• 한국임상수의학회지
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• 제23권2호
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• pp.144-148
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• 2006

Apoptotic death of articular chondrocytes has been implicated in the pathogenesis of osteoarthritis. Tartrate resistant acid phosphatase (TRAP) has been used for several years as a marker enzyme of bone-resorbing osteoclasts. This study investigated the activity of TRAP in media of apoptotic cell death-induced canine chondrocyte. We exposed canine chondrocyte to capsaicin and the results showed that capsaicin induced cell death in a dose dependent manner. And we measured TRAP activity in media of chondrocyte death induced by capsaicin treatment and the results capsaicin significantly increased the activity of TRAP in media for dose dependent. We also investigated whether the combination treatment with capsaicin and TRAIL enhance apoptotic cell death in canine chondrocyte. We exposed canine chondrocyte to capsaicin for 24 hrs at the indicated dose, and then treated with recombinant TRAIL protein for 24 hrs. TRAIL alone did not induce cell death after 24 hours, but the combined treatment of both induced more cell death compared with capsaicin alone in a dose dependent manner. Also, the combination treatment with capsaicin and TRAIL increased the activity of TRAP in culture media. These results suggest that TRAP can flow out into extracellular after chondrocyte damage, and TRAP may be a successful biomarker for detection of joint disease such as osteoarthritis.

• Journal of Dental Anesthesia and Pain Medicine
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• 제22권3호
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• pp.161-174
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• 2022

Foreign body aspiration can produce a medical emergency. Obstruction of the airways can be life-threatening, and complications may develop in less-severe cases if it is left untreated. Although it is more prevalent in children by approximately three times, adults can still experience it, and it is more frequently related to healthcare in adults. Objects used in dental treatment are usually placed in the oral cavity and can be ingested or inhaled by accident. Dental treatment has been identified as an important cause of the misplacement of foreign bodies in the airway. However, few reports have been published on dentistry-related foreign body aspiration. This paper discusses the disease course, management, and clinical outcomes of foreign body aspiration, especially those associated with dentistry. The patient must be examined for respiratory distress. If the patient is unstable, urgent airway management and the maneuvers for removal should be performed. Radiographs and computed tomography can help identify and locate the object. The treatment of choice is often bronchoscopy, and both flexible and rigid endoscopes can be used depending on the situation. Preventive measures need to be implemented to avoid inhalation accidents given the potential consequences. Though the incidence is rare, healthcare levels need to be enhanced to avert morbidity and mortality. Radiological evaluation and bronchoscopy are vital for management.

• Nutrition Research and Practice
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• 제17권4호
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• pp.641-659
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• 2023

BACKGROUND/OBJECTIVES: The skin is the outermost organ of the human body and plays a protective role against external environmental damages, such as sunlight and pollution, which affect anti-oxidant defenses and skin inflammation, resulting in erythema or skin reddening, immunosuppression, and epidermal DNA damage. MATERIALS/METHODS: The present study aimed to investigate the potential protective effects of red orange complex H extract (ROC) against ultraviolet (UV)-induced skin photoaging in Skh:HR-2 mice. ROC was orally administered at doses of 20, 40, and 80 mg/kg/day for 13 weeks, along with UV irradiation of the mice for 10 weeks. RESULTS: ROC improved UV-induced skin barrier parameters, including erythema, melanin production, transepidermal water loss, elasticity, and wrinkle formation. Notably, ROC inhibited the mRNA expression of pro-inflammatory cytokines (interleukin 6 and tumor necrosis factor α) and melanogenesis. In addition, ROC recovered the UV-induced decrease in the hyaluronic acid and collagen levels by enhancing genes expression. Furthermore, ROC significantly downregulated the protein and mRNA expression of matrix metalloproteinases responsible for collagen degradation. These protective effects of ROC against photoaging are associated with the suppression of UV-induced phosphorylation of c-Jun NH2-terminal kinase and activator protein 1 activation. CONCLUSIONS: Altogether, our findings suggest that the oral administration of ROC exerts potential protective activities against photoaging in UV-irradiated hairless mice.

• 대한예방한의학회지
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• 제28권1호
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• pp.13-30
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• 2024

Objectives : This study aimed to investigate the history, current status, and regulation of complementary medicine in Australia. Methods : To investigate complementary medicine in Australia, we searched domestic and overseas academic databases, and websites of public and private organizations related to the Australian health care. Results : Complementary medicine consists of numerous services, among which massage and chiropractic care are significantly utilized by Australians. Since 2010, Australian healthcare practitioners, in the field of complementary medicine, have been supervised by the Australian Health Practitioner Regulation Agency (AHPRA). Those who AHPRA is responsible for managing acupuncturists, chiropractors, and osteopaths. Other professions are regulated by their own respective associations. Not only aforementioned services offered by specialists, but also consumption of oral supplements accounts for considerable portion of complementary medicine in Australia. Complementary medicine products, vitamins, and minerals are managed by the Therapeutic Goods Administration (TGA). In terms of insurance policy, the reimbursement of complementary medicine expenses in Australia is covered by the public healthcare insurance system, Medicare. Medicare covers acupuncture, chiropractic, and osteopathy services. Other complementary therapies are continuously reviewed to update their coverage under this scheme. Conclusion : In Australia, practitioner qualifications, education standards, and scope of procedures related to complementary medicine are systematically managed through legal regulations of the federal and state governments.

• 한국치위생학회지
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• 제20권6호
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• pp.809-817
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• 2020

Objectives: This study aimed to analyze the relationship between socioeconomic factors and the unmet dental care needs of the living alone and living with family elderly groups to confirm the differences in their influence. Methods: Data from the Korea Health Panel Study of 2016 were used to analyze a total of 4,987 individuals: 4,008 in living with family group and 979 in living alone group. Chi-square test and multiple logistic regression analyses were performed using SPSS Version 22 (p<0.05). Results: We observed that 16.5% and 28.3% of the participants from the living with family and living alone groups had unmet dental care needs, respectively, indicating that the living alone group had more unmet dental care needs. Income level, residential area, and healthcare security were significant factors related to the living with family group. In contrast, medical aid for healthcare security was a significant factor related to the living alone group (p<0.05). Conclusions: The results confirmed that socioeconomic factors that affect unmet dental care vary according to the living situation. Therefore, the government should identify the number of elderly individuals living alone, which is increasing annually. These individuals are vulnerable in almost all aspects, and the government should establish and implement appropriate oral healthcare policies to support them.

• 한국임상보건과학회지
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• 제3권1호
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• pp.268-275
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• 2015

Purpose. Most of halitosis is found by people than by themselves in their life. There are some people who are suffering from oral malodor psychasthenia although they do not have halitosis which may disturb social life by sociophobia. Methods. The subjects of this survey were the dental hygienic college students in Busan city and Gyeongnam province from December 1 to December 20, 2013, we use the 281 parts except for the 19 parts of a bad faith response of 300 parts. Results. As a response to the awareness of the halitosis of college students, "the smell became sometime" was highest in 63.3%, and tooth brushing of halitosis, In according to about awareness of halitosis brushing the number of cases showed a 73.4% increase when you answered "no" in case one day the number of brushing at least three times less than a minute halitosis awareness conducted brushing (p<0.05),in case of less than 1 minute brushing time, this was a statistically significant increase halitosis awareness (p<0.05). Conclusions. This study assessment the association between halitosis awareness and oral care habits was to provide students with the basis for education and counseling halitosis in clinical.

• 한국치위생학회지
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• 제16권2호
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• pp.185-193
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• 2016

Objectives: The purpose of the study was to examine the recognition and satisfaction of dental care customers after 1 year national health insurance coverage of dental scaling. Methods: A self-reported questionnaire was completed by 477 dental care customers in Gyeongbuk, Busan, Yangsan, and Gyeonggido from July 18 to September 30, 2014 after receiving informed consents. The questionnaire consisted of general characteristics of the subjects(5 items), subjective awareness of oral health(4 items), recognition of scaling(5 items), and recognition and satisfaction of scaling health insurance(5 items). Data were analyzed using SPSS version 20.0 program. Results: Those who recognized the national health insurance coverage of dental scaling accounted for 80.1 percent and 47.2 percent of them got the health insurance coverage via media advertisements. Those who received the scaling service by health insurance coverage accounted for 73.8% and 66.2% of them were very satisfied with the service. Among the customers, 91.8% were satisfied with scaling health allotment. There was a statistical significance between scaling health insurance and subjective oral condition recognition(p<0.01). Through the health insurance coverage scaling service, the oral health in Korea will improve much. Conclusions: The expansion of health insurance coverage of scaling service will provide the universal oral health care for all people. Owing to low cost service, people will actively try to come in contact with public health service in the future.

• Clinical and Experimental Pediatrics
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• 제52권3호
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• pp.376-379
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• 2009

가성 저알도스테론혈증은 신장 세뇨관의 알도스테론 수용체의 이상으로 알도스테론의 분비는 증가되지만 반응성은 감소되어 저알도스테론혈증의 증상을 보이는 질병이다. 가성 저알도스테론혈증은 다뇨증, 과도한 소변 내 염분소실, 저나트륨혈증, 고칼륨혈증, 대사성 산증을 특징으로 하며, 산전부터 다뇨 증상이 시작되면 양수과다증을 초래할 수 있다. 미숙아에서는 생후 초기 불감 수분 손실량이 많으며, 폐 기능과 신장 기능이 미숙하여 전해질 이상을 흔히 동반하는데, 몸무게의 소실에도 불구하고 지속적인 다뇨와 저나트륨혈증, 고칼륨혈증의 증상이 있다면 전해질 불균형을 초래하는 기저질환을 확인하여야 한다. 저자들은 양수 과다증의 산전력이 있는 산모에게서 출생한 재태주령 32주 미숙아에서 지속적인 몸무게 감소에도 불구하고 계속되는 다뇨와 저나트륨혈증, 고칼륨혈증이 있어 17수산화프로게스테론을 조기에 선별 검사하여 선천성 부신 과형성증의 가능성을 배제함으로써 불필요한 스테로이드 치료를 피하고, 지속적인 전해질 보충으로 점차 전해질 이상의 호전을 보인 가성 저알도스테론혈증 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 대한소아치과학회지
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• 제47권4호
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• pp.359-367
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• 2020

이 연구의 목적은 칸디다증과 유아기 우식증의 연관성을 밝히고, 생후 1년 내의 칸디다증 또는 칸디다 구내염 경험이 유아기 우식증의 위험 인자로 고려될 수 있는지 알아보는 것이었다. 이를 위해 건강 보험 심사 평가원에서 2010년 1월부터 2012년 12월까지 태어난 어린이들의 의료 급여 이용 기록을 제공받았으며, 이 중 치과 진료 기록이 없는 경우는 배제하였다. 연구 대상을 칸디다증 경험 여부, 칸디다 구내염 경험 여부에 따라 나누어 치아 우식 유병률을 비교하였다. 또한 생후 1년 이내에 의료 기록을 갖는 어린이들을 만 1세 이전의 칸디다증 경험 여부, 칸디다 구내염 경험 여부에 따라 분류해 각 집단의 만 1세 이후 치아 우식 유병률을 비교하였다. 칸디다증 또는 칸디다 구내염을 진단받았던 어린이 집단의 치아 우식 유병률은 두 질환을 경험하지 않은 어린이 집단과 유의한 차이를 나타냈다. 만 1세 이전에 칸디다증 또는 칸디다 구내염을 진단받았던 어린이 집단에서 만 1세 이후부터 만 6세 이전까지 치아 우식에 이환된 어린이의 비율은 두 질환을 진단받지 않은 어린이 집단과 의미 있는 차이를 보였다.

• 대한치과교정학회지
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• 제34권2호
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• pp.189-195
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• 2004

이 연구의 목적은 고정식 교정장치 부착환자에서 음파잇솔질과 수동잇솔질의 치면세균막 제거능력을 비교, 평가하여 교정치료시 지속적이고 효과적인 구강위생 관리 방법을 제시하고자 하는데 있다. 비발치 환자로 상, 하악 제 2대구치까지 고정식 교정장치를 부착한 청소년기 아동(남자 23명, 여자 37명)과 성인(남자 15명, 여자 45명)을 대상으로 하여 각각을 수동잇솔질과 음파잇솔질 군으로 분류하였다. 음파칫솔은 Philips oral healthcare HX-4401을 사용하였으며 잇솔질시간은 음파, 수동 모두 2분으로 표준화시켰다. 잇솔질 후 치면세균막 지수는 Wilkins의 PHP를 변형시켜 측정하였다. 각 군의 치면세균막 지수를 측정하여 비교한 결과 다음과 같은 결과를 얻었다. 1. 청소년, 성인 모두에서 음파잇솔군의 치면세균막지수 감소효과가 수동잇솔군에 비해 유의하게 크게 나타났다(청소년 : p<0.01 성인 : p<0.05). 2. 청소년과 성인을 구분하여 치면세균막지수 감소양상을 비교하였을 때 청소년에서 더 큰 감소 효과를 보였다.(p<0.01). 3. 같은 칫솔종류를 사용할 경우 청소년, 성인간에 유의한 차이를 보이지 않았다.