• 대한원격탐사학회지
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• 제26권4호
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• pp.421-437
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• 2010

SeaWiFS자료를 Maximum Normalized Difference Carbon Index(MNDCI) 알고리즘을 이용하여 추정된 particulate organic carbon(POC)는 장강에서 유입된 담수의 영향을 받는 동중국해에서 시/공간적 해양환경 변화를 조사하는데 사용했다. 10년 평균한 POC 농도는 (1997년-2007년) 뚜렷한 계절적 변화를 보인다. POC 경년 변화는 전체 지역 평균값과 표준편차를 이용하여 세 개의 지역으로 나누어 평균한 결과에서 1998년 이후 꾸준한 감소를 보이는 장강과는 달리 감소되는 경향이 관측되지 않았다. 자세한 POC 시/공간적인 변화를 관측하기 위하여, 2000년부터 2007년까지 여름철 (6월-9월) 자료를 선정하여 empirical orthogonal function(EOF) 분석을 실시하였다. 첫 번째 성분은 장강으로부터 유입되는 담수의 영향으로 공간적인 변화가 이루어졌다. 두 번째 성분은 장강의 유출량과는 약한 상관관계를 보이고, 공간적으로 남-북 방향의 변화가 관측되었다. 2000년부터 2003년까지 상대적으로 높은 POC 분포는 연구지역 남쪽 부분에서 나타난다. 2004년부터 2007년까지 이런 변화는 연구지역 북쪽 부분에서 관측되었다. 장기적인 변화는 방류량의 감소에 의한 영향보다는 공간적인 변화에 기인한 것으로 사료되며, 이는 현장 관측자료에서 유사한 결과를 보였다.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.628-647
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• 2018

Purpose: Obesity is associated with metabolic dysregulation, but the underlying metabolic signatures involving clinical and inflammatory profiles of obese asthma are largely unexplored. We aimed at identifying the metabolic signatures of obese asthma. Methods: Eligible subjects with obese (n = 11) and lean (n = 22) asthma underwent body composition and clinical assessment, sputum induction, and blood sampling. Sputum supernatant was assessed for interleukin $(IL)-1{\beta}$, -4, -5, -6, -13, and tumor necrosis factor $(TNF)-{\alpha}$, and serum was detected for leptin, adiponectin and C-reactive protein. Untargeted gas chromatography time-of-flight mass spectrometry (GC-TOF-MS)-based metabolic profiles in sputum, serum and peripheral blood monocular cells (PBMCs) were analyzed by orthogonal projections to latent structures-discriminate analysis (OPLS-DA) and pathway topology enrichment analysis. The differential metabolites were further validated by correlation analysis with body composition, and clinical and inflammatory profiles. Results: Body composition, asthma control, and the levels of $IL-1{\beta}$, -4, -13, leptin and adiponectin in obese asthmatics were significantly different from those in lean asthmatics. OPLS-DA analysis revealed 28 differential metabolites that distinguished obese from lean asthmatic subjects. The validation analysis identified 18 potential metabolic signatures (11 in sputum, 4 in serum and 2 in PBMCs) of obese asthmatics. Pathway topology enrichment analysis revealed that cyanoamino acid metabolism, caffeine metabolism, alanine, aspartate and glutamate metabolism, phenylalanine, tyrosine and tryptophan biosynthesis, pentose phosphate pathway in sputum, and glyoxylate and dicarboxylate metabolism, glycerolipid metabolism and pentose phosphate pathway in serum are suggested to be significant pathways related to obese asthma. Conclusions: GC-TOF-MS-based metabolomics indicates obese asthma is characterized by a metabolic profile different from lean asthma. The potential metabolic signatures indicated novel immune-metabolic mechanisms in obese asthma with providing more phenotypic and therapeutic implications, which needs further replication and validation.

• 대한간호학회지
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• 제17권2호
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• pp.122-136
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• 1987

A group of studies revealed that family members of the seriously ill patient had some needs during the period of patient's hospitalization. Needs of the seriously-ill patient family could be classified into three aspect, i. e. needs on the prognosis of patient, needs on the well-being of family members themselves and needs on hospital environment. Several instrument were developed to measure the needs of the seriously ill patient, but their content tended to overemphasize the aspect of the prognosis of patient. The purpose of this study was to develop a new instrument to measure the needs in the aspect of the seriously ill patient's family themselves in details to increase the cummulative Percentage of the scale. Subjects were 134 family members of the seriously-ill patients, who were bung cared in ICU of seven university hospitals and data were collected from march 16, 1987 to April 11, 1987. The instrument used in this study was made by the author on the basis of results of literature review. Content valitity of the instrument was tested by a professor majoring in nursing and reliability by calculation of Cronbach's α with data of the respondents. Data was analyzed as follows, using SAS, computer system. Factor structures of the seriously ill patients' family needs were elicited by factor analysis. The programme was the Principal Component Factor Analysis Method of factoring employing Varimax Orthogonal Rotation. The influences of the demographic variables on the degree of the seriously-ill patients' family need were analyzed by t-test and P-test. Results were as follows. 1. Needs of the seriously-ill patients' family elicited and their cummulative percentage were: Needs to be supported emotionally, 29.2% Needs to be informed on facilities available, 9.6% Needs to be informed on the patient's prognosis, 7.7%. Needs to be supported spiritually, 5.1%. Needs to be informed on hospital environment, 4.2%. Needs to be helped to spare time, 3.9%. Needs to be informed on their role, 3.5%. Needs to be present near patient, 3.3%. 2. Educational background was found to influence on some factors. College-graduate group had higher Bevel of needs to be . informed on facilities available to be informed on the patient's prognosis, needs to be supported spiritually, needs to be helped to spare time, needs to be informed on their role than high school graduate group. 3. Among the parents, sons and daughters and the relative groups, the parents of the seriously ill patient had highest level of needs to be present near patient. Suggestions for further studies were as follows. 1. As the instruments used in the previous studies had high cummulative percentages in the aspect of the prognosis of patient and that in this study in the aspect of the prognosis of patient and that in this study in the aspect of the seriously ill patient's family themselves, development of a new instrument which combined the items of both of them is needed. 2. A study to clarify the influence of type and number of admission on need to be supported emotionally is needed.

• Biomolecules & Therapeutics
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• 제19권1호
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• pp.38-44
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• 2011

Cisplatin is widely used for various types of cancers. However, its side effects, most notably, renal toxicity often limit its clinical utility. Although previous metabolomic studies reported possible toxicity markers, they used small number of animals and statistical approaches that may not perform best in the presence of intra-group variation. Here, we identified urinary biomarkers associated with renal toxicity induced by cisplatin using NMR-based metabolomics combined with Orthogonal Projections to Latent Structures-Discriminant Analysis (OPLS-DA). Male Sprague-Dawley rats (n=22) were treated with cisplatin (10 mg/kg single dose), and the urines obtained before and after treatment were analyzed by NMR. Multivariable analysis of NMR data presented clear separation between non-treated and treated groups. The OPLS-DA statistical results revealed that 1,3-dimethylurate, taurine, glucose, glycine and branched-chain amino acid (isoleucine, leucine and valine) were significantly elevated in the treated group and that phenylacetylglycine and sarcosine levels were decreased in the treated group. To test the robustness of the approach, we built a prediction model for the toxicity and were able to predict all the unknown samples (n=14) correctly. We believe the proposed NMR-based metabolomics with OPLS-DA approach and the resulting urine markers can be used to augment the currently available blood markers.

• Journal of Animal Science and Technology
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• 제66권2호
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• pp.353-365
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• 2024

Rumen cannulation is a surgical technique used to collect rumen contents from ruminants. However, rumen cannulation surgery may potentially impact the composition of the rumen microbiota. This study aimed to examine the longitudinal alterations in the rumen microbiota composition of Hanwoo steers after cannulation surgery. In this study, eight Hanwoo steers were used; four steers underwent rumen cannulation surgery (cannulation group), while the remaining four were left intact (control group). Rumen samples were collected from all eight steers using the stomach tubing method on the day before surgery (day 0) and on postoperative days 1, 4, 7, 10, 14, 17, 21, 24, and 28, resulting in 80 samples (10 timepoints × 8 animals). The microbiota of all 80 samples were analyzed using 16S rRNA gene amplicon sequencing with Quantitative Insights into Microbial Ecology version 2 (QIIME2). There were no significant differences (p > 0.05) in all major phyla and most major genera representing at least 0.5% of total sequences across all 80 samples between the control and cannulation groups on the preoperative and postoperative days. However, while the alpha diversity indices did not differ (p > 0.05) between the two groups on the preoperative day, they significantly differed (p < 0.05) between the two groups on the postoperative days. Further, the overall microbial distribution based on both unweighted and weighted principal coordinate analysis plots significantly differed (p < 0.05) between the two groups on both the preoperative and postoperative days. Orthogonal polynomial contrasts indicated that major genera and microbial diversity in the cannulation group decreased following surgery but returned to their initial states by postoperative day 28. In conclusion, this study demonstrates that rumen cannulation surgery affects some major taxa and microbial diversity, suggesting that the rumen cannulation method can alter the composition of rumen microbiota in Hanwoo steers.

• 정보와 통신
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• 제15권11호
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• pp.124-142
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• 1998

ETSI BRAN (Broadband Radio Access Network)는 고속 무선 LAN 또는 고정 광대역 무선액세스 네트워크에서의 무선 접촉 계층과 ATM 및 IP(Internet Protocol) 코어 네트워크와의 연동을 위한 일부 기능을 표준화하기 위한 과제이다. 특히, BRAN의 HIPERLAN type-2(HIPERLAN/2)의 경우에는 과제의 범위는 무선 접속면, 무선 부시스템에서의 서비스 인터페이스, 서비스 구현에서 요구되는 연동 및 각종 지원 기능을 표준화하며, 무선 접속면의 경우에는 다수 벤더간의 상호 호환성을 제공할 수 있는 인터페이스를 구현하는 것이다. HIPERLAN/2의 기술 규격은 코어 네트워크와 독립적인 물리계층 및 데이터 링크 제어 (DATA Link Control: DLC) 계층과 서로 상이한 코어 네트워크와의 연동을 위한 네트워크 수렴 부계층을 다루게 될 것이며, 초기 단계에서는 ATM과 IP 코어 네트워크와의 연동 기능을 제시하게 될 것이다. 따라서 HIPERLAN/2기반의 시스템 규격을 제시하기 위해서는 네트워크 계층 및 기타 상위 계층에 대한 규격이 요규되며, 이는 ATM Forum에서의 무선 ATM 신호 방식 규격, IETF(Internet Engineering Task Force)의 IP규격, 그리고 ETSI의 SMG (Special Mobile Group) 프로젝트에서 표준화되고 있는 UMTS (Universal Mobile Telecommunication Service) 규격 등과 접목될 것이다. 결과적으로 무선 ATM 관점에서는 완전한 시스템 규격 작성은 ETSI BRAN과 ATM Forum에서 무선 접속 규격과 이동성 관리 및 신호 방식으로 각각 이원화되어 진행되고 있다. 현재 물리 계층에서의 전송 방식은 OFDM(Orthogonal Frequency Division Multiplexing)으로 확정되었으며, DLC 계층에서는 고정 길이의 TDD (Time Division Duplexing) TDMA 프레임 구조를 기반으로 AP (Access Point)에 의해 동적으로 상향 링크 자원을 예약 할당하는 매체 접근 제어 (Medium Access Control: MAC) 프로토콜이 고려되고 있다. 이와 같은 DLC 계층에서는 기본적으로 짧은 길이의 패킷을 통해 다양한 대역폭의 멀티미디어 트래픽을 효율적으로 수용하면서 ATM 네트워크뿐만 아니라 향후 IP 네트워크에서 요구하는 각 서비스별 QoS (Quality of Service)를 개별적으로 보장할 수 있는 기능을 구현하고자 한다. 향후 이 부문에 대한 표준화가 본격적으로 진행될 것으로 예상되며 HIPERLAN/2의 경우에는 1999년 중반까지 1차 기능 규격을 완료할 예정이며, BRAN 전반에 대한 완전한 규격을 2002년까지 완성하는 것을 목표로 하고 있다.

• 한국전산유체공학회지
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• 제20권2호
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• pp.7-15
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• 2015

This paper attempts to evaluate the accuracy and efficiency of a design optimization procedure by combining wavelets-based multi resolution analysis method and proper orthogonal decomposition (POD) technique. Aerodynamic design procedure calls for high fidelity computational fluid dynamic (CFD) simulations and the consideration of large number of flow conditions and design constraints. Thus, even with significant computing power advancement, current level of integrated design process requires substantial computing time and resources. POD reduces the degree of freedom of full system by conducting singular value decomposition for various field simulations. In this research, POD combined Design Optimization model is proposed and its efficiency and accuracy are to be evaluated. For additional efficiency improvement of the procedure, multi resolution analysis method is also being employed during snapshot constructions (POD training period). The proposed design procedure was applied to the optimization of wing aerodynamic performance. Throughout the research, it was confirmed that the POD/MRA design procedure could significantly reduce the total design turnaround time and also capture all detailed complex flow features as in full order analysis.

• 한국의류학회지
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• 제25권4호
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• pp.795-806
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• 2001

This study is to classify the somatotypes of middle-aged women by many critera and figure out he characteristics of each somatotypes. The subjects are 614 middle-aged women between 35 and 59 years old and the research is based on anthropometric and photometric measurement by photographing their body parts. The results are as follows; 1. The result of factor analysis indicated that 11 factors were extracted through factor analysis and orthogonal rotation by the method of varimax and those factors comprised 85.71 percent of total variance. 2. As the result of cluster analysis the group of the middle-aged women is classified as 6 types. Type 1 is short, fat, H type in front and lean-back type on the side. Type 2 is standard in height and weight. Type 3 is standard height, fat, long upper body, bend-forward type and protrude of the hip on the side. Type 4 is tall, thin, short upper body, having clearly protrude of the back and hip and lean-back type on the side. Type 5 is neither short nor tall, slim, X type in front and I type on the side. Type 6 is tall, thin and B type on the side. 3. As the result of observing the mutual corresponding relation between these 6 groups and age/Rohrers Index, the somatotype of the middle-aged women is divided at the age of 45. Accordingly when it comes to progress the study of the middle-aged women in the future, we will have to observe the characteristics for dividing the first half and the second half of age of 45.

• 대한수학회보
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• 제22권2호
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• pp.121-126
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• 1985

D.K. Harrison [5] has shown that if R and S are fields of characteristic different from 2, then two Witt rings W(R) and W(S) are isomorphic if and only if W(R)/I(R)$^{3}$ and W(S)/I(S)$^{3}$ are isomorphic where I(R) and I(S) denote the fundamental ideals of W(R) and W(S) respectively. In [1], J.K. Arason and A. Pfister proved a corresponding result when the characteristics of R and S are 2, and, in [9], K.I. Mandelberg proved the result when R and S are commutative semi-local rings having 2 a unit. In this paper, we prove the result when R and S are 2-fold full rings. Throughout this paper, unless otherwise specified, we assume that R is a commutative ring having 2 a unit. A quadratic space (V, B, .phi.) over R is a finitely generated projective R-module V with a symmetric bilinear mapping B: V*V.rarw.R which is nondegenerate (i.e., the natural mapping V.rarw.Ho $m_{R}$ (V, R) induced by B is an isomorphism), and with a quadratic mapping .phi.:V.rarw.R such that B(x,y)=(.phi.(x+y)-.phi.(x)-.phi.(y))/2 and .phi.(rx)= $r^{2}$.phi.(x) for all x, y in V and r in R. We denote the group of multiplicative units of R by U(R). If (V, B, .phi.) is a free rank n quadratic space over R with an orthogonal basis { $x_{1}$, .., $x_{n}$}, we will write < $a_{1}$,.., $a_{n}$> for (V, B, .phi.) where the $a_{i}$=.phi.( $x_{i}$) are in U(R), and denote the space by the table [ $a_{ij}$ ] where $a_{ij}$ =B( $x_{i}$, $x_{j}$). In the case n=2 and B( $x_{1}$, $x_{2}$)=1/2, we reserve the notation [ $a_{11}$, $a_{22}$] for the space.the space.e.e.e.

• 대한전자공학회논문지TC
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• 제47권7호
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• pp.85-92
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• 2010

본 연구에서는 무선 개인 영역망 (WPAN, wireless personal area network) 환경에서 OFDM기반 전송을 위한 빔 스위칭 기술과 시공간부호 기술을 고려한다. 특히, 빔포밍 방법과 시공간부호를 이용한 공간 다이버시티 방식 그리고 이 둘을 결합한 빔포밍 기반 시공간 부호화 방식에 대한 성능 평가를 수행한다. 빔 포밍의 경우 RF단에서 빔포밍을 수행하는 Front-end 방식만을 고려하며 따라서 미리 정해진 코드북을 이용하는 블록 빔스위칭 방식에 대한 성능평가를 수행한다. 시공간부호를 이용한 공간 다이버시티 방식의 경우, 여러 개의 안테나 중 SNR 이득이 가장 큰 2개의 안테나를 선택하여 Alamauti 방식을 적용하는 안테나 선택 시공간부호 방식을 가정하여 성능평가를 수행한다. 빔포밍 기반 시공간부호화 방식에 대해서는 전체 안테나를 인접한 두 개의 안테나 그룹으로 나누고 각각의 안테나 그룹에 대해 독립적인 빔스위칭을 적용하는 방식을 고려하며 송수신단의 대칭성을 고려하여 수신단에서도 2개의 수신 안테나 그룹만을 사용하는 시스템만을 고려한다. 이 세가지 방식에 대한 성능 평가결과 시공간 부호화를 추가로 적용할 때 추가적인 이득이 얻어질 수 있음을 알 수 있었다.