• 대한후두음성언어의학회지
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• 제28권2호
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• pp.89-95
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• 2017

Background and Objectives : High-speed videolaryngoscopy (HSV) is the only technique that captures the true intra-cycle vibratory behavior of the vocal folds by capturing full images of the vocal folds. However, it has problems of no immediate feedback during examination, considerable waiting time for digital kymography (DKG), recording duration limited to a few seconds, and extreme demands for storage space. Herein, we demonstrate a new post-processing method that converts HSV images to two-dimensional digital kymography (2D-DKG) images, which adopts the algorithm of 2D videokymography (2D VKG). Materials and Methods : HSV system was used to capture images of vocal folds. HSV images were post-processed in Kay image-process software (KIPS), and conventional DKG images were retrieved. Custom-made post-processing system was used to convert HSV images to 2D-DKG images. The quantitative parameters of the post-processed 2D-DKG images was validated by comparing these parameters with those of the DKG images. Results : Serial HSV images for all phases of vocal fold vibratory movement are included. The images were converted by the scanning method using U-medical image-process software. Similar to conventional DKG, post-processed 2D DKG image from the HSV image can provide quantitative information on vocal fold mucosa vibration, including the various vibratory phases. Differences in amplitude symmetry index, phase symmetry index, open quotient, and close quotient between 2D-DKG and DKG were analyzed. There were no statistical differences between the quantitative parameters of vocal fold vibratory movement in 2D-DKG and DKG. Conclusion : The post-processing method of converting HSV images to 2D DKG images could provide clinical information and storage economy.

• 대한후두음성언어의학회지
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• 제14권1호
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• pp.16-25
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• 2003

후두암은 유병율이 높지만 조기에 발견하면 90% 이상의 치유율과 발성기능의 보존이 가능하며 현재 음성분석을 이용한 진단법이 시도되고 있으나 정립된 선별검사법은 없는 실정이다. 성문전도검사(electroglottography, EGG)는 성대의 진동양상을 알 수 있는 비침습적 검사로서 발성과 음성합성의 연구에 많이 사용되고 있다. 본 연구는 EGG에서 관찰되는 파라미터들을 다층 퍼셉트론(multilayer perceptron)구조의 신경회로망(artificial neural network)으로 감별하는 기법을 이용하여 후두암 감별법에 대한 연구로서 부산대학교병원을 내원한 후두암 환자 10명과 양성후두질환 26명을 대상으로 새로 고안한 Electroglottograph(v1.0)를 이용하여 검사하고 이의 임상적 유용성을 평가하였다. EGG 파라미터인 closed quotient(CQ), speed quotient(SQ), speed index(SI), fundamental frequency(F0), Jitter, Shimmer 등은 MATLAB 6.5 (Mathwork, Inc.)로 작성한 분석 프로그램을 이용하여 추출하였다. 각 환자에서 추출된 EGG 파라미터들을 다층 퍼셉트론 구조의 신경회로망으로 감별하였다. CQ는 각 질환군 간에 유의한 차이가 없었지만 SQ, SI, Jitter, Shimmer 등은 성대질환의 특성에 따라 유의한 차이를 보였다. 신경회로망에서 감별한 결과 CQ를 제외한 SQ, SI, Jitter, Shimmer 등에서 71.3-90%의 후두암의 감별율을 보였다. 또한 SQ, SI, Jitter, Shimmer를 3개씩 조합한 실험에서는 SQ-Jitter-Shimmer와 SQ-SI-Shimmer의 후두암의 감별율이 93%로 가장 높았고, SQ-SI-Jitter 90.9%, SI-Jitter-Shimmer 88.6%로 전체적으로 85% 이상의 높은 감별율을 나타내었다. 이러한 결과는 EGG검사와 신경회로망을 이용한 양성과 악성 후두질환의 감별이 가능함을 시사한다. 향후 성대 질환의 병태생리를 대변할 수 있는 파라미터가 추가로 개발되고 분류 알고리듬이 개선된다면 EGG를 이용한 성대질환의 감별 진단이 보다 정확해질 것으로 사료되었다.

• 대한두경부종양학회지
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• 제17권1호
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• pp.59-62
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• 2001

Objectives: We report an interim result of conformal radiotherapy in a patient with early stage cancer at the base of the tongue, which developed in a previously irradiated area. Materials and Methods: A 64-year-old male patient was diagnosed with T4N0M0 supraglottic cancer. He received 72Gy of radiation therapy from 21 November 1988 to 24 February 1989. He had local failure and underwent a salvage total laryngectomy on 28 August 1989. Subsequently, he did well. In early 1999, he suffered from throat pain. He had a 2.5cm ulcerative mass at the base of his tongue, in the area that had been irradiated previously. Biopsy showed squamous cell carcinoma. After workup, he was diagnosed with base of tongue cancer with T2N0M0. Surgery was not feasible because the morbidity was not acceptable. Since it was difficult to re-irradiate the area with a curable dose using conventional 2D radiation therapy with an acceptable morbidity, we decided to try conformal radiotherapy. We used 7 static beam ports with field sizes from $7x6.4\;to\;8x8cm^2$, using 6 and 10MV photons. The fractionation regimen was 1.8Gy, 5 times per week. He received 64.8Gy in 36 fractions from 9 April 1999 to 1 June 1999. Results: In the 21 months since radiotherapy, the patient has not experienced any acute or chronic complications, such as xerostomia. He experienced relief of pain shortly after the start of radiotherapy, showed a complete response, and is still doing well. Conclusion: Conformal radiotherapy can be used to treat cancer that develops within a previously irradiated field, with curative intent.

• 대한두경부종양학회지
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• 제15권2호
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• pp.162-165
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• 1999

Background and Objectives: Multiple primary tumors of the upper aerodigestive tract are not unusual. We examined head and neck cancer patients to discover the presence of second primary cancer in their upper gastrointestinal tract, using esophagogastroscopy. Materials and Methods: Endoscopic examination of the upper gastrointestinal tract was performed on 51 patients whose head and neck cancers were treated at department of therapeutic radiology from August 1996 to April 1999. Two of all patients had been studied by barium swallowing study. In 51 patients, twenty-four had a primary tumor in the larynx, 8 in the oropharynx, 6 in the nasopharynx, 6 in the oral cavity, 6 in the hypopharynx, and 1 in the nasal cavity. Endoscopically pathologic lesions were biopsied. In control group, endoscopy was performed on 1097 patients who didn't complain any symptoms. Results: Endoscopy showed early malignant lesions in 4 cases(7.7%). Histology of esophageal cancers showed squamous cell carcinoma. Malignant lesions of stomach in 2 cases were histologically identified as adenocarcinoma. Two esophageal cancers occurred in patients whose primary lesions had oropharynx and hypopharynx. Two cases of gastric cancer were also accompanied by oropharynx and hypopharynx. The incidence of second primary cancer was 2 in oropharynx and 2 in hypopharynx. In all cases, second primary cancers were found simultaneously. In control group, 9(0.8%) of 1097 patients were confirmed as early esophageal and gastric cancers. Conclusion: The majority of esophageal and gastric cancer detected by endoscopy were early stage in both head and neck cancer and control group. The incidence of esophageal and gastric cancer of head and neck cancer patients was 10 times as high as that of control group. Although followup period was short, all second primary cancers were detected simultaneously. We would recommend that endoscopic evaluation be included in the workup and followup of all patients with newly diagnosed head and neck cancer.

• 대한두경부종양학회지
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• 제15권2호
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• pp.182-188
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• 1999

Purpose: To investigate the treatment results' and patterns of failure according to the pathologic type of the parotid malignancy who were treated with radical sugery and postoperative radiation therapy. Materials and Methods: Fifty-two patients with various type of the parotid malignancy, who were treated with combined radical surgery and post-operative irradiation at Yonsei Cancer Center, between 1981 and 1995, were retrospectively reviewed after completion treatment, all but one patients were follow up with the median follow up period of 49 months. Results: We found that pathologically confirmed neck node metastasis rate was 28.8% all case and level II was most common site. Overall failure rate was 26.9%, local recurrence rate was 13.5%, node failure rate was 7.7%, and distant failure rate was 5.8%. Five-year disease free survival rate was 70.9%, and overall survival rate was 73.8%. Recurrence rate was low in adenoid cystic carcinoma and acinic cell carcinoma. However distant metastasis was very high in undifferentiated carcinoma. Local recurrence was main pattern of failure in mucoepidermoid carcinoma and nodal failure was frequently observed in adenocarcinoma. Conclusion: Individualized treatment plan may be required to improve a treatment outcome by pathologic subtype of the parotid malignancy.

• 대한약침학회지
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• 제21권3호
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• pp.151-158
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• 2018

Objectives: We investigated the efficacy and safety of miniscalpel acupuncture (MA) for knee osteoarthritis (KOA) in an assessor-blinded randomized controlled pilot trial; this would provide information for a large-scale randomized controlled trial. Methods: Participants (n = 24) were recruited and randomly allocated to the MA group (experimental) or acupuncture group (control). The MA group received treatment once a week for 3 weeks (total of 3 treatments), while the acupuncture group received treatment two times per week for 3 weeks (total of 6 treatments). The primary outcome was pain as assessed by a visual analogue scale (VAS). The secondary outcomes (intensity of current pain, stiffness, and physical function) were assessed using the short-form McGill Pain Questionnaire (SF-MPQ) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Assessments were performed at baseline, 1, 2, and 3 during treatment and at week 5 (2 weeks after the end of treatment). Results: Of the 24 participants, 23 completed the study. Both groups showed significant improvements in VAS, SF-MPQ, and WOMAC. However, there were no significant differences between the MA and acupuncture groups. No serious adverse event occurred and blood test results were within normal limits. Conclusion: Our results suggest that although both MA and acupuncture provide similar effects with regard to pain control in patients with KOA, MA may be more effective in providing pain relief because the same relief was obtained with fewer treatments. A large-scale clinical study is warranted to further clarify these findings.

• 대한후두음성언어의학회지
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• 제22권1호
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• pp.40-46
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• 2011

Background and Objectives : Vocal fold bowing is an organic voice disorder that is associated with an abnormal structure of the vocal folds whereas vocal fold polyp is a functional voice disorder caused by an abnormal use of the vocal folds. Both types of vocal folds share a common property in that they make one's voice breathy or strained. The purpose of this study is to compare voice from two types of vocal folds and to offer information of clinical importance. Materials and Method: Vocal fold bowing and vocal fold polyp groups consisted of 7 male subjects, respectively. All subjects recorded /a/ in the state of measuring MPT (maximum phonation time), repeating 3 times, by a voice recorder (48 kHz sampling rate; 24 bit quantization). They answered the questions of K-VHI. Time domain parameters (such as perturbation parameters including HNR, Jitter, etc.) were calculated for the whole duration of /a/ and those of the frequency domain were measured in initial 40 ms and stable 40 ms of /a/, respectively. Mann-Whitney V-test was used for the time domain parameters and K-VHI survey, and Wilcoxon signed rank test was applied to the frequency domain parameters (H1, H2, H1-H2). Results: For K-VHI survey and the time domain analysis, there was no significant difference between bowing and polyp group. For frequency domain analysis, H1 and H2 showed a significantly different result between two groups. Vocal fold bowing group has longer duration and lower intensity than that of vocal fold polyp group in the 'aspirated interval', which could be observable prior to ordinary vowel oscillation. Conclusion: Both groups seem to show breathy voice. This could be referred on the basis of the value of H1-H2. The K-VHI survey says that subjects with vocal fold bowing feel more uncomfortable than subjects with vocal fold polyp.

• 생명과학회지
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• 제14권2호
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• pp.275-279
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• 2004

사이토카인과 그들 수용체의 유전자 다형성은 면역작용에 의한 질병들의 발병원인에 있어서 유전적인 인자로 여겨지는 후보물질들로서, 자가면역질환 및 염증성 그리고 감염질환에 민감하게 연관되어 있다고 알려져 있다. 최근 새롭게 보고된 Interleukin-29유전자는 유전학적 질병들의 복잡한 특성을 해결할 수 있는 중요한 후보유전자이지만 이 유전자에 대한 다형성에 대한 연구는 아직 보고된바 없다. 우리는 이 연구에서 처음으로 프로모터부분을 포함한 Interleukin-29 유전자의 전체 지름 DNA에서 유전자의 다형성을 염기서열 분석 방법을 이용하여 탐색하였다. Interleukin-29 유전자의 다형성들이 한국인의 알레르기성 비염의 감염력과 관련되어 있는지를 알아보기 위하여 알레르기성 비염환자 및 알레르기성 비염이 걸리지 않은 정상인의 다형성을 유전자형과 대립유전자의 빈도를 비교분석 하였다. 우리는 이 연구에서 사람의 Interleukin-29 유전자의 한 개의 신규의 다형성 (1184C＞A)을 intron 2에서 그리고 한 개의 신규의 변이부위 (-1842_-1841dupGA)를 프로모터에서 찾아냈다. 우리들의 연구 결과는 이들 유전자 다형성 부위 및 변이부위가 알레르기성 비염과 연관은 없는 것으로 밝혀졌다.

• Journal of Oral Medicine and Pain
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• 제34권1호
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• pp.39-48
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• 2009

본 연구는 구취생성의 주요 원인균에 대한 nanosilver의 항균효과를 조사하기 위해서 시행되었으며, 이와 더불어 이들 세균의 증식 조건도 함께 연구하였다. 포항공과대학교 나노기술센터로부터 $NANOVER^{TM}$, WA 1000 현탁액을 제공 받아 희석하여 사용하였으며, 공시균으로는 주요 구취생성균으로 알려진 Fusobacterium nucleatum (KCTC 2640), Prevotella melaninogenica (KCTC 3689), Klebsiella pneumonia (KCTC 1560) 3종의 세균류를 한국생명공학연구원 생명자원센터로부터 구입하여 사용하였다. 공시균의 배양에 혐기성세균 배양에 이용되는 tryptone- yeast extract-ammonium acetate(TYA) 배지와 chopped beef meat(CBM) 배지를 이용하였다. 1. 최적배양조건으로 감압배양, CBM 배지가 적당한 것으로 나타났다. 2. 간균인 K. pneumonia에 Nanover(5 및 10 ppm)를 처리하고 주사형 전자현미경으로 균체의 형태를 관찰한 결과는 세균의 생장점 부근에서 세포벽에 손상을 주어 세포벽을 절단하여 다량의 막상 편린을 생성하고 autolysin을 불활성화 시켜 filament형 균체를 형성하여 균의 증식은 일시적으로 억제시킬 수 있었으나 완전히 사멸시키지는 못하였으며, 구취 세균을 전혀 다른 형태로 변화시키는 것으로 나타났다. 그러나 항균제로서의 역할은 가진 것으로 확인되었다.

• 한방재활의학과학회지
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• 제26권1호
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• pp.87-93
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• 2016

Objectives To analyze the resorption of herniated lumbar intervertebral disc on MRI in patients who were treated with Korean Medicine. Methods 78 patients with lumbar disc herniation were included, 47 males and 32 females. Patients' diagnosis was based on magnetic resonance imaging (MRI). All of the patients were only treated with Korean Medicine for 6 months treatment, and underwent MRI examination twice, pre-treatment and post-treatment. MR images were assessed by reduction in diameter of T2-weighted image between pre-treatment and post-treatment, and analyzed by differences in sex, age and disc type. Results 91.2% (71 people) of total patients had extrusion type. Korean medicine treatment reduced lumbar disc herniation diameter of all the patients from 7.11 mm to 3.67 mm on average (p<0.001). The reduction of diameter in the male group was 3.52 mm on average. The reduction of diameter in the female group was 3.32 mm on average. The reduction of diameter was 3.28 mm in the group below age 29, 3.88 mm in the 30~39 age group, 3.39 mm in the 40~49 age group, and 2.71 mm in the above 50 age group on average. Conclusions The MRI results suggest that lumbar herniated disc can resorb with Korean Medicine treatment. The likelihood of lumbar disc resorption was higher at extrusion type. but there was not a significant difference between the sexes and between ages.