근치적수술과 술후방사선치료를 받은 이하선 악성종양 환자의 치료실패 양상 - 병리학적 유형에 따른 결과를 중심으로 -

Patterns of Failure after Combined Surgery and Radiation Therapy for Malignant Tumors of the Parotid Gland - Analysis of Treatment Results According to Pathologic Type -

  • 이상욱 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 장세경 (을지의과대학 치료방사선학교실) ;
  • 김귀언 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 서창옥 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 성진실 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 이창걸 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 금기창 (연세대학교 의과대학 연세암센터 치료방사선학교실) ;
  • 박정수 (연세대학교 의과대학 연세암센터 외과학교실) ;
  • 최은창 (연세대학교 의과대학 연세암센터 이비인후과학교실)
  • Lee Sang-Wook (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Chang Sei-Kyung (Department of Radiation Oncology, Eulji Medical College) ;
  • Kim Gwi-Eon (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Suh Chang-Ok (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Seong Jin-Sil (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Lee Chang-Geol (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Keum Ki-Chang (Department of Radiation Oncology, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Park Cheong-Soo (Department of Surgery, Yonsei Cancer Center, Yonsei University College of Medicine) ;
  • Choi Eun-Chang (Department of Otolaryngology, Yonsei Cancer Center, Yonsei University College of Medicine)
  • 발행 : 1999.11.01

초록

Purpose: To investigate the treatment results' and patterns of failure according to the pathologic type of the parotid malignancy who were treated with radical sugery and postoperative radiation therapy. Materials and Methods: Fifty-two patients with various type of the parotid malignancy, who were treated with combined radical surgery and post-operative irradiation at Yonsei Cancer Center, between 1981 and 1995, were retrospectively reviewed after completion treatment, all but one patients were follow up with the median follow up period of 49 months. Results: We found that pathologically confirmed neck node metastasis rate was 28.8% all case and level II was most common site. Overall failure rate was 26.9%, local recurrence rate was 13.5%, node failure rate was 7.7%, and distant failure rate was 5.8%. Five-year disease free survival rate was 70.9%, and overall survival rate was 73.8%. Recurrence rate was low in adenoid cystic carcinoma and acinic cell carcinoma. However distant metastasis was very high in undifferentiated carcinoma. Local recurrence was main pattern of failure in mucoepidermoid carcinoma and nodal failure was frequently observed in adenocarcinoma. Conclusion: Individualized treatment plan may be required to improve a treatment outcome by pathologic subtype of the parotid malignancy.

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