The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Protective Effect of Vasopurus on Atherosclerosis Induced by Dietary Cholesterol in LDL $r^{-/-}$ Mice

Vasopurus의 LDL $r^{-/-}$ Mice에서 항동맥경화 효능

  • HwangBo, Mi-Hyang (Department of Food Science and Technology, The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Kim, Hyun-Jeong (Department of Food Science and Technology, The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Lee, In-Seon (Department of Food Science and Technology, The Center for Traditional Microorganism Resources, Keimyung University) ;
  • Chung, Tae-Ho (Department of Pharmacology, Kyungpook National University School of Medicine) ;
  • Kim, In-Kyeom (Department of Pharmacology, Kyungpook National University School of Medicine) ;
  • Shin, Heung-Mook (Department of Physiology, College of Oriental Medicine, Dongguk University)
  • 황보미향 (계명대학교 식품공학부 전통미생물연구소) ;
  • 김현정 (계명대학교 식품공학부 전통미생물연구소) ;
  • 이인선 (계명대학교 식품공학부 전통미생물연구소) ;
  • 정태호 (경북대학교 의과대학 약리학교실) ;
  • 김인겸 (경북대학교 의과대학 약리학교실) ;
  • 신흥묵 (동국대학교 한의과대학 생리학교실)
  • Published : 2009.12.30
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Abstract

Objectives : The protective effect of Vasopurus, a mixture of three medicinal plants, on atherosclerosis induced by dietary cholesterol in low density lipid (LDL) receptor deficient mice was studied. Methods : Experimental groups were divided into three groups of six animals each; a normal group (N); a high cholesterol group (HC), a high cholesterol plus Vasopurus group (HCVA). The experimental groups were fed for 6 months. Results : Vasopurus supplementation significantly lowered plasma total cholesterol and LDL cholesterol conc entrations compared with the high.cholesterol (HC) diet group. In addition, supplementation with Vasopurus significantly increased fecal cholesterol contents compared to mice fed a HC diet. Mice whose diet was supplemented by Vasopurus showed considerably fewer atherosclerotic plagues in the aortic values of heart and aortas compared to mice receiving the HC diet. Conclusions : These results indicate that Vasopurus has efficacy in anti.atherosclerosis medication.

Keywords

References

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