treatment response of platinum-based chemotherapy. However, patients carrying the rs1805794 CC variant genotype had a significantly improved PFS compared to those with GG genotype (16.0 vs. 8.0 months, P = 0.040). Multivariable cox regression analysis further showed that rs1805974 was a significantly favorable prognostic factor for PFS [CC/CG vs. GG: Adjusted HR = 0.62, 95% CI: 0.39-0.99; CC vs. CG/GG: Adjusted HR = 0.56, 95% CI: 0.32-0.97). Similarly, rs13312840 with a small sample size also showed a significant association with PFS (CC vs. CT/TT: Adjusted HR = 25.62, 95% CI: 1.53-428.39). Conclusions: Our findings suggest that NBS1 polymorphisms may be genetic biomarkers for NSCLC prognosis especially PFS with platinum-based chemotherapy in the Chinese population.

리즈렐모형을 이용한 임도사업의 계량적 분석 (Analyses of Forest Road Construction Policy Using LISREL Approach)

  • 최관
    • 한국산림과학회지
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    • 제97권1호
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    • pp.22-29
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    • 2008
  • 이 연구는 주요 산림정책사업 중 하나인 임도사업의 집행분석을 통하여 효율적인 집행전략 수립에 필요한 정보를 얻고자 수행되었다. 분석에 필요한 자료는 대구경북, 울산, 부산지역의 정책집행 담당자를 대상으로 하는 설문조사를 통하여 수집되었다. 이 평가모형에서는 정책집행요인, 정책환경요인, 정책내용요인을 독립변수로, 정책결과를 종속변수로 하는 회귀식이 추정되었고 다시 정책결과를 독립변수로 정책효과를 종속변수로 하는 회귀식을 추정하였다. 그러나 이와 같은 변수들은 직접측정이 불가능한 잠재변수(latent variable)로서 이의 측정을 위한 측정지표를 설정하였다. 잠재변수들과 이들 변수들 간의 관계를 측정지표를 통하여 계량화 하고 분석하기 위하여 LISREL(Linear Structural Relationship)분석방식을 사용 하였다. LISREL 분석결과 정책결과변수는 정책집행변수, 정책내용변수와 통계적으로 유의한 관계가 있음을 확인하였다. 당초 평가모형에 포함된 정책주체요인 변수는 정책결과와는 유의성 있는 관계가 나타나지 않았고 정책효과와 유의성 있는 관계가 있는 것으로 추정되었다. 또한 정책결과는 정책효과와 유의성 있는 관계가 있는 것으로 추정되었다. 즉 임도건설은 임업기반조성, 산촌지역주민에 대한 편의 제공, 지역균형발전을 위한 유효한 정책수단임을 확인하였다. 다만, 정책결과가 측정지표의 평가에서 보는바와 같이 만족할 만한 수준에 있지 못한바, 이의 개선을 위하여 정책내용의 개선이 필요하며, 특히 적정단비의 확보와 노선의 선정, 시공방법 등에 있어서 현장집행요원의 의견이 실질적으로 반영될 수 있도록 하는 제도의 개선이 요구된다.

암환자의 삶의 질 도구개발 (Development of Quality of Life Measurement for Cancer Patients)

  • 태영숙;강은실;이명화;박금자
    • 성인간호학회지
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    • 제12권4호
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    • pp.741-757
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    • 2000
  • This study was undertaken to develop an instrument to be used for measuring the concept of quality of life of Korean patients with cancer multidimensionary and correctly. It can contribute in holistic nursing care for Korean cancer patients and also provide and validate basic data to help oncology nurses measure the outcome of nursing intervention correctly. To develop this instrument, the researchers first estabilished a conceptual framework based on the results of qualitative data analysis and indepth interview method Development of the scale was conducted using a method in which 31 items were assessed by subjects' self report using linear analogue scales. The subjects were 79 D.M. patients, 103 patients with acute illness, and 91 cancer patients residing in Busan, Korea. Data were collected during the period from July, 24 to August 14, 2000. This instrument consisted of 31 items with a self report scale. This instrument covered 4 dimensions of cancer patients : 1) physical wellbeing 2) psychological wellbeing 3) social wellbeing and 4)spiritual wellbeing. Each item had a possible score of 10. The reliability of the scale was tested with Cronbach's alpha. Validity was evaluated by examining the relationships of this scale, Youn's Quality of Life Questionnare scores and the Simple Quality of Life scale. Two separate runs of multiple regression were used to predict scores on the Simple Quality of Life measurement. Further validation was obtained by examining the correlation between the instrument subscores and Youn's Quality of Life measurement subscore for convergence of this scale. Examination of the discriminant. power of the instrument was done using ANOVA test. The results are summarized as follows: 1. The reliability of the instrument for the quality of life was 0.8321(Cronbach's alpha.), physical wellbeing dimension 0.6343, psychological wellbeing dimension 0.6501, spiritual wellbeing dimension 0.5883. 2. This instrument had a high correlation with Youn's Quality of Life measurement(r= 0.636) in cancer patients, whereas it had a low correlation with Simple Quality of Life measurement(r=0.455) in cancer patients. In the D.M. patients, the instrument correlated with both the Youn's Quality of Life measurement and Simple Quality of life measurement(r=0.313, r= 0.407) and in the acute stage patients, the instrument had no correlation. 3. Multiple regression of individual items on the Simple Quality of Life scores accounted for 56.8% of the variance in the Simple Quality of Life measurement, whereas, Youn's Quality of Life measurement scores accounts for 31.7%. 4. The correlations collected from the three group had the same patterns of variations but especially the instrument developed in this study had higher disciminant power than that of Youn's Quality of Life Measurement.

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한방 복합치료를 시행한 임신 중 요통 환자 치험 3례 (The Effect of Traditional Korean Medical Treatment on Low Back Pain during Pregnancy: a Report on Three Cases)

  • 이수연;류수형;김홍국;유덕우;김성진;정성목;구본혁;김민정;박연철;백용현;남상수;서병관
    • Journal of Acupuncture Research
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    • 제33권3호
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    • pp.197-205
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    • 2016
  • Objectives : To report the clinical application and safety of Traditional Korean Medical treatment for patients with low back pain during pregnancy. Methods : Three patients who suffered from low back pain during pregnancy were treated with acupuncture, pharmacopuncture, moxibustion, and herbal medicine for 12 to 21 days. Numeric rating scale (NRS) of low back pain and Oswestry Disability Index (ODI) were checked to measure the outcome. A liver function and renal function test was carried out to identify any drug-induced liver or renal injury, and any adverse events were monitored thoroughly until delivery. Results : Low back pain reduced on NRS in all cases, and no serious adverse effects were found in the patients or infants. Conclusion : This study suggests that Traditional Korean Medical treatment is a candidate therapy for relieving low back pain during pregnancy, and also is safe for both patients and infants.