• Asian Pacific Journal of Cancer Prevention
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• 제14권8호
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• pp.4595-4598
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• 2013

We conducted a comprehensive study to investigate the role of genes involved in transport pathways in response to chemotherapy and clinical outcome of osteosarcoma cases. Genotyping of six SNPs was performed in a 384-well plate format on the Sequenom MassARRAY platform for 208 osteosarcoma patients to reveal any correlations of the six SNPs with response to chemotherapy and clinical outcome. Individuals with the ABCB1 rs1128503 TT and ABCC3 rs4148416 TT genotypes had a higher probability of responding poorly to chemotherapy, indicated by odds ratios (ORs) of 2.46 (95%CI, 1.21-5.74) and 3.78 (95% CI, 1.20-13.85), respectively. Moreover, the ABCB1 rs1128503 TT and ABCC3 rs4148416 TT genotypes were significantly associated with shorter diseasefree survival (DFS) and overall survival (OS). Our study found the two SNPs in two transporter genes and one phase II metabolism enzyme to be associated with response to chemotherapy and overall survival in osteosarcoma patients, suggesting potential prognostic biomarker applications of the two SNPs.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.369-372
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• 1997

Socket pressure distributions with gait analyses of a transfemoral and a transtibial prostheses were measured in order to assess an optimal socket fitting and unction. Ankle joint was aligned by the neutral and the dorsi/plantar flexed positions. Compared to dorsi and plantar flexed positions of ankle joint, cadence and walking speed increased with the neutral ankle joint alignment. Other gait parameters were close to the normative data with the neutral ankle joint alignment. For the transfemoral amputee, dorsiflexed alignment of the ankle joint created high pressure on the lateral aspect of the socket, on the other hand, plantarflexed alignment resulted in increased pressure on the medial aspect of the socket. For the transtibial amputee, dorsiflexed alignment of the ankle resulted in high pressure on the antero-lateral aspect of the socket during mid-stance, but plantarflexion of the ankle joint showed slight increases in pressure at the same location in the socket. The present study clearly demonstrated that malalignment of a prosthesis results in localized increasing pressure within the socket. Proper alignment of the prosthesis is required in order to acquire an appropriate socket-limb interface as well as the proper gait.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.276-279
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• 1997

A simple bio-feedback system was developed to monitor and to analyze patient's postural balance. Two load celIs were used to measure the weight of each side. A specially designed electronic circuit was made to pick up the weight signals and to feed into the data acquisition system. Clinical trials were also made on 20-30 year-old normal subjects and nine hemiplegia patients who had the potential instability in weight bearing. A Microsoft window-based software collected and analyzed the postural balance data. Normal subjects showed only 5% deviations of their body weight. However, hemipegic patients had significant weight shifts toward the healthy limb. With the present system, patients can also exercise their balance and weight bearing. The present system should be of convenience to monitor in real-time and analyze the postural balance control of hemiplegic patients.

• 한국정밀공학회지
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• 제29권7호
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• pp.805-810
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• 2012

Determining of the exercise intensity is very important in terms of induction of low fatigue during exercise. Little information is available on the contraction level of the trunk muscles during whole body tilts with and without axial rotation. This study was to investigate the difference muscle activation level according to axial rotation. Twenty subjects were participated. The muscle activities of the five trunk muscles were bilaterally measured at eight axial rotation angles with 12 tilt angles along $15^{\circ}$ intervals. The results showed that tilt with $45^{\circ}$ axial rotation was more balanced in the same tilt angle and was maintained approximately level of 40% MVC at over $60^{\circ}$ tilt angle with respect to co-contraction of abdominal and back muscle. Lumbar stabilization exercise using whole body tilts would be more effective with axial rotation than without axial rotation in terms of muscle co-contraction.

• Clinics in Shoulder and Elbow
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• 제24권3호
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• pp.141-146
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• 2021

Background: The purpose of the present study was to determine how long superior screws alone or in combination with posterior placement of metaglene screws protruding and penetrating into the scapular spine in reverse total shoulder arthroplasty affect the strength of the scapular spine in a fresh cadaveric scapular model. Methods: Seven fresh cadaver scapulas were allocated to the control group (short posterior and superior screws) and seven scapulars to the study group (spine base fixation with a four long screws, three with both long superior and long posterior screws). Results: The failure load was lower in the spine fixation group (long screw, 869 N vs. short screw, 1,123 N); however, this difference did not reach statistical significance (p>0.05). All outside-in long superior or superior plus posterior screws failed due to scapular spine base fracture; failures in the short screw group were due to acromion fracture. An additional posterior outside-in screw failed to significantly decrease the failure load of the acromion spine. Conclusions: The present study highlights the significance of preventing a cortical breach or an outside-in configuration when a superior or posterior screw is inserted into the scapular spine base.

• 한국정밀공학회:학술대회논문집
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• 한국정밀공학회 2002년도 추계학술대회 논문집
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• pp.1070-1073
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• 2002

The biomechanical interaction between the stump and the prosthetic socket is critically important to achieve close-to-normal ambulation. Many investigators suggested that the pressure changes during gait of transfemoral amputees are closely related to the prosthetic alignment, the socket shape, the stump size, and the residual muscle activity. The effects of the prosthetic alignment, the socket shape, and the stump size on the interface pressure were investigated previously. However, there is no report how the residual muscle activities in the transfemoral stump affect the socket interface pressure characteristics during gait. Since designs of socket fur lower limb amputees need to consider the socket interface pressure characteristics, the interface pressure patterns by the residual muscle activities during gait should be investigated. In this study, myoelectric signals (MES) and socket interface pressure in residual limb of transfemoral amputees were measured during the stance and swing phases of gait. For the purpose, specially designed quadrilateral sockets that MES electrodes could be instrumented were fabricated. A total of two transfemoral amputees were participated in the experiments. The measured temporal MES amplitude and interface pressure in knee flexor (biceps femoris) and extensor (rectus femoris) had significant correlations (P ＜ 0.05). Based on the test results, It was suggested that the residual muscle activity of transfemoral amputees stump is an important factor affecting socket pressure changes during walk.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 춘계학술대회
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• pp.437-438
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• 1997

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 춘계학술대회
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• pp.331-334
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• 1996

The present study was performed to investigate gait characteristics of 30-39 year-old normal adults and 9-10 year-old children. The results focused on joint motions in the sagittal plane and ground reaction forces. The results will play an important role as a valuable data to determine normal and abnormal gait patterns as well as gait characteristics of Korean people.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2003년도 ICCAS
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• pp.1485-1488
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• 2003

This paper proposes a wireless EMG-based human-computer interface (HCI) for persons with disabilities. For the HCI, four interaction commands are defined by combining three elevation motions of shoulders such as left, right and both elevations. The motions are recognized by comparing EMG signals on the Levator scapulae muscles with double thresholds. A real-time EMG processing hardware is implemented for acquiring EMG signals and recognizing the motions. To achieve real-time processing, filters such as high- and low-pass filter and band-pass and -rejection filter, and a full rectifier and a mean absolute value circuit are embedded on a board with a high speed microprocessor. The recognized results are transferred to a wireless client system such as a mobile robot via a Bluetooth module. From experimental results using the implemented real-time EMG processing hardware, the proposed wireless EMG-based HCI is feasible for the disabled.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2005년도 제36회 하계학술대회 논문집 D
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• pp.2962-2964
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• 2005

Magneto-Rheological (MR) fluid is suspension of fine magnetic particles in a liquid carrier such as silicon oil or water. MR fluid exhibits solid-like mechanical behavior into chain or clusters with high yield stress when magnetic field is applied to the particles. The response of MR fluids is very quick and reversible after removal of the field. MR Fluids have high yield stress (up to 5kPs) and operate in low voltage power supply. Recently, MR damper using MR fluids was open used in vibration control system such as structural devices, seat vibration controllers and helicopter rotor systems, but it is too big in size and heavy. Therefore, it is not appreciate to rehabilitation devices such as prosthetic limbs.