• 한방재활의학과학회지
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• 제21권4호
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• pp.41-47
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• 2011

Objectives: This study was performed to investigate single oral dose toxicity of TB001, the extract mixture of Purple loosestrife and Aceriphyllum rossii. Methods: The mortality, general symptom, change of weight: and necropcy findings was investigated for 14 days after a dose(2000 mg/kg B.W.) of TB001 was given, using SD rats of both male and female according to "The guideline of toxicity test for medicine and others". Results: The death of rats and abnormal finding was not observed. There was no the significant difference of weight between control group and TB001 group. Conclusions: The abnormalities at the necropsy finding of all survived rats was not detected. The study suggested that there is no toxicity in single dose(2000 mg/kg B.W.) of TB001.

• 한국치위생학회지
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• 제11권4호
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• pp.523-532
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• 2011

Objectives : The purpose of this study was to measure the effect of factors analyes the associated by the dental treatment fear of level dental hygiene and non-dental hygiene students, and then to provide basic material which can help to improveoral health and effective dental treatment. Methods : The subject in this study were 275 students in Jeolla region. The data were collected from March through April 2010, by way of the self-reported questionnaire. Results : 1. Subjects, who correspond to 'high fear level' which is more than 60 points in the scale of Dental Fear Survey, were indicated to be larger in collegians of general-related departments(38.9%) than collegians of health-related department(36.3%).2. Among three detailed factors, the treatment-stimulator response factor showed the higher fear sense than other 2 factors. In the physiological response, 'muscular tension' was 2.72 points, there by having been indicated to be the highest.3. The more belonging to the group with high fear was indicated to lead to the more in direct pain experience, in non-anesthesia pain experience, and in indirect pain experience through brothers and sisters. Even the symptom and syndrome in oral disease were indicated to be much. 4. As a result of comparing difference in dental fear level depending on pain experience, it was indicated that the more belonging to the group with high fear leads to the more in direct pain experience, in non-anesthesia pain experience, and in indirect pain experience through brothers and sisters. Conclusions : Dental fear must be controlled carefully in order to promote oral health and effective dental treatment.

• 한국치위생학회지
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• 제23권1호
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• pp.73-82
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• 2023

Objectives: This study aimed to evaluate the oral symptoms experiences of Korean adolescents among multicultural families. Methods: Data on 985 participants from the 16th Korea Youth Risk Behavior Web-based Survey were collected and analyzed using complex sample descriptive statistics. Results: The foreign-born mother, foreign-born parents, and foreign-born father rates were 77.2%, 17.3%, and 5.4%, respectively. The toothache, gingival bleeding, tooth fracture, and tooth sensitivity experience rates were 21.3%, 18.8%, 13.3%, and 30.4%, respectively. The tooth fracture rate was highest in the foreign-born parents group (24.6%). The toothache odds ratio (OR) was 1.71 (95% CI: 1.24-2.37) times higher in girls. The foreign-born mother group was 2.47 (95% CI: 1.09-5.60) times higher than that of the foreign-born father or both parents foreign-born groups. The smoking group was 2.03 (95% CI: 1.20-3.43) times higher than that of the non-smoking group. The gingival bleeding OR was 5.11 (95% CI: 1.80-14.53) times higher in the lowest economic status group. The tooth fracture OR was 3.44 (95% CI: 1.01-11.70) times higher in the lowest economic status group. The tooth sensitivity OR was 1.53 (95% CI: 1.14-2.04) times higher in girls. Conclusions: It is necessary to establish a program to promote oral health of adolescents from multicultural families.

• 대한한의학회지
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• 제44권4호
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• pp.41-58
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• 2023

Objectives: This retrospective observational study aimed to investigate the efficacy and safety of Cheongpebaedok-tang, a traditional Korean herbal medicine, provided via telemedicine to patients with asymptomatic to mild COVID-19 in Korea. Methods: From February to April 2020, a retrospective analysis investigated COVID-19 patients treated via Korean telemedicine. The study involved asymptomatic to mild cases receiving Cheongpebaedok-tang more than three times, along with continuous Korean medicine care in convalescence. Diagnoses and treatment adhered to the telemedicine guidelines of the Association of Korean Medicine, with varied Cheongpebaedok-tang prescriptions based on symptom severity. Symptom evaluation involved a detailed assessment using a 15-item tool at initial and final sessions. Results: The study included 27 patients, with a mean age of 48.7 ± 2.3 years (mean ± standard error). Patients began self-administering oral Cheongpebaedok-tang for an average of 19.4 ± 1.8 days after the date of COVID-19 diagnosis confirmation and continued the medication for 15.8 ± 1.2 days. The reported side effects of the Cheongpebaedok-tang included palpitations (11.1%), insomnia (7.4%), dizziness (3.7%), and diarrhea (3.7%). All side effects disappeared after adjusting the prescription according to standard treatment guidelines. The occurrence of all COVID-19-related adverse symptoms, except fatigue and myalgia, decreased. Fatigue was the most common chronic symptom persisting after 6 months (51.9%), followed by ocular symptoms (37.0%) and sore throat (22.2%). Conclusions: This study implies Cheongpebaedok-tang may offer a potentially safe, symptom-alleviating approach for managing mild COVID-19 cases via telemedicine, although further comprehensive research is warranted.

• 한국산학기술학회논문지
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• 제21권12호
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• pp.246-252
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• 2020

본 연구는 제15차(2019년) 청소년 건강행태 조사의 원시자료를 이용하여, 우리나라 다문화 청소년들의 건강 위험 행동들이 주관적인 구강 증상에 미치는 위험요인을 조사하였다. 다문화 가족 범위는 한국인 여성과 결혼한 이주 남성 가족, 한국인 남성과 결혼한 이주 여성 가족의 자녀로 한정 지었으며, 572명을 연구 대상자로 최종 선정하였다. 연구 도구는 사회경제학적 변수로는 성별, 학년, 경제 수준, 학교 성적이 조사되었으며, 건강위험 행태로는 음주, 흡연, 약물 복용, 스트레스, 수면 만족, 자살 생각, 우울 경험, 취침 전 잇솔질 여부가 조사되었고 구강 증상으로는 치아 통증, 잇몸 통증, 입 냄새 여부가 조사되었다. 연구 결과, 치아 통증은 음주, 취침 전 잇솔질, 스트레스, 수면시간, 자살 생각, 우울 경험 여부와 관련성을 나타냈으며, 잇몸 통증은 약물복용, 수면, 자살 생각, 우울 경험에서 관련성을 나타냈다. 그리고, 구취는 약물복용, 취침 전 잇솔질, 스트레스, 자살 생각, 우울 요인과 관련성을 보였다. 건강위험 요인이 구강 증상에 미치는 요인으로는 치아 통증은 음주, 스트레스, 수면시간이 위험요인으로 나타났다. 잇몸 통증은 흡연, 수면, 자살이 위험요인으로 나타났다. 구취는 취침 전 잇솔질 여부와 스트레스가 위험요인으로 나타났다. 결론적으로 청소년들의 구강 건강 증진을 위해 국가 차원의 방과 후 활동이나, 동아리 활동 등의 시간에 구강보건교육 프로그램을 지원하는 정책 제도 마련이 필요하다.

• Journal of Hospice and Palliative Care
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• 제1권1호
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• pp.65-68
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• 1998

The neuropathic pains are not well controlled by common analgesics and opioid drugs in terminal cancer patients. The types of these pains are divided within the two cages, one is due to continuous central sensitization and the other is due to paroxymal peripheral sensitization. The mechanism of continuous central sensitization is the activity of dorsal horn neurones that are activated by C-fiber input. The tricyclic antidepressants, non-tricyclic antidepressants, and oral local anaesthesia probably produce analgesic effects in neuropathic pains through suppression of this activity. The mechanism of paroxymal peripheral sensitization is the hyper-excitability of peripheral neurones. The neuropathic pains due to peripheral sensitization respond relatively the anticonvulsants and baclofen that stabilize membranes and suppress paroxymal electrical discharge. The patients was a 38-year-old female who complained of hyperthemia on upper right extremity. The symptom of this patient was improved with anticonvulsant(dilantin 600mg).

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제17권2호
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• pp.74-79
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• 2014

Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized non-IgE-mediated gastrointestinal food allergy. The diagnosis of FPIES is based on clinical history, sequential symptoms and the timing, after excluding other possible causes. It is definitively diagnosed by an oral food challenge test. Unfortunately, the diagnosis of FPIES is frequently delayed because of non-specific symptoms and insufficient definitive diagnostic biomarkers. FPIES is not well recognized by clinicians; the affected infants are often mismanaged as having viral gastroenteritis, food poisoning, sepsis, or a surgical disease. Familiarity with the clinical features of FPIES and awareness of the indexes of suspicion for FPIES are important to diagnose FPIES. Understanding the recently defined clinical terms and types of FPIES is mandatory to suspect and correctly diagnose FPIES. The aim of this review is to provide a case-driven presentation as a guide of how to recognize the clinical features of FPIES to improve diagnosis and management of patients with FPIES.

• 한국식품위생안전성학회지
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• 제9권3호
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• pp.111-116
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• 1994

The acute toxicity of orally administered Yan-Sheng health liquid (YSHL), water extracts from twelve Chinese drugs (Cervi Cornu, Lonicerae Flos, Foeniculi Fructus, Glycyrrhizae Radix, Liriopis Tuber, Raphani Semen, Bombyx, Ginseng Radix alba, Cinnamomi loureirii Cortex, Epimedii Herba, Zingiberis Rhizoma, Lycii Fructus) was evaluated in male and female Sprague-Dawley rats and ICR mice. Rats and mice aging 5 weeks were gavaged with 0, 2.0, 3.0, 4.4, 6.7, 10.0, 66.7, or 100.0 ml/kg of YSHL. No animal died by oral treatment and no toxic symptom was observed in the treated animals during 5 days. The body weight of the treated animals was not significantly different from the controls. The results of macroscopic examination on the organs of the treated animals revealed no abnormal findings. Therefore, it was concluded that YSHL was practically non-toxic when it was orally administered to rats and mice, and its LD50 was suspected to be greater than 100 ml/kg in rats and mice.

• 한국임상약학회지
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• 제11권2호
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• pp.89-96
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• 2001

Ziprasidone is equally effective as haloperidol in treating schizophrenia with fewer side effects and drug interactions. Ziprasidone is an atypical antipsychotic agent and works by blocking serotonin and dopamine receptors in the central nervous system, specifically 5-HT2A and D2 receptors. Low anticholinergic side-effects and low EPS would recommend the drug for use in the elderly. Ziprasidone inhibits reuptake of norepinephrine and serotonin at neurojunction sites in vitro, indicating a potential efficacy for depression and negative symptoms which often follow after exacerbation of schizophrenia. Patients with recent acute myocardial infarction and uncompensated heart failure are contraindicated to the drug due to a possibility of QT prolongation. Although ziprasidone is metabolized by cytochrome P450 3A4, there is no significant drug interaction with the drugs that induce or inhibit the isoenzyme. Ziprasidone is safe with coadministration of lithium and there has been no significant drug interaction reported with oral birth control pills.

• Journal of Chest Surgery
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• 제20권2호
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• pp.374-378
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• 1987

Plummer-Vinson syndrome is also termed Paterson-Brown-Kelly syndrome and sideropenic dysphagia, because it was described originally by Paterson and Kelly in 19`19 and it was often combined with iron-deficiency anemia. The syndrome is encountered most often in middle-aged anemic female. It is characterized by dysphagia referred to the upper esophagus, atrophy of the oral or pharyngeal mucous membranes, koilonychia, and stenosis or webs of the upper esophageal mucosa. And it is also related to the late occurrence of the carcinoma of the upper esophagus. Here is presented a case of upper esophageal web with dysphagia and iron-deficiency anemia with review of literature, which was treated by the surgical esophagoplasty to relieve the symptom of dysphagia and to widen the upper esophageal narrowing.