• Asian Pacific Journal of Cancer Prevention
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• v.17 no.9
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• pp.4233-4235
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• 2016

Background: Whole brain radiotherapy (WBRT) and stereotactic radiosurgery were frequently used to palliate patients with brain metastases. It remains controversial which modality or combination of therapy is superior especially in the setting of limited number of brain metastases. The availability of newer medical therapy that improves survival highlighted the importance of reducing long term radiation toxicity associated with WBRT. In this study, we aim to demonstrate the hippocampal sparing technique with whole brain and integrated simultaneous boost Materials and Methods: Planning data from 10 patients with 1-5 brain metastases treated with SRS were identified. Based on the contouring guideline from RTOG atlas, we identified and contoured the hippocampus with 5mm isocentric expansion to form the hippocampal avoidance structure. The plan was to deliver hippocampal sparing whole brain radiotherapy (HSWBRT) of 30 Gy in 10 fractions and simultaneous boost to metastatic lesions of 30 Gy in 10 fractions each. Results: The PTV, hippocampus and hippocampal avoidance volumes ranges between 1.00 - 39.00 cc., 2.50 - 5.30 cc and 26.47 - 36.30 cc respectively. The mean hippocampus dose for the HSWBRT and HSWBRT and SIB plans was 8.06 Gy and 12.47 respectively. The max dose of optic nerve, optic chiasm and brainstem were kept below acceptable range of 37.5 Gy. Conclusions: The findings from this dosimetric study demonstrated the feasibility and safety of treating limited brain metastases with HSWBRT and SIB. It is possible to achieve the best of both worlds by combining HSWBRT and SIB to achieve maximal local intracranial control while maintaining as low a dose as possible to the hippocampus thereby preserving memory and quality of life.

• Investigative Magnetic Resonance Imaging
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• v.18 no.3
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• pp.263-268
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• 2014

Neurosyphilis is a rare infection of the brain and spinal cord caused by a spirochete named Treponema pallidum. We describe the magnetic resonance imaging of a 53-year-old man with syphilis who manifested as both meningovascular, and spinal meningomyelitic types, which involved the optic, trigeminal, facial and vestibulocochlear nerves, both middle and left posterior cerebral arteries, thoracic spinal cord and meninges of the lumbar spine. This case report suggests that neurosyphilis should be considered as a possible diagnosis in patients showing complex brain and spinal imaging features. These features include enhancing meningeal lesions with multiple cranial nerve involvement, stenoses in large to medium size cerebral arteries, and intramedullary and meningeal lesions of spine.

• Journal of Korean Neurosurgical Society
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• v.46 no.1
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• pp.77-80
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• 2009

Orbital solitary fibrous tumor (SFT) is a rare tumor originating from the mesenchyme. We describe the clinical presentations, radiological and operative findings, and pathological features of a patient with orbital SFT. The patient was a 46-year-old female who presented with progressive proptosis advanced for 20 months. On ophthalmological examination, no visual impairment was detected, but left eye was found to be obviously protruded on exophthalmometry. Orbital magnetic resonance imaging showed a 2.5 ${\times}$ 2 ${\times}$ 2 cm, intensely enhanced mass in the left orbit, which compressed the eyeball forward and the optic nerve downward. The patient underwent frontal craniotomy with superior orbitotomy and gross total resection was performed for the tumor. The histopathological diagnosis including immunohistochemistry was a SFT. After the surgery, proptosis was markedly relieved without visual impairment. Although orbital SFT is extremely rare, it should be considered in the differential diagnosis of orbital tumors. Clinical presentations such as painless proptosis and CD34 immunoreactivity play a significant role in differentiating orbital SFT from other spindle-cell neoplasms of the orbit.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1899-1909
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• 2015

Glaucoma is one of the most common causes of blindness which is caused by increase of fluid pressure in the eye which damages the optic nerve and eventually causing vision loss. An automated technique to diagnose glaucoma disease can reduce the physicians’ effort in screening of Glaucoma in a person through the fundal retinal images. In this paper, optimal hyper analytic wavelet transform for Glaucoma detection technique from fundal retinal images is proposed. The optimal coefficients for transformation process are found out using the hybrid GSO-Cuckoo search algorithm. This technique consists of pre-processing module, optimal transformation module, feature extraction module and classification module. The implementation is carried out with MATLAB and the evaluation metrics employed are accuracy, sensitivity and specificity. Comparative analysis is carried out by comparing the hybrid GSO with the conventional GSO. The results reported in our paper show that the proposed technique has performed well and has achieved good evaluation metric values. Two 10- fold cross validated test runs are performed, yielding an average fitness of 91.13% and 96.2% accuracy with CGD-BPN (Conjugate Gradient Descent- Back Propagation Network) and Support Vector Machines (SVM) respectively. The techniques also gives high sensitivity and specificity values. The attained high evaluation metric values show the efficiency of detecting Glaucoma by the proposed technique.

• Journal of Chest Surgery
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• v.13 no.2
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• pp.149-153
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• 1980

Von Recklinghausen's disease is a systemic hereditary disorder with varied manifestations in bone, soft tissue, nervous system, and skin, the most common of which is the developement of multiple, small, cutaneous tumors with a characteristic histologic picture. Tumors develop after birth and before puberty in most cases, and they increase in number until old age. Malignant neoplasms that complicate multiple neurofibromatosis include gliomas of the optic nerve, astrocytomaas of the cerebral and cerebellar hemispheres, and sarcomas of peripheral nerves (femoral, tibial and intercostal nerves) and somatic soft tissues. Little attention has been paid to the presence of cystic lung disease in association with neurofibromatosis. Currently, most think of thoracic involvement in neurofibromatosis in terms of posterior mediastinal neuroma, pheochrocytoma, meningocele or, less commonly parenchymal pulmonary neurofibromas. Author have experienced 2 cases of Von Recklinghausen's disease. One case developed a hyge malignant Schwannoma in the parietal pleura of left 4th intercostal space and multiple benign neurofibromas (two in intercostal spacees and one in the neck) , and the other has several episodes of pneumothorax resulting from diffuse cystic lung disease which required closed thoracotomy drainage.

• Annals of Clinical Neurophysiology
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• v.10 no.1
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• pp.58-61
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• 2008

Sj$\ddot{o}$gren's syndrome (SS) is an autoimmune disease characterized by keratoconjunctivitis sicca and xerostomia. About thirty percent of patients with Sj$\ddot{o}$gren's syndrome experience nervous system involvement such as myelopaty, optic neuropathy, and peripheral neuropathy. The most common pattern of peripheral nerve involvement is axonal polyneuropathy. We present a case of demyelinating polyneuropathy in a patient with Sj$\ddot{o}$gren's syndrome, which had been proven by electrophysiology and pathology.

• Archives of Plastic Surgery
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• v.33 no.3
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• pp.388-391
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• 2006

Hemangioma is one of the most common congenital tumors in the region of the face and neck. Although histologically benign, these facial masses are clinically malignant for their deforming and inexorable growth, especially in so-called 'cavernous hemangioma'. Carvenous hemangioma is the most common primary tumor occurring in the adult orbit. This tumor has symptoms that characteristically develop over several years with slowly progressive proptosis, eyeball deviation, hyperopia, diplopia and optic nerve compression. Today, hemangiomas are being treated by various methods; steroids, electrocoagulation, injection of sclerosing agent, cryotherapy, radiation therapy, laser therapy, and surgical treatment, etc. In principle, surgical approaches to the orbit must provide maximum safety and optimal visualization. We have experienced a case of large cavernous hemangioma in the orbit inferolaterally. The surgical treatment of tumor was achieved by the bicoronal approach combined with inferomedial and inferolateral orbitotomy. This surgical approach allows better visualization of the tumor and greater protection of essential anatomic structures. We obtained satisfactory results in terms of aesthetic and functional consideration. We present our case with a brief review of the literature related to orbital cavernous hemangioma.

• Journal of Acupuncture Research
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• v.20 no.1
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• pp.209-217
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• 2003

Background : Multiple Sclerosis is characterized by chronic inflammation, demyelinization and neurogliosis(plaque) in optic nerve, brain and spinal cord, which is recurrent visual disturbance, sensory disturbance, motor disturbance and sphincter disturbance, etc. Objective : This study was performed to evaluate the treatment of acupuncture therapy including Herbal Acupuncture and Bee venom Herbal Acupuncture in Multiple Sclerosis. Methods : We treated 5 cases of Multiple Sclerosis patients with mainly Bee venom Herbal Acupuncture therapy, and herbal Acupuncture, sa-am acupuncture form 18th september, 2001 to december, 2002. Results : 1 Of 5 cases who were treated with above, 3 patients were mildly reduced symptoms and 2 patients were no changes. 2. There are two patients who were definitely appeared the recurrent symptoms on treatment period, but decreased the remission period than before. 3. It has not shown noticeable recurrent symptoms of 3 patients. Conclusions : Bee Venom Herbal Acupuncture therapy and other acupuncture therapies were effective in reducing the recurrent symptoms and remission perod, but it was not evaluated the chief complaints on 5 cases of Multiple Sclerosis. We think that it need the further study and clinical trial for Multiple Sclerosis and other neurological diseases.

• Ocean and Polar Research
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• v.28 no.3
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• pp.287-290
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• 2006

Eye growth and lens diameter of brown croaker Miichthys miiuy were positively allometric between hatching and 180 days post-hatch (d.p.h.). Eye growth in relation to head length and head height was nearly isometric. Eyes were formed completely at 14 d.p.h. At this age, the eye has a crystalline lens, an optic nerve fiber layer, a ganglion cell layer, an inner plexiform layer, an inner nuclear layer, an outer plexiform layer, an outer nuclear layer, an outer limiting membrane, and a pigment epithelium. The essential demands that must be met by the retina in this species pertain to light sensitivity and spatial resolution.

• Journal of Veterinary Clinics
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• v.26 no.3
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• pp.290-297
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• 2009

A 5-year-old, castrated male Yorkshire Terrier with strabismus and exophthalmos of the right eye was referred to the Veterinary Medical Teaching Hospital, Chungnam National University. Radiography, ultrasonography(US), computed tomography(CT) and magnetic resonance imaging(MRI), demonstrated a well-circumscribed, locally calcified mass of the retrobulbar region with contiguous bone structures invaded. Surgical removal of the adnexa, globe, optic nerve and the incorporated orbital neoplasm was performed. Primary orbital meningioma was confirmed by histopathologic examination.