• Journal of Korean Academy of Fundamentals of Nursing
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• v.4 no.1
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• pp.19-30
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• 1997

This study was to investigate the method for shortening the body temperature (BT) because it takes a long time and is impractical to measure axillary or oral BT with mercury thermometer, The first approach was to identify BT change according to the measuring time and determine the clinically not statistically avaiable and optimal BT measuring time. The second was to test the accuracy of tympanic thermometer. It can measure BT within a few seconds, so if it is approved accurate, we can save BT measuring time by substitute tympanic thermometer for mercury thermometer. This study was conducted from 1, to 30 June, 1996. The subjects were 12men students of medicalk college and 29 women students of nursing school. The results were as follows ; 1) The 3, 5, 7, 9, 11, 13minute-measured axillary BT and 3, 5, 7, minute-measured BT showed somewhat linear relationship with time. It was difficult to find the optimum measuring time which were clinically significant. 2) For axillary tempeiature, the measuring time which were not statistically different was 11 and 13minute. But the real BT difference between 3 and 13minute, or between 5 and 13minute were very small and was within the range of daily variation. 3) For oral temperature, there was no intervals which showed the statistically insignificant. But like as axillary temperature, the difference between 3 and 7, or 5 and 7 minute were trivial by $0.3^{\circ}C$ and by $0.1^{\circ}C$ respectively. 4) Tympanic temperatures were lower than oral BTs which were measured with mercury thermometer by $0.26^{\circ}C$ (with ear tug) and $0.15^{\circ}C$(without ear tug). 5) The reliability of repeated measure tympanic temperature was better than without ear tug. With above results, we can't determine the optimal and cilically significant oral and axillary measuring time using mercury thermometer. However, because the real differences between measuring times were very small, so we recommend further study for the aged, the infants and the febrile patients. And we can't sure the accuracy of tympanic temperature but the reliability was better with ear tug than without ear tug.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.17 no.1
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• pp.197-207
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• 1987

This study was undertaken to investigate the relationships between film and processing solution at different processing temperatures. Three kinds of periapical film were used for this study. They included EP-2l film, DF-58, and A film Each film was processed by automatic film processor with RD-Ⅲ X-dol 90, and A processing solutions at 68° 74° 80° 86° and 92°F. Film density was measured with the densitometer, and base plus fog density, film relative speed, film contrast, and subject contrast were evaluated. The following results were obtained; 1. As the processing temperature was increased, base plus density was increased. Inadequate base plus fog densities were obtained with three films in combination with three processing solutions at 92°F. 2. Lowest base plus fog densities were obtained with A film, followed in ascending order by EP-21, and DF-58 film in combination with A or RD-Ⅲ processing solutions. The sequence of base plus fog densities was in ascending order by EP-21, A, and DF-58 film in combination with X-dol 90 processing solution. 3. The sequence of film relative speed values was in ascending order of EP-21, A, and DF-58 film in combination with A and RD-Ⅲ processing solutions, respectively. 4. As the processing temperature was increased, film contrast values was increased. The sequence of film contrast values was in descending order solution. The sequence of film contrast values was in descending order of EP-2l, DF-58, and A film in combination with RD-Ⅲ, X-dol 90 processing solution at 80°F. 5. As the processing temperature was increased, subject contrast was increased. The sequence of subject contrast was in descending order of A, X-dol 90, and RD-Ⅲ processing solution in combination with three films at 80°F. The sequence of subject contrast was in descending order of EP-21, A, and DF-58 film in combination with A processing solution at different processing temperatures.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.35 no.3
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• pp.146-152
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• 2009

Traditional surgical method or injection using filler is performed for soft tissue augmentation. Surgical methods have disadvantage of surgical morbidity. Commercially available injectable materials have the disadvantages such as resorption, short-term effect. repeated application and hypersensitivity. Significant shortcoming of cell therapy using autologous fibroblasts is delay of treatment effect. Chitosan/${\beta}$-glycerol phosphate (GP) solution has thermosensitive property and allows sol-gel transition at physiologic pH and temperature. These properties may resolve the delay of treatment effect. The purposes of this study are to evaluate the viscosity and pH changes of chitosan/${\beta}$-GP solutions and to evaluate the effect of chitosan/${\beta}$-GP solution on fibroblast proliferation and production of collagen. We measured the viscosity and pH as function of temperature, of the solution containing 1:0.7, 1:0.75, 1:0.8 chitosan (1, 10, 100, 700 kDa) /${\beta}$-GP. Fibroblasts from ears of 5 rats were cultured in chitosan/${\beta}$-GP solutions for 3 weeks. Cell proliferation and collagen contents were measured every week with WST (water-soluble tetrazolium salt) assay and Collagen assay respectively. The Results are 1) Chitosan(100 kDa<)/${\beta}$-GP solution (1:0.75) showed sol-gel transition at physiologic pH and body temperature and injectable properties. It will enable to resolve the delay in treatment effect 2) Cell proliferation and total collagen contents of the control group were increased with time. However, these decreased after the 1st week in experimental group 3) Collagen contents in the experimental group are higher than that of control group. Chitosan/${\beta}$-GP solution may provide favorable conditions for cell function

• Maxillofacial Plastic and Reconstructive Surgery
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• v.35 no.6
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• pp.427-431
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• 2013

Angioedema is defined as self-limited, localized swelling. The swelling is asymmetric, non-pitting, and non-tender. Common locations of swelling include periorbital area, lips, tongue, extremities, and bowel wall. A 54-year-old woman visited our hospital with the clinical complaint of left maxillary swelling. Swelling of the left maxillary area was diffuse and temperature of the involved area was normal. No infectious source was found on panoramic radiography and cone-beam computed tomography. After considering the patient's medical history and assessing clinical examination, we suspected angioedema and administered corticosteroid only. In the oral and maxillofacial area, proper diagnosis and prompt treatment of angioedema is important because angioedema of the tongue or larynx may lead to airway obstruction or a life-threatening condition.

• Journal of Dental Rehabilitation and Applied Science
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• v.19 no.1
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• pp.27-33
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• 2003

Excessive heat generation at the implant-bone interface may cause irreversible bone damage and loss of osseointegration. The effect of heat generation in vitro at the implant surface caused by abutment reduction with high-speed dental turbine was examined. Titanium-alloy abutments connected to a titanium alloy screw-implant embedded in an acrylic-resin block in a $37^{\circ}C$ water bath were prepared. Temperature changes were recorded via embedded thermocouples at the cervix and apex of the implant surface. Analysis of variance for repeated measures was used to compare seven treatment groups. Fifty seconds of continuous cutting with air and water coolant caused a mean temperature increase of $1.24^{\circ}C$ at apex and $5.77^{\circ}C$ at cervix. Similar intermittent cutting caused increase of $2.50^{\circ}C$ at apex and $1.64^{\circ}C$ at cervix. But, continuous cutting with air coolant caused a mean temperature increase of $6.47^{\circ}C$ at apex and $5.77^{\circ}C$ at cervix. Similar intermittent cutting caused increase of $6.47^{\circ}C$ at apex and $5.77^{\circ}C$ at cervix. Preparation of implant abutment does not lead to detrimental effect on peri-implant tissues provided that adequate cooling. However, without water cooling, extreme overheating could be provoked, reaching the critical temperature that would lead to irreversible bone damage within only a few seconds.

• The Journal of Internal Korean Medicine
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• v.39 no.4
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• pp.495-510
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• 2018

Objective: This study was designed to investigate the possibility of quantification of the diagnosis of abdominal coldness (AC) in patients with functional dyspepsia (FD). Methods: Forty-four patients with FD were enrolled in this study. Three Korean medicine doctors each randomly examined all abdomens. Diagnosis of AC was made by consensus of at least two of the doctors. Body temperature (oral by digital oral thermometer) and skin temperature (by digital infrared thermal imaging [DITI]) were measured, followed by administration of the Cold and Heat questionnaire (CHQ) and the Instrument of Pattern Identification for Functional Dyspepsia (IPIFD). Results: Of the 44 patients with FD, 22 were assigned to the AC group and 22 to the non-AC group. The concordance rate of diagnosis among the three doctors was 63.6% (28/44), with a ${\kappa}$ of 0.504, indicating means moderate agreement). Neither the oral nor the skin temperatures showed statistically significant differences between the AC and non-AC groups. However, the CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD were higher in AC group and showed statistically significant differences (p=0.010 and 0.009). Conclusions: This is the first study conducting quantitative measurements of abdominal coldness in patients with FD. Although oral and skin temperature showed no statistical significance between AC and non-AC groups, the concordance rate of diagnosis of AC among the three Korean Medicine doctors was moderate. The CHQ scores and 'Simultaneous Occurrence of Cold and Heat Syndromes pattern' scores of the IPIFD also suggest that diagnosis of AC is relevant to cold and heat patterns, and these questionnaires could be utilized as supportive data for the diagnosis of AC. Further studies should be conducted for the purpose of quantifying and standardizing abdominal examinations in Korean Medicine.

• Journal of the korean academy of Pediatric Dentistry
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• v.30 no.4
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• pp.707-714
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• 2003

Plasma Arc Curing(PAC) units operate at relatively high intensity and claimed to result in optimum properties of composite resin in a short curing time, so the interest of pediatric dentists about PAC units have been increased recently. But PAC units used for polymerizing restorative resins produce heat during operation. The purpose of this study was to evaluate temperature transmission through dentin of various depths using two types of PAC units(Flipo, Q-Lux plasma 100). The results from the present study can be summarized as follows : 1. When PAC be used continuously, temperature on tip was increased as curing times, and Q-Lux showed greater temperature rising(p<0.001). 2. Compared temperature transmission as dentin depth, temperature rising rate was decreased as dentin thickened(0.5, 1.0, 1.5, 2.0mm)(p<0.05). 3. Compared temperature transmission as resin depth, temperature rising rate was also decreased as resin thickened(1.0, 2.0mm)(p<0.05).

• Maxillofacial Plastic and Reconstructive Surgery
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• v.12 no.3
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• pp.8-22
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• 1990

This study was performed to evaluate the histopathologic changes of the rabbit tibial compact bone using internal irrigation with both cold and room - temperature saline on drilling. The medial surface of the rabbit tibia was drilled with specially designed pilot drill (2.0mm in diameter) at 300 rpm. When drilling, two different temperature salines were injected (experimental group I : $4^{\circ}C$ saline, experimental goup Ⅱ : room - temperature saline). And the control group was drilled without cooling agent. The three rabbits in each two experimental and control groups were sacrificed 1, 2, 4, and 8 weeks after. The bone tissues including the bony defects were fixed with 10% neurtal buffered formalin, decalcified with formic acid, embedded in paraplast, and sterile sectioned at 5-6${\mu}m$. And then tissue specimens were stained with H - E and observed under light microscope. The results were as follow : The experimental groups showed early bone repair than the control group at all intervals. They underwent the same course of bone repair until 4 weeks. But the experimental group I showed slightly better bone maturation than the experimental group Ⅱ at 8 weeks.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.5
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• pp.231-234
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• 2006

This study was designed to investigate the expression and production of interleukin-1beta $(IL-1{\beta})$ in human peripheral blood of trained runners and untrained controls after temporary moderate intensity exercise. Male long-distance trained runners (TR) and untrained sedentary control subjects (SED) ran for 1 h at 70% of heart rate reserve (HRR). $IL-1{\beta}$ gene and protein expressions were significantly higher in TR than those with SED at all 3 intervals examined independently. Significant increases in total sweat volume and oral temperature were observed after exercise in both groups, however, there were some differences between the groups. We conclude, therefore, that sweating due to exercise is associated with increase of $IL-1{\beta}$ and it is correlated with decrease of oral temperature.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10705-10711
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• 2015

Oral cancer is one of the most common and lethal cancers in the world. Combination chemotherapy coupled with nanoparticle drug delivery holds substantial promise in cancer therapy. This study aimed to evaluate the efficacy and safety of two dosages of our novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NPs) with attention to the MMP-2 mRNA profile in a 4-nitroquinoline-1-oxide induced oral squamous cell carcinoma (OSCC) model in the rat. Our results showed that both IV and oral dosages of DOX-MTX NP caused significant decrease in mRNA levels of MMP-2 compared to the untreated group (p<0.003). Surprisingly, MMP-2 mRNA was not affected in DOX treated compared to cancer group (p>0.05). Our results indicated that IV dosage of MTX-DOX is more effective than free DOX (12 fold) in inhibiting the activity of MMP-2 in OSCCs (P<0.001). Furthermore, MMP-2 mRNA expression in the DOX-MTX treated group showed a significant relation with histopathological changes (P=0.011). Compared to the untreated cancer group, we observed no pathological changes and neither a significant alteration in MMP-2 amount in either of healthy controls that were treated with oral and IV dosages of DOX-MTX NPs whilst cancer group showed a high level of MMP-2 expression compared to healthy controls (p<0.001).Taking together our results indicate that DOX-MTX NPs is a safe chemotherapeutic nanodrug that its oral and IV forms possess potent anti-cancer properties on aggressive tumors like OSCC, possibly by affecting the expression of genes that drive tumor invasion and metastasis.