• Animal cells and systems
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• v.3 no.1
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• pp.53-58
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• 1999

The immunocytochemical method was used to identify the existence of voltage-dependent $Ca^{2＋}$-channels in mouse follicular oocytes. Three types of voltage-dependent $Ca^{2＋}$-channels were shown to exist in the follicular oocytes for the first time, the P/Q-type $Ca^{2＋}$-channel, the N-type $Ca^{2＋}$-channel, and the L-type $Ca^{2＋}$-channel. Among proven $Ca^{2＋}$-channels distributions of the P/Q-type $Ca^{2＋}$-channel and L-type $Ca^{2＋}$-channel showed localized staining (clustered pattern) on the oolemma. The distribution of the P/Q-type $Ca^{2＋}$-channel showed all localized staining, and the range of localized staining was from 1 to 8 in staining intensity. As the staining intensity increased from 1 to 8, the number of localized staining decreased. The L-type $Ca^{2＋}$-channel are homogeneously stained (29.4%-54.2%), while some of them (around 28.7%-44.1%) showed localized staining on the oolemma. However, the rest of them showed no staining at all (17.1%- 26.5%). On the contrary, the N-type $Ca^{2＋}$-channel showed mostly homogeneous staining, while nonstaining oocytes were around 33.8%. The rest showed localized staining (10%). However, staining intensity was much weaker than those of the P/Q-type and L-type $Ca^{2＋}$-channel. In fact, the N-type $Ca^{2＋}$-channel has been known to exist only in neurons (from ectoderm origin), but it is unknown how the N-type $Ca^{2＋}$-channel exists in the follicular oocytes (from mesoderm origin). Further studies are needed to examine the expression of $Ca^{2＋}$-channels during the developmental stages of the oocytes.

• Korean Journal of Pharmacognosy
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• v.49 no.2
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• pp.145-154
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• 2018

Aconiti Kusnezoffii Tuber has been traditionally used to treat the symptoms of rheumatoid arthritis and joint pain. The main constituents are diterpenoid alkaloids such as benzoylmesaconine, benzoylaconine, mesaconitine, aconitine, and hypaconitine. In Korea, Aconiti Kusnezoffii Tuber is officially defined as the tubers of Aconitum kusnezoffii Reichb., A. ciliare Decasisne, and A. triphyllum Nakai. On the other hand, only the tuber of A. kusnezoffii is to be used in China. In order to identify the botanical origin of Aconiti Kusnezoffii Tuber circulated in Korea, we analyzed 24 samples of Aconiti Kusnezoffii Tuber obtained from local markets for comparative DNA analysis. The sequence analysis of nrRNA ITS 1 was useful to distinguish Aconitum species and revealed that the roots of A. karakolicum were circulated in Korean markets without discretion. HPLC quantitative analysis showed that aconitine was detected at the highest amount in A. karakolicum. Authentic diterpenoid alkaloids were coinjected for quantification of aconitine-type ingredients. All data were statistically grouped by Principal Component Analysis (PCA). This study suggests that both molecular and chemical analyses should be utilized for the standardization and the quality control for Aconiti Kusnezoffii Tuber.

• Journal of the Korean Society of Clothing and Textiles
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• v.38 no.5
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• pp.611-626
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• 2014

Reading and foreseeing fashion trends is crucial and difficult in the fashion industry due to accelerated and diversified changes in fashion trends. We use network analysis to investigate fashion trends from 2004 to 2013 in order to find the inter-relevance among fashion trends. We extracted words from fashion trend info for women's wear provided by Samsung Design Net, created a 2-mode network of seasons and trend languages, and visualized this network using NodeXl program. Fashion trends repeated a unique pattern during the period. In the first half (2004-2008), retro modern, feminine modern, and ecological modern were dominant trends in consecutive order. The years 2009-2013 witnessed distinctive fashion trends in S/S seasons and in F/W seasons. 11F/W, 12F/W and 13F/W seasons were characterized by artistic creative style. From 2010, natural style dominated S/S seasons. 10S/S and 12S/S seasons were distinguished as a calm natural style that reflected a peaceful and simple life. In 11S/S and 13S/S seasons, soft natural style emerged as a sign of increased importance of inner spirit and natural energy. A seasonal reappearance of trends was observed every two years in S/S seasons that enabled the prediction that 14S/S will see another version of natural style. A macroscopic trend for the last 10 years was represented by the keywords 'modern' and 'natural'. 'Modern' involved the past styles such as 60's, Baroque and the origin of human life. 'Natural' was connected with design elements such as material, silhouette and color. Managerial implications and future study directions are discussed based on the results.

• Korean Institute of Interior Design Journal
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• v.17 no.1
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• pp.93-101
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• 2008

One of the big difference between Aalto and other modem architects lies in an attitude that Aalto went beyond the principle of dogmatic functionalism. As an architect of Northern Europe, Aalto made unique architecture that showed both the language of modem architecture and vernacular architecture. He presented the best example which showed modernity in architecture without losing the meaning of the context including site, region and cultural tradition. With this background, Aalto developed his own typological design approach. As Wolfsburg church was designed in his prime of time, it showed the origin and evolutionary process of religious architecture as well as general features of Aalto's design. Clustered site plan, dynamic space of interior, the adequate control of natural light are representative characteristics found in Aalto's religious architecture. Wolfsburg church also demonstrate these features in more specific way including the continuity of wall and ceiling that showed spatial dynamics, free opening of wall which reflects on functions, and careful adjust of natural light. As a result, Aalto showed his typological design strategy that added new design ideas to the accumulated design vocabularies in the design of Wolfsburg church.

• The Bulletin of The Korean Astronomical Society
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• v.42 no.1
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• pp.36.3-36.3
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• 2017

The Telescope Array (TA) experiment reported the arrival direction distribution of ultra-high-energy cosmic rays (UHECRs) with energies above $5.7{\times}10^{19}eV$ in the northern sky. A clustering of TA events, the so-called hotspot, was found; however, its nature has not yet been understood. To understand the origin of the TA hotspot, we examine the sky distributions of the TA UHECR arrival direction and filamentary structures of galaxies in the local universe. By statistical tests for anisotropy, we find a close correlation of the TA events with the filaments of galaxies connected to the Virgo cluster. We discuss our finding and its implications.

• The Bulletin of The Korean Astronomical Society
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• v.43 no.1
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• pp.35.2-35.2
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• 2018

Magnetic fields in clusters of galaxies play a critical role in shaping up the intracluster medium. Their existence has been established through observations of synchrotron emission, especially from radio relics and halos, as well as observations of rotation measure. In the so-called Sausage relic, which is one of Mpc-size giant radio relics detected in the outskirts of merging clusters, for instance, the magnetic fields are believed to have a few ${\mu}G$ strength and a Mpc scale. The observed magnetic fields are conjectured to be produced by the process of small-scale turbulence dynamo. To investigate the dynamo origin, we simulate the development of turbulence and the follow-up amplification of magnetic fields in galaxy clusters using a three-dimensional magnetohydrodynamical(MHD) code. Turbulence is induced in highly stratified backgrounds expected in clusters, and driven sporadically mimicking major mergers. We here present preliminary results, aiming to answer whether the turbulence dynamo scenario can explain observed magnetic fields in clusters of galaxies.

• Proceedings of the Membrane Society of Korea Conference
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• 1998.04a
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• pp.31-35
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• 1998

1. INTRODUCTION : Recognition and binding of organic substrates by biological molecules are of vital importance in biophysics and biophysical chemistry. Most studies of the application focused on the development of biosensors, which detected reaction products generated by the binding between enzymes and substrates. Other types of biosensors in which membrane proteins (e.g., nicotinic acetylcholine receptor, auxin receptor ATPase, maltose bining protein, and glutmate receptor) were utilized as a receptor function were also developed. In the previous study[1], the shifts in membrane potential, caused by the injection of substrates into a permeation cell, were measured using immobilized glucose oxidase membranes. It was suggested that the reaction product was not the origin of the potential shifts, but the changes in the charge density in the membrane due to the binding between the enzyme and the substrates generated the potential shifts. In this study, $\gamma$-globulin was immobilized (entrapped) in a poly($\gamma$-amino acid) network, and the shifts in the membrane potential caused by the injection of some amino acids were investigated.

• Korean Journal of Pharmacognosy
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• v.4 no.4
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• pp.181-184
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• 1973

In the light of quality comparison the ratio of panaxadiol and panaxatriol contents was assayed in the extract of various ginseng products, whose origin of production and species of the original plants are different. Aglycone compositions of other ginsengs were not comparable with Korean ginseng in their ratio of panaxadiol and panaxatriol contents of dammarane glycosides.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.35 no.1
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• pp.1-9
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• 2009

South Asian's growing obsession with fair skin has made the cosmetic industry into a multibillion-dollar trade over the last decade alone. With reports of toxicity and potential mutagenicity of conventional skin lightening agents, cosmetic industries are looking for plant-based skin whitening formulations. In this review some potential depigmentation agents from South Asian region are discussed, including their historical background, biochemical characteristics and recent findings on their depigmenting activity.

• Journal of Integrative Natural Science
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• v.5 no.2
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• pp.72-78
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• 2012

Multidrug resistance is a major obstacle in cancer chemotherapy. Cancer cells efflux chemotherapeutic drug out of cell by means of transporter and reduce the active concentration of it inside cell. Such transporters are member of the ATP binding cassettes (ABC) protein. It includes P-gp, multiple resistant protein (MRP), and breast cancer resistant protein (BCRP). These proteins are widely distributed in the human cells such as kidney, lung, endothelial cells of blood brain barrier etc. However, there are number of drugs developed for it, but most of them are getting transported by it. So, still there is necessity of a good modulator, which could effectively combat the transport of chemotherapeutic agents. Natural products origin modulators were found to be effective against transporter such as flavonoids, which belongs to third generation modulators. They have advantage over synthetic inhibitor in the sense that they have simple structure and abundant in nature. This review focuses on the P-gp structure its architecture, efflux mechanism, herbal inhibitors and their mechanism of action.