• Journal of Information Processing Systems
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• 제15권3호
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• pp.682-693
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• 2019

The traditional classification methods mostly assume that the data for class distribution is balanced, while imbalanced data is widely found in the real world. So it is important to solve the problem of classification with imbalanced data. In Mahalanobis-Taguchi system (MTS) algorithm, data classification model is constructed with the reference space and measurement reference scale which is come from a single normal group, and thus it is suitable to handle the imbalanced data problem. In this paper, an improved method of MTS-CBPSO is constructed by introducing the chaotic mapping and binary particle swarm optimization algorithm instead of orthogonal array and signal-to-noise ratio (SNR) to select the valid variables, in which G-means, F-measure, dimensionality reduction are regarded as the classification optimization target. This proposed method is also applied to the financial distress prediction of Chinese listed companies. Compared with the traditional MTS and the common classification methods such as SVM, C4.5, k-NN, it is showed that the MTS-CBPSO method has better result of prediction accuracy and dimensionality reduction.

• Current Optics and Photonics
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• 제3권2호
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• pp.150-153
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• 2019

Larynx cancer is a potentially terminal and severe type of neck and head cancer in which malignant cells start to grow and spread upwards in the larynx, or voice box. Smoking tobacco, drinking hot beverages and drinking alcohol are the main risk factors for these tumors. In this study, we aimed to develop a precise, accurate and rapid chemometrics assisted Raman spectroscopy method for diagnosis of larynx cancer in deparaffinized tissue samples. In the proposed method, samples were deparaffinized and 20 microns of each tissue were located on a coverslip. Both healthy (n = 13) and cancerous tissues (n = 13) were exposed to a Raman laser (785 nm) and excitations were recorded between wavenumbers of $50{\sim}1500cm^{-1}$. An Orthogonal Partial Least Square algorithm was applied to evaluate the Raman spectrum obtained. Sensitivity and specificity of the proposed method is high enough with the aid of Principal Component Analysis (PCA) to test the whole model. Healthy and cancerous tissues were accurately and precisely clustered. A rapid, easy and precise diagnosis algorithm was developed for larynx cancer. By this method, some useful data about differences in biomolecules of each group (phospholipids, amides, tyrosine, phenylalanine collagen etc.) was also obtained from the spectra. It is claimed that the optimized method has a great potential for clustering and separating tumor tissues from healthy ones. This novel, rapid, precise and objective diagnosis method may be an alternative for the conventional methods in literature for diagnosis of larynx cancer.

• 한국미생물·생명공학회지
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• 제51권1호
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• pp.69-82
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• 2023

Nitrilases are a hydrolase group of enzymes that catalyzes nitrile compounds and produce industrially important organic acids. The current objective is to optimize nitrilase production using statistical methods assisted with artificial intelligence (AI) tool from novel nitrile degrading isolate. A nitrile hydrolyzing bacteria Bacillus subtilis AGAB-2 (GenBank Ascension number- MW857547) was isolated from industrial effluent waste through an enrichment culture technique. The culture conditions were optimized by creating an orthogonal design with 7 variables to investigate the effect of the significant factors on nitrilase activity. On the basis of obtained data, an AI-driven support vector machine was used for the fitted regression, which yielded new sets of predicted responses with zero mean error and reduced root mean square error. The results of the above global optimization were regarded as the theoretical optimal function conditions. Nitrilase activity of 9832 ± 15.3 U/ml was obtained under optimized conditions, which is a 5.3-fold increase in compared to unoptimized (1822 ± 18.42 U/ml). The statistical optimization method involving Plackett Burman Design and Response surface methodology in combination with an AI tool created a better response prediction model with a significant improvement in enzyme production.

• Nuclear Engineering and Technology
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• 제55권6호
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• pp.2172-2194
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• 2023

A variational nodal method (VNM) with unstructured-mesh is presented for solving steady-state and dynamic neutron diffusion equations. Orthogonal polynomials are employed for spatial discretization, and the stiffness confinement method (SCM) is implemented for temporal discretization. Coordinate transformation relations are derived to map unstructured triangular nodes to a standard node. Methods for constructing triangular prism space trial functions and identifying unique nodes are elaborated. Additionally, the partitioned matrix (PM) and generalized partitioned matrix (GPM) methods are proposed to accelerate the within-group and power iterations. Neutron diffusion problems with different fuel assembly geometries validate the method. With less than 5 pcm eigenvalue (k_eff) error and 1% relative power error, the accuracy is comparable to reference methods. In addition, a test case based on the kilowatt heat pipe reactor, KRUSTY, is created, simulated, and evaluated to illustrate the method's precision and geometrical flexibility. The Dodds problem with a step transient perturbation proves that the SCM allows for sufficiently accurate power predictions even with a large time-step of approximately 0.1 s. In addition, combining the PM and GPM results in a speedup ratio of 2-3.

• 한국통신학회논문지
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• 제31권12C호
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• pp.1135-1142
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• 2006

본 논문에서는 전송률이 서로 다른 다양한 서비스들을 지원하기 위한 새로운 비동기 MC-CDMA 시스템을 제안한다. 제안한 시스템에서는 W-CDMA 하향링크에 사용되는 채널화 코드인 OVSF 코드의 생성특성을 이용하여 발생된 OVSF 코드를 다중전송률 MC-CDMA의 확산부호로 사용한다. 사용자의 전송률에 따라 길이가 다른 OVSF 코드를 확산부호로 사용하며 OVSF 코드트리에서 같은 가지에 속한 코드들을 사용하는 사용자들을 모아 그룹화를 한다. 코드그룹화 간섭제거방식을 사용하여 그룹간 간섭을 일차적으로 제거하는데, 이때 간섭을 일으키는 다른 사용자들에 대한 정보가 요구되지 않는다. 제안된 다중 전송률 비동기 MC-CDMA 시스템을 위한 모델을 제시하고 이에 따른 시스템 성능분석을 행한다. 제안된 시스템과 직교부호를 확산부호로 사용하는 단일 전송률 MC-CDMA시스템의 성능과 비교 분석한다.

• 보건행정학회지
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• 제19권4호
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• pp.98-120
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• 2009

The purpose of this study is to elicit preference for drug listing decision criteria and to estimate the ICER threshold in South Korea using the discrete choice experiment (DCE) method. To collect the data, a DCE survey was administered to a subject sample either educated in the principle concepts of pharmacoeconomics or were decision makers within that field. Subjects chose between alternative drug profiles differing in four attributes: ICER, uncertainty, budget impact and severity of disease. The orthogonal and balanced designs were determined through computer algorithm to take the optimal set of drug profiles. The survey employed 15 hypothetical choice sets. A random effect probit model was used to analyze the relative importance of attributes and the probabilities of a recommendation response. Parameter estimates from the models indicated that three attributes (ICER, Impact, Severity of disease) influenced respondents' choice significantly(p${\pm}$0.001). In addition, each parameter displayed an expected sign. The Lower the ICER, the higher the probability of choosing that alternative. Respondents also preferred low levels of uncertainty and smaller impact on health service budget. They were also more likely to choose drugs for serious diseases rather than mild or moderate ones. Uncertainty however is not statistically significant. The ICER threshold, at which the probability of a recommendation was 0.5, was 29,000,000 KW/QALY in expert group and 46,500,000 KW/QALY in industry group. We also found that those in our sample were willing to accept high ICER to get medication for severe diseases. This study demonstrates that the cost-effectiveness, budget impact and severity of disease are the main reimbursement decision criteria in South Korea, and that DCE can be a useful tool in analyzing the decision making process where a variety of factors are considered and prioritized.

• 대한수학회보
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• 제22권1호
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• pp.11-15
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• 1985

Manddelberg [9] has shown that a Clifford algebra of a free quadratic space over an arbitrary semi-local ring R in Brawer-Wall group BW(R) is determined by its rank, determinant, and Hasse invariant. In this paper, we prove a corresponding result when R is a full ring.Throughout this paper, unless otherwise specified, we assume that R is a commutative ring having 2 a unit. A quadratic space (V, B, .phi.) over R is a finitely generated projective R-module V with a symmetric bilinear mapping B: V*V.rarw.R which is non-degenerate (i.e., the natural mapping V.rarw.Ho $m_{R}$(V,R) induced by B is an isomorphism), and with a quadratic mapping .phi.: V.rarw.R such that B(x,y)=1/2(.phi.(x+y)-.phi.(x)-.phi.(y)) and .phi.(rx) = $r^{2}$.phi.(x) for all x, y in V and r in R. We denote the group of multiplicative units of R by U9R). If (V, B, .phi.) is a free rank n quadratic space over R with an orthogonal basis { $x_{1}$,.., $x_{n}$}, we will write < $a_{1}$,.., $a_{n}$> for (V, B, .phi.) where the $a_{i}$=.phi.( $x_{i}$) are in U(R), and denote the space by the table [ $a_{ij}$ ] where $a_{ij}$ =B( $x_{i}$, $x_{j}$). In the case n=2 and B( $x_{1}$, $x_{2}$)=1/2 we reserve the notation [a $a_{11}$, $a_{22}$] for the space. A commutative ring R having 2 a unit is called full [10] if for every triple $a_{1}$, $a_{2}$, $a_{3}$ of elements in R with ( $a_{1}$, $a_{2}$, $a_{3}$)=R, there is an element w in R such that $a_{1}$+ $a_{2}$w+ $a_{3}$ $w^{2}$=unit.TEX>=unit.t.t.t.

• Journal of Communications and Networks
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• 제7권2호
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• pp.115-125
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• 2005

This paper discusses how to effectively design a next-generation wireless communication system that can possibly provide very high data-rate transmissions and versatile quality services. In order to accommodate the sophisticated user requirements and diversified user environments of the next-generation systems, it should be designed to take an efficient and flexible structure for multiple access and resource allocation. In addition, the design should be optimized for cost-effective usage of resources and for efficient operation in a multi-cell environment. As orthogonal frequency division multiple access (OFDMA) has turned out in recent researches to be one of the most promising multiple access techniques that can possibly meet all those requirements through efficient radio spectrum utilization, we take OFDMA as the basic framework in the next-generation wireless communications system design. So, in this paper, we focus on introducing an OFDMA-based downlink system design that employs the techniques of hybrid multiple access (HMA) and frequency group (FG) in conjunction with intra-frequency group averaging (IFGA). The HMA technique combines various multiple access schemes on the basis of OFDMA system, adopting the multiple access scheme that best fits to the given user condition in terms of mobility, service, and environment. The FG concept and IFGA technique help to reduce the feedback overhead of OFDMA system and the other-cell interference (OCI) problem by grouping the sub-carriers based on coherence band-widths and by harmonizing the channel condition and OCI of the grouped sub-carriers.

• Animal Bioscience
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• 제35권6호
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• pp.858-868
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• 2022

Objective: This study was conducted to evaluate the effects of dietary yeast hydrolysate (YH) supplementation on intestinal morphology, barrier, and anti-inflammatory functions of broilers. Methods: A total of 320 one day old male broilers were randomly allocated into four groups with eight replicates of ten broilers each. The broilers were supplemented with a basal diet (the control group) or basal diets adding 50, 100, 150 mg/kg YH, respectively. This trial lasted for 42 days. The orthogonal polynomial contrasts were used to determine the linear and quadratic effects of increasing levels of YH. Results: In our previous research, supplementing YH improved growth performance by enhancing body weight gain but decreased feed-to-gain ratio. In this study, compared with the control group, dietary YH addition linearly and quadratically decreased serum diamine oxidase activity (p<0.05). Additionally, supplementing YH linearly and/or quadratically decreased jejunal crypt depth (CD), tumor necrosis factor-alpha (TNF-α) concentration as well as mucin 2, interleukin-6 (IL-6), IL-1β, TNF-α, nuclear factor kappa B, and myeloid differentiation factor 88 gene expression levels (p<0.05). Whereas the jejunal villus height (VH), VH/CD, IL-10 concentration as well as zonula occludens-1 and IL-10 gene expression levels were linearly and/or quadratically increased by YH supplementation (p<0.05). Conclusion: Dietary YH supplementation improved intestinal morphology, barrier and anti-inflammatory functions while decreased intestinal permeability of broilers, which might be related with altering pertinent genes expression. This study provides evidence of YH as a promising feed additive for broilers.

• 한국의학물리학회지:의학물리
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• 제26권4호
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• pp.286-293
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• 2015

본 연구의 목적은 폐암의 정위체부방사선 치료 환자에 대하여 정위체부고정기구 사용 유무에 따른 셋업 정확성을 비교 평가하고자 한다. 본원에서 정위체부방사선치료를 받은 총 40명의 환자를 대상으로, 정위체부고정기구를 기반으로 한셋업 방식의 환자군 20명과 고정기구 없이 Wing board를 사용한 환자군 20명으로 구분하여 각 셋업오차를 비교, 분석 하였다. 폐암의 정위체부방사선치료는 총 4~5회에 걸쳐 48~60 Gy 조사되었다. 매 치료 전, 먼저 레이저를 이용하여 환자를 치료중심점에 위치시킨 후 On-board kV 영상장치를 이용하여 2차원 직각영상을 얻어 척추를 기준으로 환자의 위치를 조정한 다음, 3차원 체적 영상을 획득 하여 종양의 위치를 치료중심점에 일치시키고, 마지막으로 호흡에 의한 종양의 위치 확인 및 조정을 위해 2차원 직각 투시영상을 이용하였다. 각 과정에서 얻은 테이블 이동 및 회전 값을 조사하여, 셋업 군별로 계통오차 및 랜덤오차를 구하였다. 고정기구 사용유무에 따른 통계적 유의성을 검증하기 위하여 계통오차에 대한 t-test 시행을 하였고, 셋업의 재현성의 차이를 보기위해 랜덤오차에 대한 F-test를 시행하였다. 나아가 이러한 셋업 방식의 차이가 셋업 여유분의 크기 결정에 영향이 있는지 여부를 평가하기위해 치료계획체적의 여유분을 계산하여 두 방식의 차이를 비교하였다. 정위체부 고정기구를 사용했을 때의 셋업 오차는 수직방향, 길이방향, 수평방향으로 각각 $0.05{\pm}0.25cm$, $0.20{\pm}0.38cm$, $0.02{\pm}0.30cm$이었다. 반면에, Frameless immobilizer을 사용한 단순 고정방법을 사용했을 때의 셋업 오차는 수직방향에서만 통계적으로 유의하게 $-0.24{\pm}0.25cm$으로 증가함을 보였으나, 길이방향, 수평방향에 대해서는 각각 $0.06{\pm}0.34cm$, $-0.02{\pm}0.25cm$의 작거나 비슷한 결과값을 보였다. 정위체부 고정기구를 사용했을 경우, 수직방향, 수직방향 및 길이방향으로의 여유분은 각각, 0.67 cm, 0.99 cm, 0.83 cm였고, Frameless immobilizer시 수직방향으로 0.75 cm, 길이방향으로 0.96 cm, 수평방향으로 0.72 cm로써 수평방향에서 최대 0.11 cm 차이가 남을 알 수 있었다. 결론적으로 정위체부고정기구를 사용하는 것이 환자 자세 재현성을 향상시켜 셋업 오차를 환자의 전후, 위아래 방향으로의 약 0.1~0.2 cm씩 줄일 수 있을 것으로 평가하였다. 다만 정위체부 고정기구 사용에 따른 시간 소요 및 치료절차의 복잡성에 비해 그 효과는 그리 크지 않았다.