Sweating by Exercise Controls Body Temperature through Increase of Interleukin-1beta

  • Bae, Jun-Sang (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Shin, Young-Oh (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Lee, Jeong-Beom (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Seok, Hyun (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Physiology, College of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Physiology, College of Medicine, Soonchunhyang University)
  • Published : 2006.10.01

Abstract

This study was designed to investigate the expression and production of interleukin-1beta $(IL-1{\beta})$ in human peripheral blood of trained runners and untrained controls after temporary moderate intensity exercise. Male long-distance trained runners (TR) and untrained sedentary control subjects (SED) ran for 1 h at 70% of heart rate reserve (HRR). $IL-1{\beta}$ gene and protein expressions were significantly higher in TR than those with SED at all 3 intervals examined independently. Significant increases in total sweat volume and oral temperature were observed after exercise in both groups, however, there were some differences between the groups. We conclude, therefore, that sweating due to exercise is associated with increase of $IL-1{\beta}$ and it is correlated with decrease of oral temperature.

Keywords

References

  1. Armstrong LE, Maresh CM. The induction and decay of heat acclimatisation in trained athletes. Sports Med 12: 302-312, 1991 https://doi.org/10.2165/00007256-199112050-00003
  2. Bagby GJ, Crouch LD, Shepherd RE. Exercise and cytokines: spontaneous and elicited responses. In: Hoffman-Goetz L ed, Exercise and Immune Function. 1st ed. CRC, Boca Raton, FL, p 55-77, 1996
  3. Baumann H, Gauldie J. The acute phase response. Immunol Today 15: 74-80, 1994 https://doi.org/10.1016/0167-5699(94)90137-6
  4. Bordin JO, Heddle NM, Blajchman MA. Biologic effects of leukocytes present in transfused cellular blood products. Blood 84: 1703-1721, 1994
  5. Buono MJ, Heaney JH, Canine KM. Acclimation to humid heat lowers resting core temperature. Am J Physiol 274: R1295-R1299, 1998
  6. Cohen MC, Cohen S. Cytokine function: a study in biologic diversity. Am J Clin Pathol 105: 589-598, 1996 https://doi.org/10.1093/ajcp/105.5.589
  7. DeRijk R, Michelson D, Karp B, Petrides J, Galliven E, Deuster P, Paciotti G, Gold PW, Sternberg EM. Exercise and circadian rhythm-induced variations in plasma cortisol differentially regulate interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) production in humans: high sensitivity of TNF alpha and resistance of IL-6. J Clin Endocrinol Metab 82: 2182-2191, 1997 https://doi.org/10.1210/jc.82.7.2182
  8. Dinarello CA. The biological properties of interleukin-1. Eur Cytokine Netw 5: 517-531, 1994
  9. Dinarello CA. Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed. J Endotoxin Res 10: 201- 222, 2004
  10. Drenth JP, Van Uum SH, Van Deuren M, Pesman GJ, Van der Ven-Jongekrijg J, Van der Meer JW. Endurance run increases circulating IL-6 and IL-1ra but downregulates ex vivo TNF- alpha and IL-1 beta production. J Appl Physiol 79: 1497-1503, 1995 https://doi.org/10.1152/jappl.1995.79.5.1497
  11. Karvonen MJ, Kentala E, Mustala O. The effect of training on heart rate: a longitudinal study. Ann Med Exp Biol Fenn 35: 307-315, 1957
  12. Knudsen PJ, Dinarello CA, Strom TB. Prostaglandins posttranscriptionally inhibit monocyte expression of interleukin 1 activity by increasing intracellular cyclic adenosine monophosphate. J Immunol 137: 3189-3194, 1986
  13. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL. Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin- 6) after septic shock, hemorrhagic shock, and severe trauma. Crit Care Med 25: 1813-1819, 1997 https://doi.org/10.1097/00003246-199711000-00018
  14. Moldoveanu AI, Shephard RJ, Shek PN. Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. J Appl Physiol 89: 1499-1504, 2000 https://doi.org/10.1152/jappl.2000.89.4.1499
  15. Pedersen BK, Ostrowski K, Rohde T, Bruunsgaard H. The cytokine response to strenuous exercise. Can J Physiol Pharmacol 76: 505- 511, 1998 https://doi.org/10.1139/cjpp-76-5-505
  16. Rhind SG, Castellani JW, Brenner IK, Shephard RJ, Zamecnik J, Montain SJ, Young AJ, Shek PN. Intracellular monocyte and serum cytokine expression is modulated by exhausting exercise and cold exposure. Am J Physiol Regul Integr Comp Physiol 281: R66-R75, 2001 https://doi.org/10.1152/ajpregu.2001.281.1.R66
  17. Rivier A, Pene J, Chanez P, Anselme F, Caillaud C, Prefaut C, Godard P, Bousquet J. Release of cytokines by blood monocytes during strenuous exercise. Int J Sports Med 15: 192-198, 1994 https://doi.org/10.1055/s-2007-1021046
  18. Schimidt JA, Abdulla E. Down-regulation of IL-1b biosynthesis by inducers of the heat shock response. J Immunol 141: 2027- 2034, 1988
  19. Shin YO, Oh JK, Sohn HS, Bae JS, Lee MY, Lee JB, Yang HM, Min YK, Song HY, Ko KK, Matsumoto T. Expression of exerciseinduced HSP70 in long-distance runner's leukocytes. J Therm Biol 29: 769-774, 2004 https://doi.org/10.1016/j.jtherbio.2004.08.053
  20. Sprenger H, Jacobs C, Nain M, Gressner AM, Prinz H, Wesemann W, Gemsa D. Enhanced release of cytokines, interleukin-2 receptors, and neopterin after long-distance running. Clin Immunol Immunopathol 63: 188-195, 1992 https://doi.org/10.1016/0090-1229(92)90012-D
  21. Thorpe R, Wadhwa M, Bird CR, Mire-Sluis AR. Detection and measurement of cytokines. Blood Rev 6: 133-148, 1992 https://doi.org/10.1016/0268-960X(92)90025-L
  22. Turnbull AV, Rivier CL. Regulation of the hypothalamic-pituitaryadrenal axis by cytokines: actions and mechanisms of action. Physiol Rev 79: 1-71, 1999 https://doi.org/10.1152/physrev.1999.79.1.1
  23. Wadhwa M, Seghatchian MJ, Lubenko A, Contreras M, Dilger P, Bird C, Thorpe R. Cytokine levels in platelet concentrates: quantitation by bioassays and immunoassays. Br J Haematol 93: 225- 234, 1996 https://doi.org/10.1046/j.1365-2141.1996.4611002.x
  24. Weinstock C, Konig D, Harnischmacher R, Keul J, Berg A, Northoff H. Effect of exhaustive exercise stress on the cytokine response. Med Sci Sports Exerc 29: 345-354, 1997 https://doi.org/10.1097/00005768-199703000-00009
  25. Westwood JT, Clos J, Wu C. Stress-induced oligomerization and chromosomal relocalization of heat-shock factor. Nature 353: 822- 827, 1991 https://doi.org/10.1038/353822a0
  26. Wu C, Zimarino V, Tsai C, Walker B, Wilson S. Transcriptional regulation of heat shock genes. In: Morimoto RI, Tissieres A, Georgopulos C ed, Stress Proteins In Biology And Medicine. 1st ed. Cold Spring Harbor Laboratory Press, NY, p 429-442, 1990
  27. Wyndham CH, Rogers GG, Senay LC, Mitchell D. Acclimization in a hot, humid environment: cardiovascular adjustments. J Appl Physiol 40: 779-785, 1976 https://doi.org/10.1152/jappl.1976.40.5.779