• 제목/요약/키워드: orthogonal least square

검색결과 57건 처리시간 0.026초

Nuclear magnetic resonance-based metabolomics analysis and characteristics of beef in different fattening periods

  • Jeong, Jin Young;Baek, Youl-Chang;Ji, Sang Yun;Oh, Young Kyun;Cho, Soohyun;Seo, Hyun-Woo;Kim, Minseok;Lee, Hyun-Jeong
    • Journal of Animal Science and Technology
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    • 제62권3호
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    • pp.321-333
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    • 2020
  • Beef quality is influenced by the fattening period. Therefore, meat metabolomics profiles from the different fattening periods (e.g., short-term vs. long-term) were analyzed for identify potential indicators using nuclear magnetic resonance. Additionally, blood, free fatty acid, sensory, and mineral compositions in Korean steers were determined. Blood, free fatty acid, and mineral concentrations showed significant differences between short-term and long-term groups that were fed different diets. However, there were no sensory differences in the two fattening groups. Additionally, the metabolic profiles of meats were clearly separated based on multivariate orthogonal partial least square discriminant analysis. Six metabolites of variable importance in the projection plot were identified and showed high sensitivity as candidate markers for meat characteristics. In particular, lactate, carnosine, and creatine could be directly linked to scientific indicators of the fattening stage (31 vs. 28 mo) of meat. Our findings suggest that the metabolomics approach could be a powerful method for the detection of novel signatures underlying the managing period of beef.

DETERMINATION OF THE INVARIANT POINT OF THE KOREAN VLBI NETWORK RADIO TELESCOPES: FIRST RESULTS AT THE ULSAN AND TAMNA OBSERVATORIES

  • Yoo, Sung-Moon;Jung, Taehyun;Lee, Sung-Mo;Yoon, Ha Su;Park, Han-Earl;Chung, Jong-Kyun;Roh, Kyoung-Min;Wi, Seog Oh;Cho, Jungho;Byun, Do-Young
    • 천문학회지
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    • 제51권5호
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    • pp.143-153
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    • 2018
  • We present the first results of the invariant point (IVP) coordinates of the KVN Ulsan and Tamna radio telescopes. To determine the IVP coordinates in the geocentric frame (ITRF2014), a coordinate transformation method from the local frame, in which it is possible to survey using the optical instrument, to the geocentric frame was adopted. The least-square circles are fitted in three dimensions using the Gauss-Newton method to determine the azimuth and elevation axes in the local frame. The IVP in the local frame is defined as the mean value of the intersection points of the azimuth axis and the orthogonal vector between the azimuth and elevation axes. The geocentric coordinates of the IVP are determined by obtaining the seven transformation parameters between the local frame and the east-north-up (ENU) geodetic frame. The axis-offset between the azimuth and elevation axes is also estimated. To validate the results, the variation of coordinates of the GNSS station installed at KVN Ulsan was compared to the movement of the IVP coordinates over 9 months, showing good agreement in both magnitude and direction. This result will provide an important basis for geodetic and astrometric applications.

3차원 측정점으로부터의 객체 자동인식 (Automatic Object Recognition in 3D Measuring Data)

  • 안성준
    • 정보처리학회논문지B
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    • 제16B권1호
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    • pp.47-54
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    • 2009
  • 측정점으로부터의 3차원 객체 자동인식은 컴퓨터비전, 지능형로봇 등의 분야에서 주요 연구주제이다. 본 논문에서 저자는 측정오차가 포함되어 있으며 정렬되지 않은 대용량 3차원 측정점으로부터 객체를 자동적으로 추출하며 그 형상계수를 추정하는 소프트웨어 기술에 대한 소개를 하고자 한다. 해당 소프트웨어는 기능적으로 상호 연결된 형상모델 제시, 측정점 분할, 형상모델 맞춤의 세 부분으로 이루어졌으며 최단거리 최소제곱법(ODF)이 핵심요소이다. ODF는 형상모델과 측정점 사이의 최단거리의 제곱합을 최소화하는 형상모델 계수를 추정한다. 무작위로 선정된 부분 측정점에 대한 임시 형상모델로서 이차 곡면이 ODF에 의하여 구하여지면 우리는 이로부터 3차원 객체를 자동적으로 추출하는 과정인 최종 형상모델 제시, 측정점 분할, 형상모델 맞춤에 필요한 초기값을 제공할 수 있다. 소개된 소프트웨어 기술을 실제 3차원 측정점에 적용함으로써 그의 성능을 확인하고자 한다.

Active mass driver control system for suppressing wind-induced vibration of the Canton Tower

  • Xu, Huai-Bing;Zhang, Chun-Wei;Li, Hui;Tan, Ping;Ou, Jin-Ping;Zhou, Fu-Lin
    • Smart Structures and Systems
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    • 제13권2호
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    • pp.281-303
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    • 2014
  • In order to suppress the wind-induced vibrations of the Canton Tower, a pair of active mass driver (AMD) systems has been installed on the top of the main structure. The structural principal directions in which the bending modes of the structure are uncoupled are proposed and verified based on the orthogonal projection approach. For the vibration control design in the principal X direction, the simplified model of the structure is developed based on the finite element model and modified according to the field measurements under wind excitations. The AMD system driven by permanent magnet synchronous linear motors are adopted. The dynamical models of the AMD subsystems are determined according to the open-loop test results by using nonlinear least square fitting method. The continuous variable gain feedback (VGF) control strategy is adopted to make the AMD system adaptive to the variation in the intensity of wind excitations. Finally, the field tests of free vibration control are carried out. The field test results of AMD control show that the damping ratio of the first vibration mode increases up to 11 times of the original value without control.

Analysis of metabolomic patterns in thoroughbreds before and after exercise

  • Jang, Hyun-Jun;Kim, Duk-Moon;Kim, Kyu-Bong;Park, Jeong-Woong;Choi, Jae-Young;Oh, Jin Hyeog;Song, Ki-Duk;Kim, Suhkmann;Cho, Byung-Wook
    • Asian-Australasian Journal of Animal Sciences
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    • 제30권11호
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    • pp.1633-1642
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    • 2017
  • Objective: Evaluation of exercise effects in racehorses is important in horseracing industry and animal health care. In this study, we compared metabolic patterns between before and after exercise to screen metabolic biomarkers for exercise effects in thoroughbreds. Methods: The concentration of metabolites in muscle, plasma, and urine was measured by $^1H$ nuclear magnetic resonance (NMR) spectroscopy analysis and the relative metabolite levels in the three samples were compared between before and after exercise. Subsequently, multivariate data analysis based on the metabolic profiles was performed using orthogonal partial least square discriminant analysis (OPLS-DA) and variable important plots and t-test was used for basic statistical analysis. Results: From $^1H$ NMR spectroscopy analysis, 35, 25, and 34 metabolites were detected in the muscle, plasma, and urine. Aspartate, betaine, choline, cysteine, ethanol, and threonine were increased over 2-fold in the muscle; propionate and trimethylamine were increased over 2-fold in the plasma; and alanine, glycerol, inosine, lactate, and pyruvate were increased over 2-fold whereas acetoacetate, arginine, citrulline, creatine, glutamine, glutarate, hippurate, lysine, methionine, phenylacetylglycine, taurine, trigonelline, trimethylamine, and trimethylamine N-oxide were decreased below 0.5-fold in the urine. The OPLS-DA showed clear separation of the metabolic patterns before and after exercise in the muscle, plasma, and urine. Statistical analysis showed that after exercise, acetoacetate, arginine, glutamine, hippurate, phenylacetylglycine trimethylamine, trimethylamine N-oxide, and trigonelline were significantly decreased and alanine, glycerol, inosine, lactate, and pyruvate were significantly increased in the urine (p<0.05). Conclusion: In conclusion, we analyzed integrated metabolic patterns in the muscle, plasma, and urine before and after exercise in racehorses. We found changed patterns of metabolites in the muscle, plasma, and urine of racehorses before and after exercise.

코히어런트 다중 표적 방위 추적 알고리즘 (Coherent Multiple Target Angle-Tracking Algorithm)

  • 김진석;김현식;박명호;남기곤;황수복
    • 한국음향학회지
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    • 제24권4호
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    • pp.230-237
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    • 2005
  • 수중음향 시스템에서는 이동 표적에 대한 상태 추정 및 표적 식별 등의 목적을 위해서 표적 방위 추적은 필수적이다. 그러나 감시영역에 근접 또는 교차 표적 등이 존재하는 다수 표적 상황에서의 방위 추적은 매우 어려운 문제로 다양한 접근방법으로 연구되어 왔다. SWORD는 배열 센서 신호의 출력 공분산 행렬로부터 방위 변위를 추정하여 표적을 추적함으로써 별도의 정보 연관 과정이 필요 없는 단순한 구조의 다중 표적 방위 추적 알고리즘을 제안하였으며, RYU 등은 표적 조향 벡터 (target steering vector)와 배열 센서 공분산 행렬의 신호 고유 벡터 (signal eigenvector)가 선형결합 관계임을 이용하여 교차 표적 (cross target)에 대해서도 우수한 성능을 나타내는 효율적인 알고리즘을 제안하였다. 또한 HWANG 등은 잡음 고유 벡터 (noise eigenvector)와 표적 조향 벡터가 직교 관계임을 이용하여 RYU의 알고리즘과 동일한 성능을 유지하면서 연산량을 개선한 알고리즘을 제안하였다. 그러나 기존의 방법은 코히어런트 (coherent) 다중 표적인 경우에는 추적 성능이 저하되는 단점이 있다. 본 논문에서는 배열 센서의 공분산 행렬로부터 추정할 수 있는 신호 고유 벡터와 잡음 공분산 행렬 (noise covariance matrix)의 특성을 이용하여 코히어런트 다중 표적에 대해 추적 성능을 유지할 수 있는 다중 표적 방위 추적 알고리즘을 제안하였으며, 근접 및 교차 기동하는 표적에 대한 시뮬레이션을 통하여 비코히어런트 (incoherent)와 코히어런트 다중 표적에 대해 추적 성능이 우수함을 확인하였다.

Comparative metabolomic analysis in horses and functional analysis of branched chain (alpha) keto acid dehydrogenase complex in equine myoblasts under exercise stress

  • Jeong-Woong, Park;Kyoung Hwan, Kim;Sujung, Kim;Jae-rung, So;Byung-Wook, Cho;Ki-Duk, Song
    • Journal of Animal Science and Technology
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    • 제64권4호
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    • pp.800-811
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    • 2022
  • The integration of metabolomics and transcriptomics may elucidate the correlation between the genotypic and phenotypic patterns in organisms. In equine physiology, various metabolite levels vary during exercise, which may be correlated with a modified gene expression pattern of related genes. Integrated metabolomic and transcriptomic studies in horses have not been conducted to date. The objective of this study was to detect the effect of moderate exercise on the metabolomic and transcriptomic levels in horses. In this study, using nuclear magnetic resonance (NMR) spectroscopy, we analyzed the concentrations of metabolites in muscle and plasma; we also determined the gene expression patterns of branched chain (alpha) keto acid dehydrogenase kinase complex (BCKDK), which encodes the key regulatory enzymes in branched-chain amino acid (BCAA) catabolism, in two breeds of horses, Thoroughbred and Jeju, at different time intervals. The concentrations of metabolites in muscle and plasma were measured by 1H NMR (nuclear magnetic resonance) spectroscopy, and the relative metabolite levels before and after exercise in the two samples were compared. Subsequently, multivariate data analysis based on the metabolic profiles was performed using orthogonal partial least square discriminant analysis (OPLS-DA), and variable important plots and t-test were used for basic statistical analysis. The stress-induced expression patterns of BCKDK genes in horse muscle-derived cells were examined using quantitative reverse transcription polymerase chain reaction (qPCR) to gain insight into the role of transcript in response to exercise stress. In this study, we found higher concentrations of aspartate, leucine, isoleucine, and lysine in the skeletal muscle of Jeju horses than in Thoroughbred horses. In plasma, compared with Jeju horses, Thoroughbred horses had higher levels of alanine and methionine before exercise; whereas post-exercise, lysine levels were increased. Gene expression analysis revealed a decreased expression level of BCKDK in the post-exercise period in Thoroughbred horses.