• 한방비만학회지
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• 제17권2호
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• pp.68-76
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• 2017

Objectives: The purpose of this study was to analyze the factors affecting weight loss effect of Gamitaeumjowee-tang and to see if weight loss could be predicted using influence factors and weight loss progress. Methods: From September 2016 to March 2017, we retrospectively reviewed the medical records of 139 patients who were visited to the Korean Oriental Clinic for 3 months. We conducted a regression analysis to determine whether age, gender, initial weight, patient health questionnaire-9, heart rate variability (HRV), sleep quality, drinking habit and the medication history of weight loss affect weight loss. We found weight loss prediction equations using multiple regression analysis applying significant factors and weight loss progress. Results: Gender and initial weight had a significant effect on weight loss in all periods (P<0.001). HRV had a significant effect on primary weight loss (P<0.01). Other factors did not have any significant effect on weight loss. Using the significant factors, weight loss of each period could be predicted from 23.9% to 44.6%, and tertiary weight loss could be predicted with 76.6% using factors, primary weight loss and secondary weight loss (P<0.001). Conclusions: This study suggests that weight loss effect of Gamitaeumjowee-tang maybe be affected by influence factors and that weight loss prediction equations using them can be used for obesity treatment.

• 동의생리병리학회지
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• 제32권6호
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• pp.361-369
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• 2018

The purpose of this study was to review the herbal medications of asthma through clinical studies in Korea and to be utilized in the treatment of asthma and in other clinical studies. All clinical researches about asthma published up to 13th February 2018 were found in two domestic electric databases, Oriental Medicine Advanced Searching Integrated System(OASIS) and National Discovery for Science Library(NDSL). Twenty-seven articles were selected and of these, there were 14 articles of before and after studies(BAS), 8 of case series(CS), 4 of case reports(CR) and 1 of the randomized controlled trial(RCT). The most frequently used prescription was "Cheongsangboha-tang(淸上補下湯)". There were various TCM patterns, and Tae-Eum-In(太陰人) was the most common Sasang constitution(四象體質). Frequently used evaluations to assess treatment effects were lung function tests such as Forced expiratory volume at one second (FEV1) and Quality of Life Questionnaire for Adult Korean Asthmatics(QLQAKA) questionnaire responses. We have found that herbal medicine treatment can be an effective treatment to improve the symptoms and the quality of life of asthmatic patients. But we consider that large-scale systematically designed clinical researches are needed additionally.

• 대한한방내과학회지
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• 제42권5호
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• pp.767-776
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• 2021

Objective: This study examined a case in which insomnia and pain due to herniated intervertebral disks were improved by treatment with an oriental herbal and the administration of Uhwangchungsim-won. Case Summary: Three patients with insomnia diagnosed with herniated intervertebral disks were treated with a series of Korean medical therapies, including the herbal medication Uhwangchungsim-won, acupuncture, herbal acupuncture, and physical therapy. We used the Numerical Rating Scale (NRS) to measure subjective sleep states and the European Quality of Life Five Dimensions (EQ-5d) Scale to evaluate the therapeutic effect. Following treatment, subjective sleep states and the overall scores for pain had improved. Conclusion: The results indicate that Korean medical therapies with Uhwangchungsim-won have beneficial effects on insomnia for patients with herniated intervertebral disks.

• 대한약침학회지
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• 제23권4호
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• pp.201-211
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• 2020

Objectives: The purpose of this study is to comprehensively review Korean domestic studies and investigate the research trends of pharmacopuncture therapy on cervical pain caused by traffic accidents. Methods: Domestic studies between February 1999 and May 2020 from four Korean databases were searched with combinations of keywords 'cervical pain', 'traffic accident', 'whiplash injury', and 'pharmacopuncture'. Results: 17 studies were selected for review, including 7 randomized controlled trials, 5 retrospective observational studies, 3 case reports, and 2 non-randomized controlled trials. Each study was reviewed by published year, study type, types of pharmacopuncture solutions, selected acupuncture points, dosage of pharmacopuncture solutions, frequency of treatment, concurrent treatments, outcome measurements, and the effectiveness of pharmacopuncture therapy. The results are as follows: (1) It showed that the total number of published studies had increased slightly in the last 10 years compared to the previous decade. (2) The pharmacopuncture solutions used in the studies were in the following order: Bee-Venom (蜂毒), Jungsongouhyul (中性瘀血), Hwangryunhaedoktang (黃連解毒湯) and Soyeom (消炎). Frequently used acupuncture points were GB20, GV21, A-shi point, GV16, EX-B2, and SI15 in order. (3) The most commonly used total injection dosage was 1.0 cc at a time, and the frequency of treatment was twice a week. (4) Concurrent treatments such as acupuncture, herbal medication, physical therapy and Chuna manual therapy were performed in all 17 studies. (5) Pharmacopuncture therapy showed positive effects on cervical pain caused by traffic accidents in all 17 studies reviewed. Conclusion: Pharmacopuncture therapy was effective in cervical pain caused by traffic accidents in all 17 studies selected. Further studies will be needed using more larger scales and more objective data to confirm the effectiveness of pharmacopuncture therapy and to generalize its application.

• 한방재활의학과학회지
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• 제32권2호
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• pp.105-121
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• 2022

Objectives This study was conducted to evaluate the effect of electro-acupuncture for sciatica. Methods We searched 13 online databases (Kmbase, Research Information Sharing Service [RISS], National Digital Science Library [NDSL], Oriental Medicine Advanced Searching Integrated System [OASIS], Koreanstudies, Koreantk, DBpia, PubMed, Cochrane, EMBASE, Medline, China National Knowledge Infrastructure [CNKI], J-stage) to find randomized-controlled clinical trials (RCTs) that used electro-acupuncture for sciatica. Efficacy rate and visual analogue scale (VAS) were mainly analyzed as a main evaluation criteria. Results Among 583 articles that were searched, 24 RCTs were finally selected and 18 RCTs were statistically analyzed. Electro-acupuncture was more effective than acupuncture in terms of efficacy rate (p<0.00001) and VAS (p<0.00001). Also, Electro-acupuncture was more effective than western medication in terms of efficacy rate (p=0.0005). However, the effectiveness of electro-acupuncture was not identified compared to physical therapy (p=0.42). Electro-acupuncture significantly improved efficacy rate when combined with physical therapy than physical therapy alone (p<0.0001). In addition, electro-acupuncture plus Chuna manual therapy compared to Chuna manual therapy alone showed positive results for efficacy rate (p=0.05) and VAS (p<0.0001). Conclusions Based on results, the effectiveness of electro-acupuncture for sciatica was identified. However, this study has limitations because the RCTs included in this study were small in number and published in a particular region. Although this study could be a groundwork for well designed research for sciatica.

• 대한한의학회지
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• 제42권4호
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• pp.61-74
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• 2021

Objectives: This study aimed to analyse: 1) the clinical effectiveness and safety of traditional Korean Medicine (TKM) and frequency of TKM therapies used and their relationship with conventional treatments. Methods: This prospective observational study enrolled children with cerebral palsy (CP) aged 6-78 months (n=126). The children who used herbal medication for >30 days or acupuncture treatment >12 sessions within 6 months were defined as the integrated rehabilitation (IR) group; the remaining participants were included in the conventional rehabilitation (CR) group. Results: Changes in the Gross Motor Function Measure-66 (GMFM-66) were greater in the IR group (6.4±6.1) than in the CR group (4.6±5.8). The reduction in the number of other health problems was greater in the IR group than in the CR group. The GMFM-66 improvement was greatest in gross motor function classification system level 1. There was no between-group difference in the frequency of rehabilitation therapy (10.9±6.6 and 12.0±9.9 in the IR and CR groups, respectively). Conclusion: TKM may offer additional benefits in terms of the GMFM-66 score and other health problems. However, there is a need for further randomized controlled trials involving a restricted CP type and a controlled treatment type and intensity to confirm these findings.

• 대한본초학회지
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• 제24권4호
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• pp.49-53
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• 2009

Objectives : The protective effect of Vasopurus, a mixture of three medicinal plants, on atherosclerosis induced by dietary cholesterol in low density lipid (LDL) receptor deficient mice was studied. Methods : Experimental groups were divided into three groups of six animals each; a normal group (N); a high cholesterol group (HC), a high cholesterol plus Vasopurus group (HCVA). The experimental groups were fed for 6 months. Results : Vasopurus supplementation significantly lowered plasma total cholesterol and LDL cholesterol conc entrations compared with the high.cholesterol (HC) diet group. In addition, supplementation with Vasopurus significantly increased fecal cholesterol contents compared to mice fed a HC diet. Mice whose diet was supplemented by Vasopurus showed considerably fewer atherosclerotic plagues in the aortic values of heart and aortas compared to mice receiving the HC diet. Conclusions : These results indicate that Vasopurus has efficacy in anti.atherosclerosis medication.

• 대한한의학원전학회지
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• 제37권3호
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• pp.1-9
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• 2024

Objectives : This study aims to clarify the interpretation of the verse "jinyinhuabohetangxia(金銀花薄荷湯下)" in Zhouxuehai(周學海)'s corrective commentary in the Xiaoeryaozhenzhijue(小兒藥證直訣), by examining traditional pediatric texts in relation to the verse. Methods : For each of the three possible interpretations of the instructive phrase for taking herbal formulas-Lonicera flower with peppermint(金銀花+薄荷), gold and silver with peppermint(金銀+薄荷), and gold coin peppermint(金錢薄荷)-applications of these herbs in the various pediatric books were analyzed to determine the most appropriate interpretation. Results & Conclusions : The formulary composition of Liangjingwan(凉驚丸) and Wusewan(五色丸) seems to sufficiently target the pathology of pediatric convulsion(驚癎) and heart malnutrition(心疳). Furthermore, it seems unnecessary to add Lonicera flower(金銀花) to the gastrointestinal fragility(脾胃虛弱) of the malnourished(疳). Some of the herbal formulas in the pediatrics chapter of the Zhengzhizhunsheng(證治准繩) include Lonicera flower(金銀花) to treat only carbuncles(癰腫, 腫毒), while other books do not include it in their formulas. On the other hand, instructions to take water boiled with gold and silver appear in many texts, including the Xiaoeryaozhenzhijue(小兒藥證直訣), and sometimes include gold leaf(金箔) directly in the formula. Descriptions of gold and silver pots with instructions on how to make herbal formulas were found as well, which supports what Zhouxuehai(周學海) commented on the Xiaoeryaozhenzhijue(小兒藥證直訣). Although gold coin peppermint(金錢薄荷) is currently used as Lianqiancao(連錢草) in China, it was difficult to verify its identity as Jinqianbohe(金錢薄荷), which seems to have been recognized as a type of mint in the past. No reported anticonvulsant studies of Lonicera flower(金銀花), gold and silver(金銀), and Lianqiancao(連錢草) were found. Peppermint(薄荷) was ubiquitous in instructions for taking herbal formulas treating pediatric convulsions. Therefore, the instruction to take water boiled with gold and silver, or to take the herbal medicine in water boiled in a gold and silver pot, rather than using Lonicera flower(金銀花), could be considered as an interpretation closer to the original author's intent.

• Journal of Acupuncture Research
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• 제21권2호
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• pp.1-20
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• 2004

Objective : The aim of this study was to investigate effects of Angelica gigas Nakai(AGN) on the ischemic injury by intraluminal filament insertion in the rats. Methods : The ischemia was induced by intraluminal filament insertion into middle cerebral artery. AGN herbal acupuncture into SP10 was carried out during 3 weeks after ischemic injury. Eight-arm radial maze was designed for the behavioral task. AGN herbal acupuncture showed neuroprotective agents in cresyl violet, acetylcholinesterase(AchE), choline acetyltransferase(ChAT) and nerve growth factor(NGF)-stain. Then check the effect of regional cerebral blood flow(rCBF) according to AGN herbal acupuncture in rats. Results : The errors in the eight-arm radial maze task were significantly decreased in normal group compared with control group on 1~6days, AGN2(0.02g/kg) herbal acupuncture group on 1~5days, AGN3(0.1g/kg) on 1~3days, AGN4(0.5g/kg) on 1, 3~6days. The rate of correct choice was significantly increased in AGN1(0.01g/kg) and AGN4 herbal acupuncture groups. The density of neurons in the hippocampal CA1 was the most increased in normal group and AGN1, AGN3, AGN4 herbal acupuncture groups compared with control group. The density of AchE in the hippocampal CA1 had a tendency to increase in all the groups when they were compared with control group, but not significant. The density of ChAT in the hippocampal CA1 was significantly increased in normal group and AGN1, AGN4 herbal acupuncture groups compared with control group. The density of NGF in the hippocampal CA1 was significantly increased AGN4 herbal acupuncture group compared with control group. The rCBF was significantly increased in AGN1, AGN3 and AGN4 herbal acupuncture groups without the change of blood pressure. Conclusions : These results suggest that AGN herbal acupuncture can be used for controlling stroke in early stage as herbal medication.

• 동의신경정신과학회지
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• 제3권1호
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• pp.25-45
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• 1992

Many phychiatrists have reported that the change of serotonin concentration would cause mental disorder and affect the pathological conditions such as schizophrenia, depression and eating behabior. The end product of serotonin metabolism was excreted as 5-HIAA in urine. Serum lipids, according to the report, were concerned with obesity, said it was. This study aims to observe the changes of plasma serotonin, urinary 5-HIAA and serum lipids, making use of Fat Cell Mass rate of 27 normal persons and 42 psychosomatic patients. For this, I also observed the change of serotonin, 5-HIAA and lipids of the psychosomatic patients by the use of 3 kinds of herbs as treatment medication on the basis of physical symptoms and the results were obtained as follows; 1. Urinary 5-HIAA is correlated with the body water rate(r=0.381), while reversely correlated with the Fat Cell Mass rate(r=-0.330). 2. Compared the control group with the patients group for the serum lipids value, they showed the significant results ; $146.4{\pm}5.71$ mg/dl and $166.9{\pm}6.56$ mg/dl in the total cholestrol value over- weights, $471.2{\pm}42.99$ mg/dl in the total lipid value, and $158.1{\pm}6.50$ mg/dl and $181.1{\pm}6.30$ mg/dl in the phospholipid of the obesity, respectively. 3. With comparison of each group to other group to the others for Fat Cell Mass rate, the total cholesterol showed the significant differences when the Fat Cell Mass rate was 20% or more, HDL-cholesterol value when 30% or more, and triglyceride when 30% or more, respectively. 4. there was significant variations in the relations between Fat Cell Mass rate and body water, which body mass index was increased as the body water was decreased. 5. Fat Cell Mass rate was correlated with Cholesterol(r = 0.420), triglyceride (r = 0.443), and $\beta$-lipoprotein(r = 0.450) of serum lipids, while reversely correlated with HDL -Cholesterol(r = -0.354) and urinary 5- HIAA had the correlation coefficient of -0.330. 6. What related with body water rate urinary 5-HIAA (r = 0.381) and $\beta$-lipoprotein(r = -0.405). 7. there were significant changes in the total cholesterol value and HDL-Cholesterol Value of serum lipids after dose of Ondamtang, significant increase in the 5-HIAA value after dose of Samulansintang, and significant devrease in the Trigylceride value of serum lipids after dose of Shihosogansan. As a result, it was seen that there was direct correlations among the Fat Cell Mass, urinary 5-HIAA, and serum lipids and stress from the mental conditions was not correlated directly to Serotonin, 5-HIAA, and serum lipids. I would like to conclude, therefore, that the detailed study should be performed on the function of serotonin of hypothalamus.